Pub Date : 2021-01-01DOI: 10.53388/life2020-1230-401
R. Noor, S. Abdullah
{"title":"Growth retrieval of stressed bacterial cells: logic and contradictions","authors":"R. Noor, S. Abdullah","doi":"10.53388/life2020-1230-401","DOIUrl":"https://doi.org/10.53388/life2020-1230-401","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0401-0510.
N. Emmanuel, Nzayisenga Joseph, M. Connie, Habtu Michael
{"title":"Prevalence and factors associated with low birth weight among neonates in Rwanda: a prospective cross-sectional study","authors":"N. Emmanuel, Nzayisenga Joseph, M. Connie, Habtu Michael","doi":"10.53388/life2021-0401-0510.","DOIUrl":"https://doi.org/10.53388/life2021-0401-0510.","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0502-309
N. Chacón, L. Chacin-Bonilla, Italo M. Cesar
Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity against and during COVID-19. However, viral evasion mechanisms occur. Interference of the interferon-γ secretion, like in helminths immunomodulation, can contribute to COVID-19 severity. Immunomodulation can result in mild, moderate, or severe COVID-19 depending on which helminth is coinfecting by regulating or avoiding host cytokine and pro-inflammatory response, decreasing viral load, and affecting vaccineinduced antibody response. We discuss the implications of immunomodulation on COVID-19 caused by helminth co-infection and for public health in the context of COVID-19 vaccine use in helminth endemic zones.
{"title":"Implications of helminth immunomodulation on COVID-19 co-infections","authors":"N. Chacón, L. Chacin-Bonilla, Italo M. Cesar","doi":"10.53388/life2021-0502-309","DOIUrl":"https://doi.org/10.53388/life2021-0502-309","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity against and during COVID-19. However, viral evasion mechanisms occur. Interference of the interferon-γ secretion, like in helminths immunomodulation, can contribute to COVID-19 severity. Immunomodulation can result in mild, moderate, or severe COVID-19 depending on which helminth is coinfecting by regulating or avoiding host cytokine and pro-inflammatory response, decreasing viral load, and affecting vaccineinduced antibody response. We discuss the implications of immunomodulation on COVID-19 caused by helminth co-infection and for public health in the context of COVID-19 vaccine use in helminth endemic zones.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0518-204
Tuo Han, Haoyu Wu, Yanchao Hu, Yan Zhang, Congxia Wang
{"title":"Atypical double right coronary artery: a case report and literature review","authors":"Tuo Han, Haoyu Wu, Yanchao Hu, Yan Zhang, Congxia Wang","doi":"10.53388/life2021-0518-204","DOIUrl":"https://doi.org/10.53388/life2021-0518-204","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0524-308
A. Jafarzadeh, S. Ali, M. Nemati, Seyed Mohammad
{"title":"Combination therapy using low dose radiation, plasma exchange, and a robust antiviral may induce synergic beneficial interactions for mitigating severe COVID‐19","authors":"A. Jafarzadeh, S. Ali, M. Nemati, Seyed Mohammad","doi":"10.53388/life2021-0524-308","DOIUrl":"https://doi.org/10.53388/life2021-0524-308","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0708-111
Tuo Han, Jie Gao, M. Fatima, Yiwen Wang, Lixia Wang, Congxia Wang
{"title":"Tamoxifen does not deteriorate cardiac function in female alphaMHC-MerCreMer transgenic mice","authors":"Tuo Han, Jie Gao, M. Fatima, Yiwen Wang, Lixia Wang, Congxia Wang","doi":"10.53388/life2021-0708-111","DOIUrl":"https://doi.org/10.53388/life2021-0708-111","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/life2021-0721-536
Jingyi Liu, Qingxian Liu
{"title":"The impact of the COVID-19 outbreak on Australia’s public health and medical industry in 2020","authors":"Jingyi Liu, Qingxian Liu","doi":"10.53388/life2021-0721-536","DOIUrl":"https://doi.org/10.53388/life2021-0721-536","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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