A. Rastelli, A. C. Bernardi, C. Rodero, M. Chorilli, Kleber T. de Oliveira, D. Deng, V. Bagnato
{"title":"Antimicrobial photodynamic therapy mediated by chlorin e-6 photosensitizer against Streptococcus mutans biofilm (Conference Presentation)","authors":"A. Rastelli, A. C. Bernardi, C. Rodero, M. Chorilli, Kleber T. de Oliveira, D. Deng, V. Bagnato","doi":"10.1117/12.2528235","DOIUrl":"https://doi.org/10.1117/12.2528235","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82171365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reactive oxygen species goes beyond photodynamic therapy (Conference Presentation)","authors":"Xiaoyuan Chen","doi":"10.1117/12.2525919","DOIUrl":"https://doi.org/10.1117/12.2525919","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80742793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irati Beltrán Hernández, Tommaso Del Buono D’Ondes, Alessia Di Maggio, S. Oliveira
{"title":"Understanding the first steps towards immune-modulation triggered by nanobody-targeted photodynamic therapy (Conference Presentation)","authors":"Irati Beltrán Hernández, Tommaso Del Buono D’Ondes, Alessia Di Maggio, S. Oliveira","doi":"10.1117/12.2526108","DOIUrl":"https://doi.org/10.1117/12.2526108","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81105983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Frochot, P. Arnoux, S. Acherar, F. Baros, F. Lux, M. Verelst, O. Tillement, M. Barberi-Heyob
{"title":"Using x-ray in photodynamic therapy (Conference Presentation)","authors":"C. Frochot, P. Arnoux, S. Acherar, F. Baros, F. Lux, M. Verelst, O. Tillement, M. Barberi-Heyob","doi":"10.1117/12.2525588","DOIUrl":"https://doi.org/10.1117/12.2525588","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79835488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EGFR-targeted fluorescence guided surgery in head and neck cancer (Conference Presentation)","authors":"J. Warram","doi":"10.1117/12.2530659","DOIUrl":"https://doi.org/10.1117/12.2530659","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77827082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Furukawa, J. Usuda, M. Kimura, K. Miyajima, T. Matsubara, Shotaro Ono, E. Nakajima, N. Ikeda, H. Kato
{"title":"Combination therapy with photodynamic therapy in lung cancer (Conference Presentation)","authors":"K. Furukawa, J. Usuda, M. Kimura, K. Miyajima, T. Matsubara, Shotaro Ono, E. Nakajima, N. Ikeda, H. Kato","doi":"10.1117/12.2527891","DOIUrl":"https://doi.org/10.1117/12.2527891","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86882428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photodynamic therapy followed by abraxane chemotherapy can significantly suppress pancreatic cancer metastasis (Conference Presentation)","authors":"Zhiming Mai, Myung-Gyu Choi, T. Hasan","doi":"10.1117/12.2528195","DOIUrl":"https://doi.org/10.1117/12.2528195","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89651055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Collin T. Inglut, Yan Baglo, Barry J. Liang, Jillian Stabile, Yahya Cheema, G. Woodworth, Huang‐Chiao Huang
{"title":"Photosensitizing biomolecules and nanocrystals for anti-glioma photodynamic therapy (Conference Presentation)","authors":"Collin T. Inglut, Yan Baglo, Barry J. Liang, Jillian Stabile, Yahya Cheema, G. Woodworth, Huang‐Chiao Huang","doi":"10.1117/12.2525904","DOIUrl":"https://doi.org/10.1117/12.2525904","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85081347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Chen, Peter K. B. Palomaki, Juan He, R. Lanzafame, I. Stadler, Hamid El-Hamidi, Hui Liu, J. Celli, Michael R Hamblin, Ying-ying Huang, G. Shafirstein, H. Chung, Shin‐Tson Wu, Yajie Dong
Homogeneous, flexible light sources with pure, deep red color and sufficiently high power densities are necessary for more effective and widely used photodynamic therapy (PDT), but have been difficult to achieve with lasers or LED arrays at reasonably low cost. Quantum dot light emitting diodes (QLEDs) have outstanding wavelength tunability, ideal color purity, sufficient power density and unique form factors as thin, flexible, light weight and uniformly large area light sources, which will meet the pressing needs for PDT. Here we report QLEDs fabricated with emission wavelengths precisely tuned to match the absorption peaks of several FDA approved photosensitizers. Preliminary in-vitro studies with rigid on-glass QLEDs as photosensitizer activators demonstrate they can kill cancerous A431 cells or Methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable or better than control LED sources, indicating their potential for PDT treatments of cancers or infections. Computer simulation of light propagation in a tissue mimicking phantom suggests that about 50% of the QLED power can be delivered to a depth of about 4 mm from the treated surface. Recent progress on the fabrication of low-cost flexible QLEDs will be presented. Finally, the perspectives of using these devices for PDT to address medical conditions such as cancer treatment, wound repair or cosmetic dermatology will be discussed.
{"title":"Quantum dot light emitting diodes (QLEDs) as low-cost PDT light sources (Conference Presentation)","authors":"Hao Chen, Peter K. B. Palomaki, Juan He, R. Lanzafame, I. Stadler, Hamid El-Hamidi, Hui Liu, J. Celli, Michael R Hamblin, Ying-ying Huang, G. Shafirstein, H. Chung, Shin‐Tson Wu, Yajie Dong","doi":"10.1117/12.2525829","DOIUrl":"https://doi.org/10.1117/12.2525829","url":null,"abstract":"Homogeneous, flexible light sources with pure, deep red color and sufficiently high power densities are necessary for more effective and widely used photodynamic therapy (PDT), but have been difficult to achieve with lasers or LED arrays at reasonably low cost. Quantum dot light emitting diodes (QLEDs) have outstanding wavelength tunability, ideal color purity, sufficient power density and unique form factors as thin, flexible, light weight and uniformly large area light sources, which will meet the pressing needs for PDT.\u0000 \u0000Here we report QLEDs fabricated with emission wavelengths precisely tuned to match the absorption peaks of several FDA approved photosensitizers. Preliminary in-vitro studies with rigid on-glass QLEDs as photosensitizer activators demonstrate they can kill cancerous A431 cells or Methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable or better than control LED sources, indicating their potential for PDT treatments of cancers or infections. Computer simulation of light propagation in a tissue mimicking phantom suggests that about 50% of the QLED power can be delivered to a depth of about 4 mm from the treated surface. Recent progress on the fabrication of low-cost flexible QLEDs will be presented. Finally, the perspectives of using these devices for PDT to address medical conditions such as cancer treatment, wound repair or cosmetic dermatology will be discussed.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73145316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
THIS IS FOR THE SESSION "CAPABILITIES OF 5-ALA" The accumulation of the fluorescent photosensitizer protoporphyrin IX (PpIX) after systemic administration of 5-ALA proved high tumor selectivity and led to intra-operative fluorescence guidance during resection of malignant glioma. 5-ALA therefore also promises to be useful for PDT of malignant glioma. Preclinical investigations resulted in the establishment of an appropriate treatment planning strategy and treatment parameters. This can be outlined as follows: interstitial placement of cylindrical diffuser fibers (1 to 4 cm diffuser length) by stereotaxy after careful planning on CT/MRI scans, such that fibers are approximately 1 cm apart and as close as 3-4 mm from the contrast uptaking tumor border. Aim of the irradiation parameters (200 mW/cm diffuser length for 1 hour) is to reach >95% photobleaching of PpIX in at least one optical penetration depth (approx. 3 mm) from the fibers. The therapeutic penetration depth can be expected to reach significantly deeper and kill glioma cells within parts of the infiltration zone, which are no more highlighted by Gd-contrast uptake. So far, inoperable de novo and recurrent malignant glioma with sizes up to 3 cm in diameter proved amenable in clinical investigations. Intriguing longterm progression free and overall survivals led to the design of prospective clinical trials, which are expected to start recruitment in 2019. Further research should focus on individualizing treatment parameters, further improve PpIX accumulation, including the sensitization of cancer stem cells and explore the role of immune stimulation by PDT, including the possible synergistic effect of immune checkpoint inhibitors.
{"title":"Interstitial photodynamic therapy (iPDT) of brain tumours (Conference Presentation)","authors":"H. Stepp, A. Rühm, R. Sroka, W. Stummer","doi":"10.1117/12.2526128","DOIUrl":"https://doi.org/10.1117/12.2526128","url":null,"abstract":"THIS IS FOR THE SESSION \"CAPABILITIES OF 5-ALA\"\u0000\u0000The accumulation of the fluorescent photosensitizer protoporphyrin IX (PpIX) after systemic administration of 5-ALA proved high tumor selectivity and led to intra-operative fluorescence guidance during resection of malignant glioma. 5-ALA therefore also promises to be useful for PDT of malignant glioma. Preclinical investigations resulted in the establishment of an appropriate treatment planning strategy and treatment parameters. This can be outlined as follows: interstitial placement of cylindrical diffuser fibers (1 to 4 cm diffuser length) by stereotaxy after careful planning on CT/MRI scans, such that fibers are approximately 1 cm apart and as close as 3-4 mm from the contrast uptaking tumor border. Aim of the irradiation parameters (200 mW/cm diffuser length for 1 hour) is to reach >95% photobleaching of PpIX in at least one optical penetration depth (approx. 3 mm) from the fibers. The therapeutic penetration depth can be expected to reach significantly deeper and kill glioma cells within parts of the infiltration zone, which are no more highlighted by Gd-contrast uptake. So far, inoperable de novo and recurrent malignant glioma with sizes up to 3 cm in diameter proved amenable in clinical investigations. Intriguing longterm progression free and overall survivals led to the design of prospective clinical trials, which are expected to start recruitment in 2019. \u0000\u0000Further research should focus on individualizing treatment parameters, further improve PpIX accumulation, including the sensitization of cancer stem cells and explore the role of immune stimulation by PDT, including the possible synergistic effect of immune checkpoint inhibitors.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"665 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75941895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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