Pub Date : 2023-11-15DOI: 10.1007/s10847-023-01209-x
Wen-Chang Peng, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li, Da Ma
We use a highly water-soluble acyclic cucurbit[n]uril ACB-01 that bears eight carboxylate groups. ACB-01 has excellent solubility in water and high affinity to the cyanine dyes pseudoisocyanine (PIC) and pinacyanol (PIN) to afford 1:1 complexes. The complexation has been studied by UV–vis absorption, fluorescence and nuclear magnetic resonance (NMR) spectroscopy, and the binding constants (Ka) are determined to be (1.54 ± 0.15) × 106 M−1 and (6.09 ± 0.82) × 105 M−1, respectively. This complexation leads to the inhibition of the J-aggregation of PIC and H-aggregation of PIN. However, competitive guests methyl viologen and 1-adamantanamine hydrochloride can recover their respective J- and H-aggregation due to more stable complexation occurs between them and ACB-01. Thus, we have established a new method of reversibly controlling dye aggregation by regulating the concentration of ACB-01 and competitive guests.
{"title":"Reversible manipulation of organic dye aggregation through acyclic cucurbit[n]uril-based host-guest complexation","authors":"Wen-Chang Peng, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li, Da Ma","doi":"10.1007/s10847-023-01209-x","DOIUrl":"https://doi.org/10.1007/s10847-023-01209-x","url":null,"abstract":"<p>We use a highly water-soluble acyclic cucurbit[<i>n</i>]uril <b>ACB-01</b> that bears eight carboxylate groups. <b>ACB-01</b> has excellent solubility in water and high affinity to the cyanine dyes pseudoisocyanine (<b>PIC</b>) and pinacyanol (<b>PIN</b>) to afford 1:1 complexes. The complexation has been studied by UV–vis absorption, fluorescence and nuclear magnetic resonance (NMR) spectroscopy, and the binding constants (<i>K</i><sub>a</sub>) are determined to be (1.54 ± 0.15) × 10<sup>6</sup> M<sup>−1</sup> and (6.09 ± 0.82) × 10<sup>5</sup> M<sup>−1</sup>, respectively. This complexation leads to the inhibition of the J-aggregation of <b>PIC</b> and H-aggregation of <b>PIN</b>. However, competitive guests methyl viologen and 1-adamantanamine hydrochloride can recover their respective J- and H-aggregation due to more stable complexation occurs between them and <b>ACB-01</b>. Thus, we have established a new method of reversibly controlling dye aggregation by regulating the concentration of <b>ACB-01</b> and competitive guests.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138538465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-10DOI: 10.1007/s10847-023-01207-z
Natalya Sh. Lebedeva, Elena S. Yurina, Sabir S. Guseinov, Sergey A. Syrbu
Porphyrins, owing to their unique physicochemical properties, hold great potential as candidates for the synthesis of new materials and active pharmaceutical drugs. The introduction of functional groups into porphyrin structures enables the creation of novel compounds with finely tuned structural and optical properties, as well as complex-forming abilities. In this study, spectral and thermochemical investigations were conducted to explore the complex formation of 5-[4′-(N-methyl-1″,3″-benzoimidazol-2″-yl)phenyl]-10,15,20-tris-(N-methyl-3′-pyridyl)porphyrin triiodide with synthetic (poly[d(GC)2], poly[d(AT)2]) and natural (ssDNA, ctDNA) nucleic acids. It was observed that the porphyrin forms complexes with poly[d(AT)2] and ssDNA, localized within the major groove of the biopolymer. Additionally, the porphyrin forms multiple intercalation complexes with varying geometries when interacting with poly[d(GC)2] and ctDNA. These findings demonstrate a new potential for enhancing the selective binding of ligands with nucleic acids (NA). Moreover, the study highlights the methodological aspect that establishing the type of formed complexes based on ligands’ electronic absorption spectra, known as “fingerprints,“ may lead to incorrect conclusions.
{"title":"Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids","authors":"Natalya Sh. Lebedeva, Elena S. Yurina, Sabir S. Guseinov, Sergey A. Syrbu","doi":"10.1007/s10847-023-01207-z","DOIUrl":"10.1007/s10847-023-01207-z","url":null,"abstract":"<div><p>Porphyrins, owing to their unique physicochemical properties, hold great potential as candidates for the synthesis of new materials and active pharmaceutical drugs. The introduction of functional groups into porphyrin structures enables the creation of novel compounds with finely tuned structural and optical properties, as well as complex-forming abilities. In this study, spectral and thermochemical investigations were conducted to explore the complex formation of 5-[4′-(<i>N</i>-methyl-1″,3″-benzoimidazol-2″-yl)phenyl]-10,15,20-tris-(<i>N</i>-methyl-3′-pyridyl)porphyrin triiodide with synthetic (poly[d(GC)2], poly[d(AT)2]) and natural (ssDNA, ctDNA) nucleic acids. It was observed that the porphyrin forms complexes with poly[d(AT)2] and ssDNA, localized within the major groove of the biopolymer. Additionally, the porphyrin forms multiple intercalation complexes with varying geometries when interacting with poly[d(GC)2] and ctDNA. These findings demonstrate a new potential for enhancing the selective binding of ligands with nucleic acids (NA). Moreover, the study highlights the methodological aspect that establishing the type of formed complexes based on ligands’ electronic absorption spectra, known as “fingerprints,“ may lead to incorrect conclusions.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135137271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-04DOI: 10.1007/s10847-023-01208-y
Xia Tian, Jianrong Han, Sheng wei Zhou, Yupeng Wang, Yuting Li, Chengbin Wang, Wei Su, Shouxin Liu
A novel [c2] daisy chain was successfully constructed by the hermaphroditic monomer of dibenzo[24]-crown-8 (DB24C8) derivative bearing secondary ammonium salt (1) from the analysis of the solution-phase behavior of parent monomers and single-crystal X-ray analysis. 1H NMR spectroscopy was employed to show that the crown ether moiety and the secondary ammonium salt unit underwent acid–base and alkali metal cation dependent switches. The complexation behavior of this hermaphroditic monomer in the solution was further demonstrated to exhibit the controlled photophysical behavior as a reversible luminescent switch in the presence of acids or bases. Solid morphology was determined by SEM.
{"title":"Chemically controlled self-assembly behaviors of dibenzo-24-crown-8 bearing ammonium salt moiety","authors":"Xia Tian, Jianrong Han, Sheng wei Zhou, Yupeng Wang, Yuting Li, Chengbin Wang, Wei Su, Shouxin Liu","doi":"10.1007/s10847-023-01208-y","DOIUrl":"10.1007/s10847-023-01208-y","url":null,"abstract":"<div><p>A novel [c2] daisy chain was successfully constructed by the hermaphroditic monomer of dibenzo[24]-crown-8 (DB24C8) derivative bearing secondary ammonium salt (1) from the analysis of the solution-phase behavior of parent monomers and single-crystal X-ray analysis. <sup>1</sup>H NMR spectroscopy was employed to show that the crown ether moiety and the secondary ammonium salt unit underwent acid–base and alkali metal cation dependent switches. The complexation behavior of this hermaphroditic monomer in the solution was further demonstrated to exhibit the controlled photophysical behavior as a reversible luminescent switch in the presence of acids or bases. Solid morphology was determined by SEM.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135773674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, we designed and prepared two new β-cyclodextrins (1 and 2) bearing ethylene glycol chains to develop highly water-soluble cyclodextrins. They had excellent water solubility and could successfully dissolve 17-β-estradiol in water, which was considered a poorly soluble drug model. Additionally, the nuclear magnetic resonance structural analysis of a mixed sample of 17-β-estradiol and 1 in D2O–H2O suggested two different types of inclusion complexes with different 17-β-estradiol molecule orientations inside the cavity of 1.