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Assessment of Non-Contact Measurement Using a Microwave Sensor to Jugular Venous Pulse Monitoring 微波传感器在颈静脉脉搏监测中的非接触测量评估
Pub Date : 2021-03-09 DOI: 10.4236/JBISE.2021.143010
Satoshi Suzuki, M. Hoshiga, K. Kotani, T. Asao
The jugular venous pulse (JVP) waveform provides an insight into right heart function, and its assessment is important in patients with heart failure. However, the conventional pulse-transducer (contact) method for monitoring this waveform is not frequently used because it requires a high degree of skill. The aim of this study was to confirm the effectiveness of a prototype non-contact system that employs microwave radar (24 GHz, 7 mW; non-contact system) for JVP measurement. Experiments were conducted on eight healthy male volunteers (21.88 ± 0.99 years). JVP measurements were compared between the conventional contact method and the proposed non-contact method. Change in JVP waveform was measured in response to an angle of reclining in five steps from the supine position to 75° of elevation. The obtained JVP measurements were similar between the two methods. Because in the non-contact method the faint pulsation of the JVP is not suppressed by the pressure of a sensor placed on the skin, the prototype microwave radar system is particularly suitable for evaluating the JVP waveform.
颈静脉脉冲(JVP)波形提供了对右心功能的深入了解,其评估在心力衰竭患者中很重要。然而,用于监测该波形的传统脉冲换能器(接触)方法并不经常使用,因为它需要高度的技术。本研究的目的是确认采用微波雷达(24GHz,7mW;非接触系统)进行JVP测量的原型非接触系统的有效性。实验在8名健康男性志愿者(21.88±0.99岁)身上进行。比较了传统接触法和所提出的非接触法的JVP测量结果。JVP波形的变化是根据从仰卧位到75°仰角的五步倾斜角度测量的。所获得的JVP测量值在两种方法之间是相似的。因为在非接触方法中,JVP的微弱脉动不会被放置在皮肤上的传感器的压力抑制,所以原型微波雷达系统特别适合于评估JVP波形。
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引用次数: 3
Influence of Chitosan Characteristics in the Microencapsulation of Essential Oils 壳聚糖特性对精油微胶囊化的影响
Pub Date : 2021-03-09 DOI: 10.4236/JBISE.2021.143012
M. Arias, A. Lopez, M. Vilaseca, B. Vallès, R. Prieto, M. Simó, J. A. Valle, R. C. C. R. Valle, F. M. Bezerra, Jordi Puiggalí Bellalta
The fight against nosocomial infections in hospitals, has promoted the use of microencapsulated essential oils on medical wearing uniforms. These types of microcapsules can be improved with the use of antimicrobial polymers in the shell structure. Chitosan is one of the most used biopolymers and the effectiveness of the treatment can be increased with the combination of different molecular weight chains of chitosan. This modification in the composition of shell structure allows controlling the rate of hydrolysis and, therefore the amount of its cationic form. The main objective of this work is to define a methodology to get microcapsules with different shell compositions, using surfactants as stabilizers in their first step. Once they have been obtained, these microcapsules will be fixed into textile substrates with the objective to use these tissues as surgical and medical clothes to spread the antibacterial effect, in sanitary staff, as well as in the own patient. In the process of microencapsulation the molecular weight distribution of polymers, influences strongly the delivery mechanisms of the active principle, as well as the chemical characteristics of the textile substrate used in every case. In this work, several chitosan biopolymers have been checked. Structural changes in the stabilization first step and the influence of the cross-linking extension have been related with the final antibacterial effect when fixed on cotton substrates.
在医院抗击医院感染的斗争中,提倡在医用制服上使用微胶囊精油。这些类型的微胶囊可以通过在外壳结构中使用抗微生物聚合物来改进。壳聚糖是最常用的生物聚合物之一,不同分子量的壳聚糖链的结合可以提高处理的有效性。这种对外壳结构组成的修饰可以控制水解速率,从而控制其阳离子形式的量。这项工作的主要目的是确定一种方法来获得具有不同外壳组成的微胶囊,在第一步中使用表面活性剂作为稳定剂。一旦获得,这些微胶囊将被固定在纺织品基质中,目的是将这些组织用作外科和医疗服,在卫生人员和患者身上传播抗菌效果。在微胶囊化过程中,聚合物的分子量分布强烈影响活性成分的递送机制,以及在各种情况下使用的纺织品基质的化学特性。在这项工作中,已经检查了几种壳聚糖生物聚合物。当固定在棉花基质上时,稳定第一步的结构变化和交联延伸的影响与最终的抗菌效果有关。
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引用次数: 5
Improving CAD Hemorrhage Detection in Capsule Endoscopy 改进胶囊内窥镜对CAD出血的检测
Pub Date : 2021-03-09 DOI: 10.4236/JBISE.2021.143011
Polydorou Alexios, Sergaki Eleftheria, Polydorou Andreas, Barbagiannis Christos, Vardiambasis Ioannis, G. Giakos, Zervakis Michail
This study explores an automated framework to assist the recognition of hemorrhage traces and bleeding lesions in video streams of small bowel capsule endoscopy (SBCE). The proposed methodology aims to achieve fast image control (<10 minutes), save valuable time of the physicians, and enable high performance diagnosis. A specialized elimination algorithm excludes all identical consecutive frames by utilizing the difference of gray levels in pixel luminance. An image filtering algorithm is proposed based on an experimentally calculated bleeding index and blood-color chart, which inspects all remaining frames of the footage and identifies pixels that reflect active or potential hemorrhage in color. The bleeding index and blood-color chart are estimated of the chromatic thresholds in RGB and HSV color spaces, and have been extracted after experimenting with more than 3200 training images, derived from 99 videos of a pool of 138 patients. The dataset has been provided by a team of expert gastroenterologist surgeons, who have also evaluated the results. The proposed algorithms are tested on a set of more than 1000 selected frame samples from the entire 39 testing videos, to a prevalence of 50% pathologic frames (balanced dataset). The frame elimination of identical and consecutive frames achieved a reduction of 36% of total frames. The best statistical performance for diagnosis of positive pathological frames from a video stream is achieved by utilizing masks in the HSV color model, with sensitivity up to 99%, precision 94.41% to a prevalence of 50%, accuracy up to 96.1%, FNR 1%, FPR 6.8%. The estimated blood-color chart will be clinically validated and used in feature extraction schemes supporting machine learning ML algorithms to improve the localization potential.
本研究探索了一种自动化框架,以帮助识别小肠胶囊内窥镜检查(SBCE)视频流中的出血痕迹和出血病变。所提出的方法旨在实现快速图像控制(<10分钟),节省医生的宝贵时间,并实现高性能诊断。专门的消除算法通过利用像素亮度的灰度级差异来排除所有相同的连续帧。基于实验计算的出血指数和血液颜色图,提出了一种图像滤波算法,该算法检查镜头的所有剩余帧,并识别出颜色上反映活动或潜在出血的像素。出血指数和血液颜色图是根据RGB和HSV颜色空间中的颜色阈值估计的,并且是在对3200多个训练图像进行实验后提取的,这些图像来自138名患者的99个视频库。该数据集由胃肠病专家外科医生团队提供,他们也对结果进行了评估。所提出的算法在从整个39个测试视频中选择的1000多个帧样本上进行了测试,患病率为50%(平衡数据集)。相同帧和连续帧的帧消除实现了总帧的36%的减少。诊断视频流中阳性病理帧的最佳统计性能是通过在HSV颜色模型中使用掩码实现的,灵敏度高达99%,准确率94.41%至50%,准确率高达96.1%,FNR 1%,FPR 6.8%。估计的血液颜色图将进行临床验证,并用于支持机器学习ML算法的特征提取方案,以提高定位潜力。
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引用次数: 3
Estimation of Fatigue Strength of Reinforced Complete Upper Denture Using a Newly Designed Testing Machine: A Laboratory Research Project 基于新设计的全口义齿疲劳强度试验机的试验研究
Pub Date : 2021-02-07 DOI: 10.4236/JBISE.2021.142006
A. Prombonas, N. Poulis, E. Prombonas
In the present study, an aero pneumatic fatigue testing machine for complete dentures was designed, fabricated, and tested for the evaluation of the fatigue life of reinforced complete upper denture (CUD). On completion and testing, it was observed that the machine has the potential of generating reliable number of cyclic data. The machine’s performance was evaluated using test specimens of identical CUDs that were machined in conformity with standard procedures. The fatigue machine compressed the lower dental arch over the upper denture-specimen in centric occlusion, in the same way that the two masticatory muscles pull the lower jaw over the upper jaw during chewing. The incorporation of glass fibres into the CUD using a sandwich technique quadruples the lifespan of the denture (P = 0.004). The low standard deviation, along with the low coefficient of variation (CV) of the group of unreinforced dentures shows the repeatability of the results and the reliability of the machine. The high standard deviation and coefficient of variation of reinforced dentures was expected, since a high variation of results is usually recorded in fibre reinforcement cases. This research confirmed the view that the crack during denture fracture initiates in the anterior palatal area and propagates to the posterior.
本研究设计、制造并测试了一台用于全口义齿的气动疲劳试验机,用于评估增强型全口义齿(CUD)的疲劳寿命。在完成和测试后,观察到该机器具有生成可靠数量的循环数据的潜力。使用按照标准程序加工的相同CUD的试样来评估机器的性能。疲劳机在中心咬合的情况下将下牙弓压在上义齿样本上,就像咀嚼时两块咀嚼肌将下颌拉到上颌上一样。使用夹层技术将玻璃纤维掺入CUD可使义齿的寿命延长四倍(P=0.004)。低标准偏差以及无增强义齿组的低变异系数(CV)表明了结果的可重复性和机器的可靠性。强化义齿的标准偏差和变异系数较高,这是意料之中的事,因为在纤维强化病例中通常会记录到较高的结果变异。这项研究证实了义齿断裂过程中的裂纹从腭前部开始并向后部扩展的观点。
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引用次数: 0
Impact of Obesity in Non-Alcoholic Fatty Liver Disease 肥胖对非酒精性脂肪性肝病的影响
Pub Date : 2021-02-04 DOI: 10.4236/JBISE.2021.142004
Chanjugaa Uthayakumar, S. Kotalawala
“Non-alcoholic fatty liver disease” is the alarming health risk around the world today. Nearly 1/3 of the world’s population is affected by non-alcoholic fatty liver disease. Many scientists put forward two hit hypotheses to explain the pathophysiology of non-alcoholic fatty liver disease. With the aid of trials using Biopsy, ultrasound scan and molecular techniques, scientists explained an authentic evidence of non-alcoholic fatty liver disease progression is ultimately because of obesity and its commodities, such as Cardio vascular diseases, Diabetes and Metabolic syndrome. This review mainly focuses on how obesity leads to non-alcoholic fatty liver disease based on statistical analysis of different research studies conducted by the research scientists. In the analysis of 1980-2003, out of 505 individuals, 305 were affected with NAFLD and among them, 64.3% were obese. In the analysis of the period of 1996-2002, out of 550 NAFLD patients, 70.36% were obese. Also in the analysis of 2010-2015 period of time, mostly 90% of the NAFLD patients were obese. It was also revealed that, along with NAFLD and obesity, diabetes and hyperlipidemia also exist as the commodities of obesity. Attention of medical field is towards the treatment and analysis of non-alcoholic fatty liver disease which is expected to be the reason of liver transplant by 2020.
“非酒精性脂肪性肝病”是当今世界令人担忧的健康风险。世界上近三分之一的人口患有非酒精性脂肪性肝病。许多科学家提出了两种假说来解释非酒精性脂肪性肝病的病理生理。在活检、超声扫描和分子技术试验的帮助下,科学家们解释了非酒精性脂肪性肝病进展的真实证据,最终是由于肥胖及其衍生物,如心血管疾病、糖尿病和代谢综合征。本文主要通过对研究科学家进行的不同研究的统计分析,对肥胖如何导致非酒精性脂肪性肝病进行综述。在1980-2003年的分析中,505个人中有305人患有NAFLD,其中64.3%为肥胖。在1996-2002年期间的分析中,550例NAFLD患者中,70.36%为肥胖。同样在2010-2015年期间的分析中,90%的NAFLD患者为肥胖。研究还发现,除了NAFLD和肥胖外,糖尿病和高脂血症也作为肥胖的商品存在。医学界对非酒精性脂肪性肝病的治疗和分析日益关注,预计到2020年非酒精性脂肪性肝病将成为肝移植的主要原因。
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引用次数: 1
Can We Diminish Spreading of the COVID-19 Pandemic? 我们能减少新冠肺炎大流行的传播吗?
Pub Date : 2021-01-26 DOI: 10.4236/JBISE.2021.141002
S. Haber, A. Tsuda
We hypothesized that liquid menisci occlusions may form inside small airways, travel along the airway while losing mass and finally may disintegrate into bioaerosols. Spreading of the COVID-19 virus is strongly related to the number of such bioaerosols exhaled by “super-spreaders”. We show, employing numerical methods, that this number can be diminished by administering surfactants which lower the surface-tension of the mucus which covers the airways.
我们假设液体半月板闭塞物可能在小气道内形成,在失去质量的同时沿着气道移动,最终可能分解成生物气溶胶。COVID-19病毒的传播与“超级传播者”呼出的这种生物气溶胶的数量密切相关。我们用数值方法表明,这个数字可以通过施用表面活性剂来降低覆盖气道的粘液的表面张力而减少。
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引用次数: 1
Hammering Sound Frequency Analysis to Fix an Acetabular Cup during Total Hip Arthroplasty: Clinical Trials and Biomechanical Studies 全髋关节置换术中固定髋臼杯的锤击声频率分析:临床试验和生物力学研究
Pub Date : 2021-01-26 DOI: 10.4236/JBISE.2021.141003
R. Sakai, K. Uchiyama, Kensuke Fukushima, N. Takahira, K. Yoshida, M. Ujihira
Failure during total hip arthroplasty may lead to bedridden of the elderly. Since the acetabulum cup fix in an anatomically deep region, failures, such as loosening and fracture, occur three times more frequently compared with failures of the stem fix in the femur. We investigated the possibility of evaluating whether fixation was acquired by frequency analysis of the hammering sound of implanting a cup into the acetabulum. The subjects were 11 patients (11 joints) who underwent total hip arthroplasty, biomechanical test materials, and orthopedic models. Surgeries and experiments were performed by orthopedists specialized in the hip. A system was constructed with a tablet PC and directional microphone, the peak frequency at which the amplitude reached the maximum was determined, and judgment processing (stable, unstable) of cup fixability was performed in real time. The stable maximum peak frequency observed in the clinical trials was 4.42 ± 4.02 kHz. The mean stable maximum peak frequency in the biomechanical tests was 4.46 ± 1.19 kHz in biomechanical test materials and 4.56 ± 2.02 kHz in orthopaedicmodels. When hammering was continued, the frequency leading to fracture decreased in both biomechanical test materials and orthopaedicmodels. In conclusion, in clinical trials and biomechanical studies, variation of the maximum peak frequency decreased when fixation was acquired and the frequency stabilized. It was suggested that this method can serve as a fixability evaluation method of acetabular cups because analysis can be performed in real time during surgery, for which prevention of intraoperative fracture can be expected.
全髋关节置换术失败可能导致老年人卧床不起。由于髋臼杯固定在解剖学上较深的区域,松动和骨折等失败发生的频率是股骨柄固定失败的三倍。我们研究了通过对髋臼内植入杯的锤击声的频率分析来评估是否获得固定的可能性。研究对象为11例患者(11个关节),均采用全髋关节置换术、生物力学测试材料和骨科模型。手术和实验由专门从事髋关节的骨科医生进行。用平板电脑和定向传声器构建系统,确定振幅达到最大值时的峰值频率,并实时进行杯子固定性的判断处理(稳定、不稳定)。临床试验中观察到的稳定最高峰频率为4.42±4.02 kHz。生物力学试验中,生物力学试验材料的平均稳定峰值频率为4.46±1.19 kHz,骨科模型的平均稳定峰值频率为4.56±2.02 kHz。当持续锤击时,生物力学测试材料和矫形模型中导致骨折的频率都降低了。总之,在临床试验和生物力学研究中,获得固定后,最大峰值频率的变化减小,频率稳定。提示该方法可作为髋臼杯固定性评估方法,术中实时分析,可预防术中骨折。
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引用次数: 3
Breast Asymmetry Evaluation Using Objective Measures after Breast Cancer Surgery 癌症手术后乳腺不对称性的客观评价
Pub Date : 2021-01-26 DOI: 10.4236/JBISE.2021.141001
Jaejong Park, F. Haque, Achille Louodom Chedjou, Michael J. Miller, Alok Sutradhar
Although a positive cosmetic outcome is an important goal of breast cancer reconstruction, the objective analysis of breast aesthetics has yet to reach a gold standard or unified method to quantify breast symmetry. Several scoring systems, both subjective and objective, have been developed over the years to ensure the desirable outcome in breast symmetry, but these methods have yet to reach the unanimous acceptance in terms of accuracy, value and ease of use to be implemented in the clinical setting. By assessing several existing symmetry scores, most of which are based on 2D imaging, along with our own set of symmetry parameters applied to 3D patient images, the goal of this study is to determine if there is an advantage of 3D imaging in formulating an accurate objective breast aesthetic score over the existing objective scores. A reliable breast aesthetic score would improve the decision-making in surgery as well as improve patient satisfaction. Additionally, knowing the quantity and degree of breast asymmetry objectively will improve outcome and reduce revision rates, minimizing patient suffering and improving the overall quality of patient life and body image.
虽然积极的美容结果是乳腺癌重建的重要目标,但乳房美学的客观分析尚未达到量化乳房对称性的黄金标准或统一方法。多年来,为了确保乳房对称的理想结果,已经开发了几种主观和客观评分系统,但这些方法在准确性、价值和易用性方面尚未达到一致接受,无法在临床环境中实施。通过评估几种现有的对称评分,其中大多数是基于2D成像,以及我们自己的一套对称参数应用于3D患者图像,本研究的目的是确定3D成像在制定准确的客观乳房美学评分方面是否优于现有的客观评分。一个可靠的乳房美学评分可以改善手术决策,提高患者满意度。此外,客观地了解乳房不对称的数量和程度将改善预后,降低翻修率,最大限度地减少患者的痛苦,提高患者的整体生活质量和身体形象。
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引用次数: 1
Detection of Angioectasias and Haemorrhages Incorporated into a Multi-Class Classification Tool for the GI Tract Anomalies by Using Binary CNNs 基于二元cnn的胃肠道异常多分类工具中血管扩张和出血的检测
Pub Date : 2021-01-01 DOI: 10.4236/jbise.2021.1412034
Christos Barbagiannis, Alexios A Polydorou, M. Zervakis, A. Polydorou, Eleftheria Sergaki
The proposed deep learning algorithm will be integrated as a binary classifier under the umbrella of a multi-class classification tool to facilitate the automated detection of non-healthy deformities, anatomical landmarks, pathological findings, other anomalies and normal cases, by examining medical endoscopic images of GI tract. Each binary classifier is trained to detect one specific non-healthy condition. The algorithm analyzed in the present work expands the ability of detection of this tool by classifying GI tract image snapshots into two classes, depicting haemorrhage and non-haemorrhage state. The proposed algorithm
本文提出的深度学习算法将被整合为一个二元分类器,在多类分类工具的框架下,通过检查胃肠道的医学内窥镜图像,实现对非健康畸形、解剖标志、病理发现、其他异常和正常情况的自动检测。每个二元分类器被训练来检测一个特定的非健康状态。本工作中分析的算法通过将胃肠道图像快照分为两类,描绘出血和非出血状态,扩展了该工具的检测能力。提出的算法
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引用次数: 1
Implementation of Machine Learning Classification Regarding Hemiplegic Gait Using an Assortment of Machine Learning Algorithms with Quantification from Conformal Wearable and Wireless Inertial Sensor System 利用保形可穿戴和无线惯性传感器系统量化的机器学习算法实现偏瘫步态的机器学习分类
Pub Date : 2021-01-01 DOI: 10.4236/jbise.2021.1412035
R. LeMoyne, Timothy Mastroianni
The quantification of gait is uniquely facilitated through the conformal wearable and wireless inertial sensor system, which consists of a profile comparable to a bandage. These attributes advance the ability to quantify hemiplegic gait in consideration of the hemiplegic affected leg and unaffected leg. The recorded inertial sensor data, which is inclusive of the gyroscope signal, can be readily transmitted by wireless means to a secure Cloud. Incorporating Python to automate the post-processing of the gyroscope signal data can enable the development of a feature set suitable for a machine learning platform, such as the Waikato Environment for Knowledge Analysis (WEKA). An assortment of machine learning algorithms, such as the multilayer perceptron neural network, J48 decision tree, random forest, K-nearest neighbors, logistic regression, and naïve Bayes, were evaluated in terms of classification accuracy and time to develop the machine learning model. The K-nearest neighbors achieved optimal performance based on classification accuracy achieved for differentiating between the hemiplegic affected leg and unaffected leg for gait and the time to establish the machine learning model. The achievements of this research endeavor demonstrate the utility of amalgamating the conformal wearable and wireless inertial sensor with machine learning algorithms for distinguishing the hemiplegic affected leg and unaffected leg during gait. for characterizing the sagittal plane of the thighs during gait. The Y-direction gyroscope signal was the basis for composing the feature set for machine learning classification. The sampling rate of the BioStamp nPoint was set to 250 Hz.
通过保形可穿戴和无线惯性传感器系统,步态的量化是唯一方便的,该系统由一个类似绷带的轮廓组成。考虑到偏瘫的影响腿和未受影响的腿,这些属性提高了量化偏瘫步态的能力。记录的惯性传感器数据,包括陀螺仪信号,可以很容易地通过无线方式传输到一个安全的云。将Python集成到陀螺仪信号数据的自动后处理中,可以开发适合机器学习平台的功能集,例如Waikato Environment for Knowledge Analysis (WEKA)。各种机器学习算法,如多层感知器神经网络、J48决策树、随机森林、k近邻、逻辑回归和naïve贝叶斯,在分类精度和开发机器学习模型的时间方面进行了评估。基于区分偏瘫患腿和未患腿步态的分类精度和建立机器学习模型的时间,k近邻算法获得了最优性能。本研究的成果表明,将保形可穿戴和无线惯性传感器与机器学习算法相结合,可以在步态中区分偏瘫的影响腿和未影响腿。用于描述步态时大腿矢状面。y方向陀螺仪信号是构成机器学习分类特征集的基础。设置BioStamp nPoint的采样率为250hz。
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引用次数: 2
期刊
生物医学工程(英文)
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