Chinese Journal of Plastic and Reconstructive Surgery最新文献_第2页

TcPO2 and TcPCO2 monitoring for free flap perfusion assessment tcppo2和TcPCO2监测游离皮瓣灌注评估

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-05-10 DOI: 10.1016/j.cjprs.2025.04.001

Fangfang Liu , Nannan Han , Huimin Yuan , Lei Wang , Jinxiu Dong , Yanfen Ding , Min Ruan , Youguo Ying

Background

Free flap transplantation has emerged as a prevalent technique in reconstructive surgery for patients with oral cancer. Postoperative monitoring of flap perfusion is critical for flap survival, necessitating early detection and timely intervention. Developing a monitoring approach that is highly sensitive, specific, non-invasive, continuous, and cost-effective is crucial for accurately assessing flap perfusion and informing clinical decisions.

Methods

From April 2024 to December 2024, 20 patients with oral tumors requiring flap transplantation were enrolled at the Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Continuous monitoring of various free flaps was performed utilizing a transcutaneous blood gas analyzer, both before and after surgery. This approach allowed for real-time measurement of transcutaneous partial pressure of oxygen (TcPO₂) and transcutaneous partial pressure of carbon dioxide (TcPCO₂), facilitating the evaluation of perfusion dynamics across various free flap types.

Results

After free flap transplantation, a reduction in blood supply resulted in a rapid decline in TcPO₂ (to below 10 mmHg), accompanied by a gradual increase in TcPCO₂, peaking at 135 mmHg. Following vascular anastomosis and blood flow restoration, TcPO₂ and TcPCO₂ exhibited opposite trends. Statistical analysis revealed no significant differences in TcPO₂ and TcPCO₂ measurements among the various flap types (P<0.05), indicating a consistent pattern of change across all flaps.

Conclusion

The transcutaneous blood gas analyzer proves to be a reliable method for monitoring free flap perfusion. Dynamic changes in TcPO₂ and TcPCO₂ effectively reflect blood supply status, enabling early detection of vascular compromise and potentially enhancing flap preservation outcomes.

Trial registration

ChiCTR, ChiCTR2400086395. Registered March 4, 2024. Prospective registration. https://www.medicalresearch.org.cn/&nearr;ChiCTR2400086395.

游离皮瓣移植已成为口腔癌患者重建手术的一种流行技术。术后皮瓣灌注监测对皮瓣存活至关重要，需要及早发现并及时干预。开发一种高度敏感、特异性强、无创、连续且具有成本效益的监测方法对于准确评估皮瓣灌注并为临床决策提供信息至关重要。方法选取上海交通大学医学院附属第九人民医院于2024年4月至2024年12月收治的20例需要皮瓣移植的口腔肿瘤患者。在手术前后，利用经皮血气分析仪对各种游离皮瓣进行连续监测。这种方法允许实时测量经皮氧分压（TcPO2）和经皮二氧化碳分压（TcPCO2），便于评估各种自由皮瓣类型的灌注动力学。结果游离皮瓣移植后，血供减少导致TcPO2迅速下降（低于10 mmHg）， TcPCO2逐渐增加，峰值为135 mmHg。在血管吻合和血流恢复后，tcppo2和TcPCO2表现出相反的趋势。统计分析显示，不同皮瓣类型的tcppo2和TcPCO2测量值无显著差异（P<0.05），表明所有皮瓣的变化模式一致。结论经皮血气分析仪是监测游离皮瓣血流灌注的可靠方法。tcppo2和TcPCO2的动态变化能有效反映血供状况，有助于早期发现血管受损，并有可能提高皮瓣保存的效果。试验注册chictr， ChiCTR2400086395。注册于2024年3月4日。未来的登记。https://www.medicalresearch.org.cn/& nearr ChiCTR2400086395。

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引用次数: 0

Bibliometric analysis of three-dimensional printing in craniofacial and craniomaxillofacial applications: Research trends, key contributors, and collaboration networks 三维打印在颅面和颅颌面应用的文献计量学分析：研究趋势、主要贡献者和合作网络

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1016/j.cjprs.2025.06.004

Siddig Ibrahim Abdelwahab , Abdullah Farasani , Zenat A. Khired , Ahmad Assiri , Abdelkhalig Hussein Elhilu , Waseem Hassan

Background

Three-dimensional (3D) printing has revolutionized craniofacial and craniomaxillofacial applications, leading to substantial advancements in patient-specific treatments. In this study, a bibliometric analysis was performed to identify the key contributors, research trends, thematic developments, and collaboration networks in this evolving field.

Methods

Two search strategies were employed to ensure a comprehensive analysis: (1) a broad search, in which selected keywords were searched in the title, abstract, and keyword fields to capture all relevant publications, and (2) a title-specific search, in which keywords were restricted to the title field to identify publications with a strong focus on 3D printing in craniofacial and craniomaxillofacial applications. The retrieved dataset was analyzed using VOSviewer and RStudio (bibliometrix package).

Results

The broad search retrieved 3 534 publications, whereas the title-specific search yielded 280 publications. The analysis of these 280 papers focused on identifying the top authors, universities, and countries, as well as their research dynamics and collaboration networks. A more detailed approach was adopted by examining the titles of these 280 papers. VOSviewer segmented the titles into approximately 800 words, which were then categorized into 18 distinct thematic groups to represent research trends. The focus areas of the ten most cited papers were also analyzed.

Conclusion

This bibliometric study provides valuable insights into the progress in 3D printing for craniofacial and craniomaxillofacial applications. By highlighting the key contributors, thematic developments, and collaborative networks, this study offers a foundation for future research in this rapidly advancing field.

三维（3D）打印已经彻底改变了颅面和颅颌面应用，导致了患者特异性治疗的实质性进展。在这项研究中，进行了文献计量分析，以确定这一不断发展的领域的主要贡献者、研究趋势、主题发展和合作网络。方法采用两种搜索策略来确保全面分析：(1)广泛搜索，在标题、摘要和关键词字段中搜索选定的关键词，以捕获所有相关出版物；(2)标题特定搜索，将关键词限制在标题字段中，以识别重点关注颅面和颅颌面3D打印应用的出版物。使用VOSviewer和RStudio （bibliometrix软件包）对检索到的数据集进行分析。结果广义检索检索到文献3 534篇，标题检索检索到文献280篇。对这280篇论文的分析侧重于确定顶级作者、大学和国家，以及他们的研究动态和合作网络。通过检查这280篇论文的标题，采用了更详细的方法。VOSviewer将这些标题分割成大约800个单词，然后将其分为18个不同的主题组，以代表研究趋势。分析了十大被引论文的重点领域。结论本文献计量学研究为3D打印在颅面和颅颌面应用的进展提供了有价值的见解。通过突出关键贡献者、主题发展和协作网络，本研究为这一快速发展领域的未来研究奠定了基础。

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引用次数: 0

Prevention of postoperative complications in axillary lymphadenectomy through adhesive application 应用粘接剂预防腋窝淋巴结切除术术后并发症

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-08-28 DOI: 10.1016/j.cjprs.2025.08.004

Igor Vladimirovich Reshetov, Viktoriia Vitalievna Nebezheva, Natalya Sergeevna Sukortseva, Alim Arsenovich Nebezhev

Background

Postoperative complications, particularly those involving lymphatic drainage, remain a significant challenge for patients undergoing axillary lymphadenectomy (ALND) as part of breast cancer surgery. These complications can delay the initiation of adjuvant therapies, increase healthcare costs, and negatively affect patients’ quality of life. This study evaluated the use of a latex-based tissue adhesive (LTA) as an intraoperative strategy to prevent seroma formation and prolonged lymphorrhea following axillary dissection.

Methods

In this prospective study, 65 female patients diagnosed with stage IIb–III breast cancer and clinically confirmed axillary lymph node involvement were enrolled. Participants were divided into two groups. The study group (n=33) received an intraoperative application of LTA without drainage, while the control group (n=32) underwent standard ALND with placement of a silicone vacuum drain. Postoperative outcomes assessed included lymphatic drainage volume, number of aspirations, duration of lymphorrhea, length of hospital stay, and incidence of complications.

Results

Use of the LTA significantly reduced both the volume and duration of postoperative lymphorrhea. By postoperative day 10, the average wound exudate volume in the LTA group was 8.2 ± 3.3 mL, compared to 54.1 ± 3.9 mL in the control group—an 84.8% reduction. The LTA group also experienced shorter hospital stays and fewer cases of postoperative seroma requiring intervention.

Conclusion

LTA appears to be a safe, effective, and practical intraoperative technique for preventing lymphatic complications after ALND. Its use may reduce dependence on drainage systems, shorten hospitalization, and support earlier initiation of adjuvant therapies, ultimately improving surgical outcomes and patient recovery.

作为乳腺癌手术的一部分，腋窝淋巴结切除术（ALND）患者的术后并发症，特别是涉及淋巴引流的并发症仍然是一个重大挑战。这些并发症可延迟辅助治疗的开始，增加医疗保健费用，并对患者的生活质量产生负面影响。本研究评估了使用乳胶基组织粘接剂（LTA）作为术中策略，以防止腋窝清扫后血清肿形成和延长淋巴漏。方法本前瞻性研究纳入65例诊断为ii - iii期乳腺癌且临床证实腋窝淋巴结受累的女性患者。参与者被分成两组。研究组（n=33）采用术中应用LTA不引流，对照组（n=32）采用标准ALND并放置硅胶真空引流管。术后结果评估包括淋巴引流量、吸痰次数、淋巴漏持续时间、住院时间和并发症发生率。结果使用LTA可显著减少术后淋巴漏的数量和持续时间。术后第10天，LTA组平均创面渗出量为8.2±3.3 mL，对照组为54.1±3.9 mL，减少84.8%。LTA组的住院时间更短，术后需要干预的血肿病例也更少。结论lta是一种安全、有效、实用的预防ALND术后淋巴并发症的术中技术。它的使用可以减少对引流系统的依赖，缩短住院时间，并支持早期开始辅助治疗，最终改善手术结果和患者康复。

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引用次数: 0

Botulinum toxin in orofacial muscle hypertonicity: Clinical insights and therapeutic applications 肉毒杆菌毒素对口面肌高张力的影响：临床观察和治疗应用

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.1016/j.cjprs.2025.08.001

Rudhra Kannan, Ranjith Mari, Anitha Balaji, Preethi Padmanaban

Orofacial muscle hypertonicity, characterized by excessive muscle tension in the facial and masticatory regions, can lead to significant functional impairment and aesthetic concerns. Botulinum toxin type A (BoNT-A), widely known for its cosmetic applications, has emerged as a valuable therapeutic tool in dentistry and maxillofacial medicine. This review explores the pharmacological mechanisms, anatomical considerations, and clinical applications of BoNT-A in the treatment of functional disorders such as bruxism, masseter hypertrophy, temporomandibular joint dysfunction, and facial asymmetry. Emphasis is placed on precision-guided injection techniques, region-specific dosing trends, and formulation-specific performance. Adverse effects, although generally mild and self-limiting, are preventable through anatomical expertise and individualized protocols. Preliminary clinical observations and recent East Asian data suggest variations in the response patterns and optimal dosing strategies. This review also highlights the current gaps, including the need for long-term safety data, standardized training for dental practitioners, and comparative evaluations with non-pharmacological therapies. BoNT-A is a minimally invasive interdisciplinary approach for restoring oral function and facial harmony, supporting its integration into modern dental practice.

口面肌张力过高，其特征是面部和咀嚼区肌肉过度紧张，可导致严重的功能损害和审美问题。A型肉毒杆菌毒素（BoNT-A）因其美容用途而广为人知，已成为牙科和颌面医学中有价值的治疗工具。本文综述了BoNT-A在磨牙、咬肌肥大、颞下颌关节功能障碍和面部不对称等功能障碍治疗中的药理机制、解剖学考虑和临床应用。重点放在精确导向注射技术、特定区域的给药趋势和特定配方的性能。不良反应，虽然一般轻微和自限性，是可以预防通过解剖专业知识和个性化方案。初步的临床观察和最近的东亚数据表明，在反应模式和最佳给药策略方面存在差异。这篇综述还强调了目前的差距，包括对长期安全性数据的需要，对牙科医生的标准化培训，以及与非药物治疗的比较评估。BoNT-A是一种微创的跨学科方法，用于恢复口腔功能和面部和谐，支持其融入现代牙科实践。

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引用次数: 0

Treatment efficacy of sclerotherapy by polidocanol vs. bleomycin for pyogenic granuloma in children: A comparative study 多元醇与博来霉素硬化治疗儿童化脓性肉芽肿疗效比较研究

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1016/j.cjprs.2025.07.002

Shengmiao Li , Xiaoying Wu , Chunfen Luo , Linjun Yu

Background

Pyogenic granuloma (PG) is a benign vascular skin lesion that occurs in children. Although, sclerotherapy is a common treatment for patients with PG, all the previous studies have been case reports or series. At present, no reports have compared the efficacy of the two different sclerosing agents, polidocanol and bleomycin, in the treatment of PG. Therefore, we aimed to compare the cure rates and adverse reactions associated with these two agents in sclerotherapy for PG in children.

Methods

This retrospective analysis included children <18 years of age with PG undergoing cutaneous treatment at our hospital between January 2016 and January 2022. Two sclerosing agents, polidocanol and bleomycin, were topically injected. The efficacy and incidence of adverse reactions were compared between the two groups.

Results

A total of 117 children with PG were divided into the polidocanol (n=52) and bleomycin (n=65) groups. Lesions disappeared after one injection in 38 children, two in 11 children, and three in 3 children in the polidocanol group. A similar phenomenon was observed after one injection in 53 children, two injections in 8 children, and three injections in children in the bleomycin group. The single-injection cure rate was not significantly different between the two groups (P>0.05). The rate of adverse reactions was significantly different between the two groups (P<0.05). No severe complications occurred, and no recurrences were detected during the 6–12 months of postoperative follow-up period.

Conclusion

This study showed that both polidocanol and bleomycin are safe and effective sclerosing agents for treatment of PG in children. The incidence of adverse reactions to polidocanol was lower than that to bleomycin. We recommend sclerotherapy with polidocanol as a first-line treatment for PG, as it is suitable for application in hospitals at various levels.

背景化脓性肉芽肿（PG）是一种发生于儿童的良性血管性皮肤病变。虽然硬化治疗是PG患者的常用治疗方法，但以往的研究均为病例报告或系列研究。目前还没有报道比较两种不同的硬化剂poly - canol和博来霉素治疗PG的疗效。因此，我们的目的是比较这两种药物在儿童PG的硬化剂治疗中的治愈率和不良反应。方法回顾性分析2016年1月至2022年1月在我院接受皮肤治疗的18岁PG患儿。局部注射两种硬化剂，聚多坎醇和博来霉素。比较两组患者的疗效及不良反应发生率。结果117例PG患儿分为多元醇组（n=52）和博来霉素组（n=65）。38例患儿注射1次后病变消失，11例患儿2例，3例患儿3例。博莱霉素组53例患儿注射1次，8例患儿注射2次，3例患儿注射3次均出现类似现象。两组患者单次注射治愈率差异无统计学意义（P>0.05）。两组不良反应发生率比较，差异有统计学意义（p < 0.05）。术后随访6 ~ 12个月，无严重并发症发生，无复发。结论聚多卡因醇和博来霉素是治疗小儿PG安全有效的硬化剂。聚多卡因不良反应发生率低于博来霉素。我们推荐将聚多卡因硬化治疗作为PG的一线治疗，因为它适合于各级医院的应用。

{"title":"Treatment efficacy of sclerotherapy by polidocanol vs. bleomycin for pyogenic granuloma in children: A comparative study","authors":"Shengmiao Li , Xiaoying Wu , Chunfen Luo , Linjun Yu","doi":"10.1016/j.cjprs.2025.07.002","DOIUrl":"10.1016/j.cjprs.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Pyogenic granuloma (PG) is a benign vascular skin lesion that occurs in children. Although, sclerotherapy is a common treatment for patients with PG, all the previous studies have been case reports or series. At present, no reports have compared the efficacy of the two different sclerosing agents, polidocanol and bleomycin, in the treatment of PG. Therefore, we aimed to compare the cure rates and adverse reactions associated with these two agents in sclerotherapy for PG in children.</div></div><div><h3>Methods</h3><div>This retrospective analysis included children <18 years of age with PG undergoing cutaneous treatment at our hospital between January 2016 and January 2022. Two sclerosing agents, polidocanol and bleomycin, were topically injected. The efficacy and incidence of adverse reactions were compared between the two groups.</div></div><div><h3>Results</h3><div>A total of 117 children with PG were divided into the polidocanol (<em>n</em>=52) and bleomycin (<em>n</em>=65) groups. Lesions disappeared after one injection in 38 children, two in 11 children, and three in 3 children in the polidocanol group. A similar phenomenon was observed after one injection in 53 children, two injections in 8 children, and three injections in children in the bleomycin group. The single-injection cure rate was not significantly different between the two groups (<em>P</em>>0.05). The rate of adverse reactions was significantly different between the two groups (<em>P</em><0.05). No severe complications occurred, and no recurrences were detected during the 6–12 months of postoperative follow-up period.</div></div><div><h3>Conclusion</h3><div>This study showed that both polidocanol and bleomycin are safe and effective sclerosing agents for treatment of PG in children. The incidence of adverse reactions to polidocanol was lower than that to bleomycin. We recommend sclerotherapy with polidocanol as a first-line treatment for PG, as it is suitable for application in hospitals at various levels.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"7 3","pages":"Pages 127-132"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical refinement of the reverse homodigital dorsoradial flap: A preliminary case report on flap optimization for radial thumb defects 同指背桡侧逆行皮瓣的技术改良：拇指桡侧缺损皮瓣优化的初步病例报告

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 DOI: 10.1016/j.cjprs.2025.08.002

Nhat Dang Huy Nguyen , Huy Anh Pham , Phu Man Truong Ho , Phi Duong Nguyen

Soft tissue reconstruction of the radial thumb tip remains surgically challenging, particularly when standard options such as kite or Brünelli flaps are less suitable due to anatomical constraints. This technical note presents the case of a 37-year-old male with a radial-sided distal thumb defect reconstructed using a reverse homodigital dorsoradial flap. Two key refinements were applied: preservation of approximately 5 mm of subcutaneous tissue to support venous outflow and a 3–5 mm proximal safety margin at the pivot point based on Doppler assessment to reduce pedicle tension during 180° rotation. The flap was inset without tunneling and healed without complications. Functional recovery was confirmed by progressive improvements in the disabilities of the arm, shoulder and hand score (from 25 at 1 month to 4.2 at 1 year), normal range of motion, and two-point discrimination (from 5 mm to 4 mm). This case highlights the practical advantages of flap design refinement for radial thumb reconstruction and supports its reproducibility in similar clinical scenarios. However, as this is a single case report, further validation with studies involving multiple cases is necessary to confirm the reliability and broad applicability of these refinements.

拇指桡端软组织重建仍然具有外科挑战性，特别是当标准选择如风筝或br奈利皮瓣由于解剖限制而不太适合时。本文介绍了一名37岁男性拇远端桡骨侧缺损采用反向同指背桡侧皮瓣重建的病例。采用了两个关键的改进：保留约5mm的皮下组织以支持静脉流出，并根据多普勒评估在支点处保留3-5 mm的近端安全边缘，以减少180°旋转时的蒂张力。皮瓣植入无隧道，愈合无并发症。通过手臂、肩部和手部残疾的逐步改善（从1个月时的25分到1年时的4.2分）、正常的活动范围和两点辨别（从5毫米到4毫米），证实了功能恢复。本病例强调了皮瓣设计改进在拇指桡侧重建中的实际优势，并支持其在类似临床情况下的可重复性。然而，由于这是一份单一病例报告，需要通过涉及多个病例的研究进一步验证，以确认这些改进的可靠性和广泛适用性。

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引用次数: 0

Poland syndrome complicated by macromastia in an adolescent female: A case report and literature review 波兰综合征并发青春期女性大乳房症1例报告及文献复习

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-06-20 DOI: 10.1016/j.cjprs.2025.06.001

Huijing Wang , Dawei Li , Nan Li, Cheng Huang, Xueqing Hu

Poland syndrome (PS) is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle, frequently accompanied by breast and chest wall anomalies. We report the case of an 18-year-old Chinese female diagnosed with PS complicated by contralateral macromastia who presented with significant breast asymmetry. Magnetic resonance imaging revealed a left breast volume of 618.90 mL and a right breast volume of 1 137.04 mL. The patient underwent a staged reconstruction that included a right breast reduction mammaplasty and three sessions of autologous fat grafting to the left breast. Postoperative imaging 3 months after the final procedure confirmed near symmetry, with volumes measuring 831.37 mL (left) and 841.07 mL (right). The clinical follow-up demonstrated stable results and no complications. This case underscores the importance of individualized surgical planning, precise volumetric assessment, and the role of fat grafting in achieving satisfactory aesthetic outcomes in patients with PS and complex breast deformities.

波兰综合征（PS）是一种罕见的先天性疾病，以单侧胸大肌缺失或发育不全为特征，常伴有乳房和胸壁异常。我们报告一例18岁的中国女性，诊断为PS合并对侧大乳房症，并表现出明显的乳房不对称。磁共振成像显示左乳房体积为618.90 mL，右乳房体积为1 137.04 mL。患者接受了分阶段重建，包括右乳房缩小乳房成形术和三次自体脂肪移植到左乳房。最终手术后3个月的术后影像学证实近对称，体积分别为831.37 mL（左）和841.07 mL（右）。临床随访结果稳定，无并发症发生。本病例强调了个体化手术计划的重要性，精确的体积评估，以及脂肪移植在PS和复杂乳房畸形患者获得满意的美学结果中的作用。

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引用次数: 0

Botulinum toxin therapy for androgenetic alopecia: From mechanistic insights to clinical applications 肉毒杆菌毒素治疗雄激素性脱发：从机制的见解到临床应用

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-09-01 Epub Date: 2025-09-03 DOI: 10.1016/j.cjprs.2025.08.006

Baoyi Li , Changjiang Zhao , Ruiyu Luo , He Yan , Zihan Li , Lingling Jia , Hua Jiang , Yufei Li

Background

Androgenetic alopecia (AGA) is a common hair loss disorder that significantly affects patient’s quality of life. Botulinum toxin (BoNT) has emerged as a potential treatment; however, its effectiveness and underlying mechanisms remain unclear. This systematic review aimed to synthesize the existing evidence on BoNT for AGA, analyze its mechanisms, evaluate its efficacy, and explore its potential for precision therapy.

Methods

A PubMed search was conducted for studies published between 2020 and 2025. A total of 25 studies, including 11 clinical trials and 7 reviews, were included. The studies were analyzed for BoNT mechanisms in AGA, treatment regimens, efficacy, outcomes, cost-effectiveness, and safety profiles.

Results

Experimental evidence suggests that BoNT reduces transforming growth factor-β in dermal papilla cells, a key pathological pathway in AGA. Other hypothetical mechanisms, such as scalp muscle relaxation improving microcirculation or inhibiting androgen conversion require further validation. In clinical trials, most studies used 30–150 U of BoNT via intramuscular (six studies) or intradermal (three studies) injections, with 1–3 sessions and up to 6 months of follow-up. Early open-label trials reported response rates of 70%–79%, but recent high-quality randomized controlled trials (RCTs) showed no significant improvement in hair density compared to placebo. Combination therapy with finasteride or minoxidil enhanced treatment outcomes, though large-scale evidence is lacking. BoNT was less cost-effective than first-line therapies such as minoxidil, with session costs approximately 37 times higher. Intramuscular injection appeared more effective than intradermal injection, possibly due to scalp muscle relaxation and vascular decompression. BoNT generally had a mild safety profile.

Conclusion

Currently, BoNT lacks robust evidence to replace traditional treatments for AGA. Future research should focus on establishing standardized dosing protocols, conducting large-scale, long-term RCTs, and integrating molecular biomarkers to improve understanding and optimize the clinical use of BoNT in AGA management.

背景：雄激素性脱发（AGA）是一种常见的脱发疾病，严重影响患者的生活质量。肉毒杆菌毒素（BoNT）已成为一种潜在的治疗方法；然而，其有效性和潜在机制尚不清楚。本系统综述旨在综合BoNT治疗AGA的现有证据，分析其机制，评估其疗效，并探讨其精确治疗的潜力。方法对2020 - 2025年间发表的研究进行PubMed检索。共纳入25项研究，包括11项临床试验和7项综述。这些研究分析了BoNT在AGA中的机制、治疗方案、疗效、结果、成本效益和安全性。结果BoNT可降低AGA的一个重要病理通路——真皮乳头细胞转化生长因子-β的表达。其他假设的机制，如头皮肌肉放松改善微循环或抑制雄激素转化需要进一步验证。在临床试验中，大多数研究通过肌肉注射（6项研究）或皮内注射（3项研究）使用30 - 150u的BoNT，进行1-3次疗程和长达6个月的随访。早期的开放标签试验报告有效率为70%-79%，但最近的高质量随机对照试验（rct）显示，与安慰剂相比，头发密度没有显著改善。非那雄胺或米诺地尔联合治疗可提高治疗效果，但缺乏大规模证据。BoNT的成本效益低于一线治疗，如米诺地尔，疗程费用大约高出37倍。肌内注射似乎比皮内注射更有效，可能是由于头皮肌肉松弛和血管减压。BoNT的安全性一般较低。目前，BoNT缺乏强有力的证据来取代AGA的传统治疗。未来的研究应侧重于建立标准化的给药方案，进行大规模、长期的随机对照试验，并整合分子生物标志物，以提高对BoNT在AGA管理中的临床应用的认识和优化。

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引用次数: 0

A bibliometric and visual analysis of postburn hand reconstruction 烧伤后手部重建的文献计量学和视觉分析

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-06-01 Epub Date: 2025-04-04 DOI: 10.1016/j.cjprs.2025.03.002

Shenying Luo , Hsin Liang , Bin Gu, Tao Zan, Jieyi Ren

Background

Scar contractions caused by hand burns seriously impact both the function and appearance of the hand. Consequently, post-burn hand reconstruction is a primary focus of secondary reconstructive surgery performed within the first 10 years after a burn injury. This study aimed to identify developmental trends and research hotspots in post-burn hand reconstruction, providing insights and recommendations for researchers.

Methods

Bibliometric and visualization analyses were conducted using CiteSpace v6.4. R1 (64-bit) and VOS viewer. The Web of Science Core Collection served as the data source. A total of 136 articles between 1997 and 2025 were included based on the following keywords: “postburn hand reconstruction” or “postburn hand” or “scar contraction hand deformity.”

Results

The field of post-burn hand reconstruction is advancing, as indicated by the overall and annual increase in publications. The United States leads in number of published papers. However, major institutions show low centrality, indicating weak collaboration between countries and regions, with research still dominated by single-center studies. The top three most prolific authors were Paul P M van Zuijlen, Fatih Uyghur, and Ersin Uyghur. The keywords “double Z-plasty” and the cluster “flap” not only have high emergence intensity but also appear frequently in recent studies, marking them as current research hotspots.

Conclusion

The lack of long-term research and consensus limits further advancements in post-burn hand reconstruction. To address this, multi-center and multi-disciplinary collaborations should be encouraged. Additionally, integrating basic medical research with biomedical engineering could enhance the management and outcomes of post-burn hand reconstruction.

手烧伤引起的疤痕收缩严重影响手的功能和外观。因此，烧伤后手部重建是烧伤后10年内进行二次重建手术的主要焦点。本研究旨在确定烧伤后手部重建的发展趋势和研究热点，为研究者提供见解和建议。方法采用CiteSpace v6.4进行文献计量学分析和可视化分析。R1（64位）和VOS查看器。Web of Science核心合集作为数据来源。1997年至2025年间，基于以下关键词：“烧伤后手部重建”或“烧伤后手部”或“疤痕收缩手部畸形”，共纳入136篇文章。结果烧伤后手部重建领域不断发展，相关文献逐年增加。美国发表的论文数量居世界首位。但主要研究机构的中心性较低，表明国家和地区之间的合作较弱，研究仍以单中心研究为主。前三位最多产的作家是Paul P M van Zuijlen， Fatih Uyghur和Ersin Uyghur。“双z形”和集群“皮瓣”这两个关键词不仅出现强度高，而且在近年来的研究中频繁出现，是当前的研究热点。结论缺乏长期的研究和共识限制了烧伤后手部重建的进一步发展。为解决这一问题，应鼓励多中心、多学科合作。此外，将基础医学研究与生物医学工程相结合，可以提高烧伤后手部重建的管理水平和效果。

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引用次数: 0

Solcoseryl-enriched biodegradable diplene membrane for lower eyelid reconstruction: A novel bioactive approach 富含solcoseryl的可生物降解双膜下眼睑重建：一种新的生物活性方法

Chinese Journal of Plastic and Reconstructive Surgery

Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1016/j.cjprs.2025.05.003

Maria Cervatiuc , Igor Vladimirovich Reshetov , Eldor Jonnazarov , Svetlana Vagovna Saakyan , Dzhakhongir Shavkatdzhonovich Rakhimov , Abusaid Ibodulloevich Sadulloev , Mukhammadnazir Mukhamadzokirovich Normatov , Rustamjon Zoidovich Juraev , Bahodur Bahtiyorovich Abdurahmonov , Abduhakim Abdulatifovich Saidov , Mukhriddin Bahodurovich Mazhitov , Nekruz Rahimovich Rahmatov , Fuzliddin Botirdzhonovich Gadoev , Aminjon Nozimjonovich Shafiev , Uzak Zholdoshovich Zhumakadyrov

Background

The full-thickness excision of malignant lower-eyelid tumors, particularly those with posterior lamellar involvement, presents a reconstructive challenge. Traditional grafts often have limitations, prompting interest in biocompatible alternatives, such as biodegradable diplene membranes. This study introduces a novel modification to the standard protocol: the use of diplene membranes enriched with Solcoseryl, a metabolically active agent that enhances angiogenesis, reduces inflammation, and accelerates epithelialization.

Methods

Twenty-seven patients (mean age, 68.96 ± 8.09 years) with histologically confirmed malignant lower-eyelid tumors underwent reconstruction using diplene membranes combined with Solcoseryl. The outcomes were compared with those of a previously reported cohort treated with Diplene alone. The follow-up period ranged from 3 to 12 months.

Results

All patients achieved successful restoration of eyelid support with high aesthetic satisfaction. The Solcoseryl group demonstrated significantly faster epithelialization (mean 9.8 ± 1.2 days), improved microcirculatory parameters, and no serious complications. Minor hematomas occurred in two cases (7.4%).

Conclusion

The modified Diplene–Solcoseryl membrane enhanced wound healing and biocompatibility during lower-eyelid reconstruction by transforming the membrane into a bioactive scaffold. This innovation offers superior functional and aesthetic outcomes compared to standard diplene use and represents a significant advancement in oculoplastic and oncological reconstructive surgery.

背景：恶性下眼睑肿瘤的全层切除，尤其是累及后板层的肿瘤，是一个重建的挑战。传统的移植物通常有局限性，这促使人们对生物相容性替代品的兴趣，如可生物降解的双膜。本研究引入了对标准方案的一种新的修改：使用富含Solcoseryl的双膜，Solcoseryl是一种代谢活性物质，可以促进血管生成，减少炎症，加速上皮化。方法对27例经组织学证实的下眼睑恶性肿瘤患者（平均年龄68.96±8.09岁）行双膈膜联合索可赛利重建术。这些结果与先前报道的单用Diplene治疗的队列进行了比较。随访时间为3 ~ 12个月。结果所有患者眼睑支撑修复成功，美观满意度高。Solcoseryl组表现出明显更快的上皮化（平均9.8±1.2天），微循环参数改善，无严重并发症。2例发生轻微血肿（7.4%）。结论经修饰的双戊烯-索可丝酰基膜通过将膜转化为生物活性支架，促进了下眼睑重建术中创面的愈合和生物相容性。与标准的双双使用相比，这种创新提供了优越的功能和美观的结果，代表了眼科整形和肿瘤重建手术的重大进步。

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