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Current practice in autologous rib and costal-cartilage harvest for rhinoplasty: A systematic review 自体肋骨和肋软骨采集用于鼻整形术的当前实践:系统回顾
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.02.002
Mengyuan Jiang , Haizhong Huo , Lu Zhang

Background

Autologous costal grafts are used universally in clinical practice for rhinoplasty and reconstruction. However, surgeons worldwide have not agreed on the details of graft harvesting, including rib selection, side preference, operation mode, cutting methods, and handling of the periosteum and perichondrium. This study aimed to provide an overview of the novel techniques used for auto-rib harvesting in rhinoplasty within the past 5 years and identify potential avenues for future research.

Methods

We searched for related articles in PubMed, Embase, and Web of Science from 2019 to 2023, summarized crucial but controversial steps in recent practice, and analyzed their theoretical basis and clinical feasibility.

Results

Auto-rib and cartilage open harvest is still mainstream in rhinoplasty and reconstruction, with the 5th to 8th ribs and cartilage being the most used. The laparoscopic harvest is gaining attention, being second only to the open harvest, with the 9th/10th ribs and cartilages being particularly convenient. The clinical applications of full-cut and split-cut methods differ in their advantages. Except for some special reasons, almost all studies tended to preserve the periosteum and perichondrium in situ, and few surgeons chose to harvest the grafts on the left side.

Conclusion

Multiple techniques have emerged, requiring surgeons to balance the benefits and risks of various strategies at each step. New theories and techniques should be fully tested promptly and in clinical practice before wide application. Overall, a professional consensus is needed for better directivity, precision, and stability in clinical practice.

背景自体肋骨移植物被普遍用于鼻整形和鼻重建的临床实践中。然而,世界各地的外科医生对移植物采集的细节,包括肋骨的选择、偏好的一侧、操作模式、切割方法以及骨膜和软骨膜的处理等,尚未达成一致意见。本研究旨在概述过去 5 年中用于鼻整形术中自体肋骨采集的新技术,并确定未来研究的潜在途径。方法我们在 PubMed、Embase 和 Web of Science 中检索了 2019 年至 2023 年的相关文章,总结了近期实践中关键但有争议的步骤,并分析了其理论基础和临床可行性。结果自体肋骨和软骨开放式采集仍是鼻整形和重建的主流,其中第 5 至第 8 根肋骨和软骨使用最多。腹腔镜取材越来越受到重视,仅次于开放式取材,其中第 9/10 肋骨和软骨的取材尤为方便。全切法和分切法的临床应用优势各不相同。除一些特殊原因外,几乎所有的研究都倾向于原位保留骨膜和软骨周围,很少有外科医生选择在左侧采集移植物。新理论和新技术在广泛应用之前,应及时在临床实践中进行充分检验。总之,要想在临床实践中获得更好的指导性、精确性和稳定性,需要达成专业共识。
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引用次数: 0
History and prospect of melanocytic nevus treatment: A bibliometric analysis 黑素细胞痣治疗的历史与展望:文献计量学分析
Pub Date : 2023-10-01 DOI: 10.1016/j.cjprs.2023.10.001
Zizhen Guo, Lingling Ge, Yuehua Li, Yihui Gu, Wei Wang, Chengjiang Wei, Bin Gu, Qingfeng Li, Zhichao Wang
Melanocytic nevus is mainly treated by complete or partial removal. However, predicting the risk of malignant transformation of melanocytic nevi and which treatment patients should receive, surgical or non-surgical management, to gain the best results and aesthetic outcomes is controversial. Global literature on melanocytic nevus treatment, published between 1997 and 2022, was scanned using the Web of Science Core Collection database. Microsoft Office Excel, CiteSpace V, VOSviewer, Scimago Graphica, Bibliometrix, and Biblioshiny packages in R were used for the bibliometric analysis to summarize the leading countries, institutions, professors, and research trends in this field. This study included 1 723 articles. Publications and citations exhibited positive trends over the past 20 years. The United States had the most productive organizations and publications in the comprehensive worldwide cooperation network, and China was recently one of the most active major participants. Professor Giovanni Pellacani, whose H-index, G-index, and M-index ranked first in this field, founded a virtual biopsy using reflectance confocal microscopy. In addition, Krengel and Kinsler contributed significantly to diagnosing and treating melanocytic nevi. The top 25 keywords in recent years were mostly about the mechanisms and risk factors for the malignant transformation of nevi. The future trend for melanocytic nevi treatment is to specify genotype-phenotype and genotype-outcome correlations, choose proper therapy to reduce the risk of malignant transformation, and simultaneously achieve the best aesthetic outcomes.
黑素细胞痣主要通过完全或部分切除来治疗。然而,预测黑素细胞痣恶性转化的风险以及患者应该接受哪种治疗,手术或非手术治疗,以获得最佳效果和美观效果是有争议的。使用Web of Science Core Collection数据库对1997年至2022年间发表的关于黑素细胞痣治疗的全球文献进行了扫描。使用Microsoft Office Excel、CiteSpace V、VOSviewer、Scimago Graphica、Bibliometrix、Biblioshiny等软件包进行文献计量学分析,总结该领域的主要国家、机构、教授和研究趋势。本研究共纳入1 723篇文献。在过去的20年里,出版物和引用呈现出积极的趋势。在这一全面的全球合作网络中,美国拥有最富有成效的组织和出版物,而中国最近是最活跃的主要参与者之一。h指数、g指数和m指数在该领域排名第一的Giovanni Pellacani教授发明了利用反射共聚焦显微镜的虚拟活检。此外,Krengel和Kinsler对黑素细胞痣的诊断和治疗也做出了重要贡献。近年来排名前25位的关键词多为痣恶性转化的机制及危险因素。未来黑素细胞痣治疗的趋势是明确基因型-表型和基因型-结局的相关性,选择合适的治疗方法来降低恶性转化的风险,同时达到最佳的美学效果。
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引用次数: 0
Eight-year follow-up on postoperative improvement protocol in extensive metoidioplasty transgenders: A case series 大面积子宫内膜成形术后改良方案的8年随访:一系列病例
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.08.003
Shahryar Cohanzad

Background

This study aimed to evaluate the long-term penile size among patients who underwent extensive metoidioplasty.

Methods

An evaluation was conducted on 7 out of 14 patients (mean age: 29.71 ​± ​13.76 years) who participated in a 2015 study that introduced a postoperative protocol to improve penile size after extensive metoidioplasty. Five transsexual females (46XX karyotype) and two patients with 5-alpha reductase deficiency were retrospectively followed up in 2023 to assess the long-term efficacy of the protocol at a specialized clinic in a general hospital in Tehran, Iran. All participants were informed about the study and consented to participate.

Results

Five patients achieved increased penile size from their 2015 measurements (mean, 29.00 ​± ​13.34 ​mm). Five patients requested a larger sized penile traction device to continue the protocol.

Conclusion

The long-term implementation of this protocol can result in increased penile size. We advise highly motivated patients to continue practicing the protocol to achieve better results.

背景:本研究旨在评估接受子宫内膜成形术的患者的长期阴茎尺寸。方法对2015年一项研究中14例患者中的7例(平均年龄:29.71±13.76岁)进行评估,该研究介绍了广泛子宫内膜成形术后改善阴茎尺寸的术后方案。5名变性女性(46XX核型)和2名5- α还原酶缺乏症患者于2023年在伊朗德黑兰一家综合医院的专科诊所进行回顾性随访,以评估该方案的长期疗效。所有参与者都被告知这项研究并同意参与。结果5例患者阴茎尺寸较2015年增加(平均29.00±13.34 mm)。5名患者要求使用更大尺寸的阴茎牵引装置继续治疗。结论长期应用该方案可使阴茎尺寸增大。我们建议高度积极的患者继续实践该方案以获得更好的结果。
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引用次数: 0
Application of a jigsaw puzzle flap based on free-style perforator to repair large scalp defects after tumor resection: A case series 基于游离型穿支器的拼图皮瓣在肿瘤切除后头皮大面积缺损修复中的应用
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.07.002
Daojiang Yu , Jing Wang , Lei Chen , Lu An , Yahui Feng , Sheng Jiang , Shuyu Zhang , Xiaoming Chen , Guozhong Lv

Background

Reconstruction of large scalp defects after tumor resection is common and challenging. Free skin grafting or free flap transfer is always performed. However, these techniques can result in poor functional and cosmetic outcomes.

Methods

In the Second Affiliated Hospital of Soochow University and the Second Affiliated Hospital of Chengdu Medical College, 35 patients underwent jigsaw puzzle flap procedures based on a free-style perforator to repair large scalp defects after tumor resection from May 2013 to November 2022. The key to this procedure was to divide a large defect into several smaller parts that correspond to adjacent free-style perforators around the scalp defect. The free-style perforator flaps were designed in different ways, such as propeller flaps, rotation flaps, and V-Y advancement flaps, which were pedicled with free-style perforators. All of the small flaps were then mobilized to the defect and sutured to each other to create a new, large jigsaw puzzle-like flap to cover the large scalp defect. Finally, all the donor sites were closed directly.

Results

Overall, 35 patients were treated. The average defect size was 72 ​cm2 (range, 25–91 ​cm2). All flaps had a satisfactory appearance after follow-up periods of 6 months–10 years. Local tumor recurrence occurred in one case.

Conclusion

The application of a jigsaw puzzle flap based on a free-style perforator is a suitable option for the reconstruction of large scalp defects after resection, yielding satisfactory functional and cosmetic results.

背景头皮肿瘤切除后大面积缺损的重建是一种常见且具有挑战性的修复方法。游离皮肤移植或游离皮瓣转移是常用的方法。然而,这些技术可能导致不良的功能和美容效果。方法2013年5月至2022年11月,苏州大学第二附属医院和成都医学院第二附属医院采用自由式穿支为基础的拼图皮瓣修复大面积头皮肿瘤切除术后缺损患者35例。该手术的关键是将一个大的缺损分成几个小的部分,这些小的部分对应于头皮缺损周围邻近的自由式穿支。自由式穿支皮瓣设计了不同的方式,如螺旋桨皮瓣、旋转皮瓣和V-Y推进皮瓣,这些皮瓣以自由式穿支为蒂。然后将所有的小皮瓣移动到缺损处,并相互缝合,形成一个新的、大的、像拼图一样的皮瓣来覆盖大的头皮缺损。最后,所有的捐赠点都被直接关闭了。结果共治疗35例患者。平均缺陷尺寸为72 cm2(范围25-91 cm2)。随访6个月至10年,皮瓣外观满意。局部肿瘤复发1例。结论以自由式穿支为基础的拼图皮瓣是修复大面积头皮缺损的一种较好的选择,具有良好的功能性和美观性。
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引用次数: 0
Integrated percutaneous sclerotherapy and surgical intervention for giant cutaneomucosal venous malformation from TIE2 mutation: A case report 经皮综合硬化治疗和外科手术治疗TIE2突变引起的巨大皮肤-粘膜静脉畸形1例
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.08.002
Song Wang , Renrong Lv , Guangqi Xu , Ran Huo

Cutaneomucosal venous malformations (VMCMs) can manifest as sporadic or familial forms, following an autosomal dominant inheritance pattern. This report highlights the case of a 5-year-old girl presenting with a substantial congenital VMCM attributed to a TIE2 mutation, who underwent percutaneous sclerotherapy followed by surgery. The clinical, three-dimensional computed tomographic angiography (3D-CTA), as well as pathological and genetic findings concerning a patient with an extensive VMCM in the left pro-axillary region, are elucidated. The genetic analysis in this patient verified a missense mutation (c.2545T>C) in TIE2, confirming familial VMCMs. The combined strategy integrating percutaneous sclerotherapy and surgical excision is the most efficacious approach for managing large VMCMs and can successfully attain therapeutic goals.

皮肤粘膜静脉畸形(VMCMs)可以表现为散发性或家族性形式,遵循常染色体显性遗传模式。本报告重点报道了一名5岁女孩因TIE2突变而出现严重的先天性VMCM,她接受了经皮硬化治疗后进行了手术。临床,三维计算机断层血管造影(3D-CTA),以及病理和遗传学的发现有关患者广泛的VMCM在左腋窝前区域,阐明。该患者的遗传分析证实了TIE2的错义突变(C . 2545t>C),证实了家族性VMCMs。经皮硬化治疗联合手术切除是治疗大型vmcm最有效的方法,并能成功达到治疗目的。
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引用次数: 0
Supraclavicular artery island flap for reconstruction of hypopharynx and upper esophagus defects: A case report and literature review 锁骨上动脉岛状皮瓣修复下咽及食管上段缺损1例并文献复习
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.07.001
Xiaorong Ma , Xiaoting Sun , Yuexin Shi , Kaiyang Lv , Wenbin Chen

We report a case of a 74-year-old female with hypopharyngeal cancer who developed a pharyngoesophageal fistula and neck skin defect after total laryngectomy. To reconstruct the hypopharynx, upper esophagus, and neck skin defect, we used a supraclavicular artery island flap (SCAIF) for one-stage reconstruction. SCAIF offered reliable blood supply, minimal donor site morbidity, and excellent cosmetic outcomes. Although a small portion of the flap developed necrosis, it healed without surgical intervention. We also conducted a literature review of previously published articles on SCAIF for head and neck reconstruction. Our review highlights the advantages and limitations of SCAIF as a promising option for one-stage reconstruction of complex hypopharyngeal and upper esophageal defects with neck skin defects in selected patients. This case report provides valuable insights into the use of SCAIF in complex head and neck reconstructions, which can help improve patient outcomes and quality of life.

我们报告一位74岁女性下咽癌患者,在全喉切除术后出现咽食管瘘及颈部皮肤缺损。为了重建下咽、上食管和颈部皮肤缺损,我们使用锁骨上动脉岛状皮瓣(SCAIF)进行一期重建。SCAIF提供可靠的血液供应,最小的供体部位发病率和良好的美容效果。虽然一小部分皮瓣出现坏死,但它在没有手术干预的情况下愈合。我们还对先前发表的关于SCAIF用于头颈部重建的文章进行了文献回顾。我们的综述强调了SCAIF作为一种有前途的选择,用于一期重建复杂的下咽和上食管缺损伴颈部皮肤缺损的患者。本病例报告为SCAIF在复杂头颈部重建中的应用提供了有价值的见解,有助于改善患者的预后和生活质量。
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引用次数: 0
Absolute ethanol embolization for treatment of peripheral arteriovenous malformations 无水乙醇栓塞治疗外周动静脉畸形
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.09.002
Jingwei Zhou, Chen Hua, Xi Yang, Yuxi Chen, Yunbo Jin, Xiaoxi Lin

Arteriovenous malformations (AVMs) are aggressive congenital high-flow vascular anomalies, in which the feeding artery and draining vein are connected through fistulas without normal capillary networks. In severe cases, the condition may cause swelling, ulceration, bleeding, and even heart failure. Various treatment options are available for AVMs, including laser, surgical resection, embolization, and targeted drug therapy. With the development of endovascular treatment technology, absolute ethanol embolization of AVMs has become one of the first-line therapies owing to its sustained efficacy and low recurrence rate. However, administration of this therapy is challenging and may lead to serious complications if inappropriately managed. In this article, we reviewed and summarized previous clinical articles, literature reviews, and clinical trial data to comprehensively describe clinical manifestations of AVMs, the mechanism of ethanol embolotherapy, key points in treatment and management of complications, and issues that need to be addressed. We expect to provide a reliable information reference source for clinical physicians and researchers.

动静脉畸形(AVMs)是一种侵袭性先天性高流量血管畸形,其供血动脉和引流静脉通过瘘管连接,而没有正常的毛细血管网络。在严重的情况下,这种情况可能会导致肿胀、溃疡、出血,甚至心力衰竭。AVMs有多种治疗选择,包括激光、手术切除、栓塞和靶向药物治疗。随着血管内治疗技术的发展,AVMs的无水乙醇栓塞治疗因其持续有效、复发率低而成为一线治疗方法之一。然而,这种疗法的使用具有挑战性,如果管理不当,可能会导致严重并发症。在这篇文章中,我们回顾和总结了以往的临床文章、文献综述和临床试验数据,以全面描述动静脉畸形的临床表现、乙醇栓塞治疗的机制、并发症的治疗和管理要点以及需要解决的问题。我们希望为临床医生和研究人员提供可靠的信息参考来源。
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引用次数: 0
A comprehensive approach to the delayed treatment of post-burn facial scars 烧伤后面部疤痕延迟治疗的综合方法
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.06.002
Victoria Ivanovna Polshina , Maria Cervatiuc , Igor Vladimirovich Reshetov , Alim Arsenovich Nebejev , Eldor Jonnazarov

Background

Damage to the skin and underlying tissues due to thermal burns is relevant. Despite the success of modern medicine, repairing thermal damage to the skin is a difficult task in reconstructive plastic surgery because of the nature of the damage and the regenerative features. Characteristic post-burn changes are associated with different depths of damage when areas of deep damage are combined with more superficial areas.

Methods

We described a clinical case of the staged surgical treatment of a cicatricial deformity of the buccal-periorbital-perioral region resulting from a childhood burn injury from a hot object. The 44-year-old patient complained of an aesthetic and functional deformity of the buccal-periorbital-perioral region and had previously undergone repeated nonsurgical corrections.

Results

A comprehensive approach to the surgical treatment of a patient with post-burn deformities using a diplene adhesive membrane directly affected the stage of the surgical treatment and contributed to improved functional and aesthetic results.

Conclusion

The positive treatment results with preserved contraction and relaxation processes of the facial muscles as well as satisfactory aesthetic results allow us to recommend the use of a biodegradable diplene film during facial reconstructive operations.

背景:热烧伤对皮肤和下层组织的损伤是相关的。尽管现代医学取得了成功,但由于损伤的性质和再生特征,修复皮肤热损伤是重建整形手术中的一项艰巨任务。当深度损伤区域与浅表损伤区域合并时,典型的烧伤后变化与不同的损伤深度有关。方法报告一例儿童烧伤后颊-眶周-口周区瘢痕畸形分阶段手术治疗的临床病例。这位44岁的患者主诉颊-眶周-口周区域的美学和功能畸形,此前曾多次接受非手术矫正。结果烧伤后畸形的综合手术方法采用双双胶膜直接影响手术治疗的分期,改善了手术的功能和美观效果。结论在保留面部肌肉收缩和舒张过程的良好治疗效果和满意的美学效果的基础上,我们推荐在面部重建手术中使用可生物降解的双膜。
{"title":"A comprehensive approach to the delayed treatment of post-burn facial scars","authors":"Victoria Ivanovna Polshina ,&nbsp;Maria Cervatiuc ,&nbsp;Igor Vladimirovich Reshetov ,&nbsp;Alim Arsenovich Nebejev ,&nbsp;Eldor Jonnazarov","doi":"10.1016/j.cjprs.2023.06.002","DOIUrl":"10.1016/j.cjprs.2023.06.002","url":null,"abstract":"<div><h3>Background</h3><p>Damage to the skin and underlying tissues due to thermal burns is relevant. Despite the success of modern medicine, repairing thermal damage to the skin is a difficult task in reconstructive plastic surgery because of the nature of the damage and the regenerative features. Characteristic post-burn changes are associated with different depths of damage when areas of deep damage are combined with more superficial areas.</p></div><div><h3>Methods</h3><p>We described a clinical case of the staged surgical treatment of a cicatricial deformity of the buccal-periorbital-perioral region resulting from a childhood burn injury from a hot object. The 44-year-old patient complained of an aesthetic and functional deformity of the buccal-periorbital-perioral region and had previously undergone repeated nonsurgical corrections.</p></div><div><h3>Results</h3><p>A comprehensive approach to the surgical treatment of a patient with post-burn deformities using a diplene adhesive membrane directly affected the stage of the surgical treatment and contributed to improved functional and aesthetic results.</p></div><div><h3>Conclusion</h3><p>The positive treatment results with preserved contraction and relaxation processes of the facial muscles as well as satisfactory aesthetic results allow us to recommend the use of a biodegradable diplene film during facial reconstructive operations.</p></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"5 3","pages":"Pages 159-162"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48659766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MEK inhibitors for the treatment of extracranial arteriovenous malformations MEK抑制剂治疗颅外动静脉畸形
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.09.001
Zi’an Xu , Jingwei Zhou , Yuxi Chen, Xi Yang, Chen Hua, Yunbo Jin, Xiaoxi Lin

Arteriovenous malformations (AVMs) are serious congenital vascular anomalies in which the arteries connect directly with veins without capillaries. This condition will continue to worsen without proper intervention and cause ulcers, repeated hemorrhages, and even cardiac insufficiency. Primary treatment options for AVMs include surgery and interventional treatment; however, they are associated with high risk and recurrence rates. Recent studies revealed that excessive activation of the Ras/MAPK pathway can induce the formation and development of peripheral AVM, whereas MEK inhibitors can effectively control nidus progression, making them a potential novel treatment for AVM. This review provides an up-to-date overview of correlated laboratory and clinical research to provide information for further research and clinical practice.

动静脉畸形(AVMs)是一种严重的先天性血管畸形,动脉与静脉直接相连,没有毛细血管。如果没有适当的干预,这种情况将继续恶化,并导致溃疡、反复出血,甚至心功能不全。AVMs的主要治疗选择包括手术和介入治疗;然而,它们与高风险和复发率有关。最近的研究表明,Ras/MAPK通路的过度激活可以诱导外周AVM的形成和发展,而MEK抑制剂可以有效控制nidus的进展,使其成为AVM的一种潜在的新治疗方法。这篇综述提供了相关实验室和临床研究的最新综述,为进一步的研究和临床实践提供信息。
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引用次数: 0
Efficacy of tibial transverse transport combined with platelet-rich plasma versus platelet-rich plasma alone in the treatment of diabetic foot ulcers: A meta-analysis 胫骨横向转运联合富血小板血浆与单用富血小板血浆治疗糖尿病足溃疡的疗效:荟萃分析
Pub Date : 2023-09-01 DOI: 10.1016/j.cjprs.2023.09.003
Ke Chen , Yikang Yu , Jialu Shu , Binbin Zhang , Gang Wang , Bin Wu

Background

Diabetic foot ulcers (DBFU) are one of the main complications of diabetes. Platelet-rich plasma (PRP) treatment is a commonly used treatment option. Tibial transverse transport (TTT) also has a therapeutic effect on DBFU. Some studies have found that the TTT combined with PRP (TTT&PRP) has a significant effect on DBFU.

Methods

PubMed, Cochrane Library, Web of Science, EMBASE, Chinese Biomedical Literature, CNKI, VIP, and Wanfang databases were used to find literature on the treatment of DBFUs using the TTT and PRP treatment according to the inclusion criteria. The specific inclusion criteria are as follows: (1) research type: clinical controlled trials, including retrospective cohort and randomized controlled studies; (2) diagnosis of DBFUs that does not include a definitively diagnosed traumatic ulcer; (3) original materials of Chinese and English literature published in full text. The exclusion criteria are: (1) the research group was not defined or grouped; (2) nonrandomized controlled trials, non-cohort studies, non-case-control studies, retrospective studies, and case reports; (3) repetitive research and animal experimentation; (4) ulcers caused by other diseases; (5) conservative treatment or no use of invasive treatment methods. Review Manager software (version 5.3) was used to conduct a meta-analysis of the included results.

Result

The literature included 6 randomized controlled studies, including 508 patients, 254 patients in the PRP treatment group, and 254 patients in the TTT&PRP group. The meta-analysis results showed that in terms of treatment efficacy, the TTT&PRP combined treatment group had a higher efficacy than the PRP group. After treatment, the TTT&PRP group had better treatment effects in psychological function, physiological function, and social function compared to the PRP group. After treatment, the TTT&PRP group showed a significant increase in serum epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) levels compared to the PRP group. In terms of wound healing after treatment, the TTT&PRP group performed better than the PRP group in terms of postoperative wound reduction rate, bacterial clearance rate, granulation tissue coverage rate, and granulation tissue growth thickness.

Conclusion

TTT combined with PRP was more effective than PRP alone in treating DBFUs.

糖尿病足溃疡是糖尿病的主要并发症之一。富含血小板血浆(PRP)治疗是一种常用的治疗方案。胫骨横向运输(TTT)对DBFU也有治疗作用。一些研究发现TTT联合PRP(TTT&;PRP)对DBFU有显著影响。方法根据纳入标准,使用PubMed、Cochrane Library、Web of Science、EMBASE、中国生物医学文献、CNKI、VIP和万方数据库查找TTT和PRP治疗DBFUs的文献。具体纳入标准如下:(1)研究类型:临床对照试验,包括回顾性队列和随机对照研究;(2) 诊断DBFUs,不包括明确诊断的创伤性溃疡;(3) 全文出版的中英文文学原始资料。排除标准为:(1)未对研究组进行定义或分组;(2) 非随机对照试验、非队列研究、非病例对照研究、回顾性研究和病例报告;(3) 重复研究和动物实验;(4) 其他疾病引起的溃疡;(5) 保守治疗或不使用侵入性治疗方法。Review Manager软件(5.3版)用于对纳入的结果进行荟萃分析。结果文献包括6项随机对照研究,包括508例患者、254例PRP治疗组患者和254例TTT&;PRP组。荟萃分析结果显示,在治疗效果方面,TTT&;PRP联合治疗组的疗效高于PRP组。治疗后TTT&;PRP组在心理功能、生理功能和社会功能方面均优于PRP组。治疗后TTT&;与PRP组相比,PRP组的血清表皮生长因子(EGF)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)和血小板衍生生长因子(PDGF)水平显著升高。在治疗后的伤口愈合方面;PRP组在术后伤口缩小率、细菌清除率、肉芽组织覆盖率和肉芽组织生长厚度方面优于PRP组。结论TTT联合PRP治疗DBFUs疗效优于单纯PRP。
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引用次数: 0
期刊
Chinese Journal of Plastic and Reconstructive Surgery
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