Scalp necrosis is uncommon in malnourished children, yet temporal catheterization is frequently observed in pediatric hospital settings. The condition is characterized by a black, hard, and unresponsive scalp. Etiologies such as temporal arteritis, burns, and Takayasu’s disease, have been proposed. There is a decline in the use of peripheral catheter monitoring in hospitals. War-related food shortages and social instability significantly affect the trauma and risks that undermine the health, social, and psychological well-being of children. This report describes the case of a 5-month-old infant suffering from severe acute malnutrition following the abduction and subsequent release of his mother by armed individuals after one and a half weeks. The infant, who underwent temporal catheterization for medication administration, presented with extensive scalp necrosis. The necrotic tissue was surgically removed, and the malnutrition was successfully treated, resulting in a favorable clinical outcome. The mother received comprehensive mother-child care from a psychologist.
{"title":"Large necrosis of the scalp following temporal catheter placement in an infant with severe acute malnutrition: A case report","authors":"Mongwa Mbikilile Justin , Ntambala Prince , Nanga Batende , Alumeti Munyali","doi":"10.1016/j.cjprs.2024.10.001","DOIUrl":"10.1016/j.cjprs.2024.10.001","url":null,"abstract":"<div><div>Scalp necrosis is uncommon in malnourished children, yet temporal catheterization is frequently observed in pediatric hospital settings. The condition is characterized by a black, hard, and unresponsive scalp. Etiologies such as temporal arteritis, burns, and Takayasu’s disease, have been proposed. There is a decline in the use of peripheral catheter monitoring in hospitals. War-related food shortages and social instability significantly affect the trauma and risks that undermine the health, social, and psychological well-being of children. This report describes the case of a 5-month-old infant suffering from severe acute malnutrition following the abduction and subsequent release of his mother by armed individuals after one and a half weeks. The infant, who underwent temporal catheterization for medication administration, presented with extensive scalp necrosis. The necrotic tissue was surgically removed, and the malnutrition was successfully treated, resulting in a favorable clinical outcome. The mother received comprehensive mother-child care from a psychologist.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 196-198"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fibrosis is a pathological outcome of a dysregulated repair response to injury, which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide. However, challenges remain in delineating the complex and dynamic network regulating fibrosis, as well as translating this information into effective anti-fibrotic treatments. A comprehensive understanding of existing methodologies and the development of new research tools are essential for ensuring the transferability of findings from bench to bedside. In this review, we present a framework consisting of a large biospecimen repository that integrates diverse patient cohorts with corresponding clinical data, and a systematic research platform incorporating multiple layers of experimental strategies, primarily focused on skin fibrosis. We summarize current advancements and the applications of various tools for preclinical fibrosis research and examine the limitations of traditional methods used to simulate and investigate biomechanical signals in the fibrotic environment. Importantly, we highlight the strengths of research techniques and translational approaches of varying physiological relevance developed by us over the past decade. Collectively, we emphasize a trend toward more faithfully replicating the functional, structural, and biological complexity of fibrosis while providing high spatio-temporal control over soluble cues and intricate interactions. Our comprehensive overview of methodology paves the way for minimizing batch-to-batch variation and improving the reproducibility of experimental systems.
{"title":"Establishment and application of a fibrosis/scar biospecimen repository and systematic research platform","authors":"Zhiyuan Zhou, Ya Gao, Chiakang Ho, Dongsheng Wen, Yangdan Liu, Tingyu Tsai, Yuxin Lin, Qingfeng Li, Yifan Zhang","doi":"10.1016/j.cjprs.2024.10.003","DOIUrl":"10.1016/j.cjprs.2024.10.003","url":null,"abstract":"<div><div>Fibrosis is a pathological outcome of a dysregulated repair response to injury, which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide. However, challenges remain in delineating the complex and dynamic network regulating fibrosis, as well as translating this information into effective anti-fibrotic treatments. A comprehensive understanding of existing methodologies and the development of new research tools are essential for ensuring the transferability of findings from bench to bedside. In this review, we present a framework consisting of a large biospecimen repository that integrates diverse patient cohorts with corresponding clinical data, and a systematic research platform incorporating multiple layers of experimental strategies, primarily focused on skin fibrosis. We summarize current advancements and the applications of various tools for preclinical fibrosis research and examine the limitations of traditional methods used to simulate and investigate biomechanical signals in the fibrotic environment. Importantly, we highlight the strengths of research techniques and translational approaches of varying physiological relevance developed by us over the past decade. Collectively, we emphasize a trend toward more faithfully replicating the functional, structural, and biological complexity of fibrosis while providing high spatio-temporal control over soluble cues and intricate interactions. Our comprehensive overview of methodology paves the way for minimizing batch-to-batch variation and improving the reproducibility of experimental systems.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 199-205"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.cjprs.2024.10.002
Siddig Ibrahim Abdelwahab , Abdullah Farasani , Hassan Ahmad Alfaifi , Waseem Hassan
Background
The rise of artificial intelligence in healthcare, particularly the development of large language models like ChatGPT, has opened new avenues for innovation in medical fields, including plastic surgery. ChatGPT offers potential applications in patient education, surgical planning, and decision-making support, making it an important research subject. However, there has been limited investigation into its impact on plastic surgery. The objective of this study was to investigate the progress of research on ChatGPT and plastic surgery, focusing on key contributors and emerging topics within the field.
Methods
Five distinct search strategies were employed to analyze relevant publications from the Scopus database.
Results
The analysis identified and presented the top authors, universities, countries, sponsors, and journals (within each search strategy). The co-authorship networks of authors, universities, and countries are graphically presented. The authors’ performance was depicted by various indicators, such as total publications, citations, h-index, g-index, and m-index. A co-word analysis revealed the focus of the papers, which were presented in 15 groups. This multifaceted approach provides a detailed understanding of key themes in the field.
Conclusion
This report offers a comprehensive overview of the current state of research at the intersection of ChatGPT and plastic surgery.
{"title":"Bibliometric analysis of ChatGPT and plastic surgery research: Insights from diverse search strategies and co-word analysis","authors":"Siddig Ibrahim Abdelwahab , Abdullah Farasani , Hassan Ahmad Alfaifi , Waseem Hassan","doi":"10.1016/j.cjprs.2024.10.002","DOIUrl":"10.1016/j.cjprs.2024.10.002","url":null,"abstract":"<div><h3>Background</h3><div>The rise of artificial intelligence in healthcare, particularly the development of large language models like ChatGPT, has opened new avenues for innovation in medical fields, including plastic surgery. ChatGPT offers potential applications in patient education, surgical planning, and decision-making support, making it an important research subject. However, there has been limited investigation into its impact on plastic surgery. The objective of this study was to investigate the progress of research on ChatGPT and plastic surgery, focusing on key contributors and emerging topics within the field.</div></div><div><h3>Methods</h3><div>Five distinct search strategies were employed to analyze relevant publications from the Scopus database.</div></div><div><h3>Results</h3><div>The analysis identified and presented the top authors, universities, countries, sponsors, and journals (within each search strategy). The co-authorship networks of authors, universities, and countries are graphically presented. The authors’ performance was depicted by various indicators, such as total publications, citations, h-index, g-index, and m-index. A co-word analysis revealed the focus of the papers, which were presented in 15 groups. This multifaceted approach provides a detailed understanding of key themes in the field.</div></div><div><h3>Conclusion</h3><div>This report offers a comprehensive overview of the current state of research at the intersection of ChatGPT and plastic surgery.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 185-195"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.cjprs.2024.08.004
Enrique Chávez-Serna, Kenzo Alejandro Fukumoto-Inukai, Ricardo Romero-Caballero, José Eduardo Telich-Tarriba, Elsa Natalia Haro-Álvarez, Damián Palafox, Alexander Cárdenas-Mejía
Background
Traumatic facial nerve injury is the second leading cause of facial paralysis, presenting significant challenges such as difficulties with eating, speaking, impaired vision, and loss of facial expression. Understanding these injuries is critical for plastic surgeons to optimize recovery and functional outcomes. This study examined our experience with acute traumatic extratemporal facial nerve injuries, focusing on their characteristics, the frequency of affected nerve branches, and identification using Seckel’s facial danger zones as anatomical landmarks. We also explored the implications of surgical management based on the current literature and our experience.
Methods
We reviewed 50 patients with acute traumatic extratemporal facial nerve injuries treated at Hospital General Dr. Manuel Gea González in Mexico City from January 2019 to January 2024. The collected data included demographics (age, sex, severity, and time to medical attention), injury mechanism, affected nerve branches using Seckel’s zones, and treatment methods.
Results
The majority of the patients were male (82%), with an average age of 29 ± 16 years. Sharp trauma from assault was the most common cause (66%). The buccal and frontal branches were most frequently affected, with Seckel zones IV and II involved in 46.86% and 33.33% of cases, respectively. Primary neurorrhaphy was performed in 96% of the patients.
Conclusion
The effective management of traumatic facial nerve injuries relies on understanding the characteristics of the injury and using anatomical landmarks for prompt localization. Primary neurorrhaphy is the preferred surgical approach, with nerve grafting being an alternative. Ideally, early intervention within 72 h is crucial for optimal nerve recovery.
{"title":"Acute traumatic extratemporal facial nerve injury: A 5-year review","authors":"Enrique Chávez-Serna, Kenzo Alejandro Fukumoto-Inukai, Ricardo Romero-Caballero, José Eduardo Telich-Tarriba, Elsa Natalia Haro-Álvarez, Damián Palafox, Alexander Cárdenas-Mejía","doi":"10.1016/j.cjprs.2024.08.004","DOIUrl":"10.1016/j.cjprs.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>Traumatic facial nerve injury is the second leading cause of facial paralysis, presenting significant challenges such as difficulties with eating, speaking, impaired vision, and loss of facial expression. Understanding these injuries is critical for plastic surgeons to optimize recovery and functional outcomes. This study examined our experience with acute traumatic extratemporal facial nerve injuries, focusing on their characteristics, the frequency of affected nerve branches, and identification using Seckel’s facial danger zones as anatomical landmarks. We also explored the implications of surgical management based on the current literature and our experience.</div></div><div><h3>Methods</h3><div>We reviewed 50 patients with acute traumatic extratemporal facial nerve injuries treated at Hospital General Dr. Manuel Gea González in Mexico City from January 2019 to January 2024. The collected data included demographics (age, sex, severity, and time to medical attention), injury mechanism, affected nerve branches using Seckel’s zones, and treatment methods.</div></div><div><h3>Results</h3><div>The majority of the patients were male (82%), with an average age of 29 ± 16 years. Sharp trauma from assault was the most common cause (66%). The buccal and frontal branches were most frequently affected, with Seckel zones IV and II involved in 46.86% and 33.33% of cases, respectively. Primary neurorrhaphy was performed in 96% of the patients.</div></div><div><h3>Conclusion</h3><div>The effective management of traumatic facial nerve injuries relies on understanding the characteristics of the injury and using anatomical landmarks for prompt localization. Primary neurorrhaphy is the preferred surgical approach, with nerve grafting being an alternative. Ideally, early intervention within 72 h is crucial for optimal nerve recovery.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 161-165"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.cjprs.2024.11.003
Ming Ni , Dong Wang
Background
In Asia, facial overfilled syndrome (FOS) can arise from iatrogenic causes involving the excessive use of filling materials, as well as physiological causes such as adipose tissue hypertrophy type, age-related type, and lacuna type. This study aimed to demonstrate the safety and effectiveness of plasma radiofrequency-assisted microsuction (PRFAMS) for improving the appearance of FOS induced by various causes.
Methods
PRFAMS was performed on 84 anatomical regions of 37 female patients (including 12 with physiological causes, 6 with hyaluronic acid causes, and 19 with fat causes), aged between 20 and 50 years (mean, 35.9 years), who had FOS. Demographic and surgical data were collected retrospectively. Preoperative and postoperative photographs were taken, and satisfaction interviews were conducted at least six months after surgery.
Results
All the patients underwent successful surgery under local or intravenous anesthesia. Only four anatomic regions showed noticeable asymmetry postoperatively, requiring a secondary operation. Postoperative skin numbness, muscle paralysis, bruising, and minor contouring irregularities improved significantly within 2–3 weeks of recovery. Additionally, five patients with longer edema periods demonstrated substantial improvement after more than five weeks. No cases of skin necrosis, thermal injury, or other serious complications related to the device or procedure were reported. Ultimately, all patients expressed satisfaction with their outcomes.
Conclusion
The PRFAMS technique is a safe and effective method for treating FOS induced by various causes, while minimizing complications and ensuring high patient satisfaction.
{"title":"Plasma radiofrequency-assisted microsuction for the treatment of facial overfilled syndrome induced by diverse causes in Asians","authors":"Ming Ni , Dong Wang","doi":"10.1016/j.cjprs.2024.11.003","DOIUrl":"10.1016/j.cjprs.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>In Asia, facial overfilled syndrome (FOS) can arise from iatrogenic causes involving the excessive use of filling materials, as well as physiological causes such as adipose tissue hypertrophy type, age-related type, and lacuna type. This study aimed to demonstrate the safety and effectiveness of plasma radiofrequency-assisted microsuction (PRFAMS) for improving the appearance of FOS induced by various causes.</div></div><div><h3>Methods</h3><div>PRFAMS was performed on 84 anatomical regions of 37 female patients (including 12 with physiological causes, 6 with hyaluronic acid causes, and 19 with fat causes), aged between 20 and 50 years (mean, 35.9 years), who had FOS. Demographic and surgical data were collected retrospectively. Preoperative and postoperative photographs were taken, and satisfaction interviews were conducted at least six months after surgery.</div></div><div><h3>Results</h3><div>All the patients underwent successful surgery under local or intravenous anesthesia. Only four anatomic regions showed noticeable asymmetry postoperatively, requiring a secondary operation. Postoperative skin numbness, muscle paralysis, bruising, and minor contouring irregularities improved significantly within 2–3 weeks of recovery. Additionally, five patients with longer edema periods demonstrated substantial improvement after more than five weeks. No cases of skin necrosis, thermal injury, or other serious complications related to the device or procedure were reported. Ultimately, all patients expressed satisfaction with their outcomes.</div></div><div><h3>Conclusion</h3><div>The PRFAMS technique is a safe and effective method for treating FOS induced by various causes, while minimizing complications and ensuring high patient satisfaction.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 176-184"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.cjprs.2024.09.001
Ilgiz Gareev , Ozal Beylerli , Boxian Zhao , Elmar Musaev
A scar is a condition characterized by excessive repair of skin tissue, resulting in a fibroproliferative disorder marked by abnormal deposition of extracellular matrix. This disorder typically stems from deep dermal damage caused by burns or trauma and presents with symptoms such as itching and pain. Moreover, scarring can lead to disfigurement and psychological distress in affected individuals, making it a prevalent concern in burn plastic surgery outpatient clinics. In the current scar treatment landscape, one of the forefront approaches involves the grafting of adipose tissue and its components. This cutting-edge methodology encompasses various techniques, including nanofat grafting, adipose-derived stem cell matrigel applications, stromal vascular component transplantation, and adipose-derived mesenchymal stem cell infusion. Research in this domain has consistently demonstrated the remarkable capabilities of adipose tissue and its components in tissue regeneration, extracellular matrix remodeling, and anti-fibrotic actions. Notably, topical grafting of adipose tissue has emerged as a promising therapeutic avenue, showing significant improvements in both visual appearance and symptomatic relief associated with scars. The multifaceted functions of adipose tissue play a pivotal role in enhancing the overall outcomes of scar treatments. Therefore, this review aims to comprehensively evaluate and highlight the role of adipose tissue and its various components in scar treatment. By providing a theoretical foundation, this review aimed to serve as a valuable reference for improving the efficacy of scar management strategies.
{"title":"New frontiers in scar management: Adipose tissue transplantation techniques","authors":"Ilgiz Gareev , Ozal Beylerli , Boxian Zhao , Elmar Musaev","doi":"10.1016/j.cjprs.2024.09.001","DOIUrl":"10.1016/j.cjprs.2024.09.001","url":null,"abstract":"<div><div>A scar is a condition characterized by excessive repair of skin tissue, resulting in a fibroproliferative disorder marked by abnormal deposition of extracellular matrix. This disorder typically stems from deep dermal damage caused by burns or trauma and presents with symptoms such as itching and pain. Moreover, scarring can lead to disfigurement and psychological distress in affected individuals, making it a prevalent concern in burn plastic surgery outpatient clinics. In the current scar treatment landscape, one of the forefront approaches involves the grafting of adipose tissue and its components. This cutting-edge methodology encompasses various techniques, including nanofat grafting, adipose-derived stem cell matrigel applications, stromal vascular component transplantation, and adipose-derived mesenchymal stem cell infusion. Research in this domain has consistently demonstrated the remarkable capabilities of adipose tissue and its components in tissue regeneration, extracellular matrix remodeling, and anti-fibrotic actions. Notably, topical grafting of adipose tissue has emerged as a promising therapeutic avenue, showing significant improvements in both visual appearance and symptomatic relief associated with scars. The multifaceted functions of adipose tissue play a pivotal role in enhancing the overall outcomes of scar treatments. Therefore, this review aims to comprehensively evaluate and highlight the role of adipose tissue and its various components in scar treatment. By providing a theoretical foundation, this review aimed to serve as a valuable reference for improving the efficacy of scar management strategies.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 206-213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.cjprs.2024.09.003
Poh-Ching Tan , Eiji Kobayashi , Qingfeng Li , Shuangbai Zhou
Bioluminescence imaging (BLI) in rodent models has revolutionized preclinical research in recent decades, enabling precise and noninvasive observation of cellular and molecular processes in vivo. Among various bioluminescent systems, the firefly luciferase-luciferin system is one of the most widely employed for in vivo cell tracking. This comprehensive review focuses on using luciferase-transgenic (Luc-Tg) rat models, known as firefly rats, in conjunction with BLI to investigate tissue regeneration and stem cell dynamics. Compared with other imaging modalities, BLI offers enhanced tissue penetration, reduced background noise, and the capacity to perform longitudinal studies with fewer animals, aligning with ethical research principles. Applications of Luc-Tg rats in fat grafting, soft tissue expansion, hair growth cycle analysis, and other skin studies are discussed, demonstrating the versatility and precision of BLI in tracking complex biological processes. Integrating advanced analytical and genome-editing techniques with BLI promises to enhance data interpretation’s accuracy and efficiency. These advancements have deepened our understanding of the cellular fate and mechanisms underlying tissue regeneration, presenting promising avenues for optimizing therapeutic strategies in reconstructive surgery and regenerative medicine. Combining luciferase reporter genes and BLI is crucial to unraveling complex biological phenomena, advancing soft tissue regeneration research, and developing innovative therapeutic strategies for various medical conditions.
{"title":"Enhancing tissue regeneration studies with luciferase-transgenic rats and bioluminescence imaging: A comprehensive review","authors":"Poh-Ching Tan , Eiji Kobayashi , Qingfeng Li , Shuangbai Zhou","doi":"10.1016/j.cjprs.2024.09.003","DOIUrl":"10.1016/j.cjprs.2024.09.003","url":null,"abstract":"<div><div>Bioluminescence imaging (BLI) in rodent models has revolutionized preclinical research in recent decades, enabling precise and noninvasive observation of cellular and molecular processes <em>in vivo</em>. Among various bioluminescent systems, the firefly luciferase-luciferin system is one of the most widely employed for <em>in vivo</em> cell tracking. This comprehensive review focuses on using luciferase-transgenic (Luc-Tg) rat models, known as firefly rats, in conjunction with BLI to investigate tissue regeneration and stem cell dynamics. Compared with other imaging modalities, BLI offers enhanced tissue penetration, reduced background noise, and the capacity to perform longitudinal studies with fewer animals, aligning with ethical research principles. Applications of Luc-Tg rats in fat grafting, soft tissue expansion, hair growth cycle analysis, and other skin studies are discussed, demonstrating the versatility and precision of BLI in tracking complex biological processes. Integrating advanced analytical and genome-editing techniques with BLI promises to enhance data interpretation’s accuracy and efficiency. These advancements have deepened our understanding of the cellular fate and mechanisms underlying tissue regeneration, presenting promising avenues for optimizing therapeutic strategies in reconstructive surgery and regenerative medicine. Combining luciferase reporter genes and BLI is crucial to unraveling complex biological phenomena, advancing soft tissue regeneration research, and developing innovative therapeutic strategies for various medical conditions.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 214-218"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The inflammatory phase of acute burns can last for 7 days. Meanwhile, severe burns may exhibit persistent inflammation long after the initial tissue damage. Negative pressure wound therapy (NPWT) is recommended to treat various lesions, including burns. This study aimed to compare the number of inflammatory cells on days 3, 14, and 21 in deep dermal burns treated with two different therapies.
Methods
This experimental study was conducted at the Prof. Soeparwi Veterinary Hospital, Yogyakarta, from February to September 2022. A total of 36 wounds created in 10-kg Yorkshire pig burn models were subjected to one of the following treatments: 0.9% sodium chloride or NPWT. These wounds were then sampled as paraffin blocks for microscopic inflammatory cell counts by an anatomical pathology specialist. Comparative analyses of lymphocytes, neutrophils, and plasma cells were performed using IBM SPSS version 22 for Windows.
Results
A significant difference was found only in neutrophil counts on day 3 (5.30 ± 5.41), day 14 (42.83 ± 38.58), and day 21 (9.80 ± 8.97) (P=0.009), with notable changes from day 3 to day 14 (37.53 ± 40.51; P=0.043) and day 14 to day 21 (−33.03 ± 42.79; P=0.049). Meanwhile, no significant differences were found in either lymphocytes or plasma cells between days in either treatment group.
Conclusion
NPWT effectively reduced neutrophil counts on day 21 of treatment, indicating its beneficial effects in preventing prolonged inflammation during wound healing. This demonstrates its potential as an alternative dressing therapy for deep dermal burn injuries.
急性烧伤的炎症期可持续7天。同时，严重的烧伤可能在最初的组织损伤后很长一段时间内表现出持续的炎症。负压伤口疗法（NPWT）被推荐用于治疗各种病变，包括烧伤。本研究旨在比较两种不同治疗方法在第3天、第14天和第21天的炎症细胞数量。方法本实验研究于2022年2月至9月在日惹Soeparwi兽医医院进行。采用0.9%氯化钠或NPWT处理10公斤约克猪烧伤模型36个创面。然后由解剖病理学专家对这些伤口取样作为石蜡块进行显微镜下炎症细胞计数。使用IBM SPSS version 22 for Windows对淋巴细胞、中性粒细胞和浆细胞进行比较分析。结果中性粒细胞计数仅在第3天（5.30±5.41）天、第14天（42.83±38.58）天、第21天（9.80±8.97）天差异有统计学意义（P=0.009），第3天与第14天差异有统计学意义(37.53±40.51；P=0.043)和第14 ~ 21天(- 33.03±42.79；P = 0.049)。同时，两组间淋巴细胞和浆细胞均无明显差异。结论npwt在治疗第21天有效降低了中性粒细胞计数，提示其对预防创面愈合过程中持续炎症的有益作用。这证明了它作为深层皮肤烧伤的替代敷料疗法的潜力。
{"title":"Impact of negative pressure wound therapy on inflammatory cell counts in porcine deep dermal burn wound models","authors":"Giri Yurista , Nabilah Anisa Novebri , Irianiwati , Muhammad Rosadi Seswandhana","doi":"10.1016/j.cjprs.2024.09.002","DOIUrl":"10.1016/j.cjprs.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>The inflammatory phase of acute burns can last for 7 days. Meanwhile, severe burns may exhibit persistent inflammation long after the initial tissue damage. Negative pressure wound therapy (NPWT) is recommended to treat various lesions, including burns. This study aimed to compare the number of inflammatory cells on days 3, 14, and 21 in deep dermal burns treated with two different therapies.</div></div><div><h3>Methods</h3><div>This experimental study was conducted at the Prof. Soeparwi Veterinary Hospital, Yogyakarta, from February to September 2022. A total of 36 wounds created in 10-kg Yorkshire pig burn models were subjected to one of the following treatments: 0.9% sodium chloride or NPWT. These wounds were then sampled as paraffin blocks for microscopic inflammatory cell counts by an anatomical pathology specialist. Comparative analyses of lymphocytes, neutrophils, and plasma cells were performed using IBM SPSS version 22 for Windows.</div></div><div><h3>Results</h3><div>A significant difference was found only in neutrophil counts on day 3 (5.30 ± 5.41), day 14 (42.83 ± 38.58), and day 21 (9.80 ± 8.97) (<em>P</em>=0.009), with notable changes from day 3 to day 14 (37.53 ± 40.51; <em>P</em>=0.043) and day 14 to day 21 (−33.03 ± 42.79; <em>P</em>=0.049). Meanwhile, no significant differences were found in either lymphocytes or plasma cells between days in either treatment group.</div></div><div><h3>Conclusion</h3><div>NPWT effectively reduced neutrophil counts on day 21 of treatment, indicating its beneficial effects in preventing prolonged inflammation during wound healing. This demonstrates its potential as an alternative dressing therapy for deep dermal burn injuries.</div></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 4","pages":"Pages 166-171"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.cjprs.2024.08.002
Malay Sarkar , Nitin Kashyap , Irappa Madabhavi
Dupuytren’s disease is a well-known benign fibroproliferative disorder that affects the palmar and digital fasciae of the hands. This spectrum includes nodule formation, cord formation, and flexion contracture of the digits, which may result in functional limitations. These deformities are often progressive and irreversible. Surgery is a cornerstone therapy. This review discusses the epidemiology, pathophysiology, risk factors, clinical manifestations, and management of Dupuytren’s disease.
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Pub Date : 2024-09-01DOI: 10.1016/j.cjprs.2024.08.003
Gongxue Zhang , Wenhu Jin , Ziyang Zhang , Lei Shi , Rui Yang , Dali Wang
Background
Owing to its unique characteristics, the lateral circumflex femoral artery perforator (LCFAP) flap is often preferred for repairing head wounds with exposed skulls. However, given the vascular distribution in the head, particularly the veins, can lead to postoperative complications such as venous congestion of the flap. The rates of vascular exploration and necrosis in these flaps are significantly higher than in other body regions. Therefore, it is crucial to identify a safe and effective method for venous anastomosis of free flaps in the head region.
Methods
This retrospective case series study included 10 patients with large head soft tissue defects treated at the Burn and Plastic Surgery Department of the Affiliated Hospital of Zunyi Medical University from January 2020 to December 2022. The head defects were reconstructed using LCFAP flaps, with flap veins anastomosed to the external jugular vein in the neck, either directly or via a bridging technique.
Results
Among the 10 adult patients with massive head wound defects, 7 (70%) were men. The patients’ mean age was 53.0 years (48–59 years). The wound defects were caused by trauma in 6 (60%) patients and by tumors in 4 (40%) patients. Postoperatively, no significant complications occurred, and all LCFAP flap survived without necrosis.
Conclusion
The descending branch of the LCFAP flap effectively repairs massive head wound defects. The venous anastomosis method for this flap is associated with a low incidence of venous complications and a high patency rate, making it a clinically valuable reference.
{"title":"Lateral circumflex femoral artery perforator flap for the reconstruction of head soft tissue defects: Cross-region venous anastomosis","authors":"Gongxue Zhang , Wenhu Jin , Ziyang Zhang , Lei Shi , Rui Yang , Dali Wang","doi":"10.1016/j.cjprs.2024.08.003","DOIUrl":"10.1016/j.cjprs.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Owing to its unique characteristics, the lateral circumflex femoral artery perforator (LCFAP) flap is often preferred for repairing head wounds with exposed skulls. However, given the vascular distribution in the head, particularly the veins, can lead to postoperative complications such as venous congestion of the flap. The rates of vascular exploration and necrosis in these flaps are significantly higher than in other body regions. Therefore, it is crucial to identify a safe and effective method for venous anastomosis of free flaps in the head region.</p></div><div><h3>Methods</h3><p>This retrospective case series study included 10 patients with large head soft tissue defects treated at the Burn and Plastic Surgery Department of the Affiliated Hospital of Zunyi Medical University from January 2020 to December 2022. The head defects were reconstructed using LCFAP flaps, with flap veins anastomosed to the external jugular vein in the neck, either directly or via a bridging technique.</p></div><div><h3>Results</h3><p>Among the 10 adult patients with massive head wound defects, 7 (70%) were men. The patients’ mean age was 53.0 years (48–59 years). The wound defects were caused by trauma in 6 (60%) patients and by tumors in 4 (40%) patients. Postoperatively, no significant complications occurred, and all LCFAP flap survived without necrosis.</p></div><div><h3>Conclusion</h3><p>The descending branch of the LCFAP flap effectively repairs massive head wound defects. The venous anastomosis method for this flap is associated with a low incidence of venous complications and a high patency rate, making it a clinically valuable reference.</p></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 3","pages":"Pages 111-115"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2096691124000682/pdfft?md5=ae04b91865f365225c7df8ee0c4f9ea8&pid=1-s2.0-S2096691124000682-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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