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2019 Computing in Cardiology (CinC)最新文献

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Ring-Topology Echo State Networks for ICU Sepsis Classification 环状拓扑回声状态网络用于ICU脓毒症分类
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005810
M. Alfaras, Rui Varandas, H. Gamboa
Sepsis is a life threatening condition that can be treated if detected early. This paper presents a study of the application of a Ring Topology Echo State Network (ESN) algorithm to a sepsis prediction task based on ICU records. The implemented algorithm is compared with commonly used classifiers and a combination of both approaches. Finally, we address how different causal strategies on filling missing record values affected the final classification performances. Having a dataset with a limited number of time entries per patient, the utility score U = 0.188 obtained (team 51: PLUX) suggests that further research is needed in order for the ESN to capture the temporal dynamics of the problem at hand.
败血症是一种威胁生命的疾病,如果及早发现可以治疗。本文研究了环形拓扑回声状态网络(ESN)算法在基于ICU记录的脓毒症预测任务中的应用。将实现的算法与常用的分类器以及两种方法的组合进行了比较。最后,我们讨论了填充缺失记录值的不同因果策略如何影响最终的分类性能。拥有一个数据集,每个病人的时间条目数量有限,获得的效用得分U = 0.188(小组51:PLUX)表明,需要进一步的研究,以便回声状态网络捕捉手头问题的时间动态。
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引用次数: 4
Evaluation of Short-Term Pacing Effect to Predict Long-Term Response to Cardiac Resynchronization Therapy: the TRAJECTORIES Study 评估短期起搏效果以预测心脏再同步化治疗的长期反应:轨迹研究
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005678
G. Santarelli, Roberta Ciccotelli, G. Molon, F. Zanon, A. Corzani, A. Rossillo, M. Biffi, G. Zanotto, L. Lanzoni, S. Severi, C. Tomasi, C. Corsi
Cardiac resynchronization therapy (CRT) is an effective treatment for chronic symptomatic systolic heart failure with cardiac dyssynchrony, but about 1/3 of patients do not respond favorably to the therapy. We hypothesized that acute modifications of the coronary sinus (CS) pacing cathode movements induced by biventricular pacing may be related to resynchronization process and consequently may carry predictive power on CRT response. A method for the 3D reconstruction of CS lead’s pacing cathode trajectory (3DTJ) throughout a cardiac cycle showed that trajectory’s geometry suddenly changed in responders (R) upon starting of biventricular pacing, becoming less eccentric and more multi-directional. Our multicenter observational study aimed at evaluating the clinical value of 3DTJ. Out of 119 patients enrolled, 50 have ended follow-up and have been analyzed. Concordance between 3DTJ metrics and response was 82% overall (41/50), 91% in R (31/34), 62% in NR (10/16). The proposed 3DTJ metric showed high sensitivity (91%) with specificity=62%; PPV=84%, NPV=77%. From our data, 3DTJ seems a promising tool to acutely predict CS pacing site-specific response to CRT. Its investigational use as an intra-operatory, real-time guidance for selecting LV pacing sites may open new opportunities for CRT patients’ selection and therapy delivery.
心脏再同步化治疗(CRT)是治疗伴有心脏非同步化的慢性症状性收缩期心力衰竭的有效方法,但约1/3的患者对该治疗反应不良。我们假设双心室起搏引起的冠状窦起搏阴极运动的急性改变可能与再同步过程有关,因此可能对CRT反应具有预测作用。一种心脏周期内CS导联起搏阴极轨迹(3DTJ)的三维重建方法显示,在双心室起搏开始后,响应者(R)的轨迹几何形状突然发生变化,变得不那么偏心,更加多向。我们的多中心观察研究旨在评估3DTJ的临床价值。在纳入的119例患者中,有50例已结束随访并进行了分析。3DTJ指标与反应的一致性总体为82% (41/50),R为91% (31/34),NR为62%(10/16)。提出的3DTJ指标灵敏度高(91%),特异度为62%;PPV = 84%,净现值= 77%。从我们的数据来看,3DTJ似乎是一个很有前途的工具,可以准确预测CS起搏部位对CRT的特异性反应。它作为术中实时指导左室起搏点选择的研究应用,可能为CRT患者的选择和治疗提供新的机会。
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引用次数: 0
Factors Influencing Automated Limited Lead Detection of Atrial Fibrillation 影响心房颤动自动有限导联检测的因素
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005768
P. Macfarlane, S. Latif, B. Devine
There has been interest relating to automated analysis of a lead I ECG to detect cardiac arrhythmias. Little interest has been shown in the accuracy of using lead I as opposed to 6 limb leads or the full 12 lead ECG. The aim of this small study was to assess the efficacy of using only lead I but also to look at the effect of analysing a single 30s recording as a continuous recording versus five 10s overlapping recordings constituting a 30s record.One hundred 10s digital 12 lead ECGs with atrial fibrillation (AF) were used. Chest leads were removed and the 6 limb leads then used for analysis of rhythm. Similarly, lead I alone was used. Separately 100 single lead I ECGs classified as AF in the PhysioNet 2017 database were analysed, both as single 30s recordings and as five 10s ECGs commencing at 0, 5, 10, 15 and 20s from the start of the recording. An algorithm made the diagnosis from 5 reports. All analyses were made with the Glasgow Program. For the 10s 12 lead ECGs, 96% were reported as AF using 6 limb leads and 93% using lead I. For the 30s recordings, 92% were reported as AF using a single 30s analysis and 91% as AF using the five ECGs.In conclusion, one lead and 6 leads are not as sensitive as 12 leads in detecting AF, while five 10s reports combined are no more sensitive than a single 30s report though more specific.
有兴趣有关自动分析导联I心电图检测心律失常。与6条肢体导联或完整的12条导联心电图相比,使用导联1的准确性几乎没有什么兴趣。这项小型研究的目的是评估仅使用铅I的效果,同时也观察将单个30秒录音作为连续录音分析与将五个重叠的10秒录音组成30秒记录分析的效果。100例房颤(AF)采用数字12导联心电图。取胸导联,取6条肢体导联进行心律分析。同样地,只使用了铅1。分别分析了PhysioNet 2017数据库中分类为AF的100个单导联I心电图,包括单个30秒记录和从记录开始的0,5,10,15和20s开始的5个10秒心电图。一种算法从5份报告中进行诊断。所有的分析都是用格拉斯哥程序进行的。对于10s - 12导联心电图,使用6条肢体导联报告96%为房颤,使用1导联报告93%为房颤。对于30s记录,使用单个30s分析报告92%为房颤,使用5个心电图报告91%为房颤。综上所述,1导联和6导联对房颤的检测灵敏度不如12导联,而5个10导联加起来的灵敏度并不比单个30导联高,但特异性更强。
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引用次数: 0
A Graphical Evaluation Tool to Utilize ECG Data Without Reference Annotation 一种利用心电图数据的无参考注释的图形化评估工具
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005552
Yu-He Zhang, S. Babaeizadeh
Without reference annotation, statistical metrics such as sensitivity and positive predictive value (PPV) cannot be calculated. Annotating a large ECG database may not be feasible, hence, the interest in developing an evaluation tool that does not require reference annotation. We developed a tool for evaluating key performance attributes (KPA) including arrhythmia detection, heart rate, ST value, and noise tolerance. The tool has three layers of KPA graphics. The top layer includes interactive distribution graphs of the KPA values for aggregated results for the entire database. From this top layer the user can select an individual record to launch interactive trending graphs that display the KPA values, or their discrepancies, for a time span on that particular record. From this second layer the user can identify any KPA value of interest (e.g., a specific arrhythmia label) to view the underlying ECG waveform. Navigating through these three layers, the user is able to quickly confirm the validity of KPA reported by the algorithm. We modified the noise tolerance of an exercise ECG arrhythmia algorithm. Then used this tool to visually verify the resulting improvement on the Telemetric and Holter ECG Warehouse (THEW) stress database E-OTH-12-0927-015. We confirmed the visual verification of improvement by manually annotating a small subset of records in this database.
如果没有参考注释,则无法计算灵敏度和阳性预测值(PPV)等统计指标。对大型心电图数据库进行注释可能不可行,因此,开发一种不需要参考注释的评估工具是很有兴趣的。我们开发了一种评估关键性能属性(KPA)的工具,包括心律失常检测、心率、ST值和噪声耐受性。该工具有三层KPA图形。顶层包括整个数据库聚合结果的KPA值的交互式分布图。从这个顶层,用户可以选择一个单独的记录来启动交互式趋势图,显示特定记录上某个时间跨度的KPA值或它们的差异。从这第二层,用户可以识别任何感兴趣的KPA值(例如,特定的心律失常标签),以查看底层心电图波形。通过这三层导航,用户可以快速确认算法上报的KPA的有效性。对一种运动心律不齐算法的噪声容忍度进行了改进。然后使用该工具对遥测和动态心电图仓库(THEW)压力数据库E-OTH-12-0927-015进行可视化验证。我们通过手动标注该数据库中的一小部分记录来确认改进的视觉验证。
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引用次数: 0
Representation Learning for Early Sepsis Prediction 表征学习用于脓毒症早期预测
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005565
Luan Tran, M. Nguyen, C. Shahabi
As part of the PhysioNet/Computing in Cardiology Challenge 2019, we propose a neural network called AEC-Net to early detect sepsis based on physiological data. AEC-Net consists of two main components: 1) an Auto Encoder for dimension reduction and feature extraction, and 2) a Fully Connected Neural Network (FCNN) taking the extracted features by the Auto Encoder as the input and generating prediction of sepsis as output. The losses of both the Auto Encoder and FCNN are minimized concurrently. This concurrent optimization helps AEC-Net to have a better generalization and the extracted features by Auto Encoder to be more relevant to the classification problem. Finally, we propose an ensemble method of AEC-Net, Random Forest and Gradient Boosting Decision Trees to achieve a better prediction.We train our proposed models using data from 40336 patients with 40 physiological features ranging from 8 to 336 hours. Our team Infolab USC evaluated Ensemble with the hidden full test set of the Physionet Challenge 2019, and achieved a Utility score of 0.284 and 24th place in the challenge.
作为2019年PhysioNet/Computing in Cardiology Challenge的一部分,我们提出了一个名为AEC-Net的神经网络,根据生理数据早期检测败血症。AEC-Net主要由两个部分组成:1)用于降维和特征提取的Auto Encoder; 2)以Auto Encoder提取的特征作为输入,生成脓毒症预测作为输出的Fully Connected Neural Network (FCNN)。同时最小化了自动编码器和FCNN的损耗。这种并行优化有助于AEC-Net具有更好的泛化性,并且Auto Encoder提取的特征与分类问题更加相关。最后,我们提出了一种AEC-Net、随机森林和梯度增强决策树的集成方法,以达到更好的预测效果。我们使用40336例患者的数据来训练我们提出的模型,这些患者具有40种生理特征,时间从8到336小时不等。我们的团队Infolab USC使用Physionet Challenge 2019的隐藏完整测试集对Ensemble进行了评估,并获得了0.284的效用分数,在挑战中排名第24位。
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引用次数: 1
Local Atrial Conduction Velocity During Pacing as Indication of Atrial Fibrillation Substrate Complexity 起搏时局部心房传导速度作为心房颤动底物复杂性的指示
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005605
Frank van Rosmalen, L. Pison, T. Delhaas, H. Crijns, S. Zeemering, U. Schotten
Background: Pulmonary vein isolation (PVI) as treatment for atrial fibrillation (AF) is not effective in up to 60% of patients with persistent AF; AF drivers outside of the pulmonary veins can contribute to AF recurrences after PVI. In this study we explored the potential use of local conduction velocity (CV) during pacing as a marker of left atrial (LA) substrate complexity.Methods: LA activation times were recorded for 7 AF patients during coronary sinus (CS) pacing before PVI using a Pentaray catheter. Activation times were relative to the CS pacing spike. LA activation locations were triangularized to calculate CV: the local direction and speed of the activation wave front. CV was quantified by the total CV distribution.Results: A mean of 1622 CVs were calculated per patient. Distribution of CVs showed a similar morphology, with median CVs in the range [0.26, 0.36] and interquartile ranges in the range [0.29, 0.39].Conclusion: This study shows that although it is feasible to calculate CVs based on sequential CARTO mapping of the LA during CS pacing, the resulting distribution of CVs using this procedure is not necessarily able to identify substrate complexity because of the large similarity between distributions and the relatively small differences in medians.
背景:肺静脉隔离(PVI)作为房颤(AF)治疗在高达60%的持续性房颤患者中无效;肺静脉外的房颤驱动因素可导致PVI后房颤复发。在这项研究中,我们探讨了起搏期间局部传导速度(CV)作为左房底物复杂性标记的潜在用途。方法:对7例房颤患者在冠脉窦起搏(CS)时,使用Pentaray导管进行PVI前的LA激活次数进行记录。激活时间与CS起搏峰值相关。对LA激活位置进行三角化,计算激活波前的局部方向和速度CV。CV由总CV分布量化。结果:每位患者平均计算1622个cv。cv的分布形态相似,中位数cv在[0.26,0.36]范围内,四分位间cv在[0.29,0.39]范围内。结论:本研究表明,尽管基于CS起搏过程中LA的顺序CARTO映射计算cv是可行的,但由于分布之间的相似性很大,而中位数差异相对较小,因此使用该方法计算的cv分布不一定能够识别底物复杂性。
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引用次数: 0
Atrial Fibrillation Detection from PPG Interbeat Intervals via a Recurrent Neural Network 基于循环神经网络的PPG间隔房颤检测
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005767
J. V. Zaen, Elsa Genzoni, F. Braun, P. Renevey, E. Pruvot, J. Vesin, M. Lemay
Atrial fibrillation (AF) affects millions of individuals worldwide and can lead to serious complications such as stroke or heart failure. This arrhythmia is difficult to diagnose with ambulatory electrocardiogram monitors in the early stages due to its transient nature. Recent advances in wearable photoplethysmographic (PPG) devices are promising for screening AF in large populations as they are relatively comfortable and can be worn over long periods of time. Herein, we propose a system to detect AF from PPG recordings. This system is composed of a beat detector to extract interbeat intervals and a classifier for detection. We trained the classifier on a large public database of interbeat intervals and then evaluated the whole system on PPG recordings collected during catheter ablation procedures. We achieve an accuracy of 0.986 for the detection of AF with a sensitivity and specificity of 1.0 and 0.978 respectively. These metrics compare favorably with existing systems.
心房颤动(AF)影响着全世界数百万人,并可导致严重的并发症,如中风或心力衰竭。由于其短暂性,这种心律失常在早期很难用动态心电图监护仪诊断。可穿戴式光电脉搏波仪(PPG)设备的最新进展有望在大量人群中筛查房颤,因为它们相对舒适,可以长时间佩戴。在此,我们提出了一个从PPG记录中检测AF的系统。该系统由用于提取间歇拍的节拍检测器和用于检测的分类器组成。我们在一个大型的心跳间隔公共数据库上训练分类器,然后根据导管消融过程中收集的PPG记录评估整个系统。我们检测AF的准确度为0.986,灵敏度和特异性分别为1.0和0.978。与现有系统相比,这些指标更有优势。
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引用次数: 1
Improving the Performance of a Neural Network for Early Prediction of Sepsis 改进脓毒症早期预测的神经网络性能
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005754
ByeongTak Lee, Kyung-Jae Cho, Oyeon Kwon, Yeha Lee
Early prediction of sepsis is a clinically important, yet remains challenging. As machine learning develops, there have been many approaches for prediction of sepsis using neural network-based models. In this work, We propose various methods including feature engineering, regularization technique, and train data sampling methods, which can boost the performance of the model. Our approach consist of three-component: a feature engineering, an auxiliary loss, and a manipulation of training distribution. In feature engineering, we employed a novel input imputation method that combines input decay, masking, and duration of missing and input transformation. As for regularization, we used the reconstruction error as the auxiliary loss. Meanwhile, we manipulated the distribution of training sample using normal point re-sampling and population-based sampling. On the validation set, our approach improved the performance of LSTM as AUROC/AUPRC of 0. 045/0.017, and the performance of transformer is enhanced AUROC/AUPRC of 0.034/0.024. Finally, we submitted our transformer trained with proposed method on the official test set and obtained the utility score of 0.291 (Team name:vn, Rank:23).
脓毒症的早期预测在临床上很重要,但仍然具有挑战性。随着机器学习的发展,已经有许多方法可以使用基于神经网络的模型来预测败血症。在这项工作中,我们提出了多种方法,包括特征工程,正则化技术和训练数据采样方法,可以提高模型的性能。我们的方法由三个部分组成:特征工程、辅助损失和训练分布的操纵。在特征工程中,我们采用了一种结合输入衰减、掩蔽、缺失持续时间和输入变换的新颖输入输入方法。对于正则化,我们使用重构误差作为辅助损失。同时,我们采用正态点重抽样和基于总体抽样的方法对训练样本的分布进行了处理。在验证集上,我们的方法将LSTM的性能提高到AUROC/AUPRC为0。0.045 /0.017,提高了变压器的AUROC/AUPRC为0.034/0.024。最后,我们将用所提出的方法训练的变压器提交到官方测试集中,得到了0.291的效用分数(Team name:vn, Rank:23)。
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引用次数: 2
An Efficient Instantaneous ECG Delineation Algorithm 一种高效的瞬时心电圈定算法
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005708
Thion Ming Chieng, Y. Hau, Z. Omar, Chiao Wen Lim
An efficient electrocardiogram (ECG) delineation algorithm is proposed to instantaneously delineate the ECG characteristic points, such as peak, onset and offset points of QRS, P and T waves. It is essential to delineate the ECG characteristic waves accurately and precisely as it ensure the performance of ECG analysis and diagnosis. The proposed delineation algorithm is based on discrete wavelet transform (DWT) and moving window average (MWA) techniques. The proposed delineation algorithm is evaluated and assessed with the annotation data of QT database in term of accuracy, sensitivity and positive predictive value. With the only available 13 sets QT database records with modified Lead II data, the proposed algorithm achieved significant P peak, R peak, T peak and T offset delineation performance with the accuracy of 95.34%, 99.80%, 90.82% and 86.33% respectively when evaluated with q1c annotation file. The mean difference between detected and annotated T offset based on q1c and q2c is 13 ms and 3.6 ms respectively. The delineation of 15 minute-long ECG record only required 74.702 second. As conclusion, the proposed ECG delineation algorithm based on DWT and MWA techniques have been proven simple, efficient and accurate in delineating the significant ECG characteristic points.
提出了一种高效的心电描画算法,对QRS波、P波和T波的峰值点、起始点和偏移点等心电特征点进行实时描画。准确准确地描绘心电特征波是心电分析诊断的关键。该算法基于离散小波变换(DWT)和移动窗口平均(MWA)技术。利用QT数据库的标注数据对所提出的描述算法进行了准确性、灵敏度和阳性预测值的评价。在仅有的13组QT数据库记录中,使用修改过的Lead II数据,该算法在q1c注释文件评价时,P峰、R峰、T峰和T偏移量的描绘性能显著,准确率分别为95.34%、99.80%、90.82%和86.33%。基于q1c和q2c的检测和注释T偏移的平均差值分别为13 ms和3.6 ms。15分钟的心电记录圈定仅需74.702秒。综上所述,基于DWT和MWA技术的心电圈定算法简单、高效、准确地圈定了重要的心电特征点。
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引用次数: 1
U-Net Architecture for the Automatic Detection and Delineation of the Electrocardiogram 用于心电图自动检测和描绘的U-Net体系结构
Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005824
G. Jiménez-Pérez, A. Alcaine, O. Camara
Automatic detection and delineation of the electrocardiogram (ECG) is usually the first step for many feature extraction tasks. Although deep learning (DL) approaches have been proposed in the literature, those employ non-optimal and outdated architectures. Thus, rule-based algorithms remain as state-of-the-art. Nevertheless, those may not generalize on other datasets and require difficult offline tuning for adapting to new scenarios. This work frames this task as a segmentation problem for using an adaptation of the U-Net architecture, a fully convolutional network. The detection performance shows a precision of 89.27%, 98.18% and 93.60% for the detection of the P, QRS and T waves, respectively, and a recall of 89.07%, 99.47% and 95.21%. This work shows promising results, outperforming existing DL approaches while being more generalizable than rule-based methods.
心电图的自动检测和描绘通常是许多特征提取任务的第一步。虽然深度学习(DL)方法已经在文献中提出,但这些方法采用了非最优和过时的架构。因此,基于规则的算法仍然是最先进的。然而,这些可能不能推广到其他数据集,并且需要艰难的离线调优以适应新的场景。这项工作将这项任务定义为使用U-Net架构(一个全卷积网络)的自适应分割问题。P波、QRS波和T波的检测精度分别为89.27%、98.18%和93.60%,召回率分别为89.07%、99.47%和95.21%。这项工作显示了有希望的结果,优于现有的深度学习方法,同时比基于规则的方法更具通用性。
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引用次数: 18
期刊
2019 Computing in Cardiology (CinC)
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