Deepjyoti Boruah, Subhendu Ghosh, Raju Mandal, Bhisma K Patel
A polarity-mismatch-driven, photosensitizer-free protocol for the α,α-bis-functionalization of acetone has been developed, employing quinoxaline and maleimide as coupling partners. The photoactive species is identified as the ion-pair complex of protonated 2-phenylquinoxaline with methanesulfonate, wherein photoinduced electron transfer (PET) serves as the key mechanistic pathway. To the best of our knowledge, this is an unique photo-induced α,α-bisfunctionalization of acetone.
{"title":"Photosensitizer-free polarity-mismatched electrophilic α,α-bis-functionalization of acetone with quinoxaline and maleimide","authors":"Deepjyoti Boruah, Subhendu Ghosh, Raju Mandal, Bhisma K Patel","doi":"10.1039/d6cc00491a","DOIUrl":"https://doi.org/10.1039/d6cc00491a","url":null,"abstract":"A polarity-mismatch-driven, photosensitizer-free protocol for the α,α-bis-functionalization of acetone has been developed, employing quinoxaline and maleimide as coupling partners. The photoactive species is identified as the ion-pair complex of protonated 2-phenylquinoxaline with methanesulfonate, wherein photoinduced electron transfer (PET) serves as the key mechanistic pathway. To the best of our knowledge, this is an unique photo-induced α,α-bisfunctionalization of acetone.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"3 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Li, Pengfei Yang, Rui Wu, Qingyuan Meng, Jinyi Liu, Yan Zhao, Hongxia Yan
Incorporating α-aminophosphonate bridges into polyphosphonate chains effectively broadens the through-space conjugation (TSC), enhancing spatial electron delocalization. This results in a notable emission redshift to 630 nm with remarkable efficiency, demonstrating a robust structure-property relationship in the unconventional fluorescent polymers.
{"title":"Broadening Through-Space Conjugation in Polyphosphates through α-Aminophosphonate Bridges for a Noteworthy Red Shift in Luminescence","authors":"Zheng Li, Pengfei Yang, Rui Wu, Qingyuan Meng, Jinyi Liu, Yan Zhao, Hongxia Yan","doi":"10.1039/d5cc07165h","DOIUrl":"https://doi.org/10.1039/d5cc07165h","url":null,"abstract":"Incorporating α-aminophosphonate bridges into polyphosphonate chains effectively broadens the through-space conjugation (TSC), enhancing spatial electron delocalization. This results in a notable emission redshift to 630 nm with remarkable efficiency, demonstrating a robust structure-property relationship in the unconventional fluorescent polymers.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"11 5 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shichao Zhang, Panpan Li, Hanghang Liu, Chaofeng Zhang, Di Huang, Yingping Huang, Biao Xiong, Xiang Liu
The development of efficient CO2 capture technology coupled with its photocatalytic conversion into high-value chemicals represents a promising pathway to address environmental and energy challenges while advancing global carbon neutrality. Recently, integrated strategies coupling CO2 capture with in-situ photocatalytic conversion have attracted widespread research interest due to their potential to bypass energy-intensive steps such as CO2 desorption, purification, and compression, leading to significant progress in this field. This review systematically summarizes advances in such coupled systems, focusing on three key aspects: First, it evaluates CO2 capture media (e.g., aminebased solid adsorbents, porous materials, MOFs etc.) compatible with photocatalytic processes and analyzes the synergy between capture mechanisms and photoreduction. Furthermore, it addresses the long-overlooked issue of kinetic mismatch between capture and conversion, elucidating its impact on reaction pathways and system performance. Finally, this review proposes a paradigm shift from spatial coupling to temporal regulation and discusses remaining challenges and potential solutions. By synthesizing recent developments and identifying future directions, this review aims to provide a theoretical foundation and design principles for building efficient and stable integrated CO2 capture-photocatalysis systems, thereby accelerating their practical application and industrial adoption.
{"title":"Photocatalytic upcycling of captured carbon dioxide: current research progress and future directions","authors":"Shichao Zhang, Panpan Li, Hanghang Liu, Chaofeng Zhang, Di Huang, Yingping Huang, Biao Xiong, Xiang Liu","doi":"10.1039/d5cc06887h","DOIUrl":"https://doi.org/10.1039/d5cc06887h","url":null,"abstract":"The development of efficient CO2 capture technology coupled with its photocatalytic conversion into high-value chemicals represents a promising pathway to address environmental and energy challenges while advancing global carbon neutrality. Recently, integrated strategies coupling CO2 capture with in-situ photocatalytic conversion have attracted widespread research interest due to their potential to bypass energy-intensive steps such as CO2 desorption, purification, and compression, leading to significant progress in this field. This review systematically summarizes advances in such coupled systems, focusing on three key aspects: First, it evaluates CO2 capture media (e.g., aminebased solid adsorbents, porous materials, MOFs etc.) compatible with photocatalytic processes and analyzes the synergy between capture mechanisms and photoreduction. Furthermore, it addresses the long-overlooked issue of kinetic mismatch between capture and conversion, elucidating its impact on reaction pathways and system performance. Finally, this review proposes a paradigm shift from spatial coupling to temporal regulation and discusses remaining challenges and potential solutions. By synthesizing recent developments and identifying future directions, this review aims to provide a theoretical foundation and design principles for building efficient and stable integrated CO2 capture-photocatalysis systems, thereby accelerating their practical application and industrial adoption.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"1 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yue Yang, Yaqi Zhu, Su-Yun Zhang, Meng-Zhu Zhou, Hao Sun, Xiao-Ling Zhang, Xuan Yi, Ming-Xuan Liu
Featuring complex neural architectures, the central nervous system (CNS) poses a high risk of irreversible damage or chronic diseases upon injury by inflammatory factors. However, due to the existence of the blood-brain barrier (BBB), drugs can hardly penetrate the nervous system, making new therapeutic approaches urgently needed. Recently, single-atom nanozymes (SAzymes) have emerged as a promising platform for a wide range of therapeutic applications, capitalizing on their distinctive features including atomic-level dispersion of active sites, complete atom utilization, and a tunable coordination environment. Compared with traditional nanozymes, SAzymes exhibit superior catalytic activity, more decipherable structure-activity relationships, and greater tunability of their active site properties. Therefore, this review systematically summarizes and provides an in-depth discussion of typical single-atom nanozymes, including carbon materials, metal-organic frameworks (MOFs), metal oxides, and metal sulfides. Leveraging the anti-inflammatory and antibacterial properties, the roles of various SAzymes in brain injury, stroke, neurodegenerative diseases, biological monitoring, and neuroprotection are also elaborated in recent years. Simultaneously, based on the latest developments in SAzymes research, novel therapeutic strategies for these diseases are further proposed. Finally, we conduct an in-depth analysis of the key challenges and future research directions for SAzymes.
{"title":"Single-atom nanozymes: a new platform for central nervous system disease research","authors":"Yue Yang, Yaqi Zhu, Su-Yun Zhang, Meng-Zhu Zhou, Hao Sun, Xiao-Ling Zhang, Xuan Yi, Ming-Xuan Liu","doi":"10.1039/d6cc00053c","DOIUrl":"https://doi.org/10.1039/d6cc00053c","url":null,"abstract":"Featuring complex neural architectures, the central nervous system (CNS) poses a high risk of irreversible damage or chronic diseases upon injury by inflammatory factors. However, due to the existence of the blood-brain barrier (BBB), drugs can hardly penetrate the nervous system, making new therapeutic approaches urgently needed. Recently, single-atom nanozymes (SAzymes) have emerged as a promising platform for a wide range of therapeutic applications, capitalizing on their distinctive features including atomic-level dispersion of active sites, complete atom utilization, and a tunable coordination environment. Compared with traditional nanozymes, SAzymes exhibit superior catalytic activity, more decipherable structure-activity relationships, and greater tunability of their active site properties. Therefore, this review systematically summarizes and provides an in-depth discussion of typical single-atom nanozymes, including carbon materials, metal-organic frameworks (MOFs), metal oxides, and metal sulfides. Leveraging the anti-inflammatory and antibacterial properties, the roles of various SAzymes in brain injury, stroke, neurodegenerative diseases, biological monitoring, and neuroprotection are also elaborated in recent years. Simultaneously, based on the latest developments in SAzymes research, novel therapeutic strategies for these diseases are further proposed. Finally, we conduct an in-depth analysis of the key challenges and future research directions for SAzymes.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"29 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuehui Wang, Lele Wen, Lin Ling, Chun-Hui Xing, Long Lv
The difluoroamino (NF2) group is a highly valuable energetic moiety. This work presents a mild method for converting aromatic ketones into novel gem-difluoramino compounds using Me4NSO3NF2. Their structures were confirmed by spectroscopy and crystallography. Compound 2k exhibtis high thermal stability, lower sensitivity, and superior detonation performance, demonstrating its potential as high-energy oxidizer.
{"title":"Direct NF₂ Functionalization of Ketones: A Mild Strategy for Accessing High-Performance gem-Difluoroamino Compounds","authors":"Yuehui Wang, Lele Wen, Lin Ling, Chun-Hui Xing, Long Lv","doi":"10.1039/d6cc00009f","DOIUrl":"https://doi.org/10.1039/d6cc00009f","url":null,"abstract":"The difluoroamino (NF2) group is a highly valuable energetic moiety. This work presents a mild method for converting aromatic ketones into novel gem-difluoramino compounds using Me4NSO3NF2. Their structures were confirmed by spectroscopy and crystallography. Compound 2k exhibtis high thermal stability, lower sensitivity, and superior detonation performance, demonstrating its potential as high-energy oxidizer.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"46 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dogyeong Jeon, Heejun Park, Jong Won Baek, Ki R Yoon, Sang-Joon Kim, Il-Doo Kim
An ultrafast photothermal shock simultaneously crystallizes amorphous vanadium oxide and anchors Co single-atoms, kinetically suppressing atomic aggregation within milliseconds. Featuring a vanadium oxide crystalline phase tunable by the applied shock energy and a photothermal temperature reaching 1600 °C, the resulting self-supported electrode demonstrates a proof-of-concept application as a catalyst for the electrochemical oxygen evolution reaction, establishing an efficient route toward advanced single-atom catalysts.
{"title":"Ultrafast photothermal shock for crystallization of vanadium oxide and in situ anchoring of Co single atoms for enhanced oxygen evolution reaction","authors":"Dogyeong Jeon, Heejun Park, Jong Won Baek, Ki R Yoon, Sang-Joon Kim, Il-Doo Kim","doi":"10.1039/d5cc06213f","DOIUrl":"https://doi.org/10.1039/d5cc06213f","url":null,"abstract":"An ultrafast photothermal shock simultaneously crystallizes amorphous vanadium oxide and anchors Co single-atoms, kinetically suppressing atomic aggregation within milliseconds. Featuring a vanadium oxide crystalline phase tunable by the applied shock energy and a photothermal temperature reaching 1600 °C, the resulting self-supported electrode demonstrates a proof-of-concept application as a catalyst for the electrochemical oxygen evolution reaction, establishing an efficient route toward advanced single-atom catalysts.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"89 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian-Qian Xu, Zong-Bo Xie, Zhang-Gao Le, Zhi-Qiang Zhu
The photoexcitation of Electron Donor-Acceptor (EDA) complexes has emerged as a powerful, often metal-free strategy for generating reactive radical species under mild conditions. Ketone-derived oxime esters, particularly O-aryl oximes and cyclic O-acyl oximes, serve as exemplary electron-accepting precursors due to their tunable redox potentials and weak N–O bonds. Regarding our continuous interest in photoactive EDA driven transformations of O-acyl oximes, this review systematically organizes and analyzes the extensive literature on EDA complex-mediated reactions of these oxime derivatives by classifying the fundamental reaction pathways of the initially generated iminyl radicals: (1) iminyl radical intramolecular cyclizations for the construction of N-heterocycles; (2) iminyl radical intermolecular chemistry involving radical addition or cross-coupling; (3) cyanoalkyl radical chemistry via ring-opening of cyclic iminyl radicals, a pathway that converts iminyl radicals into synthetically versatile cyanoalkyl radicals; and (4) formal 1,3- or 1,5-hydrogen atom transfer (HAT) of iminyl radicals for remote C–H functionalization. For each category, we present mechanistic discussions underpinned by spectroscopic, kinetic, and computational evidence, highlight strategic advantages and illustrate the broad synthetic utility of this rapidly evolving platform.
{"title":"Photoinduced Transformations of Oxime Derivatives via Electron Donor-Acceptor Complexes Activation","authors":"Qian-Qian Xu, Zong-Bo Xie, Zhang-Gao Le, Zhi-Qiang Zhu","doi":"10.1039/d5cc07251d","DOIUrl":"https://doi.org/10.1039/d5cc07251d","url":null,"abstract":"The photoexcitation of Electron Donor-Acceptor (EDA) complexes has emerged as a powerful, often metal-free strategy for generating reactive radical species under mild conditions. Ketone-derived oxime esters, particularly O-aryl oximes and cyclic O-acyl oximes, serve as exemplary electron-accepting precursors due to their tunable redox potentials and weak N–O bonds. Regarding our continuous interest in photoactive EDA driven transformations of O-acyl oximes, this review systematically organizes and analyzes the extensive literature on EDA complex-mediated reactions of these oxime derivatives by classifying the fundamental reaction pathways of the initially generated iminyl radicals: (1) iminyl radical intramolecular cyclizations for the construction of N-heterocycles; (2) iminyl radical intermolecular chemistry involving radical addition or cross-coupling; (3) cyanoalkyl radical chemistry via ring-opening of cyclic iminyl radicals, a pathway that converts iminyl radicals into synthetically versatile cyanoalkyl radicals; and (4) formal 1,3- or 1,5-hydrogen atom transfer (HAT) of iminyl radicals for remote C–H functionalization. For each category, we present mechanistic discussions underpinned by spectroscopic, kinetic, and computational evidence, highlight strategic advantages and illustrate the broad synthetic utility of this rapidly evolving platform.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"8 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dongliang Ji, Jian Chen, Yifan Ma, Ningning Luo, Yangyang Jiang, Rong Cao, Dongwei Liu, Yunhao Zhang, Lei Wang, Tao Yang, Yong Ling
The novel radiation-activated prodrug NOS, derived from sorafenib, is reduced by hydrated electrons (eaq-) to enable synergistic and highly selective chemo-radiotherapy. NOS exerts its inhibitory effect by inducing DNA damage and activating the ATM/ATR pathway, effectively achieving a 90.5% tumor inhibition rate in a liver cancer xenograft model.
{"title":"Novel radiation-activated <i>N</i>-oxide prodrugs for highly selective and synergistic tumor therapy to promote DNA damage and the ATM/ATR pathway.","authors":"Dongliang Ji, Jian Chen, Yifan Ma, Ningning Luo, Yangyang Jiang, Rong Cao, Dongwei Liu, Yunhao Zhang, Lei Wang, Tao Yang, Yong Ling","doi":"10.1039/d5cc06629h","DOIUrl":"https://doi.org/10.1039/d5cc06629h","url":null,"abstract":"<p><p>The novel radiation-activated prodrug NOS, derived from sorafenib, is reduced by hydrated electrons (e<sub>aq</sub><sup>-</sup>) to enable synergistic and highly selective chemo-radiotherapy. NOS exerts its inhibitory effect by inducing DNA damage and activating the ATM/ATR pathway, effectively achieving a 90.5% tumor inhibition rate in a liver cancer xenograft model.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shabnam Raheem, Faheem Fayaz, Majid Ahmed Ganie, Masood Ahmad Rizvi, Bhahwal Ali Shah
We report the first photoredox-mediated one-step synthesis of propargylic sulfoxides from (3-chloroprop-1-yn-1-yl)benzene and thiols. The protocol obviates the need for external oxidants typically required for the oxidation of sulfides to sulfoxides. The approach offers a streamlined platform for accessing these valuable organosulfur compounds in a single step, with high chemoselectivity and functional-group tolerance.
{"title":"Photoredox mediated synthesis of propargylic sulfoxides: A one-step aerobic approach","authors":"Shabnam Raheem, Faheem Fayaz, Majid Ahmed Ganie, Masood Ahmad Rizvi, Bhahwal Ali Shah","doi":"10.1039/d6cc00022c","DOIUrl":"https://doi.org/10.1039/d6cc00022c","url":null,"abstract":"We report the first photoredox-mediated one-step synthesis of propargylic sulfoxides from (3-chloroprop-1-yn-1-yl)benzene and thiols. The protocol obviates the need for external oxidants typically required for the oxidation of sulfides to sulfoxides. The approach offers a streamlined platform for accessing these valuable organosulfur compounds in a single step, with high chemoselectivity and functional-group tolerance.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"289 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The significance of medium-sized rings is demonstrated by their being key structural cores in diverse bioactive molecules. Herein, we describe an efficient strategy for synthesizing oxindole-annulated medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement. This strategy features high substrate tolerance and yield, offering a versatile approach to such intricate skeletons.
{"title":"Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement","authors":"Yongqiang Xu, Wenkai Li, Xiaoli Gu, Yuhan Zhou, Jingping Qu, Baomin Wang","doi":"10.1039/d5cc06578j","DOIUrl":"https://doi.org/10.1039/d5cc06578j","url":null,"abstract":"The significance of medium-sized rings is demonstrated by their being key structural cores in diverse bioactive molecules. Herein, we describe an efficient strategy for synthesizing oxindole-annulated medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement. This strategy features high substrate tolerance and yield, offering a versatile approach to such intricate skeletons.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"1 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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