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Expression of hyperphosphorylated Tau protein in retrograde degeneration of neurons 过度磷酸化Tau蛋白在神经元退行性变性中的表达
Pub Date : 2020-04-10 DOI: 10.3760/CMA.J.CN311653-20190702-00188
Shan-Shan Tao, Xiao-yun Pan, Chen Liu, Jingyi Mi
Objective To explore the expression of hyperphosphorylated Tau protein in the retrograde degeneration of spinal central neurons after cervical 7 nerve transection, so as to provide a new idea for the protection of retrograde degeneration of central neurons after peripheral nerve injury. Methods Thirty-six adult female Sprague-Dawley rats were randomly divided into three groups (sham operation group, transection group, transection+drug intervention group). The rats in transection group and transection+drug intervention group were treated with bilateral cervical 7 nerve cutting to make models, and the rats in transection+drug intervention group were treated with 1 mmol/kg lithium chloride intraperitoneally every day. After 2 and 4 weeks, the spinal cords of cervical 7 of the rats were taken, and the apoptosis of neurons was analyzed by HE staining and flow cytometry. The expression of Tau protein and related protein was analyzed by Western blot. Results HE staining and flow cytometry showed that the apoptotic degree of the transection group at 2 weeks was less than that at 4 weeks. The resutls of Western blot showed that as time went on, the amount of total Tau protein decreased due to the transection of cervical 7 nerve, and the proportion of phosphorylated Tau protein increased. The difference was statistically significant. After lithium chloride administration, the degree of apoptosis and the proportion of phosphorylated Tau protein decreased significantly. Conclusion The mechanism of Tau protein hyperphosphorylation lies in the process of retrograde degeneration of spinal cord central neurons after cervical 7 transection, and lithium chloride can reduce the degree of retrograde degeneration. Key words: Tau proteins; Brachial plexus; Neuron retrograde degeneration; Hyperphosphorylation
目的探讨高磷酸化Tau蛋白在颈7神经横断后脊髓中枢神经元逆行变性中的表达,为周围神经损伤后中枢神经元逆行变性的保护提供新的思路。方法36只成年雌性Sprague-Dawley大鼠随机分为假手术组、横断组、横断+药物干预组。横断组和横断+药物干预组大鼠采用双侧颈7神经切开制作模型,横断+药物干预组大鼠每天腹腔注射1 mmol/kg氯化锂。2、4周后取颈7大鼠脊髓,采用HE染色和流式细胞术观察神经元凋亡情况。Western blot检测Tau蛋白及相关蛋白的表达。结果HE染色和流式细胞术显示,横断组2周的细胞凋亡程度低于4周。Western blot结果显示,随着时间的延长,颈7神经横断导致Tau蛋白总量减少,磷酸化Tau蛋白比例增加。差异有统计学意义。氯化锂给药后,细胞凋亡程度和磷酸化Tau蛋白比例明显降低。结论Tau蛋白过度磷酸化的机制与颈7横断后脊髓中枢神经元逆行变性过程有关,氯化锂可减轻逆行变性程度。关键词:Tau蛋白;臂神经丛;神经元逆行性变性;Hyperphosphorylation
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引用次数: 0
Clinical efficacy analysis of trans-articular plate combined with Kirschner wire for treatment of the fifth carpometacarpal joint fracture and dislocation 经关节钢板联合克氏针治疗第五腕关节骨折脱位的临床疗效分析
Pub Date : 2020-04-10 DOI: 10.3760/CMA.J.CN311653-20190724-00207
S. Gu, R. Xie, Yinjun Huang
Objective To evaluate the clinical efficacy of trans-articular plate combined with Kirschner wire for treatment of the fifth carpometacarpal joint fracture and dislocation. Methods From July 2016 to June 2018, 10 cases of the fifth carpometacarpal joint fracture and dislocation were treated with trans-articular plate combined with Kirschner wire. The pain, range of motion, function and grip strength of the wrist were followed up after operation, and the effect was evaluated by Cooney wrist function score. Results The postoperative follow-up period ranged from 10 to 33 months, with an average of 20.3 months. There were no complications such as fracture of internal fixation, nonunion and malunion of fracture. At the last follow-up, the flexion and extension range of the affected wrist was (116.2±11.9)° which was 89.6% of that of the healthy side; the grip strength of the affected side was (85.2±19.6) lb which was 91.1% of that of the healthy side. There were 7 cases without pain and 3 cases with occasional pain. All patients returned to normal work. According to Cooney's wrist function score, 2 cases were excellent and 8 cases were good. Conclusion The clinical efficacy of trans-articular plate combined with Kirschner wire for treatment of the fifth carpometacarpal joint fracture and dislocation is satisfactory and worthy of clinical application. Key words: Fractures,bone; Treatment outcome; Kirschner wire; Carpometacarpal joint
目的探讨经关节钢板联合克氏针治疗第五腕关节骨折脱位的临床疗效。方法对2016年7月~ 2018年6月收治的10例第五腕关节骨折脱位患者进行经关节钢板联合克氏针治疗。术后随访患者腕关节疼痛、活动度、功能及握力,采用Cooney腕功能评分法评价疗效。结果术后随访10 ~ 33个月,平均20.3个月。无内固定骨折、骨折不连、畸形愈合等并发症。末次随访时,患侧腕关节屈伸度为(116.2±11.9)°,为健侧的89.6%;患侧握力为(85.2±19.6)lb,为健侧握力的91.1%。无疼痛7例,偶有疼痛3例。所有患者均恢复正常工作。根据Cooney腕功能评分,优2例,良8例。结论经关节钢板联合克氏针治疗第五腕关节骨折脱位的临床疗效满意,值得临床推广应用。关键词:骨折;骨;治疗效果;柯式线;腕掌的联合
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引用次数: 1
A retrospective comparative study in the treatment of acromioclavicular joint dislocation: ligaments reconstruction with allogenic tendon versus Endobutton technique 异体肌腱重建韧带与内固定技术治疗肩锁关节脱位的回顾性比较研究
Pub Date : 2020-04-10 DOI: 10.3760/CMA.J.CN311653-20190830-06169
Guheng Wang, Shuang Li, Yalan Chen, S. Xing, Jian-wei Hou, T. Mao, Jun Tan, Ai-dong Deng, R. Xie
Objective To compare the clinical efficacy of reconstruction of trapezium ligament, conoid ligament and acromioclavicular ligament with allogeneic tendon and Endoboutton reduction and fixation in the treatment of acromioclavicular joint dislocation. Methods From February 2010 to August 2016, 16 patients with acromioclavicular joint dislocation were treated, including 8 patients who used allogeneic tendons to reconstruct trapezoid ligament, conoid ligament and the upper and lower parts of acromioclavicular ligament, and 8 patients who used Endobouton technique to reconstruct coracoclavicular ligament. The follow-up of patients' overall satisfaction, observation of shoulder shape, measurement of shoulder joint activity, X-ray evaluation of acromioclavicular joint reduction and maintenance were conducted. The Constant-Murley score and DASH score were used to evaluate the functional recovery of shoulder and upper extremity, and the visual analog scale (VAS) was used to obtain the pain of patients. The follow-up results of the two methods were compared. Results The follow-up period ranged from 34 to 60 months with an average of 48.8 months. All the patients were satisfied with the treatment results and the shape of shoulder joint was normal. In the allogeneic tendon group, the Constant-Murley score was 94.5±5.2, the DASH score was 2.1±2.6, and the VAS score was 0.4±1.1; in the Endobutton group, the Constant-Murley score was 92.8±3.7, the DASH score was 2.2±2.0, and the VAS score was 0.3±0.7. There were no significant differences between the two groups (P>0.05). Conclusion The technique of allogeneic tendon reconstruction and Endoboutton in the treatment of acromioclavicular joint dislocation can achieve satisfactory results, and the allogeneic tendon is more close to the biomechanical requirements, which is an effective method. Key words: Acromioclavicular joint; Dislocations; Allogeneic tendon; Ligament reconstruction; Endobutton technique
目的比较同种异体肌腱重建斜方韧带、圆锥韧带和肩锁韧带内固定术治疗肩锁关节脱位的临床疗效。方法2010年2月至2016年8月对16例肩锁关节脱位患者进行治疗,其中8例采用同种异体肌腱重建肩锁韧带梯形、圆锥韧带及上、下段,8例采用Endobouton技术重建喙锁韧带。随访患者总体满意度,观察肩关节形态,测量肩关节活动度,x线评价肩锁关节复位及维持情况。采用Constant-Murley评分和DASH评分评估患者肩、上肢功能恢复情况,采用视觉模拟评分(VAS)评估患者疼痛程度。比较两种方法的随访结果。结果随访34 ~ 60个月,平均48.8个月。所有患者均对治疗效果满意,肩关节形态正常。同种异体肌腱组Constant-Murley评分为94.5±5.2,DASH评分为2.1±2.6,VAS评分为0.4±1.1;Endobutton组的Constant-Murley评分为92.8±3.7,DASH评分为2.2±2.0,VAS评分为0.3±0.7。两组间比较差异无统计学意义(P < 0.05)。结论同种异体肌腱重建联合内压术治疗肩锁关节脱位可取得满意的效果,且同种异体肌腱更接近生物力学要求,是一种有效的方法。关键词:肩锁关节;混乱;同种异体肌腱;韧带重建;Endobutton技术
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引用次数: 0
Management strategy of acute hand injury in epidemic period of COVID-19 新冠肺炎流行期急性手部损伤的处理策略
Pub Date : 2020-02-28 DOI: 10.3760/CMA.J.CN311653-20200226-00000
Qishun Huang, Xia Wu, Kun Wang, Xiaobin Cong, Jia Tian, Fang-xing Ai, P. Zhou, W. Lei, G. Guo, Zhengyu Liu, Xiaofan Yang, Gongchi Li, Yutian Liu, Xiaocheng Lu, Wei Ji, Tao Li, Huaiyuan Zheng, Yan-hua Chen, Jin Li, Jing-hua Chen, Yu-xiong Weng, Zhenbing Chen
To explore how to make the hand injury patients get timely and effective treatment under the background of COVID-19 epidemic situation, and effectively prevent the spread of the epidemic situation. Through the training of relevant knowledge for medical staff, hand trauma patients were classified according to the contact history of the epidemic situation and clinical symptoms, and the corresponding treatment plan was taken. Since the outbreak of the epidemic, hand trauma patients were treated in time and effectively, no case of infection of medical staff occurred, and no epidemic spread. Combined with the emergency management regulations of infection prevention and control in the epidemic period, this paper puts forward suggestions for the treatment of hand injury in the COVID-19 epidemic period, aiming to provide a reference for hand surgeons in dealing with hand injury in the epidemic period. Key words: Hand injuries; Pneumonia; COVID-19; Infection control
探讨在新冠肺炎疫情背景下,如何使手部损伤患者得到及时有效的治疗,有效防止疫情的蔓延。通过对医护人员进行相关知识培训,根据疫情接触史和临床症状对手部创伤患者进行分类,并采取相应的治疗方案。疫情发生以来,手部外伤患者得到及时有效的治疗,未发生医务人员感染病例,未发生疫情蔓延。本文结合流行期感染防控应急管理规定,提出新冠肺炎流行期手部损伤的救治建议,旨在为手外科医生在流行期处理手部损伤提供参考。关键词:手部损伤;肺炎;COVID-19;感染控制
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引用次数: 0
Vascularized anterior subcutaneous transposition of the ulnar nerve with inferior ulnar collateral artery for treatment of severe cubital tunnel syndrome through minimal incision in elbow 尺骨下副动脉带血管化尺神经前皮下移位术治疗肘小切口重度肘管综合征
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.017
F. Zhao, Bowen Zhang, Jian Gao, Yonglu Huang, F. Gong, Xiaoliang Li, Yi Ding, Han-qi Zhang, Lipeng Zhang, Kai-Ling Peng
Objective To investigate the surgical method and clinical efficacy of vascularized anterior subcutaneous transposition of the ulnar nerve with inferior ulnar collateral artery for treatment of severe cubital tunnel syndrome through minimal incision in the medial elbow. Methods From June 2015 to June 2017, 22 patients with severe cubital tunnel syndrome were admitted and divided into two groups according to different surgical methods: the vascularized anterior subcutaneous transposition of the ulnar nerve and the vascularized anterior subcutaneous transposition of the ulnar nerve through minimal incision in elbow. The conduction velocity of ulnar nerve through elbow joint, the two-point discrimination of the distal pulp of the little finger and the length of incision were compared between the two groups. Results All the 22 patients were follow-up for 8 to 15 months, with an average of 12.2 months. The excellent and good rate was 82.29% in the vascularized anterior subcutaneous transposition of the ulnar nerve group and 80.91% in the group with minimal incision in elbow. There was no significant difference between the two groups in the changes of ulnar nerve conduction velocity before and after the operation and in the recovery of two-point discrimination of the distal pulp of the little finger. After using the minimal incision in elbow, the average conventional incision of 13.4 cm was reduced to 4.7 cm. Conclusion The vascularized anterior subcutaneous transposition of the ulnar nerve operation ensures the blood supply of the local ulnar nerve of the elbow. It is a kind of operation method for the treatment of severe cubital tunnel syndrome. On this basis, the selection of the minimal incision on the medial side of the elbow can also achieve the clinical efficacy of the conventional incision length. The minimal incision can recover more quickly and the appearance of operation area is better. Key words: Cubital tunnel syndrome; Treatment outcome; Severe; Inferior ulnar collateral artery
目的探讨经肘内侧小切口带尺侧下副动脉的尺神经前皮下移位术治疗严重肘管综合征的手术方法和临床疗效。方法自2015年6月至2017年6月,收治22例严重肘管综合征患者,根据不同的手术方法分为两组:带血管的尺神经前皮下移位术和经肘部小切口带血管的尺骨神经前皮下转位术。比较两组尺骨神经经肘关节的传导速度、小指远端髓两点辨别和切口长度。结果22例患者均随访8~15个月,平均12.2个月。带血管的尺神经前皮下移位组优良率为82.29%,肘部小切口组优良率80.91%。两组患者术前、术后尺神经传导速度的变化及小指远端髓两点辨别能力的恢复均无显著性差异。在肘部使用最小切口后,常规切口的平均13.4 cm减少到4.7 cm。结论带血管的尺神经前皮下移位术确保了肘部局部尺神经的血液供应。它是治疗严重肘管综合征的一种手术方法。在此基础上,选择肘部内侧的最小切口也可以达到常规切口长度的临床疗效。小切口可以更快地恢复,手术区域的外观更好。关键词:肘管综合征;治疗结果;严重;尺下副动脉
{"title":"Vascularized anterior subcutaneous transposition of the ulnar nerve with inferior ulnar collateral artery for treatment of severe cubital tunnel syndrome through minimal incision in elbow","authors":"F. Zhao, Bowen Zhang, Jian Gao, Yonglu Huang, F. Gong, Xiaoliang Li, Yi Ding, Han-qi Zhang, Lipeng Zhang, Kai-Ling Peng","doi":"10.3760/CMA.J.ISSN.1005-054X.2020.01.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-054X.2020.01.017","url":null,"abstract":"Objective \u0000To investigate the surgical method and clinical efficacy of vascularized anterior subcutaneous transposition of the ulnar nerve with inferior ulnar collateral artery for treatment of severe cubital tunnel syndrome through minimal incision in the medial elbow. \u0000 \u0000 \u0000Methods \u0000From June 2015 to June 2017, 22 patients with severe cubital tunnel syndrome were admitted and divided into two groups according to different surgical methods: the vascularized anterior subcutaneous transposition of the ulnar nerve and the vascularized anterior subcutaneous transposition of the ulnar nerve through minimal incision in elbow. The conduction velocity of ulnar nerve through elbow joint, the two-point discrimination of the distal pulp of the little finger and the length of incision were compared between the two groups. \u0000 \u0000 \u0000Results \u0000All the 22 patients were follow-up for 8 to 15 months, with an average of 12.2 months. The excellent and good rate was 82.29% in the vascularized anterior subcutaneous transposition of the ulnar nerve group and 80.91% in the group with minimal incision in elbow. There was no significant difference between the two groups in the changes of ulnar nerve conduction velocity before and after the operation and in the recovery of two-point discrimination of the distal pulp of the little finger. After using the minimal incision in elbow, the average conventional incision of 13.4 cm was reduced to 4.7 cm. \u0000 \u0000 \u0000Conclusion \u0000The vascularized anterior subcutaneous transposition of the ulnar nerve operation ensures the blood supply of the local ulnar nerve of the elbow. It is a kind of operation method for the treatment of severe cubital tunnel syndrome. On this basis, the selection of the minimal incision on the medial side of the elbow can also achieve the clinical efficacy of the conventional incision length. The minimal incision can recover more quickly and the appearance of operation area is better. \u0000 \u0000 \u0000Key words: \u0000Cubital tunnel syndrome; Treatment outcome; Severe; Inferior ulnar collateral artery","PeriodicalId":67383,"journal":{"name":"中华手外科杂志","volume":"36 1","pages":"55-57"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45615280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The repair of the defects of two fingertips with free tibial pedicle double flaps of the second toe 第二足趾双蒂游离皮瓣修复双指缺损
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.011
Y. Duan, J. Ju, Guangliang Zhang, Xin-yi Liu, You Li, Guodong Jiang
Objective To explore the surgical method and clinical efficacy of two free flaps pedicled with the tibial proper toe artery of the second toe for repair of the defects of two fingertips. Methods From November 2014 to September 2018, five patients with the defects of two fingertips were treated with one pedicle double flaps of the tibial side of the second toe in emergency. The proper artery of the tibial side of the second toe was used as the vascular pedicle. The blood circulation of the two flaps and the injured finger was reconstructed. The donor site was replanted with full thickness skin graft of the medial leg. Results All the 10 finger flaps survived uneventfully. The donor and recipient wounds achieved primary healing without vascular crisis. The postoperative follow-up ranged from 6 to 24 months with an average of 12 months. The appearance, sensation and function of the free flaps recovered well. No second operation was needed to thin the flaps. There were no obvious scar hyperplasia and contracture in the donor site, no abrasion resistance and pain. Conclusion The application of two free flaps from the tibial side of the second toe to repair fingertip defect of two fingers can cover the defect wound, ensure the appearance, sensation and function of the finger, reduce the number of donor sites and damage. It is an ideal repair method. Key words: Finger injuries; Surgical flaps; The second toe; One pedicle and double flaps
目的探讨以第二趾胫固有趾动脉为蒂的游离皮瓣修复两指缺损的手术方法及临床疗效。方法2014年11月~ 2018年9月,对5例双指缺损患者急诊采用第二趾胫侧一蒂双皮瓣修复。以第二趾胫骨侧的固有动脉作为血管蒂。重建了皮瓣和损伤手指的血液循环。供体部位再植小腿内侧全层皮肤。结果10个指瓣全部成活。供体和受体创面均获得初步愈合,无血管危象。术后随访6 ~ 24个月,平均12个月。皮瓣的外观、感觉和功能均恢复良好。不需要第二次手术使皮瓣变薄。供区无明显瘢痕增生和挛缩,无耐磨性和疼痛。结论应用第二趾胫侧游离皮瓣修复两指指尖缺损,可覆盖缺损创面,保证手指的外观、感觉和功能,减少供区数量和损伤。这是一种理想的修复方法。关键词:手指损伤;外科皮瓣;第二个脚趾;一花梗和双瓣瓣
{"title":"The repair of the defects of two fingertips with free tibial pedicle double flaps of the second toe","authors":"Y. Duan, J. Ju, Guangliang Zhang, Xin-yi Liu, You Li, Guodong Jiang","doi":"10.3760/CMA.J.ISSN.1005-054X.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-054X.2020.01.011","url":null,"abstract":"Objective \u0000To explore the surgical method and clinical efficacy of two free flaps pedicled with the tibial proper toe artery of the second toe for repair of the defects of two fingertips. \u0000 \u0000 \u0000Methods \u0000From November 2014 to September 2018, five patients with the defects of two fingertips were treated with one pedicle double flaps of the tibial side of the second toe in emergency. The proper artery of the tibial side of the second toe was used as the vascular pedicle. The blood circulation of the two flaps and the injured finger was reconstructed. The donor site was replanted with full thickness skin graft of the medial leg. \u0000 \u0000 \u0000Results \u0000All the 10 finger flaps survived uneventfully. The donor and recipient wounds achieved primary healing without vascular crisis. The postoperative follow-up ranged from 6 to 24 months with an average of 12 months. The appearance, sensation and function of the free flaps recovered well. No second operation was needed to thin the flaps. There were no obvious scar hyperplasia and contracture in the donor site, no abrasion resistance and pain. \u0000 \u0000 \u0000Conclusion \u0000The application of two free flaps from the tibial side of the second toe to repair fingertip defect of two fingers can cover the defect wound, ensure the appearance, sensation and function of the finger, reduce the number of donor sites and damage. It is an ideal repair method. \u0000 \u0000 \u0000Key words: \u0000Finger injuries; Surgical flaps; The second toe; One pedicle and double flaps","PeriodicalId":67383,"journal":{"name":"中华手外科杂志","volume":"36 1","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48472594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages of percutaneous minimally invasive plate internal fixation in the treatment of complex proximal humeral fractures 经皮微创钢板内固定治疗肱骨近端复杂骨折的优点
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.003
Liu Jianrui, Tuoheti Aihemaiti, L. Fang, Chen-song Yang, Yunfei Cao, Zhi Zhang, Guixin Sun
Objective To explore the clinical advantages of minimally invasive percutaneous plate osteosynthesis (MIPPO) in the treatment of proximal humerus fractures of Neer typeⅢ andⅣ. Methods From May 2015 to May 2018, 78 cases of proximal humerus fractures of Neer type Ⅲ and Ⅳ were treated with MIPPO and open reduction and internal fixation (ORIF). There were 36 cases in MIPPO group, 20 males and 16 females, including 21 cases of Part Ⅲ fractures and 15 cases of Part Ⅳ fractures; and 42 cases in ORIF group, 24 males and 18 females, including 26 cases of Part Ⅲ fractures and 16 cases of Part Ⅳ fractures. The length of incision, the amount of bleeding, the time of operation, the time of fracture healing, the UCLA score of shoulder joint before and 3, 6 months after operation, the Constant-Murley score of shoulder joint function at 3, 6, 12 months after operation, the classification of joint function at the last follow-up, the axillary nerve injury and other complications were compared. The shoulder joint function of MIPPO group was evaluated after fracture healing. Results All the 78 patients were follow-up for (17.3±2.8) months. The incision length, fracture healing time and intraoperative bleeding in MIPPO group were significantly shorter than those in ORIF group. The UCLA scores of shoulder joint in MIPPO group were 29.04±1.63 and 30.95±1.69 at 3 and 6 months after operation, which were higher than those in ORIF group 22.11±2.33 and 25.96±2.01. The shoulder function Constant-Murley scores of MIPPO group were 55.64±2.83 and 75.01±5.71 at 3 and 6 months after operation, which were higher than those of ORIF group 45.03±6.32 and 64.61±6.77. However, there was no significant difference between the two groups in the shoulder function Constant-Murley score and the last shoulder function grade at 12 months after operation. After fracture healing, the shoulder function of MIPPO group was further evaluated: the average flexion angle was 170.5 ° (ranged, 161° to 180°), the average external rotation angle was 71° (ranged, 63.5° to 83.5°), the average internal rotation angle was 73.6 ° (ranged, 68° to 79°) and the recovery of mobility was good. The complication rate of MIPPO group was 5.56%, which was better than that of ORIF group 11.90% (P<0.05). Conclusion Both MIPPO and ORIF can treat proximal humerus fractures of Neer type Ⅲ and Ⅳ. The former is superior to the latter in incision length, bleeding volume, fracture healing time, shoulder joint function recovery at 3 and 6 months after operation, complications and other aspects, which is worth clinical promotion. Key words: Humeral fractures; Fracture fixation,internal; Axillary nerve injury; Minimal invasive
目的探讨微创经皮钢板内固定(MIPPO)治疗肱骨近端Neer型Ⅲ和Ⅳ骨折的临床优势。方法2015年5月~ 2018年5月对78例肱骨近端Neer型Ⅲ和Ⅳ骨折患者行MIPPO联合切开复位内固定(ORIF)治疗。MIPPO组36例,男20例,女16例,其中Ⅲ部分骨折21例,Ⅳ部分骨折15例;ORIF组42例,男24例,女18例,其中Ⅲ部分骨折26例,Ⅳ部分骨折16例。比较两组患者的切口长度、出血量、手术时间、骨折愈合时间,术前及术后3、6个月肩关节UCLA评分,术后3、6、12个月肩关节功能Constant-Murley评分,末次随访肩关节功能分级,腋神经损伤及其他并发症。骨折愈合后评价MIPPO组肩关节功能。结果78例患者均获得随访(17.3±2.8)个月。MIPPO组切口长度、骨折愈合时间、术中出血量均明显短于ORIF组。术后3、6个月,MIPPO组肩关节UCLA评分分别为29.04±1.63、30.95±1.69,高于ORIF组(22.11±2.33、25.96±2.01)。术后3个月和6个月,MIPPO组肩关节功能Constant-Murley评分分别为55.64±2.83和75.01±5.71,高于ORIF组的45.03±6.32和64.61±6.77。然而,两组患者肩关节功能的Constant-Murley评分和术后12个月的最后一次肩关节功能评分差异无统计学意义。骨折愈合后,进一步评估MIPPO组肩关节功能:平均屈曲角度为170.5°(范围为161°~ 180°),平均外旋角度为71°(范围为63.5°~ 83.5°),平均内旋角度为73.6°(范围为68°~ 79°),活动能力恢复良好。MIPPO组的并发症发生率为5.56%,优于ORIF组的11.90% (P<0.05)。结论MIPPO和ORIF均可治疗肱骨近端Neer型骨折Ⅲ和Ⅳ。前者在切口长度、出血量、骨折愈合时间、术后3、6个月肩关节功能恢复、并发症等方面均优于后者,值得临床推广。关键词:肱骨骨折;骨折固定,内部;腋窝神经损伤;微创
{"title":"Advantages of percutaneous minimally invasive plate internal fixation in the treatment of complex proximal humeral fractures","authors":"Liu Jianrui, Tuoheti Aihemaiti, L. Fang, Chen-song Yang, Yunfei Cao, Zhi Zhang, Guixin Sun","doi":"10.3760/CMA.J.ISSN.1005-054X.2020.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-054X.2020.01.003","url":null,"abstract":"Objective To explore the clinical advantages of minimally invasive percutaneous plate osteosynthesis (MIPPO) in the treatment of proximal humerus fractures of Neer typeⅢ andⅣ. Methods From May 2015 to May 2018, 78 cases of proximal humerus fractures of Neer type Ⅲ and Ⅳ were treated with MIPPO and open reduction and internal fixation (ORIF). There were 36 cases in MIPPO group, 20 males and 16 females, including 21 cases of Part Ⅲ fractures and 15 cases of Part Ⅳ fractures; and 42 cases in ORIF group, 24 males and 18 females, including 26 cases of Part Ⅲ fractures and 16 cases of Part Ⅳ fractures. The length of incision, the amount of bleeding, the time of operation, the time of fracture healing, the UCLA score of shoulder joint before and 3, 6 months after operation, the Constant-Murley score of shoulder joint function at 3, 6, 12 months after operation, the classification of joint function at the last follow-up, the axillary nerve injury and other complications were compared. The shoulder joint function of MIPPO group was evaluated after fracture healing. Results All the 78 patients were follow-up for (17.3±2.8) months. The incision length, fracture healing time and intraoperative bleeding in MIPPO group were significantly shorter than those in ORIF group. The UCLA scores of shoulder joint in MIPPO group were 29.04±1.63 and 30.95±1.69 at 3 and 6 months after operation, which were higher than those in ORIF group 22.11±2.33 and 25.96±2.01. The shoulder function Constant-Murley scores of MIPPO group were 55.64±2.83 and 75.01±5.71 at 3 and 6 months after operation, which were higher than those of ORIF group 45.03±6.32 and 64.61±6.77. However, there was no significant difference between the two groups in the shoulder function Constant-Murley score and the last shoulder function grade at 12 months after operation. After fracture healing, the shoulder function of MIPPO group was further evaluated: the average flexion angle was 170.5 ° (ranged, 161° to 180°), the average external rotation angle was 71° (ranged, 63.5° to 83.5°), the average internal rotation angle was 73.6 ° (ranged, 68° to 79°) and the recovery of mobility was good. The complication rate of MIPPO group was 5.56%, which was better than that of ORIF group 11.90% (P<0.05). Conclusion Both MIPPO and ORIF can treat proximal humerus fractures of Neer type Ⅲ and Ⅳ. The former is superior to the latter in incision length, bleeding volume, fracture healing time, shoulder joint function recovery at 3 and 6 months after operation, complications and other aspects, which is worth clinical promotion. Key words: Humeral fractures; Fracture fixation,internal; Axillary nerve injury; Minimal invasive","PeriodicalId":67383,"journal":{"name":"中华手外科杂志","volume":"36 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45881613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on micro-hardness distribution characteristics of human metacarpal bones 人掌骨显微硬度分布特征的研究
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.020
B. Yin, X. Shao, Chang-ping Zhao, Jialiang Guo, Jian-chao Wang, Yingze Zhang
Objective To report the micro-hardness of human metacarpal bones, compare and analyze the hardness values between different anatomical parts, and explore the distribution characteristics of micro-hardness of human metacarpal bones. Methods The metacarpal bones were collected from three fresh healthy frozen specimens. The soft tissue of the right metacarpal bone was dissected. These metacarpal bones were cut into 3 mm-thick slices perpendicular to the long axis with a low-speed saw in metacarpal base, shaft and head. The Vickers method was used to measure the hardness of different areas of the palmar, dorsal, medial and lateral site of bone slices, and the standard operation method with 50 g force loading for 50 s and maintenance for 12 s was used to determine the hardness. The hardness value was compared by one-way ANOVA, and P<0.05 was statistically significant. Results Totally, 45 specimens and 900 indentations at different bones and anatomic sites were involved. The overall hardness of metacarpal bone was (38.23±7.15) HV. The third metacarpal bone had the highest hardness (41.04±6.75) HV, followed by the second metacarpal bone (39.62±7.64) HV, the first metacarpal bone (37.83±6.52) HV, the fifth metacarpal bone (36.69±7.30) HV, and the fourth metacarpal bone (35.97±6.28) HV. The metacarpal shaft hardness (43.45±6.35) HV was higher than metacarpal basal (35.82±6.17) HV and metacarpal head (35.43±5.85) HV (F=16.415, P<0.01). There was no significant difference in palmar (37.58±7.35) HV, dorsal (38.93±7.08) HV, medial (38.26±7.00) HV and lateral site (38.15±7.14) HV in hardness (F=1.352, P=0.256). Conclusion The results of this study have deepened the understanding of metacarpal micro-biomechanical properties, and can guide the placement, direction and number of internal fixators in metacarpal fracture surgery, and provide data support for 3D printing of artificial metacarpophalangeal joint for the treatment of comminuted metacarpal fracture or defect. Key words: Metacarpal bones; Biomechanics; Vickers hardness; Micro-hardness
目的报道人掌骨显微硬度,比较分析不同解剖部位的硬度值,探讨人掌骨显微硬度的分布特征。方法采集3例新鲜健康冷冻标本。解剖右掌骨软组织。这些掌骨骨被低速锯切成垂直于长轴的3毫米厚的薄片,在掌骨基部、柄和头。采用维氏法测定骨片掌部、背侧、内侧、外侧不同部位的硬度,采用50g力加载50s、维持12s的标准操作方法测定硬度。硬度值比较采用单因素方差分析,P<0.05有统计学意义。结果共涉及45个标本,900个不同骨骼和解剖部位的压痕。掌骨总硬度为(38.23±7.15)HV。第3掌骨硬度最高(41.04±6.75)HV,其次是第2掌骨(39.62±7.64)HV,第1掌骨(37.83±6.52)HV,第5掌骨(36.69±7.30)HV,第4掌骨(35.97±6.28)HV。掌骨柄硬度(43.45±6.35)HV高于掌骨基底硬度(35.82±6.17)HV和掌骨头硬度(35.43±5.85)HV (F=16.415, P<0.01)。手掌(37.58±7.35)、背侧(38.93±7.08)、内侧(38.26±7.00)、外侧(38.15±7.14)HV硬度差异无统计学意义(F=1.352, P=0.256)。结论本研究结果加深了对掌骨微力学特性的认识,可指导掌骨骨折手术中内固定物的放置、方向和数量,为3D打印人工掌骨指关节治疗粉碎性掌骨骨折或掌骨缺损提供数据支持。关键词:掌骨;生物力学;维氏硬度;微观硬度
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引用次数: 0
Clinical efficacy of arthroscope-assisted treatment of traumatic metacarpophalangeal arthritis 关节镜辅助治疗外伤性掌指关节关节炎的临床疗效观察
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.018
Fanyu Pu, Mingyu Xue, L. Qiang, Jingyi Mi, Yongjun Rui
Objective To explore the clinical efficacy of arthroscopic minimally invasive technique in the treatment of traumatic pain and dysfunction of metacarpophalangeal joint in the early and middle stages. Methods From March 2016 to December 2018, nine patients with traumatic metacarpophalangeal arthritis were treated with arthroscopic minimally invasive assistance to understand the lesions of metacarpophalangeal joint, and to clean up the osteophytes, intra-articular free bodies and synovitis. After the operation, the patients were instructed to take progressive functional exercise. The joint motion degree of the affected fingers was followed up. Whether there were swelling, deformity and pain in the fingers was observed. Results The postoperative follow-up time ranged from 6 to 24 months, with an average of 15 months. All the patients did not have any symptoms such as surgical complications and pain discomfort in a short period of time. The joint flexion and extension function were improved in varying degrees. According to the measurement standard of total active motion (TAM) of finger flexion and extension function, before operation the results were good in 1 case, fair in 5 cases and poor in 3 cases; after operation the results were excellent in 6 cases, good in 2 cases and fair in 1 case. Conclusion In the early and middle stage of traumatic arthritis of metacarpophalangeal joint, the minimally invasive treatment under arthroscope has the advantages of small trauma, high accuracy and pertinence, quick postoperative recovery, which is an effective treatment method to improve hand function and reduce joint pain, and is worthy of clinical promotion. Key words: Metacarpophalangeal joint; Treatment outcome; Traumatic arthritis; Arthroscopes
目的探讨关节镜微创技术治疗早中期创伤性掌指关节疼痛和功能障碍的临床疗效。方法2016年3月至2018年12月,对9例外伤性掌指关节关节炎患者进行关节镜微创辅助治疗,了解掌指关节病变情况,清除骨赘、关节内游离体和滑膜炎。术后指导患者进行渐进式功能锻炼。随访患指关节活动度。观察手指有无肿胀、畸形、疼痛。结果术后随访6 ~ 24个月,平均15个月。所有患者在短时间内均未出现手术并发症及疼痛不适等症状。关节屈伸功能均有不同程度改善。按手指屈伸功能总主动运动(TAM)测量标准,术前结果良好1例,一般5例,差3例;术后效果优6例,良2例,一般1例。结论关节镜下微创治疗创伤小、准确性高、针对性强、术后恢复快,是改善手部功能、减轻关节疼痛的有效治疗方法,值得临床推广。关键词:掌指关节;治疗效果;创伤性关节炎;关节内窥镜
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引用次数: 0
Electrophysiological analysis of the patients with hourglass-like constriction of radial nerve/posterior interosseous nerve 桡神经/骨间后神经沙漏样缩窄患者的电生理分析
Pub Date : 2020-02-10 DOI: 10.3760/CMA.J.ISSN.1005-054X.2020.01.006
Ya-li Xu, Ye Tian, Dongdong Zhang, X. Shao
Objective To analyze the electrophysiological characteristics of the patients with hourglass-like constriction of radial nerve (RN)/posterior interosseous nerve (PIN) and explore the possible causes. Methods From January 2011 to November 2018, 18 patients with hourglass-like constriction of RN/PIN were treated in our hospital. The electrophysiological results of them were analyzed retrospectively. The extent and degree of lesion involvement were evaluated. Results The course of disease was 3 weeks to 13 months before electrophysiological examination in 18 patients. 14 patients (77.8%) suffered from complete injury and 4 patients (22.1%) suffered from incomplete injury. The coincidence rate between electrophysiological results and intraoperative findings was 94.4%. In addition to the abnormalities directly related to hourglass-like constriction, 88.9% of RN hourglass-like constriction patients and 11.1% of PIN hourglass-like constriction patients were associated with other neurological abnormalities. Among them, 8 patients with RN hourglass-like constriction were complicated with the abnormalities of median nerve (50%), ulnar nerve (50%), musculocutaneous nerve (37.5%), axillary nerve (25%), suprascapular nerve (25%), triceps brachii branch (75%), and the nerves of contralateral upper extremity (25%), contralateral phrenic nerve (12.5%) and the nerves of four extremities (12.5%). The main manifestations were abnormal insertion potential, resting spontaneous fibrillation potential, prolongation of light contraction time limit, simple phase of forced contraction and decrease of amplitude of motor evoked potential in sensory and motor nerve conduction. There was no obvious abnormality in nerve conduction velocity. Conclusion The hourglass-like constriction of RN/PIN is often associated with other neural abnormalities. The higher the location of hourglass-like constriction, the wider the range of involvement. It is different from the electrophysiological characteristics of peripheral nerve entrapment, indicating possible presence of neuralgic amyotrophy. Key words: Electrophysiology; Radial nerve; Posterior interosseous nerve; Hourglass-like constriction
目的分析桡神经(RN)/骨间后神经(PIN)沙漏样缩窄患者的电生理特征,探讨可能的原因。方法2011年1月至2018年11月收治18例RN/PIN沙漏样缩窄患者。回顾性分析两组患者的电生理结果。评估病变受累的范围和程度。结果18例患者电生理检查前病程为3周~ 13个月。完全性损伤14例(77.8%),不完全性损伤4例(22.1%)。电生理结果与术中表现符合率为94.4%。除了与沙漏样缩窄直接相关的异常外,88.9%的RN沙漏样缩窄患者和11.1%的PIN沙漏样缩窄患者还伴有其他神经系统异常。其中8例RN沙漏样缩窄合并正中神经(50%)、尺神经(50%)、肌皮神经(37.5%)、腋窝神经(25%)、肩胛上神经(25%)、肱三头肌支(75%)、对侧上肢神经(25%)、对侧膈神经(12.5%)、四肢神经(12.5%)异常。主要表现为插入电位异常、静息自发颤动电位异常、轻收缩时限延长、强迫收缩单纯期、感觉和运动神经传导运动诱发电位幅度降低。神经传导速度未见明显异常。结论RN/PIN的沙漏样缩窄常伴有其他神经异常。沙漏状收缩的位置越高,受累范围越广。它与周围神经卡压的电生理特征不同,表明可能存在神经痛性肌萎缩。关键词:电生理;桡神经;后骨间神经;Hourglass-like收缩
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引用次数: 0
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中华手外科杂志
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