Pub Date : 1955-07-01DOI: 10.1001/archpedi.1955.04030010037006
R B SCOTT, M E JENKINS
{"title":"Studies in sickle-cell anemia. V. Sickle-cell hemoglobin C disease; report of two cases in siblings with clinical and genetic observations and a brief review of the literature.","authors":"R B SCOTT, M E JENKINS","doi":"10.1001/archpedi.1955.04030010037006","DOIUrl":"https://doi.org/10.1001/archpedi.1955.04030010037006","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"90 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"1955-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archpedi.1955.04030010037006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23907530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-07-01DOI: 10.1001/ARCHPEDI.1955.04030010030005
P. Véghelyi, J. Šoš, T. Kemény
In order to make the purpose of the experiments to be discussed below clearly understandable, it was thought necessary briefly to summarize the main results of our previous studies concerning the functional pathology of the pancreas. It has been many years since we first observed that in the first week of scarlet fever the activity of pancreatic enzymes in the duodenal juice becomes decreased and at the same time the level of both amylase and lipase is greatly increased in the blood. 1 After a week this shift characteristic of acute pancreatitis usually disappears. In some instances, however, the pancreatic dysfunction becomes permanent, similarly as after certain cases of mumps or other infectious fevers.* A short time after that observation we had occasion to become acquainted with the morphological basis of the dysfunction: In three patients who died of bacillary dysentery the pancreas presented a picture characterized by degeneration, variably
{"title":"Prenatal lesions of the pancreas.","authors":"P. Véghelyi, J. Šoš, T. Kemény","doi":"10.1001/ARCHPEDI.1955.04030010030005","DOIUrl":"https://doi.org/10.1001/ARCHPEDI.1955.04030010030005","url":null,"abstract":"In order to make the purpose of the experiments to be discussed below clearly understandable, it was thought necessary briefly to summarize the main results of our previous studies concerning the functional pathology of the pancreas. It has been many years since we first observed that in the first week of scarlet fever the activity of pancreatic enzymes in the duodenal juice becomes decreased and at the same time the level of both amylase and lipase is greatly increased in the blood. 1 After a week this shift characteristic of acute pancreatitis usually disappears. In some instances, however, the pancreatic dysfunction becomes permanent, similarly as after certain cases of mumps or other infectious fevers.* A short time after that observation we had occasion to become acquainted with the morphological basis of the dysfunction: In three patients who died of bacillary dysentery the pancreas presented a picture characterized by degeneration, variably","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"4 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"1955-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75674773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The hypothyroid infant and child; therapy with sodium l-thyroxine.","authors":"D A FISHER, G D HAMMOND, D E PICKERING","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"90 1","pages":"6-21"},"PeriodicalIF":0.0,"publicationDate":"1955-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23907527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-07-01DOI: 10.1001/ARCHPEDI.1955.04030010008003
D. Fisher, G. Hammond, D. Pickering
This communication reviews problems of diagnosis and therapy of hypothyroidism in infancy and childhood and presents 12 representative cases treated with sodium l -thyroxine. Pessimism in regard to treatment and prognosis for children with congenital athyrosis is based upon the high incidence of persisting deficits of intellect and skeletal growth which follow seemingly adequate replacement therapy. Selected experimental observations made in this laboratory regarding the physiologic role of thyroid in the growth and metabolism of I 131 -thyroid-ablated infant rhesus monkeys contribute to an understanding of clinical and metabolic features exemplified by these patients. In the athyroid infant monkey, as in the patients to be presented, it has been observed that many metabolic and clinical signs of thyroid deficiency may be controlled with doses of sodium l -thyroxine significantly smaller than those required to promote optimal central nervous system and skeletal growth and maturation.* This seeming discrepancy in tissue response
{"title":"The hypothyroid infant and child; therapy with sodium l-thyroxine.","authors":"D. Fisher, G. Hammond, D. Pickering","doi":"10.1001/ARCHPEDI.1955.04030010008003","DOIUrl":"https://doi.org/10.1001/ARCHPEDI.1955.04030010008003","url":null,"abstract":"This communication reviews problems of diagnosis and therapy of hypothyroidism in infancy and childhood and presents 12 representative cases treated with sodium l -thyroxine. Pessimism in regard to treatment and prognosis for children with congenital athyrosis is based upon the high incidence of persisting deficits of intellect and skeletal growth which follow seemingly adequate replacement therapy. Selected experimental observations made in this laboratory regarding the physiologic role of thyroid in the growth and metabolism of I 131 -thyroid-ablated infant rhesus monkeys contribute to an understanding of clinical and metabolic features exemplified by these patients. In the athyroid infant monkey, as in the patients to be presented, it has been observed that many metabolic and clinical signs of thyroid deficiency may be controlled with doses of sodium l -thyroxine significantly smaller than those required to promote optimal central nervous system and skeletal growth and maturation.* This seeming discrepancy in tissue response","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"55 1","pages":"6-21"},"PeriodicalIF":0.0,"publicationDate":"1955-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90501110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-06-01DOI: 10.1001/archpedi.1955.02050110857009
A H CHAPMAN, D G LOEB
{"title":"Psychosomatic gastrointestinal problems in children.","authors":"A H CHAPMAN, D G LOEB","doi":"10.1001/archpedi.1955.02050110857009","DOIUrl":"https://doi.org/10.1001/archpedi.1955.02050110857009","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"89 6","pages":"717-24"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archpedi.1955.02050110857009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23897105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linear growth of long bones of extremities from infancy through adolescence; continuing studies.","authors":"M M MARESH","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"89 6","pages":"725-42"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23897106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-06-01DOI: 10.1001/ARCHPEDI.1955.02050110829006
J. Warkany, G. M. Guest, W. Cochrane
Identical, or monozygotic, twins offer unusual opportunities to study the role of heredity and environment in the origin of pathologic disorders. Since Galton suggested the study of identical twins as a method for the separation of hereditary and environmental influences in the development of human traits, "Gemelloiogy" has become a science in its own rights.* The striking similarities (concordance) of identical twins in physical, physiological, psychological, and pathological characteristics have always attracted attention and aroused curiosity. They were and are welcome objects of investigation for students of human inheritance. The dissimilarities (discordance) of identical twins being less impressive to the casual observer, rarely are given the consideration they deserve. Identical twins discordant in respect to a structural or functional disorder offer convincing evidence that a pathologic manifestation, observed in one twin only, cannot be determined entirely genetically. If identical twins have the same genetic endowment, their differences or discordant properties
{"title":"Discordant monozygotic twins; diabetes mellitus and obesity.","authors":"J. Warkany, G. M. Guest, W. Cochrane","doi":"10.1001/ARCHPEDI.1955.02050110829006","DOIUrl":"https://doi.org/10.1001/ARCHPEDI.1955.02050110829006","url":null,"abstract":"Identical, or monozygotic, twins offer unusual opportunities to study the role of heredity and environment in the origin of pathologic disorders. Since Galton suggested the study of identical twins as a method for the separation of hereditary and environmental influences in the development of human traits, \"Gemelloiogy\" has become a science in its own rights.* The striking similarities (concordance) of identical twins in physical, physiological, psychological, and pathological characteristics have always attracted attention and aroused curiosity. They were and are welcome objects of investigation for students of human inheritance. The dissimilarities (discordance) of identical twins being less impressive to the casual observer, rarely are given the consideration they deserve. Identical twins discordant in respect to a structural or functional disorder offer convincing evidence that a pathologic manifestation, observed in one twin only, cannot be determined entirely genetically. If identical twins have the same genetic endowment, their differences or discordant properties","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"59 1","pages":"689-95"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88860818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-06-01DOI: 10.1001/archpedi.1955.02050110785001
F M MATEER, L GREENMAN, T S DANOWSKI
{"title":"Hemodialysis of the uremic child.","authors":"F M MATEER, L GREENMAN, T S DANOWSKI","doi":"10.1001/archpedi.1955.02050110785001","DOIUrl":"https://doi.org/10.1001/archpedi.1955.02050110785001","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"89 6","pages":"645-55"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archpedi.1955.02050110785001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23897098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-06-01DOI: 10.1001/archpedi.1955.02050110825004
H SHUKRY, S AWWAAD
{"title":"Isoniazid in tuberculous peritonitis of childhood.","authors":"H SHUKRY, S AWWAAD","doi":"10.1001/archpedi.1955.02050110825004","DOIUrl":"https://doi.org/10.1001/archpedi.1955.02050110825004","url":null,"abstract":"","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"89 6","pages":"685-8"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archpedi.1955.02050110825004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23897101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1955-06-01DOI: 10.1001/ARCHPEDI.1955.02050110883011
M. McIntire, A. Freed
WOLFF, Parkinson, and White, in 1930, first described the combination of a short P-R interval and a prolonged QRS on the electrocardiogram in frequent association with attacks of paroxysmal tachycardia.1It is usually the only cardiac anomaly present. Holtzmann and Scherf2and Wolferth and Wood3suggested that accessory atrioventricular pathways were present which would permit premature depolorization of part of the ventricle. Engle has reviewed the literature recently in infants and children.4Her youngest case was 6 days old with symptoms dating back to the first day of life, suggesting that the syndrome is congenital in origin. The symptoms of an attack are usually irritability, vomiting, prostration, and an ashen gray color. If allowed to continue it may precipitate cardiac failure. The treatment of choice is digitalis. Insofar as we were able to determine, our case is the first in which both the mother and infant
{"title":"The Wolff-Parkinson-White syndrome; report of a case occurring in a mother and infant.","authors":"M. McIntire, A. Freed","doi":"10.1001/ARCHPEDI.1955.02050110883011","DOIUrl":"https://doi.org/10.1001/ARCHPEDI.1955.02050110883011","url":null,"abstract":"WOLFF, Parkinson, and White, in 1930, first described the combination of a short P-R interval and a prolonged QRS on the electrocardiogram in frequent association with attacks of paroxysmal tachycardia.1It is usually the only cardiac anomaly present. Holtzmann and Scherf2and Wolferth and Wood3suggested that accessory atrioventricular pathways were present which would permit premature depolorization of part of the ventricle. Engle has reviewed the literature recently in infants and children.4Her youngest case was 6 days old with symptoms dating back to the first day of life, suggesting that the syndrome is congenital in origin. The symptoms of an attack are usually irritability, vomiting, prostration, and an ashen gray color. If allowed to continue it may precipitate cardiac failure. The treatment of choice is digitalis. Insofar as we were able to determine, our case is the first in which both the mother and infant","PeriodicalId":6798,"journal":{"name":"A.M.A. American journal of diseases of children","volume":"44 1","pages":"743-7"},"PeriodicalIF":0.0,"publicationDate":"1955-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90335774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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