Acta Orthopaedica最新文献

Background and purpose:  Patellofemoral arthroplasty (PFA) is a rare surgical procedure for isolated patellofemoral osteoarthritis (PFOA). This study compares patient demographics, long-term survival rates, revision risks, and causes of revision in PFA with total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA).

Methods: Data from the Norwegian Arthroplasty Register (NAR) (1994-2022) included 725 PFA, 102,135 TKA, and 14,315 UKA procedures. We used Kaplan-Meier (KM) analysis to calculate implant survival at 2, 5, 10, and 15 years and Cox regression adjusted for confounders to assess revision risks. Revision causes were analyzed for procedures after 2005.

Results:  PFA patients were more often female (72%) than TKA (62%) and UKA (51%) patients and had a lower mean age (54.3 for PFA, 69.0 for TKA, and 65.6 for UKA). At 10 years, KM survival was 85% (95% confidence interval [CI] 80.6-88.2) for PFA, 94% (CI 93.8-94.2) for TKA, and 84% (CI 83.6-85.1) for UKA. Among patients < 60 years, KM survival at 10 years was 84% (CI 79.4-88.1) for PFA, 90% (CI 89.3-90.4) for TKA, and 79% (CI 77.1-80.3) for UKA. In patients < 60 years with < 10 years' follow-up, the adjusted hazard ratios (HR) for revision were 0.9 for TKA and 1.7 for UKA compared with PFA. Adjusted HR for > 10 years' follow-up showed lower revision risks for TKA with 0.3 and no significant difference for UKA (HR 0.9). Progression of OA was the leading cause of revision in PFA (49%).

Conclusion:  PFA was predominantly performed in younger female patients. In patients < 60 years, PFA showed similar 10-year survival to TKA but inferior survival after 15 years. Revision rates for PFA are comparable to UKA but inferior to TKA.

Background and purpose:  There are still strong beliefs in medicine concerning things that bring "bad luck." It is unclear whether a suspicious component size or surgery date is related to "bad luck" in orthopedic surgery. We aimed to examine: (i) if a potentially unlucky femoral stem size 13 in total hip arthroplasty (THA), and (ii) if a possible unlucky surgery date, Friday 13th, in THA and total knee arthroplasty (TKA) have a higher revision rate.

Methods:  We analyzed 611,050 THAs and TKAs, performed in the past 13 years using Dutch Arthroplasty Register data. The revision rate of uncemented femoral stem size 13 (Corail and Taperloc) in THA was compared with all other stem sizes of the same type. Furthermore, the revision rate of THA and TKA implanted on Friday 13th was compared with all other days and with other Fridays. Both were performed using competing risk analyses with death as competing risk and cause-specific multivariable Cox proportional hazard regression analyses.

Results:  The use of an uncemented Corail or Taperloc femoral stem size 13 in THA was associated with a lower revision rate (3.0%, 95% confidence interval [CI] 2.3-4.0) compared with the revision rate of other femoral stem sizes (3.5%, CI 3.3-3.8) (hazard ratio [HR] 0.76, CI 0.65-0.87). TKA procedures on Friday 13th were not associated with increased revision rate (5.2%, CI 4.1-6.7) compared with procedures on other days (6.0%, CI 5.9-6.2) or on other Fridays (5.8%, CI 5.4-6.2) (HR 1.03, CI 0.80-1.32 and HR 1.01, CI 0.79-1.30, respectively). For THA, procedures on Friday 13th were associated with a higher revision rate (5.1%, CI 3.9-6.6) compared with procedures on other days (4.6%, CI 4.5-4.8) (HR 1.32, CI 1.04-1.67) but not compared with procedures on other Fridays (4.8%, CI 4.4-5.1) (HR 1.24, CI 0.97-1.58).

Conclusion:  Based on national arthroplasty registry data, femoral stem size 13 in THA was associated with a lower revision rate. TKA procedures on Friday 13th were not associated with increased revision rate; however, in THA there seems to be an increased risk of revision in THA procedures performed on Friday 13th compared with other days, but not when compared with other Fridays.

Background and purpose:  The optimal duration of antibiotic prophylaxis for reducing serious adverse events (SAEs) after total hip arthroplasty (THA) is unclear. We aimed to assess the comparative effectiveness of different strategies of antibiotic prophylaxis in preventing SAEs after THA.

Methods:  We searched Medline, Embase, CENTRAL, and the Clinical Trial Registration Database for randomized controlled trials evaluating antibiotic prophylaxis in patients undergoing primary THA. Two authors independently screened, extracted data, and assessed the risk of bias. We defined SAEs as prosthetic joint infections, other serious infections, major cardiovascular events, venous thromboembolisms, or mortality. The primary summary measures were odds ratios (ORs) with 95% confidence intervals (CI). The evidence was assessed using the confidence in network meta-analysis (CINeMA) framework.

Results:  Of 6,131 identified citations, 10 trials of 2-group comparisons were included, involving 9,106 patients. Duration of antibiotics was grouped as follows: placebo (3), a single dose (3), multiple doses ≤ 24 hours (6), multiple doses (> 1 day) (6), and bone cement with antibiotics (2). Compared with placebo, point estimates suggest lower odds of SAEs after THA for most antibiotic strategies, except multiple doses > 1 day. Multiple doses showed no clear evidence of superiority to single dose: OR (multiple doses ≤ 24 hours) = 0.87 (CI 0.20-3.73; very low) or over more days (> 1 day) OR = 0.40 (CI 0.07-2.42; very low) nor were multiple doses > 1 day superior to multiple doses ≤ 24 hours, OR = 0.46 (0.11-1.90; very low).

Conclusion:  Relative to placebo, point estimates suggested that most antibiotic prophylaxis regimens may reduce SAEs after THA, with no clear evidence of added benefit from multiple doses. These findings should be interpreted with caution due to the lack of precision and the corresponding very low certainty of evidence for some comparisons.

Femoral neck fractures (FNFs) are associated with loss of function in all ages and excess mortality. The societal costs are high. Treatment needs to be tailored based on fracture type, functional demand, and physiological age of the patient. Internal fixation is often preferred for undisplaced FNFs and for displaced FNFs in young patients. Anatomical reduction is essential, but slight valgus is accepted. For a majority of those with displaced FNFs, a cemented hemiarthroplasty is the best alternative. This educational article suggests a treatment algorithm for FNFs and describes the evidence base for the recommended surgical techniques. Basicervical fractures, stress and pathological fractures are not included in this review.

Background and purpose:  Revision total hip arthroplasty (rTHA) is a complex procedure that may benefit from centralization. We examined the association between annual hospital volume of rTHA and re-revision risk and mortality.

Methods:  We included all rTHAs between 2007 and 2022 in general hospitals, registered in the Dutch Arthroplasty Register (LROI; n = 12,515). Hospitals were categorized into low (< 25 rTHA/year) or high volume (≥ 25 rTHA/year). Competing-risk analyses and Cox proportional hazard regression analyses were performed to assess implant re-revision and Kaplan-Meier survival analysis for mortality. Results were stratified into septic (permanent Girdlestone, 1-stage, and 2-stage revisions) and aseptic first revisions.

Results:  1-stage septic revisions showed a higher risk of re-revision in high-volume hospitals (hazard ratio [HR] 1.6, 95% confidence interval [CI] 1.1-2.4). We found no difference in re-revision risk after DAIR (HR 1.1, CI 0.9-1.3). 2-stage septic revisions were more often performed in high-volume hospitals (5% vs 2%). There was no statistical difference in re-revision rates between hospitals after revision for aseptic loosening (HR 1.1, CI 0.9-1.4), dislocation (HR 1.1, CI 0.9-1.4), and periprosthetic fractures (HR 1.1, CI 0.8-1.5). Mortality showed no differences between groups, neither for septic nor aseptic revisions.

Conclusion:  There was no difference between high-volume hospitals and low-volume hospitals regarding risk for re-revision after aseptic loosening, dislocation and periprosthetic fracture, and septic DAIR and mortality. In high-volume hospitals, 1-stage septic revisions was associated with a significantly higher re-revision risk. 2-stage revisions are more frequent in high-volume hospitals, indicating more complex pathology.

Background and purpose:  There is no clear evidence on whether migration or wear is the best predictor for later acetabular cup loosening. We aimed to investigate whether early wear or migration, measured via radiostereometric analysis (RSA), predicts later cup loosening. We also compared long-term aseptic loosening rates between conventional (CPE) and highly crosslinked polyethylene (XLPE) cups.

Methods:  Data was drawn from a randomized controlled trial (RCT) (ClinicalTrials.Gov NCT00698672) of 150 patients receiving cemented total hip arthroplasties (THAs), with 10-year RSA follow-up. 5 groups were assessed based on implant combinations (Charnley or Spectron EF stems with CPE or XLPE cups and CoCr or Oxinium heads). Migration and wear up to 2 years were evaluated against 18-year cup survival using receiver operating characteristic (ROC) curves.

Results: 19 cups (17 CPE, 2 XLPE) were loose at final follow-up. The area under the ROC curve (AUC) was 0.56 (95% confidence interval [CI] 0.40-0.73) for early migration and 0.85 (CI 0.77-0.94) for early polyethylene (PE) wear, with a difference of 0.29 (CI 0.09-0.49). Hazard ratio for loosening was 0.88 (CI 0.20-3.89) for early migration > 0.2 mm and 19.4 (CI 2.55-147) for early wear > 0.2 mm. At 18 years, survival free of aseptic loosening was 65% (CI 48-77) for CPE and 96% (CI 85-99) for XLPE cups, with a 9-fold higher risk of loosening for CPE.

Conclusion:  Early polyethylene wear, not migration, predicted long-term cup loosening. XLPE showed superior long-term performance over CPE with less wear, cup loosening, and revision.

Background and purpose:  Return to work is an important objective and measure of treatment success in the working-age population. Many patient-related factors have been shown to be associated with failure to resume working postoperatively. The aim of this longitudinal database study was to determine return to work rates in a 24-month follow-up after lumbar fusion. We also evaluated whether return to work was affected by the physical demand of work or the preoperative dominance of leg or back pain.

Methods:  348 consecutive patients available to the workforce underwent lumbar fusion. Return to work at 12 and 24 months was evaluated by patient questionnaires. Patients rated the physical demand of work into 3 categories: light, moderately demanding, or demanding. The surgeon identified the predominant symptom preoperatively, dividing patients into back and leg pain groups.

Results:  Return to work was 69% (95% confidence interval [CI] 64-73) and 76% (CI 71-81), at 12- and 24-month follow-ups, respectively. Patients in physically demanding work were less likely to resume working than patients in light work (63% vs 86% at 24 months, respectively). The predominant symptom did not affect return to work.

Conclusion:  In patients of working age, three-quarters of lumbar spine fusion patients returned to work within 2 years of surgery. Work absenteeism was higher in physically demanding occupations and only 60% of the patients with predominant leg pain returned to their physically heavy occupation in the first year following lumbar fusion.

Background and purpose:  Data on distal radius fractures (DRFs) with concomitant metaphyseal distal ulna fractures is limited. We aimed to determine whether a combined DRF and distal ulna fracture (DRUF) predicts a worse patient-reported outcome, measured by the Disabilities of the Arm, Shoulder, and Hand (DASH) score, 1 year after injury.

Methods:  This prospective registry-based cohort study included 5,536 adult patients with a DRF between 2003 and 2018. The 1-year DASH scores were recorded. All DRUFs were identified. Multivariable binary logistic regression assessed whether the presence of a distal ulna fracture predicted a 1-year DASH score > 35, indicating severe upper-extremity symptoms.

Results:  259 of 5,536 patients (4.7%) had a DRUF. Their mean age was 73 years (SD 15), and 86% were women. The median 1-year DASH score was higher in the combined fracture group compared with those with a DRF only (23, interquartile range [IQR] 5-45] vs 9, IQR 2-27, P < 0.001). A DRUF increased the odds of a 1-year DASH > 35 by 97% (OR 1.97, 95% confidence interval [CI] 1.40-2.75, P < 0.001). Surgical fixation of the DRF in DRUF patients was associated with lower odds of a worse outcome (OR 0.44, CI 0.23-0.85, P = 0.02). Distal ulna fracture fixation did not affect 1-year DASH (P = 0.7).

Conclusion:  The odds of having a DASH > 35, indicating severe symptoms, almost doubled at 1 year in patients with a DRUF compared with those with a DRF only.

Background and purpose:  An important quality indicator of perioperative care is the all-cause 30-day mortality. Little is known about early mortality after foot and ankle fracture repair. We aimed to assess the all-cause 30-day mortality associated with surgical repair of foot and ankle fractures in Sweden during 2017-2022 and its seasonal variation.

Methods:  Foot and ankle fracture patients aged ≥ 18 years registered in the Swedish Perioperative Quality Register (SPOR) between 2017 and June 30, 2022 were included in the analysis (n = 26,404). Patient characteristics, perioperative observations, and early mortality were collected. Seasonal variation was analyzed for summer, autumn, winter, and spring. Perioperative mortality rate and odds ratio (OR) are reported with 95% confidence intervals (CI).

Results:  The all-cause 30-day mortality rate was 58 of the 26,404 studied patients (0.22%, CI 0.17-0.28). There was no change in mortality rate over the study period including the COVID-19 pandemic year. Increased adjusted odds ratio (OR) for 30-day mortality was seen among the elderly, age > 80 years, OR 22 (CI 9.2-50), and those with low health status, ASA class 3-4, OR 4.2 (CI 2.3-7.9), while surgery during summer was associated with a lower adjusted OR 0.4 (CI 0.1-0.9).

Conclusion: The all-cause 30-day mortality rate after foot and ankle fracture surgery in Sweden is reassuringly low with expected higher OR for mortality associated with age and health status, while surgery during summer months was associated with lower mortality.

Background and purpose:  Periacetabular osteotomy (PAO) is a major surgical procedure, yet data on early postoperative complications and hospitalizations remains limited. We aimed to report postoperative complications within 90 days using the modified Clavien-Dindo classification system. Our secondary aim was to report the peri- and postoperative complications observed in patients with length of hospital stay (LOS) exceeding 4 days or readmitted within 90 days following PAO.

Methods:  We identified patients who underwent PAO at a single institution between 2006 and 2021. Patient characteristics, LOS, in-hospital complications, and readmissions within 90 days postoperatively were obtained from our institutional database, patient files, and the Danish National Patient Registry to ensure complete follow up. Minor complications were defined as Clavien-Dindo grades 1 and 2, while major complications were defined as grades 3 and 4.

Results:  1,356 consecutive PAO procedures were performed in 1,096 patients with a mean age of 29.3 years (SD 11.1) and 77% females. Minor complications occurred in 499 hips (37%, 95% confidence interval [CI] 35-39) within 90 days of PAO. Only 16 (1.2%, CI 0.6-1.8) major complications were observed. LOS exceeded 4 days in 244 cases (18%) most frequently linked with nausea and emesis in 40 (2.9%). The 90-day readmission rate was 4.4% (CI 2.6-6.2), most commonly linked with pain in 11 (1.0%) and wound infection requiring antibiotics also in 11 (1.0%).

Conclusion:  PAO was associated with 37% minor complications within 90 days, while major complications were rare, occurring in only 1.2% of cases. After 18% of PAO procedures, LOS exceeded 4 days, and the 90-day readmission rate was 4.4%.