Pub Date : 2022-08-17DOI: 10.14293/s2199-rexpo22002.v1
D. Cavalla
{"title":"Barriers to successful drug repurposing, and approaches to overcoming them","authors":"D. Cavalla","doi":"10.14293/s2199-rexpo22002.v1","DOIUrl":"https://doi.org/10.14293/s2199-rexpo22002.v1","url":null,"abstract":"","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77091907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arpana Parihar, R. Khan, A. Kumar, A. Kaushik, H. Gohel
{"title":"Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection","authors":"Arpana Parihar, R. Khan, A. Kumar, A. Kaushik, H. Gohel","doi":"10.1016/c2020-0-04145-9","DOIUrl":"https://doi.org/10.1016/c2020-0-04145-9","url":null,"abstract":"","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75828592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.5772/intechopen.98522
F. Özçelik, Dursun Ali Şirin
COVID-19, which has caused a great panic by leaving millions of deaths in its wake worldwide, has affected the provision of oral and dental health services as in many fields. Especially dentists, who offer oral and dental health services by working in the oral region of the patients, are under a high risk of encountering the agent. This high risk has justifiably created a concern for them. Therefore, it has been quite challenging to provide oral and dental health services. In order to alleviate these concerns and to sustain oral and dental health services, many health organizations and institutions, especially the World Health Organization, have published recommendations and principles of practice, and announced financial support. In this section, we will examine the recommendations and practices regarding infection prevention and control measures by getting away from standard routine health service practices in order to be protected from COVID-19 epidemic and what areas they cover on a wide scale. By discussing the effects of these recommendations and practices on the provision of dental health services, we will try to determine the practices that will relieve concerns and are aimed at ensuring the provision of safe health services in terms of both patients’ health and health professionals’ health.
{"title":"Impact of COVID-19 on Oral and Dental Health Delivery and Recommendations for Continuation of Oral and Dental Health Services","authors":"F. Özçelik, Dursun Ali Şirin","doi":"10.5772/intechopen.98522","DOIUrl":"https://doi.org/10.5772/intechopen.98522","url":null,"abstract":"COVID-19, which has caused a great panic by leaving millions of deaths in its wake worldwide, has affected the provision of oral and dental health services as in many fields. Especially dentists, who offer oral and dental health services by working in the oral region of the patients, are under a high risk of encountering the agent. This high risk has justifiably created a concern for them. Therefore, it has been quite challenging to provide oral and dental health services. In order to alleviate these concerns and to sustain oral and dental health services, many health organizations and institutions, especially the World Health Organization, have published recommendations and principles of practice, and announced financial support. In this section, we will examine the recommendations and practices regarding infection prevention and control measures by getting away from standard routine health service practices in order to be protected from COVID-19 epidemic and what areas they cover on a wide scale. By discussing the effects of these recommendations and practices on the provision of dental health services, we will try to determine the practices that will relieve concerns and are aimed at ensuring the provision of safe health services in terms of both patients’ health and health professionals’ health.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.5772/intechopen.98494
Isla Camilla Carvalho Laureano, A. Leite Cavalcanti
The emergence of Coronavirus Disease 2019 (COVID-19) in late 2019 has brought great challenges to public health worldwide and, to date, there is no specific approved therapeutic protocol. Therefore, this chapter will analyze types of intervention for use in patients with COVID-19 developed by American researchers from records made on the Clinical Trials platform. For the search strategy, keywords “COVID-19” in the “Condition or Disease” section and “United States” in the “Country” section were used. No filters were applied. Data were descriptively analyzed. In total, 1,182 studies were obtained, of which 496 met the eligibility criteria. Sample size ranged from 1 to 10,000 participants. Most studies involved the age group of 18–64 years (48.6%). As for design, randomized type (80.5%), parallel (75.6%), open designs (38.7%) and those with therapeutic purpose (88.3%) were more frequent. Most clinical trials used the two-arm trial (67.3%), researched drugs (64.8%), used placebo (55.2%) and were sponsored by pharmaceutical/biotechnology companies (35.4%). Clinical trials developed by American researchers on COVID-19 involve adult and elderly participants, with predominance of randomized, parallel and open design, for therapeutic purposes and mostly evaluated immunosuppressants or combinations of antivirals/immunosuppressants. The drugs and biological products Remdesivir, Baricitinib in combination with Remdesivir, Bamlanivimab and Etesevimab, REGEN-COV and COVID-19 convalescent plasma were also used, authorized for emergency use.
{"title":"Clinical Trials on COVID-19: What is Being Researched in the United States?","authors":"Isla Camilla Carvalho Laureano, A. Leite Cavalcanti","doi":"10.5772/intechopen.98494","DOIUrl":"https://doi.org/10.5772/intechopen.98494","url":null,"abstract":"The emergence of Coronavirus Disease 2019 (COVID-19) in late 2019 has brought great challenges to public health worldwide and, to date, there is no specific approved therapeutic protocol. Therefore, this chapter will analyze types of intervention for use in patients with COVID-19 developed by American researchers from records made on the Clinical Trials platform. For the search strategy, keywords “COVID-19” in the “Condition or Disease” section and “United States” in the “Country” section were used. No filters were applied. Data were descriptively analyzed. In total, 1,182 studies were obtained, of which 496 met the eligibility criteria. Sample size ranged from 1 to 10,000 participants. Most studies involved the age group of 18–64 years (48.6%). As for design, randomized type (80.5%), parallel (75.6%), open designs (38.7%) and those with therapeutic purpose (88.3%) were more frequent. Most clinical trials used the two-arm trial (67.3%), researched drugs (64.8%), used placebo (55.2%) and were sponsored by pharmaceutical/biotechnology companies (35.4%). Clinical trials developed by American researchers on COVID-19 involve adult and elderly participants, with predominance of randomized, parallel and open design, for therapeutic purposes and mostly evaluated immunosuppressants or combinations of antivirals/immunosuppressants. The drugs and biological products Remdesivir, Baricitinib in combination with Remdesivir, Bamlanivimab and Etesevimab, REGEN-COV and COVID-19 convalescent plasma were also used, authorized for emergency use.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73820928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.5772/intechopen.98493
Arisa Yasui, M. Numada
Japan is a disaster-prone country and natural disasters could happen under COVID-19. Shelter management is especially important because many people evacuate there and there’s high risk of spreading infection. In order to establish feasible countermeasures in shelters, we conducted a survey about the current situation of preparation and experience of shelter management in Japanese local governments under COVID-19. From the answer of 346 municipalities, we found that some municipalities took measures against COVID-19 such as adding new shelters and conducting the training, and these proactive measures were very useful. However, due to the addition of infectious disease control work, it became clear that it would take time and difficulty at reception, and that it would be even more difficult to identify evacuees with the recommended distributed evacuation. These results can be useful in proceeding consideration of better shelter management under COVID-19.
{"title":"A Report of the Survey on Shelter Management under COVID-19 in Japanese Local Governments","authors":"Arisa Yasui, M. Numada","doi":"10.5772/intechopen.98493","DOIUrl":"https://doi.org/10.5772/intechopen.98493","url":null,"abstract":"Japan is a disaster-prone country and natural disasters could happen under COVID-19. Shelter management is especially important because many people evacuate there and there’s high risk of spreading infection. In order to establish feasible countermeasures in shelters, we conducted a survey about the current situation of preparation and experience of shelter management in Japanese local governments under COVID-19. From the answer of 346 municipalities, we found that some municipalities took measures against COVID-19 such as adding new shelters and conducting the training, and these proactive measures were very useful. However, due to the addition of infectious disease control work, it became clear that it would take time and difficulty at reception, and that it would be even more difficult to identify evacuees with the recommended distributed evacuation. These results can be useful in proceeding consideration of better shelter management under COVID-19.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86917713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.5772/intechopen.99785
N. Dhara, Sumana Saha, Saptarshi Chatterjee
SARS-CoV-2 infection or COVID-19, currently regarded as ‘terror’ worldwide, has spread uncontrollably as a serious menace. Till date, limited effective medicines or treatments are available. The mortality and morbidity rates have increased considerably, which have been aggravated by acute respiratory distress syndrome (ARDS) and new and old cardiovascular injuries. To control COVID-19, many drugs have been taken into consideration, like ACE2 blockers, anti-inflammatory drugs, antibodies against IL-1 and anti-IL-6, Remdesivir, Dexamethasone, Hydroxychloroquine and vaccines. In this chapter, preference is given to Tocilizumab with the latest status of clinical research update available. Despite several clinical research attempts, some have yielded promising results, others are inconclusive.
{"title":"A Clinical Update on Employing Tocilizumab to Fight COVID-19","authors":"N. Dhara, Sumana Saha, Saptarshi Chatterjee","doi":"10.5772/intechopen.99785","DOIUrl":"https://doi.org/10.5772/intechopen.99785","url":null,"abstract":"SARS-CoV-2 infection or COVID-19, currently regarded as ‘terror’ worldwide, has spread uncontrollably as a serious menace. Till date, limited effective medicines or treatments are available. The mortality and morbidity rates have increased considerably, which have been aggravated by acute respiratory distress syndrome (ARDS) and new and old cardiovascular injuries. To control COVID-19, many drugs have been taken into consideration, like ACE2 blockers, anti-inflammatory drugs, antibodies against IL-1 and anti-IL-6, Remdesivir, Dexamethasone, Hydroxychloroquine and vaccines. In this chapter, preference is given to Tocilizumab with the latest status of clinical research update available. Despite several clinical research attempts, some have yielded promising results, others are inconclusive.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83160788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-20DOI: 10.5772/intechopen.99884
Julius Manjengwa
Proper management of waste in healthcare emergencies is key to preventing spread of infections within an emergency. The risks of poor waste management are varied with the risks of spreading infectious diseases being the most important to consider. Chemical pollution should also be considered as water sources can easily be polluted. Careful thought and planning including a risk assessment should be carried out and the results should be publicized to create a common understanding of the problem at hand. This will also inform the methods to be used for the management of waste. Training of healthcare workers is key to creating common understanding of the problem at hand. The different types of waste to be generated should be well understood and methods to manage it should be well thought out before implementation. The decision on the different methods used to manage waste should be informed by the risk assessment and the available resources. However effectiveness to deal with the waste produced should be considered above all factors. Proper healthcare waste management is imperative to preventing further infections that might not be part of the original healthcare emergency. Planning to manage waste is a process that requires information before implementation.
{"title":"Management of Healthcare Waste in Healthcare Emergencies","authors":"Julius Manjengwa","doi":"10.5772/intechopen.99884","DOIUrl":"https://doi.org/10.5772/intechopen.99884","url":null,"abstract":"Proper management of waste in healthcare emergencies is key to preventing spread of infections within an emergency. The risks of poor waste management are varied with the risks of spreading infectious diseases being the most important to consider. Chemical pollution should also be considered as water sources can easily be polluted. Careful thought and planning including a risk assessment should be carried out and the results should be publicized to create a common understanding of the problem at hand. This will also inform the methods to be used for the management of waste. Training of healthcare workers is key to creating common understanding of the problem at hand. The different types of waste to be generated should be well understood and methods to manage it should be well thought out before implementation. The decision on the different methods used to manage waste should be informed by the risk assessment and the available resources. However effectiveness to deal with the waste produced should be considered above all factors. Proper healthcare waste management is imperative to preventing further infections that might not be part of the original healthcare emergency. Planning to manage waste is a process that requires information before implementation.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87857999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-29DOI: 10.5772/intechopen.99206
E. Guerrero, J. Frimpong, Angelique Hearn, V. Serret, W. K. Deen, Howard Padwa, R. Trotzky-Sirr, M. Menchine, Daniel L. Howard
This study responds to the gap in knowledge in translating team members’ interdisciplinary knowledge to address wicked problems. We use qualitative methodology to understand the team-building process and response to the opioid epidemic in emergency care. We collected data through direct observation of nine health system science researchers and thought leaders as they performed in team-building activities and semi-structured interviews. The cultural exchange framework informed our selection and assessment of team-building activities, and the science of team science (SciTS) framework informed our understanding of promoting interdisciplinary collaborations. We identified six themes representing three areas: (1) Knowledge Building and Strategy Development (need for interdisciplinary understanding of substance abuse and mental health in the emergency department (ED); interdisciplinary approaches to fight the opioid epidemic in the ED); (2) Team Demographics and Collaboration (prescribing and collaboration; the role of interdisciplinary team composition and effectiveness in the ED); and (3) Identity and Relationship Building (role of professional identity in contributing to interdisciplinary research; building effective organizational relationships in the ED). Members’ personal and professional connections are fundamental for developing nuanced interdisciplinary strategies to respond to the opioid epidemic in the ED. We discuss implications for strategies that promote team building and improve treatment practices.
{"title":"Building Interdisciplinary Teams in Emergency Care to Respond to National Emergencies: Addressing the Opioid Epidemic","authors":"E. Guerrero, J. Frimpong, Angelique Hearn, V. Serret, W. K. Deen, Howard Padwa, R. Trotzky-Sirr, M. Menchine, Daniel L. Howard","doi":"10.5772/intechopen.99206","DOIUrl":"https://doi.org/10.5772/intechopen.99206","url":null,"abstract":"This study responds to the gap in knowledge in translating team members’ interdisciplinary knowledge to address wicked problems. We use qualitative methodology to understand the team-building process and response to the opioid epidemic in emergency care. We collected data through direct observation of nine health system science researchers and thought leaders as they performed in team-building activities and semi-structured interviews. The cultural exchange framework informed our selection and assessment of team-building activities, and the science of team science (SciTS) framework informed our understanding of promoting interdisciplinary collaborations. We identified six themes representing three areas: (1) Knowledge Building and Strategy Development (need for interdisciplinary understanding of substance abuse and mental health in the emergency department (ED); interdisciplinary approaches to fight the opioid epidemic in the ED); (2) Team Demographics and Collaboration (prescribing and collaboration; the role of interdisciplinary team composition and effectiveness in the ED); and (3) Identity and Relationship Building (role of professional identity in contributing to interdisciplinary research; building effective organizational relationships in the ED). Members’ personal and professional connections are fundamental for developing nuanced interdisciplinary strategies to respond to the opioid epidemic in the ED. We discuss implications for strategies that promote team building and improve treatment practices.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88208912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-19DOI: 10.5772/intechopen.98704
Alonso Ureta Dumont, Jovanka Trebotich Zúñiga
Only a small portion of all the projects that are funded with public grants reaches the market, due to a gap known as “Death Valley” between the public and private source of resources. Know Hub Chile (KH) is a non-profit organization founded to transform scientific research results into goods and services available to the market and for the benefit of society. When the Covid-19 emergency reached Chile, the organization launched the “KH Bridge” a program of proof-of-concept and selected three technologies able to support hospitals in solving their needs. The first one was a smart shift planning platform of medical staff for reducing the virus spreading probability; the second solution aimed to assess the use of masks, and counting capacity and physical distance of patients by using video camera analytic technology in real-time; and the third project selected was an innovative design of personal protection equipment made with copper nanoparticles. All these solutions were piloted and validated into public hospitals for three months with a USD 25.000 budget. The KH Bridge experience has shown that the pandemic scenario has been an opportunity to validate university technologies in real environments and in shorter time frames, contributing to public health operations.
{"title":"Science-Based Technological Transfer as a Key Tool in Public Health","authors":"Alonso Ureta Dumont, Jovanka Trebotich Zúñiga","doi":"10.5772/intechopen.98704","DOIUrl":"https://doi.org/10.5772/intechopen.98704","url":null,"abstract":"Only a small portion of all the projects that are funded with public grants reaches the market, due to a gap known as “Death Valley” between the public and private source of resources. Know Hub Chile (KH) is a non-profit organization founded to transform scientific research results into goods and services available to the market and for the benefit of society. When the Covid-19 emergency reached Chile, the organization launched the “KH Bridge” a program of proof-of-concept and selected three technologies able to support hospitals in solving their needs. The first one was a smart shift planning platform of medical staff for reducing the virus spreading probability; the second solution aimed to assess the use of masks, and counting capacity and physical distance of patients by using video camera analytic technology in real-time; and the third project selected was an innovative design of personal protection equipment made with copper nanoparticles. All these solutions were piloted and validated into public hospitals for three months with a USD 25.000 budget. The KH Bridge experience has shown that the pandemic scenario has been an opportunity to validate university technologies in real environments and in shorter time frames, contributing to public health operations.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90604906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Health commodity supply chains are vital to a well-functioning health system and advancing national and regional health security goals. This study describes impacts of the COVID-19 pandemic on these chains, learnings from it and the challenges faced by countries. It also provides futuristic strategic recommendations for the building of the supply chain to manage the impacts and guide pandemic responsiveness. We used the PRISMA guideline for systematic review to collate relevant information from both published and unpublished literature. Out of 622 screened records, 38 were included in the review. Major impacts were innovation, collaboration, increased technology, research and development, increased prices and shortage of health products, depletion of supply chain personnel. Challenges were lack of visibility, coordination, resilience and strategy for pandemics, potential substandard medicines epidemic, travel restrictions and inadequate scientific knowledge. The studies recommended increased local production and resilience of supply chains. The pandemic disrupted national and international supply chain systems of medical devices, essential medicines and pharmaceutical products due to border closures, transportation and international trade restrictions. It however exposed hidden potentials in Sub-Saharan Africa. There is need to develop supply chain strategy for emergencies, increase local production and talent pool for supply chain management particularly in Africa.
{"title":"Global Impact of COVID-19 Pandemic on Public Health Supply Chains","authors":"U. Okafor, Modinat Aderonke Olalaye, Hillary Chukwuemeka Asobara, Ebuka Fidelis Umeodinka","doi":"10.5772/INTECHOPEN.97454","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.97454","url":null,"abstract":"Health commodity supply chains are vital to a well-functioning health system and advancing national and regional health security goals. This study describes impacts of the COVID-19 pandemic on these chains, learnings from it and the challenges faced by countries. It also provides futuristic strategic recommendations for the building of the supply chain to manage the impacts and guide pandemic responsiveness. We used the PRISMA guideline for systematic review to collate relevant information from both published and unpublished literature. Out of 622 screened records, 38 were included in the review. Major impacts were innovation, collaboration, increased technology, research and development, increased prices and shortage of health products, depletion of supply chain personnel. Challenges were lack of visibility, coordination, resilience and strategy for pandemics, potential substandard medicines epidemic, travel restrictions and inadequate scientific knowledge. The studies recommended increased local production and resilience of supply chains. The pandemic disrupted national and international supply chain systems of medical devices, essential medicines and pharmaceutical products due to border closures, transportation and international trade restrictions. It however exposed hidden potentials in Sub-Saharan Africa. There is need to develop supply chain strategy for emergencies, increase local production and talent pool for supply chain management particularly in Africa.","PeriodicalId":69212,"journal":{"name":"走近科学","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81791663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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