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Brentuximab Vedotin-induced Tumour Lysis Syndrome in Mycosis Fungoides: A Case Report. 布伦妥昔单抗维多汀诱发的真菌病肿瘤溶解综合征:病例报告。
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-11-05 DOI: 10.2340/actadv.v104.41982
Berenika Olszewska, Anna Zaryczańska, Roman J Nowicki, Małgorzata Sokołowska-Wojdyło

is missing (Short communication).

缺失(短讯)。
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引用次数: 0
Characteristics of Psychogenic Pruritus or Functional Itch Disorder: A Controlled Study. 精神性瘙痒症或功能性瘙痒症的特征:对照研究
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-11-01 DOI: 10.2340/actadv.v104.41352
Bárbara Roque Ferreira, Laurent Misery
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引用次数: 0
Sleep Efficiency and Neurocognitive Decline in Atopic Dermatitis: A Systematic Review. 特应性皮炎患者的睡眠效率和神经认知能力下降:系统回顾
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-30 DOI: 10.2340/actadv.v104.40459
Alireza Khosravi, Julia Glińska, Wioletta Barańska-Rybak

Atopic dermatitis is often accompanied by a lack of sleep efficiency, which may impact neurocognitive functions. This review assesses the association between sleep quality in atopic dermatitis patients and neurocognitive decline. Databases searched included PubMed, Scopus, and Web of Science from inception to 8 January 2024, adhering to PRISMA guidelines. Cross-sectional and longitudinal studies were included. Records were screened and assessed for eligibility, with 13 studies included in the final analysis. From an initial pool of 4,529 records, 13 studies involving 272,868 participants met the inclusion criteria. The review identified a consistent pattern of sleep disruption in individuals with atopic dermatitis, which was associated with various short-term neurocognitive challenges such as impaired focus, decreased sleep efficiency, and lower IQ. Limited evidence was found for potential long-term cognitive decline associated with chronic atopic dermatitis. Lower sleep quality in atopic dermatitis is associated with neurocognitive deficits. While immediate effects are evident, further research is needed to understand potential long-term consequences. Integrating sleep management into atopic dermatitis care is imperative.

特应性皮炎通常伴有睡眠不足,这可能会影响神经认知功能。本综述评估了特应性皮炎患者的睡眠质量与神经认知功能下降之间的关系。根据PRISMA指南,检索的数据库包括PubMed、Scopus和Web of Science,检索时间从开始到2024年1月8日。包括横断面研究和纵向研究。对记录进行了筛选和资格评估,最终分析纳入了 13 项研究。从最初的 4529 条记录中,有 13 项研究符合纳入标准,涉及 272868 名参与者。研究发现,特应性皮炎患者的睡眠紊乱模式与各种短期神经认知挑战有关,如注意力不集中、睡眠效率下降和智商降低。对于与慢性特应性皮炎相关的潜在长期认知能力下降,发现的证据有限。特应性皮炎患者睡眠质量下降与神经认知缺陷有关。虽然直接影响显而易见,但要了解潜在的长期后果,还需要进一步的研究。将睡眠管理纳入特应性皮炎的治疗中势在必行。
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引用次数: 0
An Elderly Man with Facial Oedema and a Photosensitive Rash: A Quiz. 一位患有面部水肿和光敏性皮疹的老人:小测验
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-30 DOI: 10.2340/actadv.v104.42012
Jakob L Drivenes, Anette Bygum
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引用次数: 0
Haemorrhagic Bullous Wound Changes After a Knee Joint Replacement: A Quiz. 膝关节置换术后出血性大疱性伤口变化:小测验
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-24 DOI: 10.2340/actadv.v104.41347
Lina Weiss, Matiar Madanchi, Beda Muehleisen
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引用次数: 0
Abstracts from 14th Georg Rajka International Symposium on Atopic Dermatitis. 第 14 届 Georg Rajka 特应性皮炎国际研讨会摘要。
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-23 DOI: 10.2340/actadv.v104.42247
No Authors Listed

Abstracts from 14th Georg Rajka International Symposium on Atopic Dermatitis Doha, Qatar October 24-26, 2024.

第 14 届 Georg Rajka 特应性皮炎国际研讨会摘要 卡塔尔多哈,2024 年 10 月 24-26 日。
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引用次数: 0
Somatic Variants of KRT1/KRT10 Identified by Next-generation Sequencing in Patients with Epidermal Nevi. 通过下一代测序在表皮痣患者中发现 KRT1/KRT10 的体细胞变异。
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-22 DOI: 10.2340/actadv.v104.40958
Shuya Sun, Ran Mo, Zhiming Chen, Yong Yang, Ruiyu Xiang
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引用次数: 0
Efficacy of Intralesional Candida Injection in the Treatment of Cutaneous Warts: A Systematic Review and Meta-Analysis. 局部注射念珠菌治疗皮肤疣的疗效:系统回顾与元分析》。
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-18 DOI: 10.2340/actadv.v104.40819
Chin-Hsuan Chang, Zih-Yi Sung, Yu-Chen Huang

Recent studies that examined the treatment efficacy of Candida antigen injection for both non-genital and genital warts yield inconsistent results. To address this, a systematic review and meta-analysis was conducted, comparing the treatment response between Candida antigen injection therapy and other intralesional immunotherapies across all types of warts. PubMed, Cochrane Library, and Embase were searched for relevant randomized controlled trials (RCTs) from inception to 16 September 2023, and 24 eligible RCTs were identified. A protocol was developed using the PRISM A-P checklist. In terms of complete clearance, intralesional Candida injection therapy demonstrated a significant improvement compared with saline (risk ratio [RR] 5.39; 95% confidence interval [CI] 3.49-8.33; I2=0%). However, no statistically significant differences were observed when compared with other therapies such as mumps-measles-rubella vaccines, purified protein derivative, vitamin D3, bivalent human papillomavirus vaccine, and zinc sulphate. Adverse effects associated with intralesional Candida therapy were generally reported as mild and manageable. In conclusion, intralesional Candida injection therapy for cutaneous warts may exhibit a superior complete and distant response rate. Nevertheless, owing to a limited sample size and other limitations, future research should aim for larger studies to provide more conclusive evidence.

最近的一些研究对白色念珠菌抗原注射治疗非生殖器疣和生殖器疣的疗效进行了调查,结果并不一致。为了解决这个问题,我们进行了一项系统性回顾和荟萃分析,比较了念珠菌抗原注射疗法和其他局部免疫疗法对所有类型尖锐湿疣的治疗效果。在PubMed、Cochrane Library和Embase上搜索了从开始到2023年9月16日的相关随机对照试验(RCT),并确定了24项符合条件的RCT。采用 PRISM A-P 核对表制定了研究方案。在完全清除率方面,念珠菌区域内注射疗法与生理盐水相比有显著改善(风险比 [RR] 5.39;95% 置信区间 [CI] 3.49-8.33;I2=0%)。不过,与其他疗法(如流行性腮腺炎-风疹-麻疹疫苗、纯化蛋白衍生物、维生素 D3、二价人类乳头瘤病毒疫苗和硫酸锌)相比,在统计学上未发现明显差异。与局部念珠菌治疗相关的不良反应一般报告为轻微且可控。总之,皮肤疣的局部念珠菌注射疗法可能会表现出较高的完全反应率和远期反应率。然而,由于样本量有限以及其他限制因素,未来的研究应以更大规模的研究为目标,以提供更确凿的证据。
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引用次数: 0
A Giant Pedunculated Mass on the Left Buttock: A Quiz. 左臀部巨大带蒂肿块:小测验
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-18 DOI: 10.2340/actadv.v104.42013
Masakazu Kakurai, Kazuma Iwamoto, Yoshihiro Moriyama
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引用次数: 0
Decreased Neutrophil-to-lymphocyte Ratio in Patients with Vitiligo: National Data Analysis. 白癜风患者中性粒细胞与淋巴细胞比率降低:全国数据分析。
IF 3.5 4区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-15 DOI: 10.2340/actadv.v104.35406
Sarah Weissmann, Amit Shira Babyev, Michal Gordon, Inbal Golan-Tripto, Amir Horev

Vitiligo is characterized by depigmented skin lesions involving melanocyte defects and immune dysregulation. Haematological markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been explored in various skin disorders. Given vitiligo's proposed pathogenesis, we hypothesized differences in NLR and PLR in vitiligo patients compared to controls. In a national retrospective cohort study (2005-2020) in Israel, blood count data from patients diagnosed with vitiligo (ICD-10 codes) were analysed, excluding patients with recent infections, surgeries, or malignancies. Controls matched for age and sex were selected. Sub-analyses examined age groups, treatment type, and matched controls. Children (n = 3,796) and adults (n = 38,608) with vitiligo showed significant differences in gender distribution, cell counts, and ratios. Vitiligo patients (n = 38,358) exhibited lower NLR, decreased neutrophils and platelets, and increased lymphocytes compared with controls. Non-systemically treated vitiligo patients (n = 33,871) displayed lower NLR and neutrophils compared with matched controls. Systemically treated vitiligo patients (n = 4,487) showed lower NLR, higher PLR, and reduced lymphocytes. Logistic regression identified associations between increased lymphocyte and platelet counts and being systemically treated. This study highlights significant haematological differences in vitiligo patients, emphasizing the potential utility of NLR as an accessible tool for vitiligo assessment. Further investigations are warranted to elucidate the roles of neutrophils and lymphocytes in vitiligo pathogenesis.

白癜风的特征是黑色素细胞缺陷和免疫功能失调导致的皮肤脱色病变。中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)等血液学指标已在各种皮肤疾病中进行了研究。鉴于白癜风的发病机制,我们假设白癜风患者的 NLR 和 PLR 与对照组相比存在差异。在以色列进行的一项全国性回顾性队列研究(2005-2020 年)中,我们分析了确诊为白癜风患者(ICD-10 编码)的血细胞计数数据,排除了近期感染、手术或恶性肿瘤患者。同时选择了年龄和性别匹配的对照组。子分析对年龄组、治疗类型和匹配对照进行了研究。儿童白癜风患者(n = 3,796 例)和成人白癜风患者(n = 38,608 例)在性别分布、细胞数量和比率方面存在显著差异。与对照组相比,白癜风患者(n = 38 358)的NLR较低,中性粒细胞和血小板减少,淋巴细胞增加。与匹配的对照组相比,未接受系统治疗的白癜风患者(n = 33 871)的NLR和中性粒细胞较低。接受系统治疗的白癜风患者(n = 4 487)显示出较低的 NLR、较高的 PLR 和较低的淋巴细胞。逻辑回归确定了淋巴细胞和血小板计数增加与接受系统治疗之间的关联。这项研究强调了白癜风患者在血液学方面的显著差异,强调了 NLR 作为白癜风评估工具的潜在用途。有必要进行进一步研究,以阐明中性粒细胞和淋巴细胞在白癜风发病机制中的作用。
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引用次数: 0
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Acta dermato-venereologica
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