The OBGYN Editors' Integrity Group (OGEIG), Vincenzo Berghella
<p>Meta-analysis is a quantitative statistical technique used to combine and analyze data from the results of multiple previous independent studies on a particular topic, to derive overall conclusions or effect estimates. In general (but not exclusively), meta-analyses are based on RCTs. The results are often used to develop standard practice or clinical guidelines. However, RCTs may be inaccurate or fabricated, leading to journal withdrawal or retraction. This article aims to expand upon the list of RCT quality criteria for authors of meta-analyses of RCTs, so that low-quality and fabricated studies are excluded from meta-analyses.</p><p>The editors in the group were invited to participate in monthly or bimonthly calls regarding trustworthiness in OBGYN publishing, with the aim of preventing publication of untrustworthy science in women's health. Using data from the published literature, including our prior work,<span><sup>1, 2</sup></span> Cochrane guidance,<span><sup>3</sup></span> the TRACT Checklist,<span><sup>4</sup></span> the author instructions of the various journals, and other publications related to trustworthiness of meta-analyses of RCTs,<span><sup>5</sup></span> criteria for meta-analyses were reviewed, reaching consensus by majority.</p><p>By consensus, 21 quality criteria were agreed upon by the editors. The aim is for authors to check and confirm the quality criteria for <i>each</i> identified RCT when carrying out a meta-analysis of RCTs (Tables 1 and 2). These criteria help to identify trustworthy RCTs, and are assigned to two groups: absolute criteria and “other quality” criteria. “Absolute” trustworthiness criteria are those that, if not met, would suggest noninclusion in the main results of meta-analyses of RCTs (Table 1). “Other quality” criteria are those that, if not met, would suggest lower quality of RCTs (Table 2). In addition, the meta-analysis should be prospectively registered in the PROSPERO database (or a similar international, publicly accessible database, eg INPLASY; Research Registry – Registry of Systematic Review/Meta-Analysis).</p><p>The consensus decision was that the abstract and primary analysis of meta-analyses should report only trustworthy, “high-quality” RCTs that meet all of the “absolute” criteria (Table 1). Authors of meta-analyses are encouraged to contact RCT authors for additional information regarding the criteria in Tables 1 and 2 if the details cannot be found in the published manuscript or registered protocol. At a minimum, all coauthors of meta-analyses should confirm at the point of submission that each included article meets the criteria included in Table 1. Individual journals may also ask authors to confirm that each article meets the criteria in Table 2, or may go further and ask authors to complete and submit a checklist for the criteria in Tables 1 and 2 for each article included in the meta-analysis. In general, RCTs that are published as an abstract only seldom report all criteria
{"title":"Trustworthiness criteria for meta-analyses of randomized controlled studies: OBGYN Journal guidelines","authors":"The OBGYN Editors' Integrity Group (OGEIG), Vincenzo Berghella","doi":"10.1111/aogs.14942","DOIUrl":"10.1111/aogs.14942","url":null,"abstract":"<p>Meta-analysis is a quantitative statistical technique used to combine and analyze data from the results of multiple previous independent studies on a particular topic, to derive overall conclusions or effect estimates. In general (but not exclusively), meta-analyses are based on RCTs. The results are often used to develop standard practice or clinical guidelines. However, RCTs may be inaccurate or fabricated, leading to journal withdrawal or retraction. This article aims to expand upon the list of RCT quality criteria for authors of meta-analyses of RCTs, so that low-quality and fabricated studies are excluded from meta-analyses.</p><p>The editors in the group were invited to participate in monthly or bimonthly calls regarding trustworthiness in OBGYN publishing, with the aim of preventing publication of untrustworthy science in women's health. Using data from the published literature, including our prior work,<span><sup>1, 2</sup></span> Cochrane guidance,<span><sup>3</sup></span> the TRACT Checklist,<span><sup>4</sup></span> the author instructions of the various journals, and other publications related to trustworthiness of meta-analyses of RCTs,<span><sup>5</sup></span> criteria for meta-analyses were reviewed, reaching consensus by majority.</p><p>By consensus, 21 quality criteria were agreed upon by the editors. The aim is for authors to check and confirm the quality criteria for <i>each</i> identified RCT when carrying out a meta-analysis of RCTs (Tables 1 and 2). These criteria help to identify trustworthy RCTs, and are assigned to two groups: absolute criteria and “other quality” criteria. “Absolute” trustworthiness criteria are those that, if not met, would suggest noninclusion in the main results of meta-analyses of RCTs (Table 1). “Other quality” criteria are those that, if not met, would suggest lower quality of RCTs (Table 2). In addition, the meta-analysis should be prospectively registered in the PROSPERO database (or a similar international, publicly accessible database, eg INPLASY; Research Registry – Registry of Systematic Review/Meta-Analysis).</p><p>The consensus decision was that the abstract and primary analysis of meta-analyses should report only trustworthy, “high-quality” RCTs that meet all of the “absolute” criteria (Table 1). Authors of meta-analyses are encouraged to contact RCT authors for additional information regarding the criteria in Tables 1 and 2 if the details cannot be found in the published manuscript or registered protocol. At a minimum, all coauthors of meta-analyses should confirm at the point of submission that each included article meets the criteria included in Table 1. Individual journals may also ask authors to confirm that each article meets the criteria in Table 2, or may go further and ask authors to complete and submit a checklist for the criteria in Tables 1 and 2 for each article included in the meta-analysis. In general, RCTs that are published as an abstract only seldom report all criteria","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"103 11","pages":"2118-2121"},"PeriodicalIF":3.5,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yannick Hurni, Colin Simonson, Marcello Di Serio, Régine Lachat, Pauline Bodenmann, Stéphanie Seidler, Daniela Huber
Introduction
Evidence about intra- and postoperative complication rates related to transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for benign gynecological conditions is still limited. We report and analyze data from a large cohort of patients operated in a single institution during 3.5 years.
Material and Methods
To evaluate the safety and feasibility of vNOTES for benign gynecological indications, we performed a single-center observational study reporting and analyzing perioperative outcomes of 550 consecutive patients operated between 2020 and 2024.
Results
Of the 550 included patients, 365 (66.4%) underwent a vNOTES hysterectomy, 167 (30.4%) a procedure limited to the adnexa, and 18 (3.3%) other interventions, including myomectomy, pelvic adhesiolysis, post-hysterectomy pelvic hematoma drainage, pelvic organ prolapse repair, and appendectomy. The mean age was 49.4 ± 12.2 years, and the mean BMI was 26.2 ± 5.8 kg/m2. The total complication rate was 6.5% (36 cases), of which 2.7% (15 cases) were intraoperative complications and 4.0% (22 cases) were postoperative complications. Patients presented postoperative complications classified as Clavien–Dindo (CD) grade I in 4 cases (0.7%), grade II in 10 cases (1.8%), and grade III in 8 cases (1.5%). We observed no CD grade IV and V complications. Three patients (0.5%) were rehospitalized for postoperative complications management. The conversion rate was 1.6%, with nine cases of conversion to conventional laparoscopy and none to laparotomy.
Conclusions
The application of vNOTES appears safe and feasible for most benign gynecological surgeries. Our study focused on surgical complications and demonstrated a profile similar to those reported in previous studies.
{"title":"Early surgical outcomes of 550 consecutive patients treated for benign gynecological conditions by transvaginal natural orifice transluminal endoscopic surgery","authors":"Yannick Hurni, Colin Simonson, Marcello Di Serio, Régine Lachat, Pauline Bodenmann, Stéphanie Seidler, Daniela Huber","doi":"10.1111/aogs.14889","DOIUrl":"10.1111/aogs.14889","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Evidence about intra- and postoperative complication rates related to transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for benign gynecological conditions is still limited. We report and analyze data from a large cohort of patients operated in a single institution during 3.5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>To evaluate the safety and feasibility of vNOTES for benign gynecological indications, we performed a single-center observational study reporting and analyzing perioperative outcomes of 550 consecutive patients operated between 2020 and 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 550 included patients, 365 (66.4%) underwent a vNOTES hysterectomy, 167 (30.4%) a procedure limited to the adnexa, and 18 (3.3%) other interventions, including myomectomy, pelvic adhesiolysis, post-hysterectomy pelvic hematoma drainage, pelvic organ prolapse repair, and appendectomy. The mean age was 49.4 ± 12.2 years, and the mean BMI was 26.2 ± 5.8 kg/m<sup>2</sup>. The total complication rate was 6.5% (36 cases), of which 2.7% (15 cases) were intraoperative complications and 4.0% (22 cases) were postoperative complications. Patients presented postoperative complications classified as Clavien–Dindo (CD) grade I in 4 cases (0.7%), grade II in 10 cases (1.8%), and grade III in 8 cases (1.5%). We observed no CD grade IV and V complications. Three patients (0.5%) were rehospitalized for postoperative complications management. The conversion rate was 1.6%, with nine cases of conversion to conventional laparoscopy and none to laparotomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The application of vNOTES appears safe and feasible for most benign gynecological surgeries. Our study focused on surgical complications and demonstrated a profile similar to those reported in previous studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"103 11","pages":"2203-2210"},"PeriodicalIF":3.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Introduction</h3> <p>Intra-amniotic inflammation is causally linked to spontaneous preterm labor. The gold standard for the diagnosis of intra-amniotic inflammation is the determination of an amniotic fluid profile obtained from transabdominal amniocentesis, which is invasive. Cervicovaginal fluid fetal fibronectin (fFN) is a widely-used predictive biomarker for spontaneous preterm labor. The aims of this study are to determine (1) whether a quantitative cervicovaginal fluid fFN test can be used to identify the presence of intra-amniotic inflammation; and (2) an appropriate cut-off value of a cervicovaginal fluid fFN concentration for the identification of intra-amniotic inflammation.</p> </section> <section> <h3> Material and Methods</h3> <p>This prospective cohort study included 78 patients with preterm labor and intact membranes who had a sample collected for quantitative cervicovaginal fluid fFN measurement and underwent transabdominal amniocentesis. Intra-amniotic inflammation was defined as an amniotic fluid interleukin-6 concentration ≥2.6 ng/mL. Clinicians were masked from the results of cervicovaginal fluid fFN and amniotic fluid interleukin-6 concentrations. Logistic regression analysis was used to determine which factors were significant predictors of intra-amniotic inflammation. The diagnostic indices of the cervicovaginal fluid fFN test for the identification of intra-amniotic inflammation were calculated.</p> </section> <section> <h3> Results</h3> <p>(1) Frequency of intra-amniotic inflammation was 26.9% (21/78); (2) the higher the cervicovaginal fluid fFN concentration, the greater the risk of intra-amniotic inflammation (<i>p</i> < 0.001); (3) cervicovaginal fluid fFN concentration ≥125 ng/mL had an area under the curve of 0.91 (95% confidence interval: 0.83–0.96) for the identification of intra-amniotic inflammation with 100% sensitivity, 100% negative predictive value, 82.46% specificity and a positive likelihood ratio of 5.7; and (4) cervicovaginal fluid fFN cut-off of 125 ng/mL had a significant higher predictive performance than the traditional cut-off (50 ng/mL) for the identification of intra-amniotic inflammation.</p> </section> <section> <h3> Conclusions</h3> <p>Quantitative cervicovaginal fluid fFN with a cut-off of 125 ng/mL had a high sensitivity and a negative predictive value as well as a positive likelihood ratio for the identification of intra-amniotic inflammation. Its high sensitivity and negative predictive value can be used to decrease an index of suspicion of intra-amniotic inflammation.
{"title":"Quantitative cervicovaginal fluid fetal fibronectin: A liquid biopsy for intra-amniotic inflammation","authors":"Puntabut Warintaksa, Roberto Romero, Waranyu Lertrat, Nutnaree Yuenyongdechawat, Paninee Mongkolsuk, Supakorn Chaiyakarn, Rapeewan Settacomkul, Pisut Pongchaikul, Pornpun Vivithanaporn, Piya Chaemsaithong","doi":"10.1111/aogs.14899","DOIUrl":"10.1111/aogs.14899","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Intra-amniotic inflammation is causally linked to spontaneous preterm labor. The gold standard for the diagnosis of intra-amniotic inflammation is the determination of an amniotic fluid profile obtained from transabdominal amniocentesis, which is invasive. Cervicovaginal fluid fetal fibronectin (fFN) is a widely-used predictive biomarker for spontaneous preterm labor. The aims of this study are to determine (1) whether a quantitative cervicovaginal fluid fFN test can be used to identify the presence of intra-amniotic inflammation; and (2) an appropriate cut-off value of a cervicovaginal fluid fFN concentration for the identification of intra-amniotic inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 78 patients with preterm labor and intact membranes who had a sample collected for quantitative cervicovaginal fluid fFN measurement and underwent transabdominal amniocentesis. Intra-amniotic inflammation was defined as an amniotic fluid interleukin-6 concentration ≥2.6 ng/mL. Clinicians were masked from the results of cervicovaginal fluid fFN and amniotic fluid interleukin-6 concentrations. Logistic regression analysis was used to determine which factors were significant predictors of intra-amniotic inflammation. The diagnostic indices of the cervicovaginal fluid fFN test for the identification of intra-amniotic inflammation were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>(1) Frequency of intra-amniotic inflammation was 26.9% (21/78); (2) the higher the cervicovaginal fluid fFN concentration, the greater the risk of intra-amniotic inflammation (<i>p</i> < 0.001); (3) cervicovaginal fluid fFN concentration ≥125 ng/mL had an area under the curve of 0.91 (95% confidence interval: 0.83–0.96) for the identification of intra-amniotic inflammation with 100% sensitivity, 100% negative predictive value, 82.46% specificity and a positive likelihood ratio of 5.7; and (4) cervicovaginal fluid fFN cut-off of 125 ng/mL had a significant higher predictive performance than the traditional cut-off (50 ng/mL) for the identification of intra-amniotic inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Quantitative cervicovaginal fluid fFN with a cut-off of 125 ng/mL had a high sensitivity and a negative predictive value as well as a positive likelihood ratio for the identification of intra-amniotic inflammation. Its high sensitivity and negative predictive value can be used to decrease an index of suspicion of intra-amniotic inflammation. ","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"103 11","pages":"2252-2263"},"PeriodicalIF":3.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aogs.14899","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Introduction</h3> <p>The aim of this study was to investigate the presence of aortic isthmus flow reversal and its associated factors in fetuses with positive and false-positive coarctation of the aorta (CoA) compared with normal controls.</p> </section> <section> <h3> Material and Methods</h3> <p>Pregnant women with fetuses suspected of CoA and normal control were enrolled, and these women experienced prenatal ultrasound scan and followed up for 6 months after birth to confirm the presence of CoA. All the ultrasound parameters were analyzed.</p> </section> <section> <h3> Results</h3> <p>A total of 134 pregnant women were enrolled, with 43 CoA-positive fetuses and 91 CoA false-positive fetuses, and 334 matched pregnant women were enrolled in the control group. Aortic isthmus flow reversal occurred in 28 (65.1%) fetuses in the CoA-positive group, significantly (<i>p</i> < 0.05) more than in the false-positive (37 or 40.7%) or control group (64 or 19.2%). Aortic isthmus flow reversal was mostly in the full systole (<i>n</i> = 17 or 60.7%) or late systole and early-middle diastole (<i>n</i> = 10 or 35.7%) in the CoA-positive fetuses (<i>n</i> = 27 or 96.4%), significantly (<i>p</i> < 0.001) different from that in the false-positive or control group. The aortic isthmus flow reversal peak systolic velocity (PSV), flow volume, and ratio of reversed flow/forward flow were significantly (<i>p</i> < 0.05) increased in the CoA-positive and false-positive groups than in the control group. The aortic isthmus flow reversal incidence was significantly (<i>p</i> < 0.05) correlated with the middle cerebral artery (MCA) PSV in the total three groups or in the false-positive group but was significantly (<i>p</i> < 0001) negatively correlated with the MCA resistance index (RI) in the CoA-positive group. The incidence of the aortic isthmus flow reversal was significantly (<i>p</i> < 0.05) positively correlated with the umbilical artery (UA) RI in the false-positive group and with the UA RI in the total three groups. Independently associated factors for aortic isthmus flow reversal were isthmic flow volume/CCO (combined cardiac output) in the CoA-positive group.</p> </section> <section> <h3> Conclusions</h3> <p>Reversal of flow in the aortic isthmus is much more common in true-positive cases of CoA as compared to controls, and isthmic flow reversal in the full systolic phase only suggests presence of CoA. The aortic isthmic reversed flow volume accounts for over half of the isthmic forward flow volume in the CoA-positive fetuses t
引言 本研究旨在探讨主动脉瓣狭窄（CoA）阳性和假阳性胎儿与正常对照组相比是否存在主动脉峡部血流逆转及其相关因素。结果 共纳入 134 名孕妇，其中有 43 名 CoA 阳性胎儿和 91 名 CoA 假阳性胎儿，对照组纳入 334 名匹配孕妇。CoA阳性组中有28个（65.1%）胎儿出现主动脉峡部血流逆转，显著（p < 0.05）高于假阳性组（37或40.7%）或对照组（64或19.2%）。CoA阳性胎儿（n = 27 或 96.4%）的主动脉峡部血流逆转多发生在完全收缩期（n = 17 或 60.7%）或收缩晚期和舒张早中期（n = 10 或 35.7%），与假阳性组或对照组有明显差异（p < 0.001）。与对照组相比，CoA 阳性组和假阳性组的主动脉峡部血流反向收缩峰值速度（PSV）、血流量和反向血流/正向血流比率均明显增加（p <0.05）。在所有三组或假阳性组中，主动脉峡部血流逆转发生率与大脑中动脉（MCA）PSV 显著相关（p < 0.05），但在 CoA 阳性组中，主动脉峡部血流逆转发生率与 MCA 阻力指数（RI）显著负相关（p < 0001）。在假阳性组中，主动脉峡部血流逆转的发生率与脐动脉（UA）RI 呈显著正相关（p <0.05），而在所有三组中，主动脉峡部血流逆转的发生率与 UA RI 呈显著正相关（p <0.05）。主动脉峡部血流逆转的独立相关因素是 CoA 阳性组的峡部血流量/CCO（合并心输出量）。与正常对照组相比，CoA 阳性胎儿的主动脉峡部反向血流量占峡部正向血流量的一半以上。
{"title":"Aortic isthmus flow reversal in fetal coarctation of the aorta and the associated factors","authors":"Guihong Chen, Yongfeng Han, Congxin Sun, Wei Xiang, Wei Zhao, Pei Zhou, Tianxiao Yu, Zhuo Chen, Bulang Gao, Shuping Ge, Jie Mi","doi":"10.1111/aogs.14940","DOIUrl":"10.1111/aogs.14940","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The aim of this study was to investigate the presence of aortic isthmus flow reversal and its associated factors in fetuses with positive and false-positive coarctation of the aorta (CoA) compared with normal controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Pregnant women with fetuses suspected of CoA and normal control were enrolled, and these women experienced prenatal ultrasound scan and followed up for 6 months after birth to confirm the presence of CoA. All the ultrasound parameters were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 134 pregnant women were enrolled, with 43 CoA-positive fetuses and 91 CoA false-positive fetuses, and 334 matched pregnant women were enrolled in the control group. Aortic isthmus flow reversal occurred in 28 (65.1%) fetuses in the CoA-positive group, significantly (<i>p</i> < 0.05) more than in the false-positive (37 or 40.7%) or control group (64 or 19.2%). Aortic isthmus flow reversal was mostly in the full systole (<i>n</i> = 17 or 60.7%) or late systole and early-middle diastole (<i>n</i> = 10 or 35.7%) in the CoA-positive fetuses (<i>n</i> = 27 or 96.4%), significantly (<i>p</i> < 0.001) different from that in the false-positive or control group. The aortic isthmus flow reversal peak systolic velocity (PSV), flow volume, and ratio of reversed flow/forward flow were significantly (<i>p</i> < 0.05) increased in the CoA-positive and false-positive groups than in the control group. The aortic isthmus flow reversal incidence was significantly (<i>p</i> < 0.05) correlated with the middle cerebral artery (MCA) PSV in the total three groups or in the false-positive group but was significantly (<i>p</i> < 0001) negatively correlated with the MCA resistance index (RI) in the CoA-positive group. The incidence of the aortic isthmus flow reversal was significantly (<i>p</i> < 0.05) positively correlated with the umbilical artery (UA) RI in the false-positive group and with the UA RI in the total three groups. Independently associated factors for aortic isthmus flow reversal were isthmic flow volume/CCO (combined cardiac output) in the CoA-positive group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Reversal of flow in the aortic isthmus is much more common in true-positive cases of CoA as compared to controls, and isthmic flow reversal in the full systolic phase only suggests presence of CoA. The aortic isthmic reversed flow volume accounts for over half of the isthmic forward flow volume in the CoA-positive fetuses t","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"103 11","pages":"2264-2272"},"PeriodicalIF":3.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aogs.14940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Katrina Fraser, Naomi Cano-Ibáñez, Carmen Amezcua-Prieto, Khalid Saeed Khan, Ronald F. Lamont, Jan Stener Jørgensen
Obstetric violence, or mistreatment of women in obstetric care, can have severe consequences such as fear of future childbirth, post-traumatic stress disorder, and depression.
产科暴力或在产科护理中对妇女的虐待会造成严重后果，如对未来生育的恐惧、创伤后应激障碍和抑郁症。
{"title":"Prevalence of obstetric violence in high-income countries: A systematic review of mixed studies and meta-analysis of quantitative studies","authors":"Laura Katrina Fraser, Naomi Cano-Ibáñez, Carmen Amezcua-Prieto, Khalid Saeed Khan, Ronald F. Lamont, Jan Stener Jørgensen","doi":"10.1111/aogs.14962","DOIUrl":"https://doi.org/10.1111/aogs.14962","url":null,"abstract":"Obstetric violence, or mistreatment of women in obstetric care, can have severe consequences such as fear of future childbirth, post-traumatic stress disorder, and depression.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"12 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arwa Hanidu, Mariya Kovalenko, Sana Usman, Lorenzo Monasta, Giulia Zamagni, Tamara Stampalija, Christoph Lees
Digital vaginal examination (DVE) is considered the standard of care for assessing labor progress and cervical dilatation. However, it may be painful and is a subjective method that can increase the risk of chorioamnionitis. Known inter- and intra-observer variability exists in measurements of cervical dilatation obtained digitally. However, little is known about the inter- and intra-observer variability when using intrapartum transperineal ultrasound (TPUS). Our objectives were to investigate the relationship between cervical dilatation as assessed by TPUS and DVE. To assess inter- and intra-observer variability in both single and repeated ultrasound assessments of cervical dilatation during active labor.
数字阴道检查（DVE）被认为是评估产程进展和宫颈扩张的标准护理方法。然而，它可能会带来疼痛，而且是一种主观的方法，可能会增加绒毛膜羊膜炎的风险。通过数字化方法测量宫颈扩张程度存在已知的观察者之间和观察者内部的差异性。然而，人们对使用产前经会阴超声（TPUS）时观察者之间和观察者内部的变异性知之甚少。我们的目的是研究 TPUS 和 DVE 评估的宫颈扩张度之间的关系。评估在活跃产程中对宫颈扩张进行单次和重复超声评估时观察者之间和观察者内部的变异性。
{"title":"Intrapartum ultrasound for cervical dilatation: Inter- and intra-observer agreement","authors":"Arwa Hanidu, Mariya Kovalenko, Sana Usman, Lorenzo Monasta, Giulia Zamagni, Tamara Stampalija, Christoph Lees","doi":"10.1111/aogs.14970","DOIUrl":"https://doi.org/10.1111/aogs.14970","url":null,"abstract":"Digital vaginal examination (DVE) is considered the standard of care for assessing labor progress and cervical dilatation. However, it may be painful and is a subjective method that can increase the risk of chorioamnionitis. Known inter- and intra-observer variability exists in measurements of cervical dilatation obtained digitally. However, little is known about the inter- and intra-observer variability when using intrapartum transperineal ultrasound (TPUS). Our objectives were to investigate the relationship between cervical dilatation as assessed by TPUS and DVE. To assess inter- and intra-observer variability in both single and repeated ultrasound assessments of cervical dilatation during active labor.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"53 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Lecic Bonnichsen, Nina Gunnes, Lill Trine Nyfløt, Guttorm Haugen, Marie Cecilie Roland
Pregnancy involves changes in maternal metabolism that differ between normal-weight women and women with overweight or obesity, including changes in glucose, insulin, lipids, and adipokines. These changes contribute to altered risk profiles for adverse outcomes for both mother and child during pregnancy, childbirth, and postpartum. We explored associations between visceral fat and prepregnancy body mass index (pBMI), respectively, with glucose and lipid metabolism, as well as with adipokines and C-reactive protein (CRP), measured fasting in early and late pregnancy. We hypothesized that among women with pBMI ≥35 kg/m2, visceral fat measured around gestational week 18 (visceral fat18) would show associations with greater number of metabolic variables during pregnancy, than pBMI.
妊娠会导致母体新陈代谢发生变化，正常体重妇女与超重或肥胖妇女的新陈代谢有所不同，包括葡萄糖、胰岛素、血脂和脂肪因子的变化。这些变化导致孕期、分娩和产后母婴不良后果的风险特征发生变化。我们探讨了内脏脂肪和孕前体重指数（pBMI）分别与葡萄糖和脂质代谢以及脂肪因子和 C 反应蛋白（CRP）（在孕早期和孕晚期空腹测量）之间的关系。我们假设，在 pBMI≥35 kg/m2 的妇女中，在妊娠第 18 周左右测量的内脏脂肪（内脏脂肪 18）与孕期代谢变量的相关性大于 pBMI。
{"title":"Prepregnancy body mass index and visceral fat exhibit divergent associations with metabolic factors in pregnant women with obesity: A Norwegian cohort study","authors":"Maja Lecic Bonnichsen, Nina Gunnes, Lill Trine Nyfløt, Guttorm Haugen, Marie Cecilie Roland","doi":"10.1111/aogs.14968","DOIUrl":"https://doi.org/10.1111/aogs.14968","url":null,"abstract":"Pregnancy involves changes in maternal metabolism that differ between normal-weight women and women with overweight or obesity, including changes in glucose, insulin, lipids, and adipokines. These changes contribute to altered risk profiles for adverse outcomes for both mother and child during pregnancy, childbirth, and postpartum. We explored associations between visceral fat and prepregnancy body mass index (pBMI), respectively, with glucose and lipid metabolism, as well as with adipokines and C-reactive protein (CRP), measured fasting in early and late pregnancy. We hypothesized that among women with pBMI ≥35 kg/m<sup>2</sup>, visceral fat measured around gestational week 18 (visceral fat18) would show associations with greater number of metabolic variables during pregnancy, than pBMI.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"117 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clara Rollet, Camille Le Ray, Françoise Vendittelli, Béatrice Blondel, Anne Alice Chantry
The establishment of midwife-led birth centers (MLBCs) is still being debated. The study aimed to compare severe adverse outcomes and mode of birth in low-risk women according to their birth planned in MLBCs or in obstetric-led units (OUs) in France.
{"title":"Severe adverse maternal and neonatal outcomes according to the planned birth setting being midwife-led birth centers or obstetric-led units","authors":"Clara Rollet, Camille Le Ray, Françoise Vendittelli, Béatrice Blondel, Anne Alice Chantry","doi":"10.1111/aogs.14971","DOIUrl":"https://doi.org/10.1111/aogs.14971","url":null,"abstract":"The establishment of midwife-led birth centers (MLBCs) is still being debated. The study aimed to compare severe adverse outcomes and mode of birth in low-risk women according to their birth planned in MLBCs or in obstetric-led units (OUs) in France.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"102 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parnian Hossein-Pour, Maya Rajasingham, Giulia M. Muraca
Cervical laceration is an obstetric injury associated with severe postpartum hemorrhage and subsequent spontaneous preterm birth. While operative vaginal delivery is a known risk factor for cervical laceration, it is unclear whether forceps and vacuum deliveries incur the same risk. The aim of this systematic review was to compare the risk of cervical laceration between operative instruments (forceps vs vacuum).
{"title":"Risk of cervical laceration in forceps vs vacuum delivery: A systematic review and meta-analysis","authors":"Parnian Hossein-Pour, Maya Rajasingham, Giulia M. Muraca","doi":"10.1111/aogs.14969","DOIUrl":"https://doi.org/10.1111/aogs.14969","url":null,"abstract":"Cervical laceration is an obstetric injury associated with severe postpartum hemorrhage and subsequent spontaneous preterm birth. While operative vaginal delivery is a known risk factor for cervical laceration, it is unclear whether forceps and vacuum deliveries incur the same risk. The aim of this systematic review was to compare the risk of cervical laceration between operative instruments (forceps vs vacuum).","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"24 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1111/j.1600-0412.1981.tb00041.x
Menachem Granat, Shmuel Evron, Danny Navot
A rare genital anomaly is described, consisting of a right hemiulerus with a rudimentary horn and a remotely located left fallopian tube, totally disconnected from the pelvic genitalia, and ruptured by an ectopic pregnancy. An associated finding was a unilateral hyperstimulated ovary (post HMO‐HCG therapy), confined to an acessory ovary on the left. The case is presented in detail, and the unusual anatomical and functional features are discussed.
{"title":"PREGNANCY IN HETEROTOPIC FALLOPIAN TUBE AND UNILATERAL OVARIAN HYPERSTIMULATION","authors":"Menachem Granat, Shmuel Evron, Danny Navot","doi":"10.1111/j.1600-0412.1981.tb00041.x","DOIUrl":"https://doi.org/10.1111/j.1600-0412.1981.tb00041.x","url":null,"abstract":"A rare genital anomaly is described, consisting of a right hemiulerus with a rudimentary horn and a remotely located left fallopian tube, totally disconnected from the pelvic genitalia, and ruptured by an ectopic pregnancy. An associated finding was a unilateral hyperstimulated ovary (post HMO‐HCG therapy), confined to an acessory ovary on the left. The case is presented in detail, and the unusual anatomical and functional features are discussed.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142211552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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