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Strategic approach to embolization of coronary to pulmonary artery fistulas: a technical note. 冠状动脉至肺动脉瘘栓塞的策略方法:技术注意事项。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-16 DOI: 10.1177/02841851241300332
Michael Johannes Montag, Stefan Möhlenkamp, Martha von Dohna

Background: Congenital coronary artery to pulmonary artery fistulas (CPAFs) are extremely rare congenital vascular malformations.

Purpose: To give a practical approach and consider technical challenges and pitfalls for endovascular embolization of CPAF.

Material and methods: Anatomic, technical, and pathophysiologic considerations are given and demonstrated for antegrade and retrograde endovascular embolization of CPAF.

Results: Antegrade embolization is easier to perform, saves radiation exposure, and is recommended especially in younger patients. In case of a single dominant feeder, antegrade embolization of this feeder might sufficiently treat the CPAF. Retrograde embolization from the pulmonary orifice is technically more challenging but leads to a complete and definite closure of the fistula in one single step.

Conclusion: Patient age and fistula configuration must be taken into consideration for appropriate treatment approach in CPAF. Prerequisite for successful embolization of CPAF is profound clinical and interventional experience, why we highly recommend to both plan and carry out embolization of CPAF as interdisciplinary procedure.

背景:先天性冠状动脉肺动脉瘘(CPAFs)是极其罕见的先天性血管畸形。目的:提供一种实用的方法,并考虑CPAF血管内栓塞的技术挑战和陷阱:材料和方法:给出并演示CPAF逆行和顺行血管内栓塞的解剖学、技术和病理生理学注意事项:结果:逆行栓塞术更容易操作,节省放射线照射,尤其适合年轻患者。如果是单个优势馈源,对该馈源进行逆行栓塞可能足以治疗 CPAF。从肺动脉口逆行栓塞在技术上更具挑战性,但只需一步就能完全、明确地关闭瘘管:结论:CPAF 的适当治疗方法必须考虑患者年龄和瘘管结构。成功栓塞 CPAF 的先决条件是丰富的临床和介入经验,因此我们强烈建议将栓塞 CPAF 作为跨学科手术来计划和实施。
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引用次数: 0
YOLOv8 algorithm-aided detection of patellar instability or dislocation on knee joint MRI images. YOLOv8算法辅助检测膝关节MRI图像上髌骨不稳或脱位。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-16 DOI: 10.1177/02841851241300617
Ting Li, Nadeer M Gharaibeh, Shanru Jia, Zierdi Qinaer, Saidaitiguli Aihemaiti, AiShengBaTi HaNaTe, Gang Wu

Background: Patellar instability (PI) or patellar dislocation (PD) is challenging to diagnose accurately based on medical history and clinical manifestations alone. While X-ray, computed tomography (CT), and magnetic resonance imaging (MRI) are commonly employed for detecting PI or PD, computer vision has not yet been widely utilized for this purpose.

Purpose: To explore the feasibility of computer vision, specifically the You Only Look Once (YOLO) algorithm, in identifying patellar instability or dislocation.

Material and methods: A total of 550 patients (190 diagnosed with patellar instability or dislocation) were divided into a training set (n = 360), validation set (n = 90), and external test set (n = 100). Four indicators were measured on transverse knee MRI scans to determine the presence of patellar instability, and 450 images were labeled using Labelme software. YOLO version 8 (YOLOv8) was refined using these labeled images and validated on 100 unlabeled images. The diagnostic accuracy of YOLOv8 was compared with that of a junior radiologist.

Results: The sensitivity, specificity, and accuracy of the refined YOLO model and the junior radiologist were 62%, 97%, and 83%, and 62%, 82%, and 74%, respectively. Although the YOLO model demonstrated slightly higher accuracy, the difference did not reach statistical significance (P = 0.093). The YOLO model required approximately 14.01 ± 10.34 ms to interpret each image, significantly shorter than the 9.55 ± 2.39 s required by the radiologist (P < 0.001).

Conclusion: The refined YOLOv8 model is not inferior to junior radiologists in identifying patellar instability or dislocation and offers a significantly faster interpretation time.

背景:髌骨不稳(PI)或髌骨脱位(PD)仅根据病史和临床表现难以准确诊断。虽然x射线、计算机断层扫描(CT)和磁共振成像(MRI)通常用于检测PI或PD,但计算机视觉尚未广泛用于此目的。目的:探讨计算机视觉,特别是You Only Look Once (YOLO)算法在识别髌骨不稳定或脱位中的可行性。材料和方法:共550例患者(其中诊断为髌骨不稳或脱位的190例)分为训练集(n = 360)、验证集(n = 90)和外部测试集(n = 100)。在膝关节横向MRI扫描中测量四项指标以确定髌骨不稳定的存在,并使用Labelme软件标记450张图像。YOLO版本8 (YOLOv8)使用这些标记的图像进行了改进,并在100张未标记的图像上进行了验证。将YOLOv8的诊断准确性与初级放射科医生的诊断准确性进行比较。结果:改进后的YOLO模型和初级放射科医师的敏感性、特异性和准确性分别为62%、97%和83%,62%、82%和74%。虽然YOLO模型的准确率略高,但差异没有达到统计学意义(P = 0.093)。YOLO模型解译每张图像所需时间约为14.01±10.34 ms,明显短于放射科医生所需的9.55±2.39 s (P结论:改进的YOLOv8模型在识别髌骨不稳定或脱位方面并不逊色于初级放射科医生,并且解译时间明显更快。
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引用次数: 0
Comparison of 68Ga-FAPI PET CT/MRI and 18F-FDG PET/CT in metastatic lesions of gynecological cancers: a systematic review and head-to-head meta-analysis. 68Ga-FAPI PET CT/MRI与18F-FDG PET/CT在妇科肿瘤转移病灶中的比较:系统综述与头对头荟萃分析
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-15 DOI: 10.1177/02841851241297836
Lixin Sun, Pan Hao, Ruchen Peng

Background: 68Ga-labled fibroblast activating protein inhibitor (68Ga-FAPI) represents a new and exciting positron emission tomography-computed tomography/magnetic resonance (PET-CT/MR) radiotracer.

Purpose: To compare the diagnostic efficacy of 68Ga-FAPI PET CT/MR and 18F-fluorodeoxyglucose (18F-FDG) PET/CT in metastatic lesions of gynecological cancers (GCs).

Material and methods: The PubMed, Embase, and Web of Science databases were thoroughly investigated from inception until 22 December 2023. A head-to-head contrast between 18F-FDG PET/CT as well as 68Ga-FAPI PET CT/MR for the assessment of GCs was presented by the included studies. A random variable model was employed to examine the sensitivity in detection of lymph node (LN) and peritoneal metastases (PM).

Results: The pooled sensitivity for 68Ga-FAPI PET CT/MR and 18F-FDG PET/CT in lymph node metastases (LNM) of GC were 0.98 (95% confidence interval [CI] = 0.86-1) and 0.85 (95% CI = 0.65-0.98), respectively, while the results about peritoneal metastases in ovarian cancer were 0.98 (95% CI = 0.93-1) and 0.71 (95% CI = 0.55-0.86). Compared with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in peritoneal involvement of ovarian cancer with a relative risk of 0.24 (95% CI = 0.09-0.40) and P = 0.002.

Conclusion: 68Ga-FAPI PET CT/MR displayed a superior sensitivity over 18F-FDG PET/CT in detecting metastatic lesions of ovarian cancer. However, there was insufficient evidence to favor the superiority of 68Ga-FAPI PET CT/MR in LNM of CC. Further studies are needed for evaluating primary and metastatic lesions of 68Ga-FAPI PET CT/MR in different GC.

目的:比较68Ga-FAPI PET CT/MR和18F-氟脱氧葡萄糖(18F-FDG)PET/CT对妇科癌症(GCs)转移病灶的诊断效果:对PubMed、Embase和Web of Science数据库从开始到2023年12月22日的数据进行了全面调查。纳入的研究对 18F-FDG PET/CT 和 68Ga-FAPI PET CT/MR 评估 GCs 进行了头对头对比。结果显示,68Ga-FAPI正电子发射计算机断层扫描/MR对淋巴结转移和腹膜转移的敏感性高于18F-FDG正电子发射计算机断层扫描/CT:结果:68Ga-FAPI PET CT/MR和18F-FDG PET/CT对GC淋巴结转移(LNM)的汇总灵敏度分别为0.98(95%置信区间[CI] = 0.86-1)和0.85(95% CI = 0.65-0.98),而对卵巢癌腹膜转移的灵敏度分别为0.98(95% CI = 0.93-1)和0.71(95% CI = 0.55-0.86)。结论:与 18F-FDG PET/CT 相比,68Ga-FAPI PET CT/MR 对卵巢癌腹膜受累的敏感性更高,相对风险为 0.24(95% CI = 0.09-0.40),P = 0.002。然而,没有足够的证据表明68Ga-FAPI PET CT/MR在CC的LNM中更具优势。还需要进一步的研究来评估68Ga-FAPI PET CT/MR在不同GC中的原发病灶和转移病灶。
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引用次数: 0
Reliability, reproducibility, and potential pitfalls of the O-RADS scoring with non-dynamic MRI. 使用非动态磁共振成像进行 O-RADS 评分的可靠性、可重复性和潜在缺陷。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1177/02841851241279897
Gulsum Kılıçkap, Betül Akdal Dölek, Serhat Kaya, Numan Ilteriş Çevik

Background: The O-RADS scoring has been proposed to standardize the reporting of adnexal lesions using magnetic resonance imaging (MRI).

Purpose: To assess intra- and inter-observer agreement of the O-RADS scoring using non-dynamic MRI and its agreement with pathologic diagnosis, and to provide the pitfalls in the scoring based on discordant ratings.

Material and methods: Adnexal lesions that were diagnosed using non-dynamic MRI at two centers were scored using O-RADS. Intra- and inter-observer agreements were assessed using kappa statistics. Cross-tabulations were made for intra- and inter-observer ratings and for O-RADS scores and pathological findings.

Results: Intra- and inter-observer agreements were assessed for 404 lesions in 339 patients who were admitted to center 1. Intra-observer agreement was almost perfect (97.8%, kappa = 0.963) and inter-observer agreement was substantial (83.2%, kappa = 0.730). The combined data from center 1 and center 2 included 496 patients; of them, 295 (59.5%) were operated. There was no borderline or malignant pathology for the lesions with O-RADS 1 or 2. Of those with an O-RADS score of 3, 3 (4.1%) lesions were borderline and none were malignant. The O-RADS scoring in discriminating borderline/malignant lesions from benign lesions was outstanding (area under the ROC curve 0.950, 95% CI = 0.923-0.971). Sensitivity, specificity, positive, and negative predictive values of O-RADS 4/5 lesions for borderline/malignant lesions were 96.2%, 87.1%, 72.8%, and 98.4%, respectively.

Conclusion: The O-RADS scoring using non-dynamic MRI is a reproducible method and has good discrimination for borderline/malignant lesions. Potential factors that may lead to discordant ratings are provided here.

背景:目的:评估使用非动态 MRI 的 O-RADS 评分在观察者内部和观察者之间的一致性及其与病理诊断的一致性,并根据不一致的评分提供评分中的误区:在两个中心使用非动态 MRI 诊断的附件病变均使用 O-RADS 进行评分。使用卡帕统计法评估观察者内部和观察者之间的一致性。对观察者内部和观察者之间的评分以及 O-RADS 评分和病理结果进行交叉分析:对第一中心收治的 339 名患者的 404 个病灶进行了观察者内部和观察者之间的一致性评估。观察者内部几乎完全一致(97.8%,kappa = 0.963),观察者之间也非常一致(83.2%,kappa = 0.730)。中心1和中心2的合并数据包括496名患者,其中295人(59.5%)接受了手术。O-RADS为1或2的病变没有边界或恶性病变。在 O-RADS 评分为 3 分的病灶中,3 个(4.1%)病灶为边缘病变,无恶性病变。O-RADS 评分在区分边缘/恶性病变和良性病变方面表现突出(ROC 曲线下面积为 0.950,95% CI = 0.923-0.971)。O-RADS 4/5 病变对边缘/恶性病变的敏感性、特异性、阳性和阴性预测值分别为 96.2%、87.1%、72.8% 和 98.4%:结论:使用非动态磁共振成像进行O-RADS评分是一种可重复的方法,对边缘/恶性病变具有良好的辨别能力。本文提供了可能导致评分不一致的潜在因素。
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引用次数: 0
A survey of bridging bone on chest radiography shows a greater than expected prevalence of marginal syndesmophytes. 对胸片上桥骨的调查显示,边缘联合骨赘的发病率高于预期。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1177/02841851241289562
Ankur Srivastava, Timothy Miao, Yi Yan, Artur Wozniak, Joanne Howey, Michael Roth, Gregory J Garvin

Background: The recognition of thin marginal spinal syndesmophytes is important, in part due to their association with non-traumatic or mildly traumatic vertebral fractures.

Purpose: To determine a lower limit on the prevalence of marginal spinal syndesmophytes using chest radiographs.

Material and methods: We conducted a retrospective analysis of 500 chest radiographs, assessing the prevalence of thin marginal syndesmophytes, bridging or near-bridging osteophytes, and flowing paravertebral ossifications in the thoracic intervertebral discs among individuals aged 16 years and older in a North American city.

Results: Among the 500 participants, we observed that thin vertical marginal syndesmophytes were present in 17 (3.4%) cases, bridging or near-bridging osteophytes were present in 126 (25.2%) cases, and flowing paravertebral ossifications were present in 37 (7.4%) cases. Out of the 17 participants with thin marginal syndesmophytes, 10 exhibited a bamboo-like spine appearance, defined as the presence of ≥4 contiguous levels of bridging marginal syndesmophytes. Analysis of syndesmophyte distribution per vertebral level indicated a higher frequency of involvement in the mid to lower thoracic spine, maximal at T9/10.

Conclusions: The presence of thin marginal syndesmophytes in the thoracic spine on routine chest radiographs is substantially more prevalent than would be anticipated based on the existing literature. The feasibility of reliably identifying these syndesmophytes in the spine and the impact of this on morbidity should be further investigated due to their association with advanced ankylosing spondylitis and their susceptibility to fractures.

背景:目的:利用胸部X光片确定脊柱边缘骨赘患病率的下限。材料与方法:我们对500张胸部X光片进行了回顾性分析,评估了脊柱边缘骨赘、桥接或近桥接骨赘以及椎旁流动骨赘的患病率:我们对500张胸片进行了回顾性分析,评估了北美某城市16岁及以上人群胸椎椎间盘薄边缘联合骨赘、桥接或近似桥接骨赘以及流动椎旁骨化的患病率:在 500 名参与者中,我们发现有 17 例(3.4%)存在薄型垂直边缘联合骨赘,126 例(25.2%)存在桥状或近桥状骨质增生,37 例(7.4%)存在流动性椎旁骨化。在 17 例边缘骨赘较薄的患者中,有 10 例表现出竹节状脊柱外观,其定义为存在≥4 层连续的桥状边缘骨赘。对每个椎体水平的联合鞘状突起分布进行的分析表明,中下胸椎的联合鞘状突起受累频率较高,T9/10椎体的联合鞘状突起最多:结论:在常规胸片上发现胸椎薄缘联合骨赘的发生率远高于现有文献的预期。由于它们与晚期强直性脊柱炎及其骨折易感性有关,因此应进一步研究在脊柱中可靠识别这些联合骨赘的可行性及其对发病率的影响。
{"title":"A survey of bridging bone on chest radiography shows a greater than expected prevalence of marginal syndesmophytes.","authors":"Ankur Srivastava, Timothy Miao, Yi Yan, Artur Wozniak, Joanne Howey, Michael Roth, Gregory J Garvin","doi":"10.1177/02841851241289562","DOIUrl":"10.1177/02841851241289562","url":null,"abstract":"<p><strong>Background: </strong>The recognition of thin marginal spinal syndesmophytes is important, in part due to their association with non-traumatic or mildly traumatic vertebral fractures.</p><p><strong>Purpose: </strong>To determine a lower limit on the prevalence of marginal spinal syndesmophytes using chest radiographs.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of 500 chest radiographs, assessing the prevalence of thin marginal syndesmophytes, bridging or near-bridging osteophytes, and flowing paravertebral ossifications in the thoracic intervertebral discs among individuals aged 16 years and older in a North American city.</p><p><strong>Results: </strong>Among the 500 participants, we observed that thin vertical marginal syndesmophytes were present in 17 (3.4%) cases, bridging or near-bridging osteophytes were present in 126 (25.2%) cases, and flowing paravertebral ossifications were present in 37 (7.4%) cases. Out of the 17 participants with thin marginal syndesmophytes, 10 exhibited a bamboo-like spine appearance, defined as the presence of ≥4 contiguous levels of bridging marginal syndesmophytes. Analysis of syndesmophyte distribution per vertebral level indicated a higher frequency of involvement in the mid to lower thoracic spine, maximal at T9/10.</p><p><strong>Conclusions: </strong>The presence of thin marginal syndesmophytes in the thoracic spine on routine chest radiographs is substantially more prevalent than would be anticipated based on the existing literature. The feasibility of reliably identifying these syndesmophytes in the spine and the impact of this on morbidity should be further investigated due to their association with advanced ankylosing spondylitis and their susceptibility to fractures.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1499-1505"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic susceptibility contrast-enhanced MRI with USPIO in evaluating angiogenesis of the peri-infarction zones in subacute ischemic stroke in a permanent middle cerebral artery occlusion rat model. 用 USPIO 动态感性对比增强磁共振成像评估永久性大脑中动脉闭塞大鼠模型亚急性缺血性中风梗死周围区域的血管生成。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1177/02841851241290646
Yuanchao Li, Fang Lu, Cheng Zhang, Huihui Xu, Shuohui Yang

Background: Dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) can reflect the angiogenesis of ischemic stroke.

Purpose: To investigate the value of DSC-MRI with ultrasmall superparamagnetic particles of iron oxides (USPIO) in evaluating angiogenesis in the peri-infarction zones in subacute ischemic stroke in a permanent middle cerebral artery occlusion (pMCAO) rat model.

Material and methods: A total of 21 Sprague-Dawley rats were randomly divided into the pMCAO and sham operation groups. Every rat in each group underwent DSC-MRI with USPIO at 3, 5, and 7 days. DSC-MRI parameters of the relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), relative mean transit time (rMTT), and relative time to peak (rTTP) were measured, calculated, and compared among the different times. Sequential correlations were analyzed among the histopathological indexes with the microvascular density (MVD) and percentage of vascular area (%VA), the serum factors with vascular endothelial growth factor (VEGF), vascular cell adhesion molecule 1 (VCAM-1), and perfusion parameters, respectively.

Results: The rCBV and rCBF in the peri-infarction area of pMCAO rats were significantly higher on day 7 than on day 3, whereas no significant changes in rMTT and rTTP were observed at 3, 5, and 7 days. Significantly positive correlations were found between rCBV and MVD, %VA, VEGF, VCAM-1, between rCBF and MVD, %VA, VEGF, and VCAM-1 at 3, 5, and 7 days in the pMCAO group.

Conclusion: The rCBV and rCBF deriving from USPIO-DSC may be potentially useful for evaluating the angiogenesis of the peri-infarction zones in the subacute phase of ischemic stroke.

背景:目的:在永久性大脑中动脉闭塞(pMCAO)大鼠模型中,研究超小型超顺磁性氧化铁颗粒(USPIO)DSC-MRI在评估亚急性缺血性卒中梗死周围血管生成中的价值:将 21 只 Sprague-Dawley 大鼠随机分为 pMCAO 组和假手术组。每组的每只大鼠都在 3 天、5 天和 7 天时接受了 USPIO 的 DSC-MRI 检查。DSC-MRI参数包括相对脑血容量(rCBV)、相对脑血流量(rCBF)、相对平均通过时间(rMTT)和相对达峰时间(rTTP),这些参数在不同时间进行测量、计算和比较。分析了组织病理学指标与微血管密度(MVD)和血管面积百分比(%VA)之间的序列相关性,血清因子与血管内皮生长因子(VEGF)、血管细胞粘附分子1(VCAM-1)和灌注参数之间的序列相关性:pMCAO大鼠梗死周围区域的rCBV和rCBF在第7天显著高于第3天,而rMTT和rTTP在第3、5和7天均无显著变化。在 pMCAO 组中,rCBV 与 MVD、%VA、VEGF 和 VCAM-1 之间,rCBF 与 MVD、%VA、VEGF 和 VCAM-1 之间在 3、5 和 7 天内均呈显著正相关:结论:USPIO-DSC 得出的 rCBV 和 rCBF 可能有助于评估缺血性中风亚急性阶段梗死周围区域的血管生成情况。
{"title":"Dynamic susceptibility contrast-enhanced MRI with USPIO in evaluating angiogenesis of the peri-infarction zones in subacute ischemic stroke in a permanent middle cerebral artery occlusion rat model.","authors":"Yuanchao Li, Fang Lu, Cheng Zhang, Huihui Xu, Shuohui Yang","doi":"10.1177/02841851241290646","DOIUrl":"10.1177/02841851241290646","url":null,"abstract":"<p><strong>Background: </strong>Dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) can reflect the angiogenesis of ischemic stroke.</p><p><strong>Purpose: </strong>To investigate the value of DSC-MRI with ultrasmall superparamagnetic particles of iron oxides (USPIO) in evaluating angiogenesis in the peri-infarction zones in subacute ischemic stroke in a permanent middle cerebral artery occlusion (pMCAO) rat model.</p><p><strong>Material and methods: </strong>A total of 21 Sprague-Dawley rats were randomly divided into the pMCAO and sham operation groups. Every rat in each group underwent DSC-MRI with USPIO at 3, 5, and 7 days. DSC-MRI parameters of the relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), relative mean transit time (rMTT), and relative time to peak (rTTP) were measured, calculated, and compared among the different times. Sequential correlations were analyzed among the histopathological indexes with the microvascular density (MVD) and percentage of vascular area (%VA), the serum factors with vascular endothelial growth factor (VEGF), vascular cell adhesion molecule 1 (VCAM-1), and perfusion parameters, respectively.</p><p><strong>Results: </strong>The rCBV and rCBF in the peri-infarction area of pMCAO rats were significantly higher on day 7 than on day 3, whereas no significant changes in rMTT and rTTP were observed at 3, 5, and 7 days. Significantly positive correlations were found between rCBV and MVD, %VA, VEGF, VCAM-1, between rCBF and MVD, %VA, VEGF, and VCAM-1 at 3, 5, and 7 days in the pMCAO group.</p><p><strong>Conclusion: </strong>The rCBV and rCBF deriving from USPIO-DSC may be potentially useful for evaluating the angiogenesis of the peri-infarction zones in the subacute phase of ischemic stroke.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1529-1539"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-reader agreement of LI-RADS treatment response algorithm among three readers with different seniorities for hepatocellular carcinoma after locoregional therapy. 三位不同资历的读者对局部区域治疗后肝细胞癌的 LI-RADS 治疗反应算法的读者间一致性。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-11-03 DOI: 10.1177/02841851241289130
Yuxin Wang, Himeko Asayo, Wei Wang, Hui Xu, Dawei Yang, Lixue Xu, Siwei Yang, Zhenghan Yang

Background: The accurate evaluation of tumor response after locoregional therapy is crucial for adjusting therapeutic strategy and guiding individualized follow-up.

Purpose: To determine the inter-reader agreement of the LR-TR algorithm for hepatocellular carcinoma treated with locoregional therapy among radiologists with different seniority.

Material and methods: A total of 275 treated observations on 249 MRI scans from 99 patients were retrospectively collected. Three readers of different seniorities (senior, intermediate, and junior with 10, 6, and 2 years of experience in hepatic imaging, respectively) analyzed the presence or absence of features (arterial-phase hyperenhancement and washout) and evaluated LR-TR category.

Results: There were substantial inter-reader agreements for overall LR-TR categorization (kappa = 0.704), LR-TR viable (kappa = 0.715), and LR-TR non-viable (kappa = 0.737), but fair inter-reader agreement for LR-TR equivocal (kappa = 0.231) among three readers. The inter-reader agreement was substantial for arterial-phase hyperenhancement (kappa = 0.725), but moderate for washout (kappa = 0.443) among three readers. The inter-reader agreements between two readers were substantial for overall LR-TR categorization (kappa = 0.734, 0.727, 0.652), LR-TR viable (kappa = 0.719, 0.752, 0.678), and LR-TR non-viable (kappa = 0.758, 0.760, 0.694), which were at the same level as the inter-reader agreements among three readers. In addition, the inter-reader agreements between two readers were substantial for arterial-phase hyperenhancement (kappa = 0.733, 0.766, 0.678), but moderate for washout (kappa = 0.473, 0.422, 0.446), which were at the same level as the inter-reader agreements among three readers.

Conclusion: LR-TR algorithm demonstrated overall substantial inter-reader agreement among radiologists with different seniority.

背景:准确评估局部治疗后的肿瘤反应对于调整治疗策略和指导个体化随访至关重要:目的:确定不同资历的放射科医生对肝细胞癌局部治疗后LR-TR算法的阅片者间一致性:回顾性收集了99名患者的249次核磁共振扫描共275个治疗观察结果。三位不同资历的读者(高级、中级和初级,分别有 10 年、6 年和 2 年的肝脏成像经验)分析了有无特征(动脉期高增强和冲刷)并评估了 LR-TR 类别:三位读者在LR-TR总体分类(kappa = 0.704)、LR-TR存活(kappa = 0.715)和LR-TR不存活(kappa = 0.737)方面的读者间一致性很高,但在LR-TR等效(kappa = 0.231)方面的读者间一致性一般。三位读者在动脉期高增强方面的读数一致性很好(kappa = 0.725),但在冲洗方面的读数一致性一般(kappa = 0.443)。在整体 LR-TR 分类(kappa = 0.734、0.727、0.652)、LR-TR 可行(kappa = 0.719、0.752、0.678)和 LR-TR 不可行(kappa = 0.758、0.760、0.694)方面,两名读者之间的读数差异很大,与三名读者之间的读数差异处于同一水平。此外,在动脉期高增强方面,两名读者之间的读数一致性很好(kappa = 0.733, 0.766, 0.678),但在冲洗方面,读数一致性一般(kappa = 0.473, 0.422, 0.446),与三名读者之间的读数一致性处于同一水平:结论:LR-TR 算法在不同资历的放射科医生之间表现出了很高的读片者间一致性。
{"title":"Inter-reader agreement of LI-RADS treatment response algorithm among three readers with different seniorities for hepatocellular carcinoma after locoregional therapy.","authors":"Yuxin Wang, Himeko Asayo, Wei Wang, Hui Xu, Dawei Yang, Lixue Xu, Siwei Yang, Zhenghan Yang","doi":"10.1177/02841851241289130","DOIUrl":"10.1177/02841851241289130","url":null,"abstract":"<p><strong>Background: </strong>The accurate evaluation of tumor response after locoregional therapy is crucial for adjusting therapeutic strategy and guiding individualized follow-up.</p><p><strong>Purpose: </strong>To determine the inter-reader agreement of the LR-TR algorithm for hepatocellular carcinoma treated with locoregional therapy among radiologists with different seniority.</p><p><strong>Material and methods: </strong>A total of 275 treated observations on 249 MRI scans from 99 patients were retrospectively collected. Three readers of different seniorities (senior, intermediate, and junior with 10, 6, and 2 years of experience in hepatic imaging, respectively) analyzed the presence or absence of features (arterial-phase hyperenhancement and washout) and evaluated LR-TR category.</p><p><strong>Results: </strong>There were substantial inter-reader agreements for overall LR-TR categorization (kappa = 0.704), LR-TR viable (kappa = 0.715), and LR-TR non-viable (kappa = 0.737), but fair inter-reader agreement for LR-TR equivocal (kappa = 0.231) among three readers. The inter-reader agreement was substantial for arterial-phase hyperenhancement (kappa = 0.725), but moderate for washout (kappa = 0.443) among three readers. The inter-reader agreements between two readers were substantial for overall LR-TR categorization (kappa = 0.734, 0.727, 0.652), LR-TR viable (kappa = 0.719, 0.752, 0.678), and LR-TR non-viable (kappa = 0.758, 0.760, 0.694), which were at the same level as the inter-reader agreements among three readers. In addition, the inter-reader agreements between two readers were substantial for arterial-phase hyperenhancement (kappa = 0.733, 0.766, 0.678), but moderate for washout (kappa = 0.473, 0.422, 0.446), which were at the same level as the inter-reader agreements among three readers.</p><p><strong>Conclusion: </strong>LR-TR algorithm demonstrated overall substantial inter-reader agreement among radiologists with different seniority.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1458-1464"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a radiomic model for cervical cancer staging based on pathologically verified, retrospective metastatic lymph node data. 根据病理验证的回顾性转移淋巴结数据,开发宫颈癌分期的放射学模型。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1177/02841851241291931
Bin Zhang, Liang Liu, Deyue Meng, Chin Siang Kue

Background: Cervical cancer is a major cause of morbidity and mortality among gynecological malignancies. Diagnostic imaging of lymph node (LN) metastasis for prognosis and staging is used; however, the accuracy in classifying the stage needs to improve.

Purpose: To examine the accuracy of AI-based radiomics in diagnosis, prognosis assessment and predicting the diagnostic value of radiomics for pelvic LN metastasis in cervical cancer patients.

Material and methods: The study included 118 female patients with 660 LNs and 118 merged LNs. Four imaging histology models-decision tree, random forest, logistic regression, and support vector machine (SVM)-were created in this study. The imaging histology features were extracted from both the independent and merged LN groups. The AUC values for the test sets and the training sets of the four imaging histology models were compared for the independent LN group and the merged LN group. The DeLong test was used to compare the models.

Result: The imaging histology prediction model developed in the merged LN group outperformed the independent LN group in terms of test set AUC (0.668 vs. 0.535 for decision tree, 0.841 vs. 0.627 for logistic regression, 0.785 vs. 0.637 for random forest, 0.85 vs. 0.648 for SVM) and accuracy (0.754 vs. 0.676 for decision tree, 0.780 vs. 0.671 for random forest, 0.848 vs. 0.685 for logistic regression, 0.822 vs. 0.657 for SVM).

Conclusion: The constructed SVM imaging histology model for the merged LN group might be advantageous in predicting pelvic LN metastasis in cervical cancer.

背景:宫颈癌是妇科恶性肿瘤中发病率和死亡率的主要原因。目的:研究基于人工智能的放射组学在诊断、预后评估方面的准确性,并预测放射组学对宫颈癌患者盆腔 LN 转移的诊断价值:研究纳入了 118 名女性患者,其中有 660 个 LN 和 118 个合并的 LN。本研究创建了四种影像组学模型--决策树、随机森林、逻辑回归和支持向量机(SVM)。成像组织学特征是从独立 LN 组和合并 LN 组中提取的。比较了独立 LN 组和合并 LN 组四个成像组学模型的测试集和训练集的 AUC 值。使用 DeLong 检验对模型进行比较:结果:在合并 LN 组中开发的成像组织学预测模型的测试集 AUC 优于独立 LN 组(决策树为 0.668 vs. 0.535,逻辑回归为 0.841 vs. 0.627,Logistic 回归为 0.785 vs. 0.637 for random forest, 0.85 vs. 0.648 for SVM)和准确率(0.754 vs. 0.676 for decision tree, 0.780 vs. 0.671 for random forest, 0.848 vs. 0.685 for logistic regression, 0.822 vs. 0.657 for SVM).结论:结论:针对合并 LN 组构建的 SVM 影像组织学模型在预测宫颈癌盆腔 LN 转移方面可能具有优势。
{"title":"Development of a radiomic model for cervical cancer staging based on pathologically verified, retrospective metastatic lymph node data.","authors":"Bin Zhang, Liang Liu, Deyue Meng, Chin Siang Kue","doi":"10.1177/02841851241291931","DOIUrl":"10.1177/02841851241291931","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a major cause of morbidity and mortality among gynecological malignancies. Diagnostic imaging of lymph node (LN) metastasis for prognosis and staging is used; however, the accuracy in classifying the stage needs to improve.</p><p><strong>Purpose: </strong>To examine the accuracy of AI-based radiomics in diagnosis, prognosis assessment and predicting the diagnostic value of radiomics for pelvic LN metastasis in cervical cancer patients.</p><p><strong>Material and methods: </strong>The study included 118 female patients with 660 LNs and 118 merged LNs. Four imaging histology models-decision tree, random forest, logistic regression, and support vector machine (SVM)-were created in this study. The imaging histology features were extracted from both the independent and merged LN groups. The AUC values for the test sets and the training sets of the four imaging histology models were compared for the independent LN group and the merged LN group. The DeLong test was used to compare the models.</p><p><strong>Result: </strong>The imaging histology prediction model developed in the merged LN group outperformed the independent LN group in terms of test set AUC (0.668 vs. 0.535 for decision tree, 0.841 vs. 0.627 for logistic regression, 0.785 vs. 0.637 for random forest, 0.85 vs. 0.648 for SVM) and accuracy (0.754 vs. 0.676 for decision tree, 0.780 vs. 0.671 for random forest, 0.848 vs. 0.685 for logistic regression, 0.822 vs. 0.657 for SVM).</p><p><strong>Conclusion: </strong>The constructed SVM imaging histology model for the merged LN group might be advantageous in predicting pelvic LN metastasis in cervical cancer.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1548-1559"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of pediatric breast ultrasound less is more: a practical imaging approach. 小儿乳腺超声评估少即是多:实用成像方法。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1177/02841851241287924
Elisabetta Giannotti, Rachel Sun, Nuala Healy, Fleur Kilburn-Toppin, Carmelo Sofia, Andrew Hs Lee, Maria Adele Marino

Background: Breast cancer in pediatric patients is rare, but ultrasound (US) is widely utilized for symptomatic cases.

Purpose: To determine biopsy and cancer detection rates of pediatric patients and to assess if breast US can be omitted.

Material and methods: A retrospective review of a 5-year period was conducted of single-center breast US performed in patients aged <19 years. Data regarding presentation, clinical opinion (P1-5 score), and US (U1-5 score) were collected. If biopsy or surgery was performed, pathology was reviewed (B1-5 score).

Results: In total, 579 patients were included (19 boys, 560 girls; mean age=16.2±1.9 years; age range=0-18 years). Clinical examination was normal or benign (P1/P2) in all boys (100%) and 557/560 (99.5%) girls, and P3 in 3 (0.5%) girls. Of US, 52% demonstrated normal findings (U1) for both sexes (300/579); in the remaining cases, the most frequent findings were gynecomastia in 12/19 boys and well-defined breast masses in 208/560 girls. Of the 560 girls, 6 (1%) underwent US-guided biopsy, with final histology of fibroadenoma (B2) in all cases, while 27 (5%) had a surgical excision, with final histology of fibroadenoma (22/27, 81.5%), hamartoma (2/27, 7.4%), benign phyllodes tumor (2/27, 7.4%), and angiomyxoma skin lesion (1/27, 3.7%). No malignant lesions were diagnosed at the time of clinical referral or during the 18-month follow-up in patients with a well-defined mass on US.

Conclusion: Breast malignancy is extremely rare in pediatric population. US can be safely omitted if clinical examination is normal; this approach would have avoided breast US in 52% of patients in this study.

背景:目的:确定儿童患者的活检率和癌症检出率,并评估是否可以省略乳腺超声检查:材料和方法:对单中心乳腺 US 进行了为期 5 年的回顾性审查:共纳入579名患者(19名男孩,560名女孩;平均年龄=16.2±1.9岁;年龄范围=0-18岁)。所有男孩(100%)和 557/560 名女孩(99.5%)的临床检查结果均为正常或良性(P1/P2),3 名女孩(0.5%)的临床检查结果为 P3。在 US 检查中,52% 的男女受检者(300/579)的检查结果均为正常(U1);在其余受检者中,最常见的检查结果是 12/19 名男孩患有妇科炎症,208/560 名女孩患有轮廓清晰的乳房肿块。在 560 名女孩中,有 6 人(1%)在 US 引导下进行了活组织检查,所有病例的最终组织学结果均为纤维腺瘤(B2),有 27 人(5%)进行了手术切除,最终组织学结果为纤维腺瘤(22/27,81.5%)、火腿肠瘤(2/27,7.4%)、良性植物瘤(2/27,7.4%)和血管瘤皮损(1/27,3.7%)。在临床转诊时或18个月的随访中,US检查发现肿块轮廓清晰的患者均未确诊恶性病变:结论:乳腺恶性肿瘤在儿童中极为罕见。结论:乳腺恶性肿瘤在儿童人群中极为罕见,如果临床检查结果正常,可以放心地省略 US 检查;在本研究中,52% 的患者可以通过这种方法避免乳腺 US 检查。
{"title":"Assessment of pediatric breast ultrasound less is more: a practical imaging approach.","authors":"Elisabetta Giannotti, Rachel Sun, Nuala Healy, Fleur Kilburn-Toppin, Carmelo Sofia, Andrew Hs Lee, Maria Adele Marino","doi":"10.1177/02841851241287924","DOIUrl":"10.1177/02841851241287924","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer in pediatric patients is rare, but ultrasound (US) is widely utilized for symptomatic cases.</p><p><strong>Purpose: </strong>To determine biopsy and cancer detection rates of pediatric patients and to assess if breast US can be omitted.</p><p><strong>Material and methods: </strong>A retrospective review of a 5-year period was conducted of single-center breast US performed in patients aged <19 years. Data regarding presentation, clinical opinion (P1-5 score), and US (U1-5 score) were collected. If biopsy or surgery was performed, pathology was reviewed (B1-5 score).</p><p><strong>Results: </strong>In total, 579 patients were included (19 boys, 560 girls; mean age=16.2±1.9 years; age range=0-18 years). Clinical examination was normal or benign (P1/P2) in all boys (100%) and 557/560 (99.5%) girls, and P3 in 3 (0.5%) girls. Of US, 52% demonstrated normal findings (U1) for both sexes (300/579); in the remaining cases, the most frequent findings were gynecomastia in 12/19 boys and well-defined breast masses in 208/560 girls. Of the 560 girls, 6 (1%) underwent US-guided biopsy, with final histology of fibroadenoma (B2) in all cases, while 27 (5%) had a surgical excision, with final histology of fibroadenoma (22/27, 81.5%), hamartoma (2/27, 7.4%), benign phyllodes tumor (2/27, 7.4%), and angiomyxoma skin lesion (1/27, 3.7%). No malignant lesions were diagnosed at the time of clinical referral or during the 18-month follow-up in patients with a well-defined mass on US.</p><p><strong>Conclusion: </strong>Breast malignancy is extremely rare in pediatric population. US can be safely omitted if clinical examination is normal; this approach would have avoided breast US in 52% of patients in this study.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1465-1472"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning and radiomics for ventricular tachyarrhythmia prediction in hypertrophic cardiomyopathy: insights from an MRI-based analysis. 肥厚型心肌病室性心动过速预测的机器学习和放射组学:基于核磁共振成像的分析见解。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1177/02841851241283041
Emine Sebnem Durmaz, Mert Karabacak, Burak Berksu Ozkara, Osman Aykan Kargın, Bilal Demir, Damla Raimoglou, Ahmet Atil Aygun, Ibrahim Adaletli, Ahmet Bas, Eser Durmaz

Background: Myocardial fibrosis is often detected in patients with hypertrophic cardiomyopathy (HCM), which causes left ventricular (LV) dysfunction and tachyarrhythmias.

Purpose: To evaluate the potential value of a machine learning (ML) approach that uses radiomic features from late gadolinium enhancement (LGE) and cine images for the prediction of ventricular tachyarrhythmia (VT) in patients with HCM.

Material and methods: Hyperenhancing areas of LV myocardium on LGE images were manually segmented, and the segmentation was propagated to corresponding areas on cine images. Radiomic features were extracted using the PyRadiomics library. The least absolute shrinkage and selection operator (LASSO) method was employed for radiomic feature selection. Our model development employed the TabPFN algorithm, an adapted Prior-Data Fitted Network design. Model performance was evaluated graphically and numerically over five-repeat fivefold cross-validation. SHapley Additive exPlanations (SHAP) were employed to determine the relative importance of selected radiomic features.

Results: Our cohort consisted of 60 patients with HCM (73.3% male; median age = 51.5 years), among whom 17 had documented VT during the follow-up. A total of 1612 radiomic features were extracted for each patient. The LASSO algorithm led to a final selection of 18 radiomic features. The model achieved a mean area under the receiver operating characteristic curve of 0.877, demonstrating good discrimination, and a mean Brier score of 0.119, demonstrating good calibration.

Conclusion: Radiomics-based ML models are promising for predicting VT in patients with HCM during the follow-up period. Developing predictive models as clinically useful decision-making tools may significantly improve risk assessment and prognosis.

背景:目的:评估一种机器学习(ML)方法的潜在价值,该方法利用晚期钆增强(LGE)和电影图像的放射学特征来预测肥厚型心肌病(HCM)患者的室性快速性心律失常(VT)。材料和方法:手动分割 LGE 图像上左心室心肌的高增强区域,并将分割结果传播到 cine 图像上的相应区域。使用 PyRadiomics 库提取放射组学特征。采用最小绝对收缩和选择算子(LASSO)方法进行放射体特征选择。我们的模型开发采用了 TabPFN 算法,这是一种经过调整的先验数据拟合网络设计。通过五次重复五倍交叉验证,对模型性能进行了图形和数值评估。采用了SHAPLEY Additive exPlanations(SHAP)来确定所选放射学特征的相对重要性:我们的队列由 60 名 HCM 患者组成(73.3% 为男性;中位年龄 = 51.5 岁),其中 17 人在随访期间有 VT 记录。每位患者共提取了 1612 个放射学特征。通过 LASSO 算法,最终选择了 18 个放射学特征。该模型的接收者操作特征曲线下的平均面积为 0.877,显示了良好的分辨能力,平均 Brier 分数为 0.119,显示了良好的校准能力:结论:基于放射组学的 ML 模型有望在随访期间预测 HCM 患者的 VT。开发预测模型作为临床有用的决策工具,可显著改善风险评估和预后。
{"title":"Machine learning and radiomics for ventricular tachyarrhythmia prediction in hypertrophic cardiomyopathy: insights from an MRI-based analysis.","authors":"Emine Sebnem Durmaz, Mert Karabacak, Burak Berksu Ozkara, Osman Aykan Kargın, Bilal Demir, Damla Raimoglou, Ahmet Atil Aygun, Ibrahim Adaletli, Ahmet Bas, Eser Durmaz","doi":"10.1177/02841851241283041","DOIUrl":"10.1177/02841851241283041","url":null,"abstract":"<p><strong>Background: </strong>Myocardial fibrosis is often detected in patients with hypertrophic cardiomyopathy (HCM), which causes left ventricular (LV) dysfunction and tachyarrhythmias.</p><p><strong>Purpose: </strong>To evaluate the potential value of a machine learning (ML) approach that uses radiomic features from late gadolinium enhancement (LGE) and cine images for the prediction of ventricular tachyarrhythmia (VT) in patients with HCM.</p><p><strong>Material and methods: </strong>Hyperenhancing areas of LV myocardium on LGE images were manually segmented, and the segmentation was propagated to corresponding areas on cine images. Radiomic features were extracted using the PyRadiomics library. The least absolute shrinkage and selection operator (LASSO) method was employed for radiomic feature selection. Our model development employed the TabPFN algorithm, an adapted Prior-Data Fitted Network design. Model performance was evaluated graphically and numerically over five-repeat fivefold cross-validation. SHapley Additive exPlanations (SHAP) were employed to determine the relative importance of selected radiomic features.</p><p><strong>Results: </strong>Our cohort consisted of 60 patients with HCM (73.3% male; median age = 51.5 years), among whom 17 had documented VT during the follow-up. A total of 1612 radiomic features were extracted for each patient. The LASSO algorithm led to a final selection of 18 radiomic features. The model achieved a mean area under the receiver operating characteristic curve of 0.877, demonstrating good discrimination, and a mean Brier score of 0.119, demonstrating good calibration.</p><p><strong>Conclusion: </strong>Radiomics-based ML models are promising for predicting VT in patients with HCM during the follow-up period. Developing predictive models as clinically useful decision-making tools may significantly improve risk assessment and prognosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1473-1481"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta radiologica
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