Pub Date : 2024-07-01Epub Date: 2024-05-20DOI: 10.1177/02841851241251639
Flemming Kromann Nielsen, Flemming Brandt Sørensen, Niels Egund, Lene Warner Boel, Carsten Holm, Anne Grethe Jurik
Background: Bone marrow lesions (BMLs) in knee osteoarthritis (OA) have been assessed histopathologically and by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); however, a direct comparison of the results has not been reported.
Purpose: To evaluate and compare the findings by DCE-MRI and histopathology of subchondral BMLs in knee OA.
Material and methods: In total, 19 patients with medial tibiofemoral knee OA undergoing total knee arthroplasty were analyzed. Preoperative MRI, including a DCE sequence, was performed, and bone biopsies were obtained from the resected specimens corresponding to BML areas. The contrast enhancement by DCE-MRI was analyzed using semi-quantitative (area under the curve [AUC]), peak enhancement [PE]), and quantitative (Ktrans, Kep) methods. Enhancement in the medial OA compartment was compared with similar areas in a normal lateral compartment, and the DCE characteristics of BMLs were correlated with semi-quantitatively graded histopathological features.
Results: AUC and PE were significantly higher in medial tibial and femoral BMLs compared with the values in the lateral condyles; Ktrans and Kep were only significantly higher in the tibial plateau. In the tibia, AUC and PE were significantly correlated with the grade of vascular proliferation, and PE also with the degree of marrow fibrosis. There was no significant correlation between AUC/PE and histopathological findings in the femur and no correlation between quantitative DCE parameters and histopathological findings.
Conclusion: BML characteristics by semi-quantitative DCE in the form of AUC and PE may be used as parameters for the degree of histopathological vascularization in the bone marrow whereas quantitative DCE data were less conclusive.
背景:目的:评估和比较膝关节骨关节炎(OA)软骨下骨髓病变(BMLs)的DCE-MRI和组织病理学结果:共分析了19名接受全膝关节置换术的胫股骨内侧膝关节OA患者。术前进行了包括 DCE 序列在内的核磁共振成像检查,并从切除的标本中获取了与 BML 区域相对应的骨活检组织。采用半定量(曲线下面积 [AUC])、峰值增强 [PE])和定量(Ktrans、Kep)方法分析了 DCE-MRI 的对比增强。将内侧 OA 室的增强与正常外侧室的类似区域进行比较,并将 BML 的 DCE 特征与半定量分级的组织病理学特征相关联:结果:与外侧髁的值相比,胫骨内侧和股骨BML的AUC和PE明显更高;只有胫骨平台的Ktrans和Kep明显更高。在胫骨中,AUC 和 PE 与血管增生的等级明显相关,PE 与骨髓纤维化的程度也明显相关。股骨的AUC/PE与组织病理学结果无明显相关性,DCE定量参数与组织病理学结果也无相关性:结论:以AUC和PE为形式的半定量DCE的BML特征可用作骨髓组织病理学血管化程度的参数,而定量DCE数据则不太确定。
{"title":"Bone marrow lesions in knee osteoarthritis assessed by dynamic contrast-enhanced MRI with histopathological correlations.","authors":"Flemming Kromann Nielsen, Flemming Brandt Sørensen, Niels Egund, Lene Warner Boel, Carsten Holm, Anne Grethe Jurik","doi":"10.1177/02841851241251639","DOIUrl":"10.1177/02841851241251639","url":null,"abstract":"<p><strong>Background: </strong>Bone marrow lesions (BMLs) in knee osteoarthritis (OA) have been assessed histopathologically and by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); however, a direct comparison of the results has not been reported.</p><p><strong>Purpose: </strong>To evaluate and compare the findings by DCE-MRI and histopathology of subchondral BMLs in knee OA.</p><p><strong>Material and methods: </strong>In total, 19 patients with medial tibiofemoral knee OA undergoing total knee arthroplasty were analyzed. Preoperative MRI, including a DCE sequence, was performed, and bone biopsies were obtained from the resected specimens corresponding to BML areas. The contrast enhancement by DCE-MRI was analyzed using semi-quantitative (area under the curve [AUC]), peak enhancement [PE]), and quantitative (Ktrans, Kep) methods. Enhancement in the medial OA compartment was compared with similar areas in a normal lateral compartment, and the DCE characteristics of BMLs were correlated with semi-quantitatively graded histopathological features.</p><p><strong>Results: </strong>AUC and PE were significantly higher in medial tibial and femoral BMLs compared with the values in the lateral condyles; Ktrans and Kep were only significantly higher in the tibial plateau. In the tibia, AUC and PE were significantly correlated with the grade of vascular proliferation, and PE also with the degree of marrow fibrosis. There was no significant correlation between AUC/PE and histopathological findings in the femur and no correlation between quantitative DCE parameters and histopathological findings.</p><p><strong>Conclusion: </strong>BML characteristics by semi-quantitative DCE in the form of AUC and PE may be used as parameters for the degree of histopathological vascularization in the bone marrow whereas quantitative DCE data were less conclusive.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-05-22DOI: 10.1177/02841851241253936
Sungeun Park, Hee Sun Park, Siwon Jang, Jungheum Cho, Jae Hyun Kim, Mi Hye Yu, Sung Il Jung, Young Jun Kim, Dae-Yong Hwang
Background: Post-treatment evaluation of patients with rectal cancer (RC) using magnetic resonance imaging (MRI) burdens medical resources, necessitating an exploration of abbreviated protocols.
Purpose: To evaluate the diagnostic performance of abbreviated MRI (A-MRI) for the post-treatment evaluation of RC patients.
Material and methods: This retrospective study included RC patients who underwent non-contrast rectal MRI and standard liver MRI, as well as abdominal contrast-enhanced computed tomography (CECT) for post-treatment evaluation. A-MRI comprised diffusion-weighted imaging (DWI) and T2-weighted imaging of the upper abdomen and the pelvic cavity. Three radiologists independently reviewed A-MRI, CECT, and standard liver MRI in the detection of viable disease. The diagnostic performances were compared using a reference standard considering all available information, including pathology, FDG-PET, endoscopic results, and clinical follow-up.
Results: We included 78 patients (50 men, 28 women; mean age=60.9 ± 10.2 years) and observed viable disease in 34 (43.6%). On a per-patient-basis analysis, A-MRI showed significantly higher sensitivity (95% vs. 81%, P = 0.04) and higher accuracy (93% vs. 82%, P < 0.01), compared to those of CECT, while A-MRI showed comparable sensitivity (91% vs. 91%, P = 0.42) and accuracy (97% vs. 98%, P = 0.06) to that of standard liver MRI. On a per-lesion-based analysis, A-MRI exhibited significantly superior lesion detectability than that of CECT (figure of merit 0.91 vs. 0.77, P < 0.01) and comparable to that of standard liver MRI (figure of merit 0.91 vs. 0.92, P = 0.75).
Conclusion: A-MRI exhibited higher sensitivity and diagnostic accuracy than those of CECT in the post-treatment evaluation of RC, while it showed comparable performances with standard liver MRI. A-MRI provides diagnostic added value in the follow-up of RC patients.
{"title":"Utility of abbreviated MRI in the post-treatment evaluation of rectal cancer.","authors":"Sungeun Park, Hee Sun Park, Siwon Jang, Jungheum Cho, Jae Hyun Kim, Mi Hye Yu, Sung Il Jung, Young Jun Kim, Dae-Yong Hwang","doi":"10.1177/02841851241253936","DOIUrl":"10.1177/02841851241253936","url":null,"abstract":"<p><strong>Background: </strong>Post-treatment evaluation of patients with rectal cancer (RC) using magnetic resonance imaging (MRI) burdens medical resources, necessitating an exploration of abbreviated protocols.</p><p><strong>Purpose: </strong>To evaluate the diagnostic performance of abbreviated MRI (A-MRI) for the post-treatment evaluation of RC patients.</p><p><strong>Material and methods: </strong>This retrospective study included RC patients who underwent non-contrast rectal MRI and standard liver MRI, as well as abdominal contrast-enhanced computed tomography (CECT) for post-treatment evaluation. A-MRI comprised diffusion-weighted imaging (DWI) and T2-weighted imaging of the upper abdomen and the pelvic cavity. Three radiologists independently reviewed A-MRI, CECT, and standard liver MRI in the detection of viable disease. The diagnostic performances were compared using a reference standard considering all available information, including pathology, FDG-PET, endoscopic results, and clinical follow-up.</p><p><strong>Results: </strong>We included 78 patients (50 men, 28 women; mean age=60.9 ± 10.2 years) and observed viable disease in 34 (43.6%). On a per-patient-basis analysis, A-MRI showed significantly higher sensitivity (95% vs. 81%, <i>P </i>= 0.04) and higher accuracy (93% vs. 82%, <i>P </i>< 0.01), compared to those of CECT, while A-MRI showed comparable sensitivity (91% vs. 91%, <i>P </i>= 0.42) and accuracy (97% vs. 98%, <i>P</i> = 0.06) to that of standard liver MRI. On a per-lesion-based analysis, A-MRI exhibited significantly superior lesion detectability than that of CECT (figure of merit 0.91 vs. 0.77, <i>P </i>< 0.01) and comparable to that of standard liver MRI (figure of merit 0.91 vs. 0.92, <i>P = </i>0.75).</p><p><strong>Conclusion: </strong>A-MRI exhibited higher sensitivity and diagnostic accuracy than those of CECT in the post-treatment evaluation of RC, while it showed comparable performances with standard liver MRI. A-MRI provides diagnostic added value in the follow-up of RC patients.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Focal liver lesions (FLLs) are a common form of liver disease, and identifying accurate pathological types is required to guide treatment and evaluate prognosis.
Purpose: To compare and analyze the application effect of contrast-enhanced ultrasound (CEUS) and conventional ultrasound (US) in the clinical diagnosis of focal liver lesions.
Material and methods: A retrospective analysis was performed on 682 patients with space-occupying liver lesions admitted to our hospital between December 2015 and August 2021. Of these, 280 underwent CEUS-guided biopsies and 402 underwent conventional US biopsies, with the results of each biopsy subsequently compared between the two groups. The success rate and accuracy of the biopsies and their relationship with different pathological features were also analyzed.
Results: The success rate, sensitivity, diagnostic accuracy, positive predictive value, and negative predictive value of the CEUS group were significantly higher than those of the US group (P < 0.05). Lesion size accuracy in the CEUS group was significantly higher than that in the US group (89.29% vs. 40.55%; P < 0.05). Lesion type accuracy in the CEUS group was significantly higher than that in the US group (86.49% vs. 43.59%), and the difference between the two groups was statistically significant (P < 0.05). The logistic regression analysis indicated that malignant lesions, lesions ≥5 cm, and lesions ≤1 cm were independent factors affecting the success rate of the puncture procedure (P < 0.05).
Conclusion: The sensitivity, specificity, and diagnostic accuracy of lesion size and type in the CEUS group were higher than those in the US group.
背景:目的:比较分析对比增强超声(CEUS)与常规超声(US)在肝脏局灶性病变临床诊断中的应用效果:对我院2015年12月至2021年8月期间收治的682例肝脏占位性病变患者进行回顾性分析。其中,280 例患者接受了 CEUS 引导下的活检,402 例患者接受了传统 US 活检,随后对两组患者的活检结果进行了比较。此外,还分析了活检的成功率、准确率及其与不同病理特征的关系:CEUS 组对病变大小和类型的敏感性、特异性和诊断准确性均高于 US 组。
{"title":"Clinical value of contrast-enhanced ultrasound versus conventional ultrasound in biopsy of focal liver lesions.","authors":"Cheng Lou, Yin-Xia Li, Bi-Bo Tan, Chen-Jie Tao, Cheng-Chuan Xu, Ying-Ying Liao","doi":"10.1177/02841851241257607","DOIUrl":"10.1177/02841851241257607","url":null,"abstract":"<p><strong>Background: </strong>Focal liver lesions (FLLs) are a common form of liver disease, and identifying accurate pathological types is required to guide treatment and evaluate prognosis.</p><p><strong>Purpose: </strong>To compare and analyze the application effect of contrast-enhanced ultrasound (CEUS) and conventional ultrasound (US) in the clinical diagnosis of focal liver lesions.</p><p><strong>Material and methods: </strong>A retrospective analysis was performed on 682 patients with space-occupying liver lesions admitted to our hospital between December 2015 and August 2021. Of these, 280 underwent CEUS-guided biopsies and 402 underwent conventional US biopsies, with the results of each biopsy subsequently compared between the two groups. The success rate and accuracy of the biopsies and their relationship with different pathological features were also analyzed.</p><p><strong>Results: </strong>The success rate, sensitivity, diagnostic accuracy, positive predictive value, and negative predictive value of the CEUS group were significantly higher than those of the US group (<i>P</i> < 0.05). Lesion size accuracy in the CEUS group was significantly higher than that in the US group (89.29% vs. 40.55%; <i>P</i> < 0.05). Lesion type accuracy in the CEUS group was significantly higher than that in the US group (86.49% vs. 43.59%), and the difference between the two groups was statistically significant (<i>P</i> < 0.05). The logistic regression analysis indicated that malignant lesions, lesions ≥5 cm, and lesions ≤1 cm were independent factors affecting the success rate of the puncture procedure (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The sensitivity, specificity, and diagnostic accuracy of lesion size and type in the CEUS group were higher than those in the US group.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-01-09DOI: 10.1177/02841851231222360
Xue Wang, Zhijun Ye, Shujian Li, Zhihan Yan, Jingliang Cheng, Gang Ning, Zujun Hou
Background: Parameters from diffusion-weighted imaging (DWI) have been increasingly used as imaging biomarkers for the diagnosis and monitoring of treatment responses in cancer. The consistency of DWI measurements across different centers remains uncertain, which limits the widespread use of quantitative DWI in clinical settings.
Purpose: To investigate the consistency of quantitative metrics derived from DWI between different scanners in a multicenter clinical setting.
Material and methods: A total of 193 patients with cervical cancer from four scanners (MRI1, MRI2, MRI3, and MRI4) at three centers were included in this retrospective study. DWI data were processed using the mono-exponential and intravoxel incoherent motion (IVIM) model, yielding the following parameters: apparent diffusion coefficient (ADC); true diffusion coefficient (D); pseudo-diffusion coefficient (D*); perfusion fraction (f); and the product of f and D* (fD*). Various parameters of cervical cancer obtained from different scanners were compared.
Results: The parameters D and ADC derived from MRI1 and MRI2 were significantly different from those derived from MRI3 or MRI4 (P <0.01 for all comparisons). However, there was no significant difference in cervical cancer perfusion parameters (D* and fD*) between the different scanners (P >0.05). The P values of comparisons of all DWI parameters (D, D*, fD*, and ADC) between MRI3 and MRI4 (same vendor in different centers) for cervical cancer were all >0.05, except for f (P = 0.05).
Conclusion: Scanners of the same model by the same vendor can yield close measurements of the ADC and IVIM parameters. The perfusion parameters showed higher consistency among the different scanners.
背景:弥散加权成像(DWI)参数已越来越多地被用作诊断和监测癌症治疗反应的成像生物标志物。不同中心的 DWI 测量结果的一致性仍不确定,这限制了定量 DWI 在临床环境中的广泛应用。目的:在多中心临床环境中研究不同扫描仪的 DWI 定量指标的一致性:这项回顾性研究共纳入了三个中心四台扫描仪(MRI1、MRI2、MRI3 和 MRI4)的 193 名宫颈癌患者。采用单指数和体素内不连贯运动(IVIM)模型处理 DWI 数据,得出以下参数:表观扩散系数(ADC);真实扩散系数(D);假扩散系数(D*);灌注分数(f);以及 f 与 D* 的乘积(fD*)。对不同扫描仪获得的宫颈癌各种参数进行了比较:结果:核磁共振成像 1 和核磁共振成像 2 得出的 D 和 ADC 参数与核磁共振成像 3 或核磁共振成像 4 得出的参数有显著差异(P P >0.05)。宫颈癌 MRI3 和 MRI4(不同中心的同一供应商)的所有 DWI 参数(D、D*、fD* 和 ADC)比较的 P 值均大于 0.05,但 f 除外(P = 0.05):结论:同一供应商生产的同型号扫描仪可以测量出接近的 ADC 和 IVIM 参数。不同扫描仪的灌注参数一致性更高。
{"title":"A multicenter study of cervical cancer using quantitative diffusion-weighted imaging.","authors":"Xue Wang, Zhijun Ye, Shujian Li, Zhihan Yan, Jingliang Cheng, Gang Ning, Zujun Hou","doi":"10.1177/02841851231222360","DOIUrl":"10.1177/02841851231222360","url":null,"abstract":"<p><strong>Background: </strong>Parameters from diffusion-weighted imaging (DWI) have been increasingly used as imaging biomarkers for the diagnosis and monitoring of treatment responses in cancer. The consistency of DWI measurements across different centers remains uncertain, which limits the widespread use of quantitative DWI in clinical settings.</p><p><strong>Purpose: </strong>To investigate the consistency of quantitative metrics derived from DWI between different scanners in a multicenter clinical setting.</p><p><strong>Material and methods: </strong>A total of 193 patients with cervical cancer from four scanners (MRI1, MRI2, MRI3, and MRI4) at three centers were included in this retrospective study. DWI data were processed using the mono-exponential and intravoxel incoherent motion (IVIM) model, yielding the following parameters: apparent diffusion coefficient (ADC); true diffusion coefficient (D); pseudo-diffusion coefficient (D*); perfusion fraction (f); and the product of f and D* (fD*). Various parameters of cervical cancer obtained from different scanners were compared.</p><p><strong>Results: </strong>The parameters D and ADC derived from MRI1 and MRI2 were significantly different from those derived from MRI3 or MRI4 (<i>P</i> <0.01 for all comparisons). However, there was no significant difference in cervical cancer perfusion parameters (D* and fD*) between the different scanners (<i>P</i> >0.05). The <i>P</i> values of comparisons of all DWI parameters (D, D*, fD*, and ADC) between MRI3 and MRI4 (same vendor in different centers) for cervical cancer were all >0.05, except for f (<i>P</i> = 0.05).</p><p><strong>Conclusion: </strong>Scanners of the same model by the same vendor can yield close measurements of the ADC and IVIM parameters. The perfusion parameters showed higher consistency among the different scanners.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hypertension and cerebral amyloid angiopathy are the most common causes of spontaneous intracerebral hemorrhage (ICH); however, these conditions do not imply macrovascular pathology. Still, computed tomography (CT) angiography (CTA) is often performed in the acute phase in patients with ICH.
Purpose: To assess the diagnostic yield of CTA in the detection of secondary etiology in consecutive patients with spontaneous ICH.
Material and methods: We performed a retrospective analysis of data from a prospective single-center cohort study of 203 patients presenting with spontaneous ICH admitted to a comprehensive stroke center over a two-year period (15 October 2016 to 15 October 2018). The underlying vascular pathology was assessed using CTA.
Results: CTA was performed in addition to non-contrast CT and/or magnetic resonance imaging (MRI). Vascular pathology was found in 11 of 203 (5.4%) patients and included arteriovenous malformations (n=4), aneurysms (n=4), vasospasms (n=1), cerebral venous thrombosis (n=1), and other vascular malformations (n=1). In eight cases, the finding was deemed symptomatic. Patients with vascular pathology on CTA more often had lobar located hemorrhages (63.6% vs. 36.4%, P = 0.049). Numerically, patients with vascular pathology were younger, had smaller hematoma volumes, and lower mortality.
Conclusion: Underlying macrovascular pathology was detected on CTA in only approximately 1 of 20 consecutive patients with ICH. The patients with vascular pathology more often had a hemorrhage with a lobar location and young age and the present study is supportive of a risk-based stratification approach in performing CTA.
{"title":"Diagnostic yield of computed tomography angiography in patients presenting with spontaneous intracerebral hemorrhage.","authors":"Maria Kjølhede, Niels Hjort, Sif Homburg, Morten Nørholt, Rikke Beese Dalby, Claus Ziegler Simonsen, Rolf Ankerlund Blauenfeldt","doi":"10.1177/02841851241254516","DOIUrl":"10.1177/02841851241254516","url":null,"abstract":"<p><strong>Background: </strong>Hypertension and cerebral amyloid angiopathy are the most common causes of spontaneous intracerebral hemorrhage (ICH); however, these conditions do not imply macrovascular pathology. Still, computed tomography (CT) angiography (CTA) is often performed in the acute phase in patients with ICH.</p><p><strong>Purpose: </strong>To assess the diagnostic yield of CTA in the detection of secondary etiology in consecutive patients with spontaneous ICH.</p><p><strong>Material and methods: </strong>We performed a retrospective analysis of data from a prospective single-center cohort study of 203 patients presenting with spontaneous ICH admitted to a comprehensive stroke center over a two-year period (15 October 2016 to 15 October 2018). The underlying vascular pathology was assessed using CTA.</p><p><strong>Results: </strong>CTA was performed in addition to non-contrast CT and/or magnetic resonance imaging (MRI). Vascular pathology was found in 11 of 203 (5.4%) patients and included arteriovenous malformations (n=4), aneurysms (n=4), vasospasms (n=1), cerebral venous thrombosis (n=1), and other vascular malformations (n=1). In eight cases, the finding was deemed symptomatic. Patients with vascular pathology on CTA more often had lobar located hemorrhages (63.6% vs. 36.4%, <i>P</i> = 0.049). Numerically, patients with vascular pathology were younger, had smaller hematoma volumes, and lower mortality.</p><p><strong>Conclusion: </strong>Underlying macrovascular pathology was detected on CTA in only approximately 1 of 20 consecutive patients with ICH. The patients with vascular pathology more often had a hemorrhage with a lobar location and young age and the present study is supportive of a risk-based stratification approach in performing CTA.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1177/02841851241265251
{"title":"Call for a new Editor-in-Chief: <i>Acta Radiologica</i> / <i>Acta Radiologica Open</i>.","authors":"","doi":"10.1177/02841851241265251","DOIUrl":"https://doi.org/10.1177/02841851241265251","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-06-13DOI: 10.1177/02841851241257775
Mei Wei, Haitao Yang, Zhihua Li, Wei Hu, Yong Qin, Liangbin Wan
Background: Preoperative effective assessment of cervical lymph node metastasis in thyroid cancer plays an important role in formulating the surgical plan.
Purpose: To investigate the significance of synthetic magnetic resonance imaging (MRI) for quantitatively analyzing cervical lymph node metastasis in thyroid cancer.
Material and methods: A retrospective analysis was conducted on 30 patients with thyroid cancer, consisting of 19 thyroid cancer nodules, 45 metastatic lymph nodes, and 47 non-metastatic lymph nodes. Regions of interest (ROIs) for each type of nodule were manually delineated using a workstation. Quantitative parameters, such as T1, T2, and proton density (PD) values, were automatically extracted from synthetic MRI scans. Statistical tests and regression analysis were performed to assess differences and correlations among the quantitative parameters.
Results: There were no significant differences in the quantitative parameter values between the primary tumor and metastatic lymph node tissues (P > 0.05). However, significant differences were observed in the quantitative parameters between the primary tumor and non-metastatic lymph node tissues and between the metastatic and non-metastatic lymph node tissues (P < 0.05). The diagnostic accuracy for cervical lymph node metastasis in thyroid cancer was 94.4% for the T1 and T2 combined index, 91.9% for T2, 86.8% for T1, and 71.7% for PD values.
Conclusion: The application of quantitative parameters from synthetic MRI can assist clinicians in accurately planning surgical interventions for thyroid cancer patients before surgery.
{"title":"The value of synthetic MRI for quantitative analysis in the diagnosis of cervical lymph node metastasis in thyroid cancer.","authors":"Mei Wei, Haitao Yang, Zhihua Li, Wei Hu, Yong Qin, Liangbin Wan","doi":"10.1177/02841851241257775","DOIUrl":"10.1177/02841851241257775","url":null,"abstract":"<p><strong>Background: </strong>Preoperative effective assessment of cervical lymph node metastasis in thyroid cancer plays an important role in formulating the surgical plan.</p><p><strong>Purpose: </strong>To investigate the significance of synthetic magnetic resonance imaging (MRI) for quantitatively analyzing cervical lymph node metastasis in thyroid cancer.</p><p><strong>Material and methods: </strong>A retrospective analysis was conducted on 30 patients with thyroid cancer, consisting of 19 thyroid cancer nodules, 45 metastatic lymph nodes, and 47 non-metastatic lymph nodes. Regions of interest (ROIs) for each type of nodule were manually delineated using a workstation. Quantitative parameters, such as T1, T2, and proton density (PD) values, were automatically extracted from synthetic MRI scans. Statistical tests and regression analysis were performed to assess differences and correlations among the quantitative parameters.</p><p><strong>Results: </strong>There were no significant differences in the quantitative parameter values between the primary tumor and metastatic lymph node tissues (<i>P</i> > 0.05). However, significant differences were observed in the quantitative parameters between the primary tumor and non-metastatic lymph node tissues and between the metastatic and non-metastatic lymph node tissues (<i>P</i> < 0.05). The diagnostic accuracy for cervical lymph node metastasis in thyroid cancer was 94.4% for the T1 and T2 combined index, 91.9% for T<sub>2</sub>, 86.8% for T1, and 71.7% for PD values.</p><p><strong>Conclusion: </strong>The application of quantitative parameters from synthetic MRI can assist clinicians in accurately planning surgical interventions for thyroid cancer patients before surgery.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1177/02841851241257524
Güneş Açikgöz, Aydın Bora, Süreyya Nur
Background: The use of dual-energy X-ray absorptiometry (DEXA) and quantitative computed tomography (QCT) methods are important for the diagnosis and follow-up of osteoporosis, and are used especially in cases to determine the degree of osteoporosis and the risk of fracture, monitoring the effectiveness of the treatment applied.
Purpose: To compare the parameters measured using the DEXA method from the lumbar (L1-L4) vertebrae and the Hounsfield unit (HU) values measured with QCT at the same levels among young adults and the elderly.
Material and methods: The study included 155 patients (age range = 26-93 years). A total of 57 (36.8%) patients (age range = 26-64 years) were defined as the first group, and 98 (63.2%) patients (aged ≥65 years) were defined as the second group. T-test and correlation analysis were performed to compare bone mineral density (BMD), T score, and HU values measured using DEXA and QCT.
Results: A statistically significant difference was found between T score, lumbar total BMD, and HU values according to age and sex (P < 0.05). When the values measured from lumbar vertebrae were compared using both DEXA and CT, a high correlation was found between them.
Conclusion: In the study, it was observed that QCT attenuation measurements of the lumbar spine measured between different age groups provided reliable results in terms of BMD scanning, as in DEXA. It should be noted that QCT has a longer imaging time and higher radiation dose compared to DEXA, and unnecessary scans should be avoided.
{"title":"Comparison of QCT and DEXA findings for lumbar vertebra in young adults and the elderly.","authors":"Güneş Açikgöz, Aydın Bora, Süreyya Nur","doi":"10.1177/02841851241257524","DOIUrl":"https://doi.org/10.1177/02841851241257524","url":null,"abstract":"<p><strong>Background: </strong>The use of dual-energy X-ray absorptiometry (DEXA) and quantitative computed tomography (QCT) methods are important for the diagnosis and follow-up of osteoporosis, and are used especially in cases to determine the degree of osteoporosis and the risk of fracture, monitoring the effectiveness of the treatment applied.</p><p><strong>Purpose: </strong>To compare the parameters measured using the DEXA method from the lumbar (L1-L4) vertebrae and the Hounsfield unit (HU) values measured with QCT at the same levels among young adults and the elderly.</p><p><strong>Material and methods: </strong>The study included 155 patients (age range = 26-93 years). A total of 57 (36.8%) patients (age range = 26-64 years) were defined as the first group, and 98 (63.2%) patients (aged ≥65 years) were defined as the second group. T-test and correlation analysis were performed to compare bone mineral density (BMD), T score, and HU values measured using DEXA and QCT.</p><p><strong>Results: </strong>A statistically significant difference was found between T score, lumbar total BMD, and HU values according to age and sex (<i>P</i> < 0.05). When the values measured from lumbar vertebrae were compared using both DEXA and CT, a high correlation was found between them.</p><p><strong>Conclusion: </strong>In the study, it was observed that QCT attenuation measurements of the lumbar spine measured between different age groups provided reliable results in terms of BMD scanning, as in DEXA. It should be noted that QCT has a longer imaging time and higher radiation dose compared to DEXA, and unnecessary scans should be avoided.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Discriminating the stage of Graves' ophthalmopathy (GO) is crucial for clinical decision. Application of conventional T2-weighted imaging in the staging is still limited.
Purpose: To evaluate the performance of T2 mapping based on two different regions of interest (ROIs) for staging GO.
Material and methods: In total, 56 GO patients were retrospectively enrolled and divided into two groups according to the clinical activity score (CAS). T2 relaxation time (T2RT) of extraocular muscle (EOM) on T2 mapping based on two different ROIs (T2RTROI-1: ROIs were drawn separately in the four EOMs; T2RTROI-2: ROI was drawn in the most inflamed EOM) was measured and compared between active and inactive groups.
Results: Both T2RTROI-1 and T2RTROI-2 values in the active GO were significantly higher than those of inactive GO (P <0.001). T2RTROI-1 and T2RTROI-2 values were positively correlated with CAS (rs=0.73, 0.69; P <0.001). When the T2RTROI-1 value of 83.3 ms and T2RTROI-2 value of 106.3 ms were used as cutoff values for staging GO, respectively, the best results were obtained with areas under the curve (AUCs) of 0.822 and 0.827. There was no significant difference for AUCs between T2RTROI-1 and T2RTROI-2 (P = 0.751). Excellent and good inter-observer agreements were achieved in quantitative measurements for T2RTROI-1 and T2RTROI-2 values, respectively, with intraclass correlation coefficients of 0.954 and 0.882.
Conclusion: The T2RT values derived from two different ROIs were useful for assessment of disease activity. Taking reproducibility and diagnostic performance into consideration, T2RTROI-1 would be an ideal image biomarker for staging GO compared to T2RTROI-2.
背景:判定巴塞杜氏眼病(Graves' ophthalmopathy,GO)的分期对临床决策至关重要。目的:评估基于两个不同感兴趣区(ROI)的T2成像在GO分期中的表现:共回顾性纳入56例GO患者,并根据临床活动评分(CAS)将其分为两组。根据两个不同的 ROI(T2RTROI-1:在四个眼外肌分别绘制 ROI;T2RTROI-2:在炎症最严重的眼外肌绘制 ROI)测量眼外肌(EOM)在 T2 映像上的 T2 驰豫时间(T2RT),并在活动组和非活动组之间进行比较:结果:活动组的 T2RTROI-1 和 T2RTROI-2 值均明显高于非活动组(P s=0.73, 0.69; P P = 0.751)。在 T2RTROI-1 和 T2RTROI-2 值的定量测量中,观察者之间的一致性极佳,类内相关系数分别为 0.954 和 0.882:从两个不同的 ROI 得出的 T2RT 值有助于评估疾病的活动性。考虑到再现性和诊断性能,与 T2RTROI-2 相比,T2RTROI-1 是对 GO 进行分期的理想图像生物标志物。
{"title":"Performance of T2 mapping in the staging of Graves' ophthalmopathy based on different region of interest selection methods.","authors":"Libin Yang, Xiaomin Dai, Jiawei Su, Shengsheng Yang, Yonghong Zheng, Mingping Ma, Shun Yu","doi":"10.1177/02841851241248640","DOIUrl":"10.1177/02841851241248640","url":null,"abstract":"<p><strong>Background: </strong>Discriminating the stage of Graves' ophthalmopathy (GO) is crucial for clinical decision. Application of conventional T2-weighted imaging in the staging is still limited.</p><p><strong>Purpose: </strong>To evaluate the performance of T2 mapping based on two different regions of interest (ROIs) for staging GO.</p><p><strong>Material and methods: </strong>In total, 56 GO patients were retrospectively enrolled and divided into two groups according to the clinical activity score (CAS). T2 relaxation time (T2RT) of extraocular muscle (EOM) on T2 mapping based on two different ROIs (T2RTROI-1: ROIs were drawn separately in the four EOMs; T2RTROI-2: ROI was drawn in the most inflamed EOM) was measured and compared between active and inactive groups.</p><p><strong>Results: </strong>Both T2RTROI-1 and T2RTROI-2 values in the active GO were significantly higher than those of inactive GO (<i>P</i> <0.001). T2RTROI-1 and T2RTROI-2 values were positively correlated with CAS (r<sub>s</sub>=0.73, 0.69; <i>P </i><0.001). When the T2RTROI-1 value of 83.3 ms and T2RTROI-2 value of 106.3 ms were used as cutoff values for staging GO, respectively, the best results were obtained with areas under the curve (AUCs) of 0.822 and 0.827. There was no significant difference for AUCs between T2RTROI-1 and T2RTROI-2 (<i>P </i>= 0.751). Excellent and good inter-observer agreements were achieved in quantitative measurements for T2RTROI-1 and T2RTROI-2 values, respectively, with intraclass correlation coefficients of 0.954 and 0.882.</p><p><strong>Conclusion: </strong>The T2RT values derived from two different ROIs were useful for assessment of disease activity. Taking reproducibility and diagnostic performance into consideration, T2RTROI-1 would be an ideal image biomarker for staging GO compared to T2RTROI-2.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-05-27DOI: 10.1177/02841851241254746
Leah R Gerlach, Vivek Prabhakaran, Piero G Antuono, Elias Granadillo
Background: Alzheimer's disease (AD) and frontotemporal dementia (FTD) require different treatments. Since clinical presentation can be nuanced, imaging biomarkers aid in diagnosis. Automated software such as Neuroreader (NR) provides volumetric imaging data, and indices between anterior and posterior brain areas have proven useful in distinguishing dementia subtypes in research cohorts. Existing indices are complex and require further validation in clinical settings.
Purpose: To provide initial validation for a simplified anterior-posterior index (API) from NR in distinguishing FTD and AD in a clinical cohort.
Material and methods: A retrospective chart review was completed. We derived a simplified API: API = (logVA/VP-μ)/σ where is weighted volume of frontal and temporal lobes and of parietal and occipital lobes. and are the mean and standard deviation of logVA/VP computed for AD participants. Receiver operating characteristic (ROC) curves and regression analyses assessed the efficacy of the API versus brain areas in predicting diagnosis of AD versus FTD.
Results: A total of 39 participants with FTD and 78 participants with AD were included. The API had an excellent performance in distinguishing AD from FTD with an area under the ROC curve of 0.82 and a positive association with diagnostic classification on logistic regression analysis (B = 1.491, P < 0.001).
Conclusion: The API successfully distinguished AD and FTD with excellent performance. The results provide preliminary validation of the API in a clinical setting.
背景:阿尔茨海默病(AD)和额颞叶痴呆(FTD)需要不同的治疗方法。由于临床表现可能有细微差别,成像生物标志物有助于诊断。神经读取器(NR)等自动化软件可提供容积成像数据,而大脑前部和后部区域之间的指数已被证明有助于区分研究队列中的痴呆亚型。现有指数比较复杂,需要在临床环境中进一步验证。目的:在临床队列中初步验证 NR 的简化前后指数(API)在区分 FTD 和 AD 方面的作用:我们完成了一项回顾性病历审查。我们得出了简化的 API:API = (logVA/VP-μ)/σ 其中 VA 是额叶和颞叶的加权体积,VP 是顶叶和枕叶的加权体积。接受者操作特征曲线(ROC)和回归分析评估了API与脑区在预测AD与FTD诊断中的有效性:共纳入 39 名 FTD 患者和 78 名 AD 患者。API在区分AD和FTD方面表现出色,其ROC曲线下面积为0.82,在逻辑回归分析中与诊断分类呈正相关(B = 1.491,P 结论:API在区分AD和FTD方面表现出色,其ROC曲线下面积为0.82,在逻辑回归分析中与诊断分类呈正相关(B = 1.491,P 结论):API成功区分了AD和FTD,表现出色。这些结果初步验证了 API 在临床环境中的有效性。
{"title":"The use of an anterior-posterior atrophy index to distinguish Alzheimer's disease from frontotemporal disorders: an automated volumetric MRI Study.","authors":"Leah R Gerlach, Vivek Prabhakaran, Piero G Antuono, Elias Granadillo","doi":"10.1177/02841851241254746","DOIUrl":"10.1177/02841851241254746","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) and frontotemporal dementia (FTD) require different treatments. Since clinical presentation can be nuanced, imaging biomarkers aid in diagnosis. Automated software such as Neuroreader (NR) provides volumetric imaging data, and indices between anterior and posterior brain areas have proven useful in distinguishing dementia subtypes in research cohorts. Existing indices are complex and require further validation in clinical settings.</p><p><strong>Purpose: </strong>To provide initial validation for a simplified anterior-posterior index (API) from NR in distinguishing FTD and AD in a clinical cohort.</p><p><strong>Material and methods: </strong>A retrospective chart review was completed. We derived a simplified API: <i>API = (logV<sub>A</sub>/V<sub>P</sub>-μ)/σ</i> where <math><msub><mi>V</mi><mi>A</mi></msub></math> is weighted volume of frontal and temporal lobes and <math><msub><mi>V</mi><mi>P</mi></msub></math> of parietal and occipital lobes. <math><mi>μ</mi></math> and <math><mi>σ</mi></math> are the mean and standard deviation of <i>logV<sub>A</sub>/V<sub>P</sub></i> computed for AD participants. Receiver operating characteristic (ROC) curves and regression analyses assessed the efficacy of the API versus brain areas in predicting diagnosis of AD versus FTD.</p><p><strong>Results: </strong>A total of 39 participants with FTD and 78 participants with AD were included. The API had an excellent performance in distinguishing AD from FTD with an area under the ROC curve of 0.82 and a positive association with diagnostic classification on logistic regression analysis (B = 1.491, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The API successfully distinguished AD and FTD with excellent performance. The results provide preliminary validation of the API in a clinical setting.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141156814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}