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Preliminary differentiation of benign and malignant gastric wall thickening using dual-layer spectral-detector CT. 使用双层光谱探测器 CT 初步区分良性和恶性胃壁增厚。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-07-25 DOI: 10.1177/02841851241260873
Hongjian Li, Qianni Zhu, Linjiang Liu, Haijun Zou, Dayong Gu, Cheng Wu, Weihua Li

Background: Dual-layer spectral-detector computed tomography (DLCT) may have the potential to evaluate gastric wall thickening.

Purpose: To evaluate the efficacy of DLCT quantitative parameters in differentiating between benign and malignant thickening of the gastric wall.

Material and methods: A total of 58 patients with "gastric wall thickening" who underwent multi-phase abdominal enhanced DLCT scans were included in this study. Of these patients, 33 were malignant and 25 were benign. Parameters such as iodine concentration (IC), effective atomic number (Zeff), and attenuation of the lesions were measured during the arterial phase (AP) and venous phase (VP). Binary logistic regression was employed to calculate the combined prediction probabilities. The accuracy of the DLCT parameters was assessed using receiver operating characteristic (ROC) curves.

Results: The values of IC, nIC, Zeff, normalized Zeff, and attenuation in the AP and VP were significantly higher (all P < 0.05) in the malignant group compared to the benign group. The ROC curves revealed that the IC, Zeff, and attenuation in the VP exhibited high diagnostic performance, with area under the ROC curve (AUC) values of 0.864, 0.862, and 0.840, respectively. The new combination of these three factors and gastric wall thickness had an AUC of 0.884, and the sensitivity and specificity were determined to be 81.8% and 92.0%, respectively.

Conclusion: Spectral CT parameters, particularly the combination of gastric wall thickness, attenuation, IC, and Zeff in VP, have value in distinguishing between benign and malignant gastric wall thickening.

背景:目的:评估DLCT定量参数在区分胃壁良性和恶性增厚方面的有效性:本研究共纳入 58 例接受腹部多相增强 DLCT 扫描的 "胃壁增厚 "患者。其中 33 例为恶性,25 例为良性。在动脉期(AP)和静脉期(VP)测量了病变部位的碘浓度(IC)、有效原子序数(Zeff)和衰减等参数。采用二元逻辑回归计算综合预测概率。使用接收器操作特征曲线(ROC)评估 DLCT 参数的准确性:AP期和VP期的IC值、nIC值、Zeff值、归一化Zeff值和衰减值均显著升高(均为P 结论:DLCT参数的准确性与AP期和VP期的预测值密切相关:光谱 CT 参数,尤其是 VP 的胃壁厚度、衰减、IC 和 Zeff 的组合,在区分良性和恶性胃壁增厚方面具有价值。
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引用次数: 0
Major brain injuries at term continue to influence DTI parameters in adolescents born very preterm: a 13-year follow-up study. 足月时的重大脑损伤继续影响早产青少年的 DTI 参数:一项为期 13 年的随访研究。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-05-17 DOI: 10.1177/02841851241252716
Sirkku Setänen, Harri Merisaari, Virva Saunavaara, Karoliina Uusitalo, Katri Lahti, Peter Ngum, Leena Haataja, Riitta Parkkola

Background: Major brain injuries in structural brain magnetic resonance imaging (MRI) at term affect concurrent diffusion tensor imaging (DTI) parameters in very preterm infants. White matter is known to gradually maturate along with increasing gestational age, which is characterized by increasing fractional anisotropy (FA) and decreasing mean diffusivity (MD).

Purpose: To study the difference between DTI parameters at term and 13 years in adolescents born very preterm with and without major pathologies in structural brain MRI at term.

Material and methods: Adolescents born very preterm (gestational age <32 weeks and/or birth weight ≤1500 g) in 2004-2006 at Turku University Hospital, Finland were included. We evaluated FA and MD at term and 13 years in 18 regions of interest using the JHU-neonate-SS atlas to compare the differences in these parameters between adolescents with and without major injuries identified on MRI at term.

Results: A total of 24 adolescents underwent brain MRI including DTI both at term and 13 years. Adolescents with major brain injury pathologies (n = 6) in structural MRI at term had decreased FA in the left corpus callosum and right cingulate gyrus part, and increased MD in the left corpus callosum, right anterior limb of internal capsule, and right posterior limb of the internal capsule at 13 years, in comparison with adolescents without major brain injuries (n = 18) in structural MRI at term.

Conclusion: Our findings suggest that major brain injuries identified on structural MRI at term affect brain maturation, with adverse effects in FA and MD still during adolescence.

背景:足月时脑结构磁共振成像(MRI)中的主要脑损伤会影响早产儿的同期弥散张量成像(DTI)参数。众所周知,白质会随着胎龄的增加而逐渐成熟,其特点是分数各向异性(FA)增加和平均扩散率(MD)降低。目的:研究在胎龄和 13 岁时,在胎龄时脑磁共振成像结构中存在重大病变和未出现重大病变的早产儿青少年的 DTI 参数之间的差异:材料和方法:早产青少年(胎龄结果:共有 24 名青少年在足月和 13 岁时接受了包括 DTI 在内的脑磁共振成像检查。与足月时在结构磁共振成像中未发现重大脑损伤的青少年(18 人)相比,足月时在结构磁共振成像中发现重大脑损伤病变的青少年(6 人)在 13 岁时左侧胼胝体和右侧扣带回部分的 FA 值降低,左侧胼胝体、内囊右前肢和内囊右后肢的 MD 值升高:我们的研究结果表明,胎儿期结构性磁共振成像中发现的重大脑损伤会影响大脑的成熟,并在青春期对FA和MD产生不利影响。
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引用次数: 0
Enhancement of image quality in rectal cancer imaging through MRI supplemented with rectal micro-enema. 通过辅以直肠微水肿的核磁共振成像提高直肠癌成像质量。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI: 10.1177/02841851241256326
Søren Rafael Rafaelsen
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引用次数: 0
A quantitative analysis of progressive fibrosing interstitial lung disease on computed tomography for the assessment of decreased vital capacity. 通过计算机断层扫描对进行性纤维化间质性肺病进行定量分析,以评估肺活量下降。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1177/02841851241246881
Yoshie Kunihiro, Tsuneo Matsumoto, Hideko Onoda, Tomoyuki Murakami, Masato Iduki, Yasushi Hirano, Katsuyoshi Ito

Background: The results of a quantitative analysis of computed tomography (CT) of interstitial lung disease (ILD) using a computer-aided detection (CAD) technique were correlated with the results of pulmonary function tests.

Purpose: To evaluate the correlation between a quantitative analysis of CT of progressive fibrosing interstitial lung disease (PF-ILD) including idiopathic pulmonary fibrosis (IPF) and non-IPF, which can manifest progressive pulmonary fibrosis and the vital capacity (VC), and to identify indicators for the assessment of a decreased VC.

Material and methods: A total of 73 patients (46 patients with IPF and 27 patients with non-IPF) were included in this study. Associations between the quantitative analysis of CT and the %VC using a CAD software program were investigated using Spearman's rank correlation and a logistic regression analysis. The appropriate cutoff vale for predicting a decreased VC was determined (%VC <80) and the area under the curve (AUC) was calculated.

Results: A multiple logistic regression analysis showed that the total extent of interstitial pneumonia on CT was a significant indicator of a decreased VC (P = 0.0001; odds ratio [OR]=1.15; 95% confidence interval [CI]=1.06-1.27 in IPF and P = 0.0025; OR=1.16; 95% CI=1.03-1.30 in non-IPF). The cutoff values of the total extent of interstitial pneumonia in IPF and non-IPF for predicting a decreased VC were determined to be 23.3% and 21.5%, and the AUCs were 0.83 and 0.91, respectively.

Conclusion: A quantitative analysis of CT of PF-ILD using a CAD software program could be useful for predicting a decreased VC.

背景:目的:评估进行性纤维化间质性肺病(PF-ILD)(包括特发性肺纤维化(IPF)和非 IPF)CT 定量分析与肺活量(VC)之间的相关性,并确定肺活量下降的评估指标:本研究共纳入 73 名患者(46 名 IPF 患者和 27 名非 IPF 患者)。通过斯皮尔曼等级相关性和逻辑回归分析,研究了使用 CAD 软件程序进行的 CT 定量分析与 %VC 之间的关联。确定了预测 VC 下降的适当临界值(%VC 结果):多重逻辑回归分析表明,CT 上间质性肺炎的总范围是 VC 下降的一个重要指标(IPF 患者的 P = 0.0001;几率比 [OR]= 1.15;95% 置信区间 [CI]= 1.06-1.27;非 IPF 患者的 P = 0.0025;OR=1.16;95% CI=1.03-1.30)。IPF和非IPF间质性肺炎总范围预测VC下降的临界值分别为23.3%和21.5%,AUC分别为0.83和0.91:结论:使用CAD软件程序对PF-ILD的CT进行定量分析有助于预测VC的下降。
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引用次数: 0
Radiolabeling and preclinical animal model evaluation of DTPA coupled 99mTc-labelled flutamide complex ([99mTc]DTPA-FLUT) as a potential radiotracer for cancer imaging. DTPA 偶联 99mTc 标记氟他胺复合物([99mTc]DTPA-FLUT)作为一种潜在的癌症成像放射性示踪剂的放射性标记和临床前动物模型评估。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1177/02841851241249161
Syed Ali Raza Naqvi, Ahmad Junaid Hassan, Muhammad Ramzan Saeed Ashraf Janjua, Naseem Abbas, Ameer Fawad Zahoor, Sadaf Ul Hassan, Amjad Hussain

Background: Advances in molecular imaging strategies have had an effect on precise diagnosis and treatment. Research has been intensified to develop more effective and versatile radiopharmaceuticals to uplift diagnostic efficiency and, consequently, the treatment.

Purpose: To label the flutamide (FLUT) coupled with diethylenetriamine pentaacetate (DTPA) with technetium-99 m (99mTc) and to evaluate its binding efficiency with rhabdomyosarcoma (RMS) cancer cells.

Material and methods: Radiolabeling of FLUT with 185 MBq freshly eluted 99mTcO4-1 was carried out via DTPA bifunctional chelating agent using stannous chloride reducing agent at pH 5. The labeled compound was assessed for its purity using chromatography analysis, stability in saline and blood serum, AND charge using paper electrophoresis. Normal biodistribution was studied using a mouse model, while binding affinity with RMS cancer cells was studied using an internalization assay. The in vivo accumulation of RMS cancer cells in a rabbit model was monitored using a SPECT gamma camera.

Results: Radiolabeling reaction displayed a pharmaceutical yield of 97% and a stability assay showed >95% intact radiopharmaceutical up to 6 h in saline and blood serum. In vitro internalization studies showed the potential of [99mTc]DTPA-FLUT to enter into cancer cells. This biodistribution study showed rapid blood clearance and minimum uptake by body organs, and scintigraphy displayed the [99mTc]DTPA-FLUT uptake by lesion, induced by RMS cancer cell lines in rabbit.

Conclusion: Stable, newly developed [99mTc]DTPA-FLUT seeks its way to internalize into RMS cancer cells, indicating it could be a potential candidate for the diagnosis of RMS cancer.

背景:分子成像策略的进步对精确诊断和治疗产生了影响。目的:用锝-99 m (99mTc)标记氟他胺 (FLUT)和五乙酸二乙烯三胺 (DTPA),并评估其与横纹肌肉瘤 (RMS) 癌细胞的结合效率:在 pH 值为 5 的条件下,使用氯化亚锡还原剂,通过 DTPA 双功能螯合剂对 FLUT 进行 185 MBq 新鲜洗脱的 99mTcO4-1 放射性标记。利用小鼠模型研究了正常生物分布,同时利用内化试验研究了与 RMS 癌细胞的结合亲和力。使用 SPECT 伽玛相机监测了 RMS 癌细胞在兔子模型中的体内蓄积情况:结果:放射性标记反应的药物收率为97%,稳定性测定显示,在生理盐水和血清中6小时内,放射性药物的完整率大于95%。体外内化研究表明,[99mTc]DTPA-FLUT 有可能进入癌细胞。这项生物分布研究显示,[99mTc]DTPA-FLUT在血液中清除迅速,被身体器官摄取的量最少,闪烁成像显示,[99mTc]DTPA-FLUT被病变组织摄取,由兔RMS癌细胞株诱发:结论:新开发的稳定的[99mTc]DTPA-FLUT可内化到RMS癌细胞中,表明它可能成为诊断RMS癌的潜在候选物质。
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引用次数: 0
Comparison of lung lesion assessment using free-breathing dynamic contrast-enhanced 1.5-T MRI with a golden-angle radial stack-of-stars VIBE sequence and CT. 使用自由呼吸动态对比增强型 1.5 T 磁共振成像与黄金角径向堆叠星形 VIBE 序列和 CT 评估肺部病变的比较。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-06-17 DOI: 10.1177/02841851241259924
Jiliang Chen, Qunfeng Tang, Yang Song, Xinwei Tao, Jingwen Chen, Jun Zhao, Zhen Jiang

Background: Few studies have investigated the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a free-breathing golden-angle radial stack-of-stars volume-interpolated breath-hold examination (FB radial VIBE) sequence in the lung.

Purpose: To investigate whether DCE-MRI using the FB radial VIBE sequence can assess morphological and kinetic parameters in patients with pulmonary lesions, with computed tomography (CT) as the reference.

Material and methods: In total, 43 patients (30 men; mean age = 64 years) with one lesion each were prospectively enrolled. Morphological and kinetic features on MRI were calculated. The diagnostic performance of morphological MR features was evaluated using a receiver operating characteristic (ROC) curve. Kinetic features were compared among subgroups based on histopathological subtype, lesion size, and lymph node metastasis.

Results: The maximum diameter was not significantly different between CT and MRI (3.66 ± 1.62 cm vs. 3.64 ± 1.72 cm; P = 0.663). Spiculation, lobulation, cavitation or bubble-like areas of low attenuation, and lymph node enlargement had an area under the ROC curve (AUC) >0.9, while pleural indentation yielded an AUC of 0.788. The lung cancer group had significantly lower Ktrans, Ve, and initial AUC values than the other cause inflammation group (0.203, 0.158, and 0.589 vs. 0.597, 0.385, and 1.626; P < 0.05) but significantly higher values than the tuberculosis group (P < 0.05).

Conclusion: Morphology features derived from FB radial VIBE have high correlations with CT, and kinetic analyses show significant differences between benign and malignant lesions. DCE-MRI with FB radial VIBE could serve as a complementary quantification tool to CT for radiation-free assessments of lung lesions.

背景:目的:以计算机断层扫描(CT)为参照,研究使用FB径向VIBE序列的动态对比增强磁共振成像(DCE-MRI)能否评估肺部病变患者的形态学和动力学参数:前瞻性地纳入了 43 名各有一个病灶的患者(30 名男性,平均年龄 = 64 岁)。计算核磁共振成像的形态学和动力学特征。使用接收器操作特征曲线(ROC)评估了形态学 MR 特征的诊断性能。根据组织病理学亚型、病灶大小和淋巴结转移情况,比较了不同亚组的动力学特征:CT 和 MRI 的最大直径无明显差异(3.66 ± 1.62 厘米 vs. 3.64 ± 1.72 厘米;P = 0.663)。棘突、分叶、低衰减的空洞或气泡样区域以及淋巴结肿大的 ROC 曲线下面积(AUC)大于 0.9,而胸膜压痕的 AUC 为 0.788。肺癌组的 Ktrans、Ve 和初始 AUC 值明显低于其他原因引起的炎症组(0.203、0.158 和 0.589 vs. 0.597、0.385 和 1.626;P P 结论:FB径向VIBE得出的形态学特征与CT具有高度相关性,动力学分析显示良性和恶性病变之间存在显著差异。在对肺部病变进行无辐射评估时,DCE-MRI 与 FB 径向 VIBE 可作为 CT 的补充量化工具。
{"title":"Comparison of lung lesion assessment using free-breathing dynamic contrast-enhanced 1.5-T MRI with a golden-angle radial stack-of-stars VIBE sequence and CT.","authors":"Jiliang Chen, Qunfeng Tang, Yang Song, Xinwei Tao, Jingwen Chen, Jun Zhao, Zhen Jiang","doi":"10.1177/02841851241259924","DOIUrl":"10.1177/02841851241259924","url":null,"abstract":"<p><strong>Background: </strong>Few studies have investigated the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a free-breathing golden-angle radial stack-of-stars volume-interpolated breath-hold examination (FB radial VIBE) sequence in the lung.</p><p><strong>Purpose: </strong>To investigate whether DCE-MRI using the FB radial VIBE sequence can assess morphological and kinetic parameters in patients with pulmonary lesions, with computed tomography (CT) as the reference.</p><p><strong>Material and methods: </strong>In total, 43 patients (30 men; mean age = 64 years) with one lesion each were prospectively enrolled. Morphological and kinetic features on MRI were calculated. The diagnostic performance of morphological MR features was evaluated using a receiver operating characteristic (ROC) curve. Kinetic features were compared among subgroups based on histopathological subtype, lesion size, and lymph node metastasis.</p><p><strong>Results: </strong>The maximum diameter was not significantly different between CT and MRI (3.66 ± 1.62 cm vs. 3.64 ± 1.72 cm; <i>P</i> = 0.663). Spiculation, lobulation, cavitation or bubble-like areas of low attenuation, and lymph node enlargement had an area under the ROC curve (AUC) >0.9, while pleural indentation yielded an AUC of 0.788. The lung cancer group had significantly lower K<sup>trans</sup>, V<sub>e</sub>, and initial AUC values than the other cause inflammation group (0.203, 0.158, and 0.589 vs. 0.597, 0.385, and 1.626; <i>P</i> < 0.05) but significantly higher values than the tuberculosis group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Morphology features derived from FB radial VIBE have high correlations with CT, and kinetic analyses show significant differences between benign and malignant lesions. DCE-MRI with FB radial VIBE could serve as a complementary quantification tool to CT for radiation-free assessments of lung lesions.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"930-939"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Individualized driver amplitude in liver MR elastography: a linear regression study". 肝脏磁共振弹性成像中的个体化驱动振幅:线性回归研究 "的更正。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI: 10.1177/02841851241263854
{"title":"Corrigendum to \"Individualized driver amplitude in liver MR elastography: a linear regression study\".","authors":"","doi":"10.1177/02841851241263854","DOIUrl":"10.1177/02841851241263854","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1015"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting cachexia in hepatocellular carcinoma patients: a nomogram based on MRI features and body composition. 预测肝细胞癌患者的恶病质:基于磁共振成像特征和身体成分的提名图。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-07-25 DOI: 10.1177/02841851241261703
Xin-Xiang Li, Bing Liu, Yu-Fei Zhao, Yang Jiang, Hui Mao, Xin-Gui Peng

Background: Approximately half of all patients with hepatocellular carcinoma (HCC) develop cachexia during the course of the disease. It is important to be able to predict which patients will develop cachexia at an early stage.

Purpose: To develop and validate a nomogram based on the magnetic resonance imaging (MRI) features of HCC and body composition for potentially predicting cachexia in patients with HCC.

Material and methods: A retrospective two-center study recruited the pretreatment clinical and MRI data of 411 patients with HCC undergoing abdominal MRI. The data were divided into three cohorts for development, internal validation, and external validation. Patients were followed up for six months after the MRI scan to record each patient's weight to diagnose cachexia. Logistic regression analyses were performed to identify independent variables associated with cachexia in the development cohort used to build the nomogram.

Results: The multivariable analysis suggested that the MRI parameters of tumor size > 5 cm (P = 0.001), intratumoral artery (P = 0.004), skeletal muscle index (P < 0.001), and subcutaneous fat area (P = 0.004) were independent predictors of cachexia in patients with HCC. The nomogram derived from these parameters in predicting cachexia reached an area under receiver operating characteristic curve of 0.819, 0.783, and 0.814 in the development, and internal and external validation cohorts, respectively.

Conclusion: The proposed multivariable nomogram suggested good performance in predicting the risk of cachexia in HCC patients.

背景:大约一半的肝细胞癌(HCC)患者会在病程中出现恶病质。目的:根据 HCC 的磁共振成像(MRI)特征和身体成分,开发并验证一种可能预测 HCC 患者恶病质的提名图:一项双中心回顾性研究收集了411名接受腹部磁共振成像检查的HCC患者的治疗前临床和磁共振成像数据。这些数据被分为三组,分别用于开发、内部验证和外部验证。在 MRI 扫描后对患者进行为期 6 个月的随访,记录每位患者的体重,以诊断恶病质。在用于建立提名图的开发队列中,进行了逻辑回归分析,以确定与恶病质相关的独立变量:结果:多变量分析表明,肿瘤大小> 5 cm(P = 0.001)、瘤内动脉(P = 0.004)、骨骼肌指数(P = 0.004)等 MRI 参数是预测 HCC 患者恶病质的独立因素。根据这些参数推导出的预测恶病质的提名图在开发队列、内部和外部验证队列中的接收者操作特征曲线下面积分别为 0.819、0.783 和 0.814:结论:所提出的多变量提名图在预测 HCC 患者恶病质风险方面表现良好。
{"title":"Predicting cachexia in hepatocellular carcinoma patients: a nomogram based on MRI features and body composition.","authors":"Xin-Xiang Li, Bing Liu, Yu-Fei Zhao, Yang Jiang, Hui Mao, Xin-Gui Peng","doi":"10.1177/02841851241261703","DOIUrl":"10.1177/02841851241261703","url":null,"abstract":"<p><strong>Background: </strong>Approximately half of all patients with hepatocellular carcinoma (HCC) develop cachexia during the course of the disease. It is important to be able to predict which patients will develop cachexia at an early stage.</p><p><strong>Purpose: </strong>To develop and validate a nomogram based on the magnetic resonance imaging (MRI) features of HCC and body composition for potentially predicting cachexia in patients with HCC.</p><p><strong>Material and methods: </strong>A retrospective two-center study recruited the pretreatment clinical and MRI data of 411 patients with HCC undergoing abdominal MRI. The data were divided into three cohorts for development, internal validation, and external validation. Patients were followed up for six months after the MRI scan to record each patient's weight to diagnose cachexia. Logistic regression analyses were performed to identify independent variables associated with cachexia in the development cohort used to build the nomogram.</p><p><strong>Results: </strong>The multivariable analysis suggested that the MRI parameters of tumor size > 5 cm (<i>P</i> = 0.001), intratumoral artery (<i>P</i> = 0.004), skeletal muscle index (<i>P</i> < 0.001), and subcutaneous fat area (<i>P</i> = 0.004) were independent predictors of cachexia in patients with HCC. The nomogram derived from these parameters in predicting cachexia reached an area under receiver operating characteristic curve of 0.819, 0.783, and 0.814 in the development, and internal and external validation cohorts, respectively.</p><p><strong>Conclusion: </strong>The proposed multivariable nomogram suggested good performance in predicting the risk of cachexia in HCC patients.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"898-906"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinguishing between aldosterone-producing adenomas and non-functional adrenocortical adenomas using the YOLOv5 network. 利用 YOLOv5 网络区分醛固酮分泌腺瘤和非功能性肾上腺皮质腺瘤。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1177/02841851241251446
Zeyu Piao, Mingzhu Meng, Huijie Yang, Tongqing Xue, Zhongzhi Jia, Wei Liu

Background: You Only Look Once version 5 (YOLOv5), a one-stage deep-learning (DL) algorithm for object detection and classification, offers high speed and accuracy for identifying targets.

Purpose: To investigate the feasibility of using the YOLOv5 algorithm to non-invasively distinguish between aldosterone-producing adenomas (APAs) and non-functional adrenocortical adenomas (NF-ACAs) on computed tomography (CT) images.

Material and methods: A total of 235 patients who were diagnosed with ACAs between January 2011 and July 2022 were included in this study. Of the 215 patients, 81 (37.7%) had APAs and 134 (62.3%) had NF-ACAs' they were randomly divided into either the training set or the validation set at a ratio of 9:1. Another 20 patients, including 8 (40.0%) with APA and 12 (60.0%) with NF-ACA, were collected for the testing set. Five submodels (YOLOv5n, YOLOv5s, YOLOv5m, YOLOv5l, and YOLOv5x) of YOLOv5 were trained and evaluated on the datasets.

Results: In the testing set, the mAP_0.5 value for YOLOv5x (0.988) was higher than the values for YOLOv5n (0.969), YOLOv5s (0.965), YOLOv5m (0.974), and YOLOv5l (0.983). The mAP_0.5:0.95 value for YOLOv5x (0.711) was also higher than the values for YOLOv5n (0.587), YOLOv5s (0.674), YOLOv5m (0.671), and YOLOv5l (0.698) in the testing set. The inference speed of YOLOv5n was 2.4 ms in the testing set, which was the fastest among the five submodels.

Conclusion: The YOLOv5 algorithm can accurately and efficiently distinguish between APAs and NF-ACAs on CT images, especially YOLOv5x has the best identification performance.

背景:目的:研究在计算机断层扫描(CT)图像上使用YOLOv5算法无创区分醛固酮腺瘤(APA)和非功能性肾上腺皮质腺瘤(NF-ACA)的可行性:本研究共纳入2011年1月至2022年7月期间确诊的235例ACA患者。在这 215 名患者中,81 人(37.7%)患有 APA,134 人(62.3%)患有 NF-ACA,他们按 9:1 的比例被随机分为训练集或验证集。另外收集了 20 名患者作为测试集,其中包括 8 名(40.0%)APA 患者和 12 名(60.0%)NF-ACA 患者。在数据集上对 YOLOv5 的五个子模型(YOLOv5n、YOLOv5s、YOLOv5m、YOLOv5l 和 YOLOv5x)进行了训练和评估:在测试集中,YOLOv5x 的 mAP_0.5 值(0.988)高于 YOLOv5n 的 mAP_0.5 值(0.969)、YOLOv5s 的 mAP_0.5 值(0.965)、YOLOv5m 的 mAP_0.5 值(0.974)和 YOLOv5l 的 mAP_0.5 值(0.983)。在测试集中,YOLOv5x 的 mAP_0.5:0.95 值(0.711)也高于 YOLOv5n (0.587)、YOLOv5s (0.674)、YOLOv5m (0.671) 和 YOLOv5l (0.698)。在测试集中,YOLOv5n 的推理速度为 2.4 毫秒,是五个子模型中最快的:结论:YOLOv5 算法能准确、高效地区分 CT 图像上的 APA 和 NF-ACA,尤其是 YOLOv5x 的识别性能最好。
{"title":"Distinguishing between aldosterone-producing adenomas and non-functional adrenocortical adenomas using the YOLOv5 network.","authors":"Zeyu Piao, Mingzhu Meng, Huijie Yang, Tongqing Xue, Zhongzhi Jia, Wei Liu","doi":"10.1177/02841851241251446","DOIUrl":"10.1177/02841851241251446","url":null,"abstract":"<p><strong>Background: </strong>You Only Look Once version 5 (YOLOv5), a one-stage deep-learning (DL) algorithm for object detection and classification, offers high speed and accuracy for identifying targets.</p><p><strong>Purpose: </strong>To investigate the feasibility of using the YOLOv5 algorithm to non-invasively distinguish between aldosterone-producing adenomas (APAs) and non-functional adrenocortical adenomas (NF-ACAs) on computed tomography (CT) images.</p><p><strong>Material and methods: </strong>A total of 235 patients who were diagnosed with ACAs between January 2011 and July 2022 were included in this study. Of the 215 patients, 81 (37.7%) had APAs and 134 (62.3%) had NF-ACAs' they were randomly divided into either the training set or the validation set at a ratio of 9:1. Another 20 patients, including 8 (40.0%) with APA and 12 (60.0%) with NF-ACA, were collected for the testing set. Five submodels (YOLOv5n, YOLOv5s, YOLOv5m, YOLOv5l, and YOLOv5x) of YOLOv5 were trained and evaluated on the datasets.</p><p><strong>Results: </strong>In the testing set, the mAP_0.5 value for YOLOv5x (0.988) was higher than the values for YOLOv5n (0.969), YOLOv5s (0.965), YOLOv5m (0.974), and YOLOv5l (0.983). The mAP_0.5:0.95 value for YOLOv5x (0.711) was also higher than the values for YOLOv5n (0.587), YOLOv5s (0.674), YOLOv5m (0.671), and YOLOv5l (0.698) in the testing set. The inference speed of YOLOv5n was 2.4 ms in the testing set, which was the fastest among the five submodels.</p><p><strong>Conclusion: </strong>The YOLOv5 algorithm can accurately and efficiently distinguish between APAs and NF-ACAs on CT images, especially YOLOv5x has the best identification performance.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1007-1014"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of clinical and safety profiles after reperfusion therapy in acute posterior circulation strokes: insights and implications. 急性后循环脑卒中再灌注治疗后临床和安全性的元分析:见解与启示。
IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1177/02841851241255313
Ashek Chowdhury, Murray C Killingsworth, Zeljka Calic, Sonu Mm Bhaskar

Background: Posterior circulation stroke (PCS) accounts for approximately 20% of all acute ischemic strokes. The optimal reperfusion therapy for PCS management remains uncertain.

Purpose: To evaluate the prevalence and outcomes of intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), and bridging therapy in PCS patients.

Material and methods: We conducted a meta-analysis of 19 studies examining reperfusion therapy outcomes in PCS patients, including 9765 individuals. We pooled prevalence data and assessed associations between reperfusion therapies and clinical, safety, and recanalization outcomes using random-effects models.

Results: The pooled prevalence of reperfusion therapies post-acute PCS was 39% for IVT, 54% for EVT, and 48% for bridging therapy. EVT was associated with significantly higher odds of favorable functional outcomes (modified Rankin Score [mRS] 0-3) at 90 days compared to standard medical therapy (odds ratio [OR] = 5.68; 95% confidence interval [CI]=2.07-15.59; P = 0.001). Conversely, bridging therapy was linked to reduced odds of favorable functional outcomes at 90 days compared to EVT (OR = 0.35; 95% CI=0.26-0.47; P < 0.001). Bridging therapy was also significantly associated with lower odds of good functional outcomes (mRS 0-2) (OR = 0.25; 95% CI=0.11-0.54; P < 0.001), reduced risk of symptomatic intracranial hemorrhage (OR = 0.26; 95% CI=0.07-0.68; P = 0.009), lower mortality (OR = 0.13; 95% CI=0.04-0.44; P = 0.001), and less successful recanalization (OR = 0.35; 95% CI=0.13-0.94; P = 0.038) relative to EVT.

Conclusion: Our meta-analysis underscores the favorable outcomes associated with EVT in PCS cases. With notable reperfusion rates, understanding factors influencing PCS outcomes can inform patient selection and prognostic considerations.

背景:后循环卒中(PCS)约占所有急性缺血性卒中的 20%。目的:评估静脉溶栓(IVT)、血管内血栓切除术(EVT)和桥接疗法在 PCS 患者中的应用率和效果:我们对19项研究进行了荟萃分析,这些研究考察了PCS患者的再灌注治疗效果,共包括9765名患者。我们汇总了患病率数据,并使用随机效应模型评估了再灌注疗法与临床、安全性和再通畅结果之间的关联:急性 PCS 后再灌注疗法的汇总流行率分别为:IVT 39%、EVT 54%、桥接疗法 48%。与标准药物治疗相比,EVT与90天后良好功能预后(改良Rankin评分[mRS] 0-3)的几率明显相关(几率比[OR]=5.68;95%置信区间[CI]=2.07-15.59;P=0.001)。相反,与EVT相比,桥接疗法降低了90天后出现良好功能预后的几率(OR=0.35;95% CI=0.26-0.47;P=0.009),降低了死亡率(OR=0.13;95% CI=0.04-0.44;P=0.001),而且与EVT相比,桥接疗法的再通畅成功率较低(OR=0.35;95% CI=0.13-0.94;P=0.038):我们的荟萃分析强调了EVT在PCS病例中的良好疗效。由于再灌注率显著提高,了解影响 PCS 结局的因素可为患者选择和预后考虑提供依据。
{"title":"Meta-analysis of clinical and safety profiles after reperfusion therapy in acute posterior circulation strokes: insights and implications.","authors":"Ashek Chowdhury, Murray C Killingsworth, Zeljka Calic, Sonu Mm Bhaskar","doi":"10.1177/02841851241255313","DOIUrl":"10.1177/02841851241255313","url":null,"abstract":"<p><strong>Background: </strong>Posterior circulation stroke (PCS) accounts for approximately 20% of all acute ischemic strokes. The optimal reperfusion therapy for PCS management remains uncertain.</p><p><strong>Purpose: </strong>To evaluate the prevalence and outcomes of intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), and bridging therapy in PCS patients.</p><p><strong>Material and methods: </strong>We conducted a meta-analysis of 19 studies examining reperfusion therapy outcomes in PCS patients, including 9765 individuals. We pooled prevalence data and assessed associations between reperfusion therapies and clinical, safety, and recanalization outcomes using random-effects models.</p><p><strong>Results: </strong>The pooled prevalence of reperfusion therapies post-acute PCS was 39% for IVT, 54% for EVT, and 48% for bridging therapy. EVT was associated with significantly higher odds of favorable functional outcomes (modified Rankin Score [mRS] 0-3) at 90 days compared to standard medical therapy (odds ratio [OR] = 5.68; 95% confidence interval [CI]=2.07-15.59; <i>P</i> = 0.001). Conversely, bridging therapy was linked to reduced odds of favorable functional outcomes at 90 days compared to EVT (OR = 0.35; 95% CI=0.26-0.47; <i>P</i> < 0.001). Bridging therapy was also significantly associated with lower odds of good functional outcomes (mRS 0-2) (OR = 0.25; 95% CI=0.11-0.54; <i>P</i> < 0.001), reduced risk of symptomatic intracranial hemorrhage (OR = 0.26; 95% CI=0.07-0.68; <i>P</i> = 0.009), lower mortality (OR = 0.13; 95% CI=0.04-0.44; <i>P</i> = 0.001), and less successful recanalization (OR = 0.35; 95% CI=0.13-0.94; <i>P</i> = 0.038) relative to EVT.</p><p><strong>Conclusion: </strong>Our meta-analysis underscores the favorable outcomes associated with EVT in PCS cases. With notable reperfusion rates, understanding factors influencing PCS outcomes can inform patient selection and prognostic considerations.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"982-998"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta radiologica
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