We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by -56%, -56%, -50%, -12%, and -58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.
{"title":"Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis.","authors":"Hisashi Komoto, Kazuhiro Kitajima, Naoto Azuma, Masao Tamura, Hiroyuki Yokoyama, Tatsuya Tsuchitani, Koichiro Yamakado","doi":"10.1177/20584601221128409","DOIUrl":"https://doi.org/10.1177/20584601221128409","url":null,"abstract":"<p><p>We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by -56%, -56%, -50%, -12%, and -58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 10","pages":"20584601221128409"},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/73/10.1177_20584601221128409.PMC9536095.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a rare case of retroperitoneal pseudotumor caused by Schistosoma japonicum that was diagnosed by computed tomography (CT) guided percutaneous biopsy in a 15-year-old Filipino male. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a mass lesion, including a mesenteric artery, in the right retroperitoneal space. His mother had a history of S. japonicum infection but his initial stool examination was negative. As schistosomiasis was suspected, cone-beam CT-guided biopsy was performed to enable transcatheter therapeutic arterial embolization to be performed immediately in the event of hemorrhage. Histopathological examination revealed schistosomal eggs. Cone-beam CT-guided technique with a coaxial biopsy system is a safe and accurate diagnostic procedure for S. japonicum retroperitoneal pseudotumor.
{"title":"A case of Schistosoma japonicum retroperitoneal pseudotumor diagnosed by cone-beam CT-guided coaxial biopsy system.","authors":"Shu Matsushita, Shinichi Hamamoto, Ryo Morita, Michinori Shirano, Takeshi Inoue, Tomohisa Okuma, Takao Manabe","doi":"10.1177/20584601221129153","DOIUrl":"https://doi.org/10.1177/20584601221129153","url":null,"abstract":"<p><p>We report a rare case of retroperitoneal pseudotumor caused by <i>Schistosoma japonicum</i> that was diagnosed by computed tomography (CT) guided percutaneous biopsy in a 15-year-old Filipino male. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a mass lesion, including a mesenteric artery, in the right retroperitoneal space. His mother had a history of <i>S. japonicum</i> infection but his initial stool examination was negative. As schistosomiasis was suspected, cone-beam CT-guided biopsy was performed to enable transcatheter therapeutic arterial embolization to be performed immediately in the event of hemorrhage. Histopathological examination revealed schistosomal eggs. Cone-beam CT-guided technique with a coaxial biopsy system is a safe and accurate diagnostic procedure for <i>S. japonicum</i> retroperitoneal pseudotumor.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":" ","pages":"20584601221129153"},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/7d/10.1177_20584601221129153.PMC9513577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40385665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20eCollection Date: 2022-09-01DOI: 10.1177/20584601221128405
J Altenbernd, S Zimmer, L Andrae, B Labonte, J Gruber, H Beier, M Abdulgader, M Buechter, M Forsting, J Theysohn
Background: Imaging of the portal vein prior to puncture for TIPS is essential. Purpose: With this study, we examined a modified retrograde portography with regard to the reliable representation of the portal vein. Material and Methods: Prospective evaluation of 65 TIPS interventions with regard to the delimitation of the portal vein and the exact parameters of retrograde portography such as catheter diameter and contrast medium volume per injection. Results: Retrograde portographies with a large-lumen catheter (10 F) and a large contrast medium volume (40 mL) were performed in 35/63 patients with significantly better delineation of the portal vein than when using 5 F catheters with 10 mL contrast medium. Conclusion: The so-called high volume retrograde portography leads to better delimitation of the portal vein during TIPS application.
{"title":"High volume retrograde portography for better discrimination of the portal vein during TIPS procedure.","authors":"J Altenbernd, S Zimmer, L Andrae, B Labonte, J Gruber, H Beier, M Abdulgader, M Buechter, M Forsting, J Theysohn","doi":"10.1177/20584601221128405","DOIUrl":"https://doi.org/10.1177/20584601221128405","url":null,"abstract":"<p><p><b>Background:</b> Imaging of the portal vein prior to puncture for TIPS is essential. <b>Purpose:</b> With this study, we examined a modified retrograde portography with regard to the reliable representation of the portal vein. <b>Material and Methods:</b> Prospective evaluation of 65 TIPS interventions with regard to the delimitation of the portal vein and the exact parameters of retrograde portography such as catheter diameter and contrast medium volume per injection. <b>Results:</b> Retrograde portographies with a large-lumen catheter (10 F) and a large contrast medium volume (40 mL) were performed in 35/63 patients with significantly better delineation of the portal vein than when using 5 F catheters with 10 mL contrast medium. <b>Conclusion:</b> The so-called high volume retrograde portography leads to better delimitation of the portal vein during TIPS application.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":" ","pages":"20584601221128405"},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33482822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-17eCollection Date: 2022-09-01DOI: 10.1177/20584601221128415
Louise Tram, Magdalena Kubik, Kristina Kvist Jensen, Charlotte E Almasi
Brown tumors are uncommon manifestations of hyperparathyroidism (HPT) that without awareness are easily misdiagnosed as metastases. This short report highlights the importance of clinical context and clear communication between medical specialties when interpreting complex radiologic findings.
{"title":"Brown tumor mimicking metastases-the late manifestation of hyperparathyroidism.","authors":"Louise Tram, Magdalena Kubik, Kristina Kvist Jensen, Charlotte E Almasi","doi":"10.1177/20584601221128415","DOIUrl":"https://doi.org/10.1177/20584601221128415","url":null,"abstract":"<p><p>Brown tumors are uncommon manifestations of hyperparathyroidism (HPT) that without awareness are easily misdiagnosed as metastases. This short report highlights the importance of clinical context and clear communication between medical specialties when interpreting complex radiologic findings.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":" ","pages":"20584601221128415"},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/51/10.1177_20584601221128415.PMC9484045.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33466321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1177/20584601221122421
Jonas Auer, Joachim Braun, Julian Lenk, Johannes Gollrad, Sa-Ra Ro, Bernd Hamm, Maximilian de Bucourt
Background: One major challenge when inserting a tunneled, cuffed central venous catheter (CVC) for hemodialysis under fluoroscopy is to accurately place the catheter tip by assessing its position in relation to the cardiac silhouette to approximate the right atrium (RA).
Purpose: To investigate whether a weighted mean calculated from published results for two two-dimensional landmark reference distances may be useful in assessing CVC tip positions in relation to the RA.
Material and methods: Central venous catheter tip positions attained under fluoroscopic imaging during insertion using the cardiac silhouette as approximation were retrospectively related to two reference distances (carina to cranial RA border and craniocaudal RA extent), which were used to group catheter tip locations above (1), within (2), or below (3) the RA (henceforth referred to as landmark technique approximation, LTA). The LTA-derived catheter tip locations were validated by correlation with postinterventional computed tomography (CT) datasets acquired shortly after implantation (if available).
Results: Based on LTA, 45 catheter tips (10.6%) were above, 179 (42.2%) within, and 200 (47.2%) below the RA. Postinterventional CT (n = 57; 13.4%) visualized 26.3% above, 66.7% within, and 7.0% below the RA.
Conclusion: The LTA reference distances appear to lead to a rather low categorization of the CVC tips, or the tips have been placed rather low in the study population. Validation using postinterventional CT indicated an underestimation of the RA in the LTA. Patient characteristics with a higher risk of false estimation through LTA have been defined.
{"title":"Tunneled hemodialysis catheter insertion: Above, within, or below the right atrium-Where is the tip?","authors":"Jonas Auer, Joachim Braun, Julian Lenk, Johannes Gollrad, Sa-Ra Ro, Bernd Hamm, Maximilian de Bucourt","doi":"10.1177/20584601221122421","DOIUrl":"https://doi.org/10.1177/20584601221122421","url":null,"abstract":"<p><strong>Background: </strong>One major challenge when inserting a tunneled, cuffed central venous catheter (CVC) for hemodialysis under fluoroscopy is to accurately place the catheter tip by assessing its position in relation to the cardiac silhouette to approximate the right atrium (RA).</p><p><strong>Purpose: </strong>To investigate whether a weighted mean calculated from published results for two two-dimensional landmark reference distances may be useful in assessing CVC tip positions in relation to the RA.</p><p><strong>Material and methods: </strong>Central venous catheter tip positions attained under fluoroscopic imaging during insertion using the cardiac silhouette as approximation were retrospectively related to two reference distances (carina to cranial RA border and craniocaudal RA extent), which were used to group catheter tip locations above (1), within (2), or below (3) the RA (henceforth referred to as landmark technique approximation, LTA). The LTA-derived catheter tip locations were validated by correlation with postinterventional computed tomography (CT) datasets acquired shortly after implantation (if available).</p><p><strong>Results: </strong>Based on LTA, 45 catheter tips (10.6%) were above, 179 (42.2%) within, and 200 (47.2%) below the RA. Postinterventional CT (<i>n</i> = 57; 13.4%) visualized 26.3% above, 66.7% within, and 7.0% below the RA.</p><p><strong>Conclusion: </strong>The LTA reference distances appear to lead to a rather low categorization of the CVC tips, or the tips have been placed rather low in the study population. Validation using postinterventional CT indicated an underestimation of the RA in the LTA. Patient characteristics with a higher risk of false estimation through LTA have been defined.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 9","pages":"20584601221122421"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/bd/10.1177_20584601221122421.PMC9483979.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16eCollection Date: 2022-08-01DOI: 10.1177/20584601221088922
Sine Hylenius, Wei Uldall, Gro Qvamme, Niels Kroman
Radioactive seed localization is a method widely used within breast cancer treatment. This case represents a 43-year-old male patient with a foreign body in his left axilla. We used radioactive seed localization for marking the foreign body, which made the subsequent surgery possible, quick, and minimal invasive.
{"title":"Radioactive seed localization of foreign body.","authors":"Sine Hylenius, Wei Uldall, Gro Qvamme, Niels Kroman","doi":"10.1177/20584601221088922","DOIUrl":"https://doi.org/10.1177/20584601221088922","url":null,"abstract":"<p><p>Radioactive seed localization is a method widely used within breast cancer treatment. This case represents a 43-year-old male patient with a foreign body in his left axilla. We used radioactive seed localization for marking the foreign body, which made the subsequent surgery possible, quick, and minimal invasive.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 8","pages":"20584601221088922"},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/05/10.1177_20584601221088922.PMC9386870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-11eCollection Date: 2022-08-01DOI: 10.1177/20584601221117251
Sachila Niroshani, Tokiko Nakamura, Nikaidou Michiru, Toru Negishi
Background: Dual-energy contrast-enhanced mammography (DECEM) is an advanced breast imaging technique of digital mammography.
Purpose: To assess the total radiation dose received from complete DECEM using different combinations of exposure parameters for low- and high-energy images.
Materials and methods: A dedicated phantom with three different concentrations of iodine inserts was used. Each iodine insert was 10 mm in diameter and concentration of 1.0 mgI/cm3, 2.0 mgI/cm3, and 4.0 mgI/cm3. The phantom was exposed at varying kVp levels. Mean glandular dose (MGD) was estimated. Contrast to noise ratio (CNR) and figure of merit (FOM) of the iodine inserts were used to assess the image quality.
Results: The optimum CNR of the recombined images was obtained by using 28 kVp + 49 kVp tube voltage combination for 50 mm thickness, 50% fibroglandular phantom only with a 26% dose increase compared to the highest voltages (32 kVp + 49 kVp) that can be used for low energy (LE) and high energy (HE) imaging. The CNR value was increased with increasing iodine concentration (R2 > 0.99).
Conclusion: The use of as low as possible tube voltage for the LE imaging of standard 50% fibroglandular-50% adipose, 50 mm thickness breast while using the highest tube voltage for HE imaging has reduced the MGD while keeping optimum image quality.
{"title":"Evaluation of exposure factors of dual-energy contrast-enhanced mammography to optimize radiation dose with improved image quality.","authors":"Sachila Niroshani, Tokiko Nakamura, Nikaidou Michiru, Toru Negishi","doi":"10.1177/20584601221117251","DOIUrl":"https://doi.org/10.1177/20584601221117251","url":null,"abstract":"<p><strong>Background: </strong>Dual-energy contrast-enhanced mammography (DECEM) is an advanced breast imaging technique of digital mammography.</p><p><strong>Purpose: </strong>To assess the total radiation dose received from complete DECEM using different combinations of exposure parameters for low- and high-energy images.</p><p><strong>Materials and methods: </strong>A dedicated phantom with three different concentrations of iodine inserts was used. Each iodine insert was 10 mm in diameter and concentration of 1.0 mgI/cm<sup>3</sup>, 2.0 mgI/cm<sup>3</sup>, and 4.0 mgI/cm<sup>3</sup>. The phantom was exposed at varying kVp levels. Mean glandular dose (MGD) was estimated. Contrast to noise ratio (CNR) and figure of merit (FOM) of the iodine inserts were used to assess the image quality.</p><p><strong>Results: </strong>The optimum CNR of the recombined images was obtained by using 28 kVp + 49 kVp tube voltage combination for 50 mm thickness, 50% fibroglandular phantom only with a 26% dose increase compared to the highest voltages (32 kVp + 49 kVp) that can be used for low energy (LE) and high energy (HE) imaging. The CNR value was increased with increasing iodine concentration (<i>R</i> <sup><i>2</i></sup> > 0.99).</p><p><strong>Conclusion: </strong>The use of as low as possible tube voltage for the LE imaging of standard 50% fibroglandular-50% adipose, 50 mm thickness breast while using the highest tube voltage for HE imaging has reduced the MGD while keeping optimum image quality.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 8","pages":"20584601221117251"},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/6a/10.1177_20584601221117251.PMC9379970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40638209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cardiothoracic ratio (CTR) is the ratio of the diameter of the heart to the diameter of the thorax. An abnormal CTR (>0.55) is often an indicator of an underlying pathological condition. The accurate prediction of an abnormal CTR chest X-rays (CXRs) aids in the early diagnosis of clinical conditions.
Purpose: We propose a deep learning (DL)-based model for automatic CTR calculation to assist radiologists with rapid diagnosis of cardiomegaly and thus optimise the radiology flow.
Material and methods: The study population included 1012 posteroanterior CXRs from a single institution. The Attention U-Net DL architecture was used for the automatic calculation of CTR. An observer performance test was conducted to assess the radiologist's performance in diagnosing cardiomegaly with and without artificial intelligence assistance.
Results: U-Net model exhibited a sensitivity of 0.80 [95% CI: 0.75, 0.85], specificity >99%, precision of 0.99 [95% CI: 0.98, 1], and a F1 score of 0.88 [95% CI: 0.85, 0.91]. Furthermore, the sensitivity of the reviewing radiologist in identifying cardiomegaly increased from 40.50% to 88.4% when aided by the AI-generated CTR.
Conclusion: Our segmentation-based AI model demonstrated high specificity (>99%) and sensitivity (80%) for CTR calculation. The performance of the radiologist on the observer performance test improved significantly with provision of AI assistance. A DL-based segmentation model for rapid quantification of CTR can therefore have significant potential to be used in clinical workflows by reducing radiologists' burden and alerting to an abnormal enlarged heart early on.
{"title":"Observer performance evaluation of the feasibility of a deep learning model to detect cardiomegaly on chest radiographs.","authors":"Pranav Ajmera, Amit Kharat, Tanveer Gupte, Richa Pant, Viraj Kulkarni, Vinay Duddalwar, Purnachandra Lamghare","doi":"10.1177/20584601221107345","DOIUrl":"https://doi.org/10.1177/20584601221107345","url":null,"abstract":"<p><strong>Background: </strong>Cardiothoracic ratio (CTR) is the ratio of the diameter of the heart to the diameter of the thorax. An abnormal CTR (>0.55) is often an indicator of an underlying pathological condition. The accurate prediction of an abnormal CTR chest X-rays (CXRs) aids in the early diagnosis of clinical conditions.</p><p><strong>Purpose: </strong>We propose a deep learning (DL)-based model for automatic CTR calculation to assist radiologists with rapid diagnosis of cardiomegaly and thus optimise the radiology flow.</p><p><strong>Material and methods: </strong>The study population included 1012 posteroanterior CXRs from a single institution. The Attention U-Net DL architecture was used for the automatic calculation of CTR. An observer performance test was conducted to assess the radiologist's performance in diagnosing cardiomegaly with and without artificial intelligence assistance.</p><p><strong>Results: </strong>U-Net model exhibited a sensitivity of 0.80 [95% CI: 0.75, 0.85], specificity >99%, precision of 0.99 [95% CI: 0.98, 1], and a F1 score of 0.88 [95% CI: 0.85, 0.91]. Furthermore, the sensitivity of the reviewing radiologist in identifying cardiomegaly increased from 40.50% to 88.4% when aided by the AI-generated CTR.</p><p><strong>Conclusion: </strong>Our segmentation-based AI model demonstrated high specificity (>99%) and sensitivity (80%) for CTR calculation. The performance of the radiologist on the observer performance test improved significantly with provision of AI assistance. A DL-based segmentation model for rapid quantification of CTR can therefore have significant potential to be used in clinical workflows by reducing radiologists' burden and alerting to an abnormal enlarged heart early on.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 7","pages":"20584601221107345"},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/b4/10.1177_20584601221107345.PMC9309780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Backgrounds: There is a lack of universally available biomarker to differentiate rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Purpose: to see if the size of the axillary lymphnodes (ALNs) and the frequency of lymphadenopathy are useful biomarker to differentiate RA and PsA.
Material and methods: Forty RA and 19 PsA patients without previous biologics usage were retrospectively included. Chest CT was assessed for the presence of lymphadenopathy and the size of the largest ALN. Frequency of lymphadenopathies was statistically compared between RA and PsA. The short axis and the long axis of the largest ALN were also compared and receiver operating characteristic (ROC) curve analysis was performed.
Results: Frequency of axillary lymphadenopathy was significantly higher in RA than in PsA (80% vs 31.6%, p < .001). Number of lymphadenopathies in each patient was also significantly higher in RA than in PsA (3.0 vs 1.2 per patient, p = .005). Sensitivity and specificity for differentiating RA from PsA by the presence of at least one axillary lymphadenopathy were 0.8 and 0.68, respectively.The short axis of the largest ALNs in RA was significantly longer than in PsA (6.5 ± 1.6 mm vs 4.7 ± 1.7 mm, p < .001). ROC curve analysis of the short axis showed AUC of 0.75 (p = .002) and the cutoff value of 5.1 mm with a sensitivity of 0.83 and specificity of 0.74, when differentiating RA and PsA.
Conclusion: Presence of ALN lymphadenopathy and the short axis of the largest ALN may have a potential utility in differentiating RA and PsA.
背景:类风湿关节炎(RA)和银屑病关节炎(PsA)缺乏普遍可用的生物标志物来区分。目的:探讨腋窝淋巴结(ALNs)的大小和淋巴结病变的频率是否可作为鉴别RA和PsA的有用生物标志物。材料和方法:回顾性分析40例RA和19例PsA患者,既往未使用过生物制剂。胸部CT检查是否有淋巴结病变和最大ALN的大小。对RA和PsA的淋巴结病变频率进行统计学比较。比较最大ALN的短轴和长轴,并进行受试者工作特征(ROC)曲线分析。结果:RA患者腋窝淋巴结病变发生率明显高于PsA患者(80% vs 31.6%, p < 0.001)。RA患者中每个患者的淋巴结病变数量也显著高于PsA患者(每个患者3.0 vs 1.2, p = 0.005)。通过存在至少一个腋窝淋巴结病变来区分RA和PsA的敏感性和特异性分别为0.8和0.68。RA组最大aln的短轴明显长于PsA组(6.5±1.6 mm vs 4.7±1.7 mm, p < 0.001)。短轴ROC曲线分析显示,鉴别RA与PsA的AUC为0.75 (p = 0.002), cut - off值为5.1 mm,敏感性为0.83,特异性为0.74。结论:ALN淋巴结病变的存在和最大ALN的短轴可能对RA和PsA的鉴别有潜在的价值。
{"title":"Comparison of the axillary lymph node between rheumatoid arthritis and psoriatic arthritis with computed tomography.","authors":"Takeshi Fukuda, Reina Kayama, Sho Ogiwara, Takenori Yonenaga, Hiroya Ojiri","doi":"10.1177/20584601221112616","DOIUrl":"https://doi.org/10.1177/20584601221112616","url":null,"abstract":"<p><strong>Backgrounds: </strong>There is a lack of universally available biomarker to differentiate rheumatoid arthritis (RA) and psoriatic arthritis (PsA).</p><p><strong>Purpose: </strong>to see if the size of the axillary lymphnodes (ALNs) and the frequency of lymphadenopathy are useful biomarker to differentiate RA and PsA.</p><p><strong>Material and methods: </strong>Forty RA and 19 PsA patients without previous biologics usage were retrospectively included. Chest CT was assessed for the presence of lymphadenopathy and the size of the largest ALN. Frequency of lymphadenopathies was statistically compared between RA and PsA. The short axis and the long axis of the largest ALN were also compared and receiver operating characteristic (ROC) curve analysis was performed.</p><p><strong>Results: </strong>Frequency of axillary lymphadenopathy was significantly higher in RA than in PsA (80% vs 31.6%, <i>p</i> < .001). Number of lymphadenopathies in each patient was also significantly higher in RA than in PsA (3.0 vs 1.2 per patient, <i>p</i> = .005). Sensitivity and specificity for differentiating RA from PsA by the presence of at least one axillary lymphadenopathy were 0.8 and 0.68, respectively.The short axis of the largest ALNs in RA was significantly longer than in PsA (6.5 ± 1.6 mm vs 4.7 ± 1.7 mm, <i>p</i> < .001). ROC curve analysis of the short axis showed AUC of 0.75 (<i>p</i> = .002) and the cutoff value of 5.1 mm with a sensitivity of 0.83 and specificity of 0.74, when differentiating RA and PsA.</p><p><strong>Conclusion: </strong>Presence of ALN lymphadenopathy and the short axis of the largest ALN may have a potential utility in differentiating RA and PsA.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 7","pages":"20584601221112616"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/59/10.1177_20584601221112616.PMC9284224.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40600214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lumbar spinal stenosis is one of the most commonly diagnosed pathological conditions of the spine. Patients with lumbar spinal stenosis can be symptomatic or asymptomatic. Regardless of the clinical presentation, a combination of radiological imaging modalities including magnetic resonance imaging, CT, and dynamic X-rays can be used to evaluate the severity. An often underrecognized aspect of severe lumbar spinal stenosis is its effect on nerve roots. We propose coining the term "GatorSign" to describe nerve root edema above the area of severe central canal stenosis. This radiological finding can help identify patients with severe central canal stenosis in patients who would likely be neurologically symptomatic, requiring an invasive intervention such as epidural injections or surgical decompression for relief as conservative treatments such as physical therapy and/or medications are less likely to be effective.
{"title":"\"GatorSign\" for severe lumbar spinal canal stenosis: Magnetic resonance imaging evidence of lumbar perineural edema in the central canal.","authors":"Dharam Persaud-Sharma, Ashlyn Mason, Sanjeev Kumar","doi":"10.1177/20584601221112615","DOIUrl":"https://doi.org/10.1177/20584601221112615","url":null,"abstract":"<p><p>Lumbar spinal stenosis is one of the most commonly diagnosed pathological conditions of the spine. Patients with lumbar spinal stenosis can be symptomatic or asymptomatic. Regardless of the clinical presentation, a combination of radiological imaging modalities including magnetic resonance imaging, CT, and dynamic X-rays can be used to evaluate the severity. An often underrecognized aspect of severe lumbar spinal stenosis is its effect on nerve roots. We propose coining the term \"GatorSign\" to describe nerve root edema above the area of severe central canal stenosis. This radiological finding can help identify patients with severe central canal stenosis in patients who would likely be neurologically symptomatic, requiring an invasive intervention such as epidural injections or surgical decompression for relief as conservative treatments such as physical therapy and/or medications are less likely to be effective.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"11 7","pages":"20584601221112615"},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/24/10.1177_20584601221112615.PMC9272058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40520828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}