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Speech and language deficits in separation anxiety disorder 分离焦虑障碍的言语和语言缺陷
Pub Date : 2016-01-01 DOI: 10.12715/APR.2016.3.7
Roha M. Thomas, R. Kaipa
Separation anxiety disorder (SAD) is one of the most commonly occurring pediatric anxiety disorders. Children with SAD are characterized by excessive anxiety of separation from the primary attachment figure. These children exhibit fear of separation from their parents and display behaviors such as clinging, excessive crying, and tantrums. Children with SAD are found to have significant brain changes. SAD can co-occur with other conditions such as autism spectrum disorders, and attention deficit hyperactivity disorder. Past studies have identified not only cognitive deficits in children diagnosed with SAD, but also speech and language deficits, which vary depending on comorbidities. A team-centered approach is essential in the assessment and treatment of children diagnosed with SAD.
分离焦虑障碍(SAD)是最常见的儿童焦虑症之一。SAD儿童的特征是对与主要依恋对象分离的过度焦虑。这些孩子表现出对与父母分离的恐惧,并表现出依恋、过度哭泣和发脾气等行为。患有SAD的儿童被发现有显著的大脑变化。SAD可以与其他疾病共同发生,如自闭症谱系障碍和注意缺陷多动障碍。过去的研究发现,被诊断患有SAD的儿童不仅存在认知缺陷,还存在言语和语言缺陷,这些缺陷因合并症而异。以团队为中心的方法在诊断患有SAD的儿童的评估和治疗中是必不可少的。
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引用次数: 1
Intensive gait training in toddlers with cerebral palsy: A pilot study 脑性麻痹幼儿强化步态训练:一项初步研究
Pub Date : 2016-01-01 DOI: 10.12715/apr.2016.3.8
A. Herskind, M. Willerslev-Olsen, A. Ritterb, Rosenbaum, L. Greve, JakobLorentzen, J. Nielsen
Background: Reduced muscle growth may be involved in the development of contractures in children with cerebral palsy (CP). Here, we report data from a pilot study of intensive gait training in CP toddlers. Methods: Five children with CP aged 8-30 months performed activity-based gait training for one hour/day, five days/week for three consecutive months. Included children were diagnosed with spastic CP, had a Gross Motor Function Classification System (GMFCS) score of I–II, and were not epileptic. All children wore pedometers during training. Before and after the training period, kinematic and qualitative gait analysis, clinical and objective evaluation of spasticity, Gross Motor Function Measure-66 (GMFM-66), and ultrasound of the affected medial gastrocnemius (MG) muscle were performed. Two children were also tested before and after three months of receiving only standard care (SC). Results: On average 1410 steps/session were logged during 63 days of training. More steps were achieved at home than at a central facility. During training, MG muscle volume increased significantly, while it decreased for SC children. Gait improved qualitatively in all children, and GMFM-66 score improved in four of the five children. Similar improvements were seen among the SC children. Two children had pathologically increased muscle stiffness prior to training, which was reduced during training. Reflex stiffness was unchanged in all five children. Conclusions: This pilot study suggests that intensive gait training may increase muscle volume, improve walking skills and reduce passive muscle stiffness in toddlers with CP.
背景:肌肉生长减少可能与脑瘫(CP)患儿挛缩的发生有关。在这里,我们报告了来自CP幼儿强化步态训练的初步研究数据。方法:5例8-30月龄CP患儿,连续3个月进行基于活动的步态训练,每天1小时,每周5天。纳入的儿童被诊断为痉挛性CP,大运动功能分类系统(GMFCS)评分为I-II,并且没有癫痫。所有孩子在训练时都戴着计步器。训练前后分别进行运动学和定性步态分析、痉挛的临床和客观评价、大运动功能测量-66 (GMFM-66)和受损伤腓肠肌内侧(MG)的超声检查。两名儿童在接受标准护理(SC)三个月前后也进行了测试。结果:在63天的训练中,平均每节记录1410步。在国内完成的步骤比在中央设施完成的要多。训练过程中,MG组肌肉体积显著增加,SC组肌肉体积减少。所有儿童的步态都得到了质的改善,5名儿童中有4名的GMFM-66评分得到了改善。SC儿童也有类似的改善。两名儿童在训练前出现了病理性的肌肉僵硬增加,在训练期间有所减少。所有5名儿童的反射僵硬没有变化。结论:本初步研究表明,强化步态训练可以增加CP患儿的肌肉体积,提高步行技能,减少被动肌肉僵硬。
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引用次数: 2
Television access, dinnertime food consumption and obesity amongyoung children in Oklahoma 俄克拉何马州儿童的电视收看、晚餐食物消费和肥胖
Pub Date : 2016-01-01 DOI: 10.12715/apr.2016.3.3
A. H. Rasbold, S. Sisson, K. Lora, C. M. Mitchell
Background: Excessive television viewing has been associated with obesity and greater food intake but research has rarely focused on young children. This study aimed to determine relationships between home television access, dinnertime food consumption and obesity among children aged 3–5 years. Methods: Caregivers of children (n=72) reported: 1) children’s bedroom television access; 2) number of televisions in the home; 3) frequency of child eating dinner in front of the television; 4) presence of television viewable from dining areas; and a three-day dietary recall of child’s dinner food intake. Total kilocalories (kcal), fruit and vegetable servings, and body mass index percentiles (BMI%ile) were calculated. Results: Children were 3.7±0.7 years old, 43% male, 47% white, 26% overweight or obese, and mean BMI%iles were 68.6±28.8. At dinner, children consumed 426±146 kcals, 0.12±0.25 fruit, 0.59±0.59 vegetable, and 0.69±0.58 combined fruit and vegetable. Children without bedroom television’s consumed more vegetables (0.80±0.67 vs. 0.39±0.41; t=3.091, p=0.003) and combined fruit and vegetables (0.90±0.66 vs. 0.5±0.44; t=2.963, p=0.004). Children with ≥3 televisions in the home had higher BMI%iles than those with ≤2 televisions (68.8±27.3 vs. 54.3±29.3; F=4.629, p=0.035). Neither frequency of dining while watching television nor presence of television viewable from dining areas were associated with the BMI%ile. Conclusions: Greater television access in the home, including bedroom televisions and the overall number of televisions, is associated with lower fruit and vegetable intake and higher BMI%ile among young children. This study supports recommendations that children should not have bedroom television access and could help inform future childhood obesity prevention and intervention strategies.
背景:过度看电视与肥胖和更多的食物摄入有关,但研究很少关注幼儿。这项研究旨在确定3-5岁儿童的家庭电视收看、晚餐食物消费和肥胖之间的关系。方法:儿童照顾者(n=72)报告:1)儿童卧室电视接入情况;2)家里电视机的数量;3)孩子在电视机前吃饭的频率;4)从用餐区可以看到电视;并对儿童的晚餐食物摄入量进行为期三天的饮食召回。计算了总千卡(kcal)、水果和蔬菜摄入量以及体重指数百分位数(BMI%ile)。结果:患儿年龄3.7±0.7岁,男性43%,白人47%,超重或肥胖26%,平均BMI%iles为68.6±28.8。晚餐时,儿童摄入426±146千卡,水果0.12±0.25千卡,蔬菜0.59±0.59千卡,水果和蔬菜混合摄入0.69±0.58千卡。无卧室电视的儿童食用蔬菜较多(0.80±0.67 vs. 0.39±0.41);T =3.091, p=0.003)和混合水果和蔬菜(0.90±0.66 vs. 0.5±0.44;t = 2.963, p = 0.004)。家中电视机≥3台的儿童BMI%iles高于家中电视机≤2台的儿童(68.8±27.3 vs. 54.3±29.3;F = 4.629, p = 0.035)。看电视时吃饭的频率和从用餐区看电视都与BMI指数无关。结论:家里有更多的电视,包括卧室的电视和电视机的总数量,与幼儿水果和蔬菜的摄入量较低和较高的BMI%ile有关。这项研究支持了儿童不应该在卧室看电视的建议,并有助于为未来的儿童肥胖预防和干预策略提供信息。
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引用次数: 2
Energy density and feeding frequency of complementary foods affectsmeal-specific food consumption and meal duration by healthy, breast fedBangladeshi children 辅食的能量密度和喂养频率影响健康的母乳喂养的孟加拉国儿童的特定食物消耗和用餐时间
Pub Date : 2016-01-01 DOI: 10.12715/apr.2016.3.4
M. Islam, T. Ahmed, J. Peerson, M. Mollah, MakhdumaKhatun, K. Dewey, K. Brown
Background: Appropriate feeding of infants and young children is necessary to prevent growth faltering and optimize health during the first two years of life. There is little information on the effects of dietary energy density and feeding frequency of complementary foods on food consumption during individual meals and the amount of caregiver time expended in child feeding. Methods: During nine separate, randomly ordered dietary periods lasting 3-6 days each, we measured selfdetermined intakes of semi-solid cereal porridges by 18 healthy, breastfed children 8-11 months of age. The infants were fed coded porridges with energy densities of 0.5, 1.0 or 1.5 kcal/g, during three, four, or five meals/day. Complementary food intake was measured by weighing the feeding bowl before and after every meal. Results: Children consumed greater amounts of complementary foods per meal when they received diets with lower energy density and fewer meals per day. Greater time was expended per meal when fewer meals were offered. The time expended per meal did not vary with dietary energy density, but the children ate more and faster for the lower energy density diets. Conclusions: We conclude that the energy density and feeding frequency of complementary foods affect meal-specific food intake. Meal frequency also influences the duration of individual meals, but energy density does not. These results provide further evidence of young children’s ability to regulate their energy intakes, even during infancy, and convey information on factors that affect the amount of time that caregivers must devote to child feeding.
背景:婴儿和幼儿的适当喂养是必要的,以防止生长迟缓和优化健康在生命的头两年。关于膳食能量密度和辅食喂养频率对单餐期间的食物消耗和照料者在儿童喂养中花费的时间的影响的信息很少。方法:在9个独立的,随机排序的饮食周期中,每个周期持续3-6天,我们测量了18个健康的,母乳喂养的8-11个月大的儿童自测的半固体谷物粥的摄入量。这些婴儿在每天三餐、四餐或五餐期间被喂食能量密度为0.5、1.0或1.5千卡/克的编码粥。通过每餐前和餐后称重来测量辅食的摄入量。结果:当儿童每天接受低能量密度和少餐的饮食时,他们每餐消耗更多的辅食。当提供的食物较少时,每顿饭花费的时间就会更多。每餐所花费的时间与膳食能量密度无关,但对于能量密度较低的饮食,孩子们吃得更多、更快。结论:辅食的能量密度和喂养频次影响特定餐的食物摄取量。进餐频率也会影响每顿饭的持续时间,但能量密度不会。这些结果进一步证明,幼儿即使在婴儿期也有能力调节自己的能量摄入,并传达了影响照顾者必须投入儿童喂养时间的因素的信息。
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引用次数: 2
Social and individual influences on eating in preadolescents: the role of friends’ eating behaviours and individual anxiety and depression 社会和个人对青春期前饮食的影响:朋友饮食行为和个人焦虑和抑郁的作用
Pub Date : 2015-09-19 DOI: 10.12715/APR.2015.2.22
L. Houldcroft, E. Haycraft, C. Farrow
Background: Friends are important role models for the formation of social norms and behaviour comparisons, particularly in children. This study examined the similarities between pre-adolescent children’s own eating behaviours with the eating behaviours of those in their friendship group. It also evaluated whether symptoms of anxiety and depression were related to eating behaviours in this age group. Methods: Three hundred and forty three children (mean age 8.75 years) completed questionnaires designed to measure dietary restraint, emotional eating and external eating, as well as general and social anxiety, and symptoms of depression. Children also provided details about their friendship groups. Results: Pre-adolescents’ dietary restraint was positively predicted by the dietary restraint of members of their friendship groups, and their individual levels of anxiety and depression. The levels of general anxiety exhibited by pre-adolescents predicted emotional and external eating behaviours. Younger children were significantly more likely to report higher levels of emotional and external eating than older children, and boys were more likely to report more external eating behaviours than girls. Conclusions: These results suggest that greater dieting behaviours in pre-adolescents are related to their friends’ reports of greater dieting behaviours. In contrast, greater levels of eating governed by emotions, and eating in response to external hunger cues, are related to greater symptoms of anxiety in pre-adolescent children. Such findings underline the importance of friends’ social influences on dieting behaviours in this age group and highlight the value of targeting healthy eating and eating disorder prevention interventions at pre-adolescents.
背景:朋友是形成社会规范和行为比较的重要榜样,尤其是在儿童中。这项研究调查了青春期前儿童自己的饮食行为与他们的朋友群体的饮食行为之间的相似性。该研究还评估了该年龄组的焦虑和抑郁症状是否与饮食行为有关。方法:343名儿童(平均年龄8.75岁)完成了旨在测量饮食限制、情绪性饮食和外部饮食、一般焦虑和社交焦虑以及抑郁症状的问卷调查。孩子们还提供了他们朋友圈的细节。结果:青少年前期饮食限制与朋友群体成员的饮食限制、个体焦虑和抑郁水平呈正相关。青春期前表现出的一般焦虑水平可以预测情绪和外部饮食行为。年龄较小的孩子比年龄较大的孩子更有可能报告更高水平的情绪和外部饮食,男孩比女孩更有可能报告更多的外部饮食行为。结论:这些结果表明,青少年前期的节食行为与他们的朋友报告的更多的节食行为有关。相比之下,受情绪控制的饮食水平更高,以及对外部饥饿暗示的反应,与青春期前儿童更严重的焦虑症状有关。这些发现强调了朋友对这一年龄组饮食行为的社会影响的重要性,并强调了在青春期前针对健康饮食和饮食失调预防干预的价值。
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引用次数: 1
Community-based obesity prevention in Australia: Background, methods and recruitment outcomes for the evaluation of the effectiveness of OPAL (Obesity Prevention and Lifestyle) 澳大利亚以社区为基础的肥胖预防:OPAL(肥胖预防和生活方式)有效性评估的背景、方法和招募结果
Pub Date : 2015-09-01 DOI: 10.12715/apr.2015.2.23
E. Leslie, A. Magarey, Tim Olds, J. Ratcliffe, Michelle Jones, L. Cobiac
Background: The Obesity Prevention and Lifestyle (OPAL) intervention program targets families and communities to improve children’s eating and physical activity patterns. We outline the quantitative evaluation design and recruitment results for baseline data collection. Methods: A longitudinal quasi-experimental design, with baseline data collection and five-year follow-up. Participants targeted are children, parents, and school principals/directors from primary, secondary/R-12 schools, pre-schools, childcare and out-of-school-hours-care (OSHC) centers in 20 selected communities across South Australia (SA), and one in the Northern Territory (NT). A total of 277 (262 SA, 15 NT) schools participated; 4860 9-11 year olds and 1164 12-16 year olds completed a questionnaire. Anthropometric measures were taken from 5531 students; 6552 parents, 276 pre/school/childcare directors, 139 OSHC directors and 237 principals completed questionnaires. Data include measurements of child participants’ weight/height/waist circumference; paper-based/online surveys of informants in early childhood, primary/secondary school and community settings; and secondary growth check data for 4-5 year old children. Serial cross-sectional analyses will compare intervention to matched comparison communities. Results: Overall school response rate was 50%. Student response rates were 20-22% and 11-13% (questionnaires and measurements respectively); 14-21% of parents, 49-55% of directors, and 26-44% of principals completed and returned questionnaires. Changes to child weight status; eating practices; sleep, physical activity/sedentary behaviors; physical environments; community capacity; and economic evaluation (Quality Adjusted Life year gain) will examine program effectiveness. Conclusions: As the most significant program of its kind in Australia, OPAL will contribute to obesity prevention efforts on an international scale.
背景:肥胖预防和生活方式(OPAL)干预计划以家庭和社区为目标,改善儿童的饮食和身体活动模式。我们概述了基线数据收集的定量评估设计和招聘结果。方法:采用纵向准实验设计,基线数据收集和5年随访。参与者的目标是来自南澳大利亚州(SA)和北领地(NT)的20个选定社区的小学、中学/R-12学校、学前班、儿童保育和校外护理(OSHC)中心的儿童、家长和校长/主任。共有277所学校(南州262所,新界15所)参与;4860名9-11岁的孩子和1164名12-16岁的孩子完成了一份调查问卷。对5531名学生进行了人体测量;6552名家长、276名幼稚园主任、139名职安健中心主任及237名校长完成问卷。数据包括儿童参与者的体重/身高/腰围;对幼儿、小学/中学和社区环境中的举报人进行纸质/在线调查;4-5岁儿童二次生长检查数据。连续横断面分析将比较干预与匹配的比较社区。结果:学校总体反应率为50%。学生反应率分别为20-22%和11-13%(问卷调查和测量);14-21%的家长、49-55%的董事和26-44%的校长完成并上交了问卷。儿童体重状况的变化;饮食习惯;睡眠,身体活动/久坐行为;物理环境;社会能力;经济评估(质量调整生命年收益)将检查项目的有效性。结论:作为澳大利亚同类项目中最重要的项目,OPAL将在国际范围内为预防肥胖做出贡献。
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引用次数: 15
Chronic stunting among under-5 children in Bangladesh: A situation analysis 孟加拉国5岁以下儿童慢性发育迟缓:情况分析
Pub Date : 2015-08-01 DOI: 10.12715/apr.2015.2.18
A. Islam, T. Biswas
Malnutrition is a major problem in many developing countries, including Bangladesh. Chronic malnutrition is a major cause of mortality and morbidity among children under the age of five years. Although Bangladesh has made remarkable progress in reducing mortality in the under-fives, chronic stunting remains a formidable challenge for the country. Based on an analysis of available secondary data, this paper illustrates the current status of chronic stunting in Bangladesh. Data on selected relevant indicators such as gender, urban/rural residence, level of mother’s education, and income by wealth quintiles were extracted from the Bangladesh Health and Demography Surveys from 2004, 2007, and 2011. The data clearly suggest a strong relationship between selected socio-economic variables and stunting among children under the age of five. In rural areas, stunting prevalence rate was found to be more than six times higher than in urban areas. Income inequality was also a significant predictor of stunting. Children from the lowest wealth quintile are twice as likely to be stunted as children from the highest wealth quintile (54% of children under five in the lowest quintile compared to 27% of their counterparts in the highest wealth quintile). Similarly, the level of mother’s education is strongly related to stunting: the higher the level of mothers’ education, the lower the prevalence rate of stunting among children under five. Since wealth or income is a strong predictor of place of residence (urban/rural) as well as mothers’ level of education, it can be generally concluded that inequity is the primary determinant of stunting among children under five. Bangladesh must forcefully address inequity in order to tackle the overwhelming prevalence of stunting among children under five. Despite making impressive gains to improve major health and development indicators at the macro level, Bangladesh has so far failed to adequately address the underlying issue of inequity
营养不良是包括孟加拉国在内的许多发展中国家的一个主要问题。慢性营养不良是五岁以下儿童死亡和发病的一个主要原因。尽管孟加拉国在降低五岁以下儿童死亡率方面取得了显著进展,但慢性发育迟缓仍然是该国面临的巨大挑战。基于对现有二手数据的分析,本文阐述了孟加拉国慢性发育迟缓的现状。从2004年、2007年和2011年的孟加拉国卫生和人口调查中提取了性别、城市/农村居住、母亲教育水平和按财富五分位数划分的收入等选定相关指标的数据。数据清楚地表明,选定的社会经济变量与五岁以下儿童发育迟缓之间存在密切关系。在农村地区,发育迟缓患病率是城市地区的六倍多。收入不平等也是发育迟缓的重要预测因素。来自最低财富五分之一家庭的儿童发育迟缓的可能性是来自最高财富五分之一家庭的儿童的两倍(最低财富五分之一家庭的五岁以下儿童中有54%发育迟缓,而最高财富五分之一家庭的这一比例为27%)。同样,母亲的受教育程度与发育迟缓密切相关:母亲的受教育程度越高,5岁以下儿童发育迟缓的发生率就越低。由于财富或收入是居住地(城市/农村)以及母亲受教育水平的有力预测指标,因此一般可以得出结论,不平等是五岁以下儿童发育迟缓的主要决定因素。孟加拉国必须大力解决不平等问题,以解决五岁以下儿童发育迟缓的普遍问题。尽管在宏观层面上,孟加拉国在改善主要健康和发展指标方面取得了令人印象深刻的进展,但迄今未能充分解决不平等的根本问题
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引用次数: 26
Effects of two different memory training approaches in very preterm-born children 两种不同的记忆训练方法对早产儿的影响
Pub Date : 2015-05-25 DOI: 10.12715/APR.2015.2.13
R. Everts, M. Wapp, B. Ritter, W. Perrig, M. Steinlin
Background: Little research has been conducted to assess the effect of using memory training with schoolaged children who were born very preterm. This study aimed to determine whether two types of memory training approaches resulted in an improvement of trained functions and/or a generalization of the training effect to non-trained cognitive domains. Methods: Sixty-eight children born very preterm (7-12 years) were randomly allocated to a group undertaking memory strategy training (n=23), working memory training (n=22), or a waiting control group (n=23). Neuropsychological assessment was performed before and immediately after the training or waiting period, and at a six-month follow-up. Results: In both training groups, significant improvement of different memory domains occurred immediately after training (near transfer). Improvement of non-trained arithmetic performance was observed after strategy training (far transfer). At a six-month follow-up assessment, children in both training groups demonstrated better working memory, and their parents rated their memory functions to be better than controls. Performance level before the training was negatively associated with the training gain. Conclusions: These results highlight the importance of cognitive interventions, in particular the teaching of memory strategies, in very preterm-born children at early school age to strengthen cognitive performance and prevent problems at school.
背景:很少有研究评估对早产儿学龄儿童进行记忆训练的效果。本研究旨在确定两种类型的记忆训练方法是否导致训练功能的改善和/或将训练效果推广到未训练的认知领域。方法:68例早产儿(7 ~ 12岁)随机分为记忆策略训练组(n=23)、工作记忆训练组(n=22)和等待对照组(n=23)。在训练或等待期之前和之后立即进行神经心理学评估,并在六个月的随访中进行评估。结果:在两个训练组中,不同的记忆领域在训练后(接近迁移)立即出现显著改善。策略训练(远迁移)后,非训练的算术性能得到改善。在六个月的随访评估中,两个训练组的孩子都表现出更好的工作记忆,他们的父母认为他们的记忆功能比对照组好。训练前的表现水平与训练收益呈负相关。结论:这些结果强调了认知干预的重要性,特别是记忆策略的教学,在极早产儿童的早期学龄期加强认知表现和预防学校问题。
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引用次数: 5
Ethanol, Neurodevelopment, Infant and Child Health (ENRICH) prospective cohort: Study design considerations. 乙醇、神经发育、婴幼儿健康(ENRICH)前瞻性队列:研究设计考虑。
Pub Date : 2015-04-28 DOI: 10.12715/apr.2015.2.10
Ludmila N Bakhireva, Jean R Lowe, Hilda L Gutierrez, Julia M Stephen

Background: While intervention is the leading factor in reducing long-term disabilities in children with fetal alcohol spectrum disorder (FASD), early identification of children affected by prenatal alcohol exposure (PAE) remains challenging. Deficits in higher-order cognitive domains (e.g. executive function) might be more specific to FASD than global neurodevelopmental tests, yet these functions are not developed in very young children. Measures of early sensorimotor development may provide early indications of atypical brain development during the first two years of life.

Methods: This paper describes the novel methodology of the Ethanol, Neurodevelopment, Infant and Child Health (ENRICH) prospective cohort study of 120 maternal-infant pairs with a goal to identify early indices of functional brain impairment associated with PAE. The cohort is established by recruiting women early in pregnancy and classifying them into one of three study groups: patients on opioid-maintenance therapy who consume alcohol during pregnancy (Group 1), patients on opioid-maintenance therapy who abstain from alcohol during pregnancy (Group 2), and healthy controls (Group 3). After the initial prenatal assessment (Visit 1), patients are followed to Visit 2 occurring at delivery, and two comprehensive assessments of children at six (Visit 3) and 20 months (Visit 4) of age. ENRICH recruitment started in November 2013 and 87 women were recruited during the first year. During Year 1, the biospecimen (maternal whole blood, serum, urine, dry blood spots of a newborn) collection rate was 100% at Visit 1, and 97.6% for those who completed Visit 2.

Discussion: The tiered screening approach, evaluation of confounders, neurocognitive and magneto-/electro-encephalography (MEG/EEG) outcomes, and ethical considerations are discussed.

背景:虽然干预是减少胎儿酒精谱系障碍(FASD)儿童长期残疾的主要因素,但早期识别受产前酒精暴露(PAE)影响的儿童仍然具有挑战性。高阶认知领域(如执行功能)的缺陷可能比整体神经发育测试更适合FASD,但这些功能在非常年幼的儿童中并没有发展。早期感觉运动发育的测量可以提供生命头两年非典型大脑发育的早期迹象。方法:本文描述了一项针对120对母婴的乙醇、神经发育、婴儿和儿童健康(ENRICH)前瞻性队列研究的新方法,目的是确定与PAE相关的功能性脑损伤的早期指标。该队列是通过招募怀孕早期的妇女,并将她们分为三个研究组之一来建立的:接受阿片类药物维持治疗的妊娠期饮酒患者(第1组)、接受阿片类药物维持治疗的妊娠期戒酒患者(第2组)和健康对照者(第3组)。在初始产前评估(访1)后,随访患者至分娩时的访2,并在6个月(访3)和20个月(访4)时对儿童进行两次综合评估。2013年11月开始招募,第一年招募了87名女性。在第一年,生物标本(产妇全血、血清、尿液、新生儿干血斑)采集率在第一次访问时为100%,在第二次访问时为97.6%。讨论:讨论了分层筛选方法,混杂因素的评估,神经认知和磁/脑电图(MEG/EEG)结果,以及伦理考虑。
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引用次数: 19
Early assessment of oculomotor behavior in infants withbronchopulmonarydysplasia: A transversal study 支气管肺发育不良婴儿动眼力行为的早期评估:一项横向研究
Pub Date : 2015-01-01 DOI: 10.12715/apr.2015.2.16
S. Pereira, V. D. R. M. França, K. G. Sousa, Marcelo Fern, E. D. Costa
Background: In Brazil, where there are difficulties in accessing health services, the increasing number of comorbidities in preterm survivors diagnosed with bronchopulmonary dysplasia (BPD) necessitate the creation of a tool to effectively evaluate aspects of visual function in a short time. The objective of this study was to develop a simple protocol to evaluate the oculomotor system in newborns with BPD. Methods: Our study compared two groups of preterm-born infants: those who were oxygen-dependent for longer than 28 days were included in the BPD group (BG), while babies given oxygen for a maximum of 10 days were included in the premature group (PG). Exclusion criteria were: babies under mechanical ventilation and/or vasoactive drugs, those with intracranial hemorrhage, retinopathy of prematurity, motor and/or neurological malformation. Assessments were performed while the baby was comfortably seated and evaluated four eye movement types: saccadic movements (SAC), smooth pursuit (SP), vestibulo-ocular reflex (VOR), and optokinetic nystagmus (OKN). Results: Fifty-two infants were evaluated and of these, 22 were included in the BPD group and 30 in the premature group. Birth weight, gestational age and Apgar score at one and five minutes did not differ significantly between the two groups. Infants with BPD demonstrated the absence of three of the four eye movements types; according to a Chi-square test, this was statistically significant when compared with the premature group. Conclusions: The protocol considered in this study was sufficient to evaluate the oculomotor system in newborns diagnosed with BPD. Ocular motility in these infants was found to be impaired when compared to babies without a BPD diagnosis.
背景:在巴西,在获得保健服务方面存在困难,诊断为支气管肺发育不良(BPD)的早产儿幸存者的合共病越来越多,因此有必要创建一种工具,以便在短时间内有效评估视觉功能的各个方面。本研究的目的是制定一个简单的方案来评估新生儿BPD的动眼肌系统。方法:我们的研究比较了两组早产儿:那些氧气依赖超过28天的婴儿被纳入BPD组(BG),而给予氧气最多10天的婴儿被纳入早产儿组(PG)。排除标准为:使用机械通气和/或血管活性药物的婴儿、颅内出血、早产儿视网膜病变、运动和/或神经畸形的婴儿。在婴儿舒适的坐姿下进行评估,并评估四种眼球运动类型:眼跳运动(SAC)、平滑追踪(SP)、前庭眼反射(VOR)和光动性眼球震颤(OKN)。结果:对52例婴儿进行了评估,其中22例为BPD组,30例为早产儿组。出生体重、胎龄和1分钟和5分钟时的Apgar评分在两组之间没有显著差异。患有BPD的婴儿没有四种眼动类型中的三种;根据卡方检验,这与早产组相比具有统计学意义。结论:本研究中考虑的方案足以评估诊断为BPD的新生儿的动眼肌系统。与没有BPD诊断的婴儿相比,这些婴儿的眼球运动被发现受损。
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Advances in pediatric research
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