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Giant Lipoma in the Trapezius Muscle: A Rare Case Report. 斜方肌巨型脂肪瘤:罕见病例报告
Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae081
Javier Meza-Hernandez, Iván Gonzalez-Cantú, Ignacio Del Carmen-Ortega, Hernando Alberto Vázquez-Sánchez, Armando Guillermo Apellaniz-Campo

Intramuscular lipomas, although rare, are benign growths within muscle tissue. Typically occurring between ages 40 and 70, they present as infiltrative masses, with the thigh being the most common location. Lipomas exceeding 5 cm are termed giant lipomas. Instances within the trapezius muscle are notably scarce, necessitating further research due to their relative rarity. A 40-year-old male presented with a 2-year history of a tumor on his right shoulder, causing mild limitation but no pain or tingling. Initial attempts at removal failed due to depth. Imaging revealed a well-defined, vascular mass, confirmed by MRI as a 1041 cm3 intramuscular lipoma in the right trapezius muscle. Surgical extraction was successful without complications. Few cases of intramuscular lipomas in the trapezius muscle have been reported. These slow-growing masses can cause discomfort and mimic other conditions. MRI is crucial for accurate diagnosis, distinguishing them from other soft tissue tumors. Surgical excision is preferred for symptomat cases, with low recurrence rates. This case highlights a rare giant intramuscular lipoma in the trapezius muscle, emphasizing the importance of precise imaging for diagnosis. Further epidemiological research on intramuscular lipomas is needed, particularly in the trapezius muscle.

Level of evidence 5 therapeutic:

肌肉内脂肪瘤虽然罕见,但却是肌肉组织内的良性肿瘤。通常发生在 40 岁至 70 岁之间,表现为浸润性肿块,最常见的部位是大腿。超过 5 厘米的脂肪瘤被称为巨型脂肪瘤。斜方肌内的脂肪瘤很少见,因此有必要对其进行进一步研究。一名 40 岁的男性患者因右肩肿瘤就诊 2 年,肿瘤导致轻度活动受限,但无疼痛或刺痛感。由于肿瘤太深,最初的切除尝试失败了。影像学检查发现了一个轮廓清晰的血管性肿块,经核磁共振成像确认为右侧斜方肌内的 1041 立方厘米肌肉脂肪瘤。手术摘除成功,未出现并发症。关于斜方肌内脂肪瘤的报道很少。这些生长缓慢的肿块可引起不适,并可模拟其他疾病。核磁共振成像对准确诊断至关重要,可将其与其他软组织肿瘤区分开来。有症状的病例首选手术切除,复发率较低。本病例强调了斜方肌内巨大脂肪瘤的罕见性,强调了精确成像诊断的重要性。需要对肌肉内脂肪瘤进行进一步的流行病学研究,尤其是在斜方肌:
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引用次数: 0
The Impact of the Number and Duration of Treatments With a 1064 nm Diode Laser on Adipocyte Apoptosis: Implications for Noninvasive Fat Reduction Strategies. 1064 nm 二极管激光治疗的次数和持续时间对脂肪细胞凋亡的影响:对无创减脂策略的启示。
Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae082
Fares Salameh, Ariane Lazzarini, Jeffrey Kenkel, Yucel Akgul

Background: Noninvasive treatment with a 1064 nm diode laser, generating hypodermal temperatures between 42 and 47 °C, induces adipocyte cell death, offering a solution to reduce fat in problematic areas.

Objectives: The objective of the authors of this study is to determine whether a 15 min treatment provides similar efficacy as the standard 25 min treatment.

Methods: Pigs underwent a 15 or 25 min 1064 nm laser treatment on 6 × 6 cm areas of abdominal skin. Single treatments were administered 14 or 28 days before biopsy, whereas dual treatments were performed at both 14 and 28 days prebiopsy. Hematoxylin and TUNEL staining were used to detect histological changes and apoptosis in harvested skin tissue.

Results: Pig skin subjected to a 25 min diode laser treatment exhibited nearly twice the apoptotic counts in the hypodermis compared with the 15 min treatment (10.5 vs 5.7) at 28 days following treatment. The degree of apoptosis increased with time following the treatment, with nearly twice the apoptosis counts at 28 days than at 14 days following a single 25 min treatment (10.5 vs 5.8). When testing 1 vs 2 treatments, 2 treatments (28 and 14 days before harvesting the tissue) did not result in significantly higher apoptosis than 1 treatment 28 days before harvesting. Apoptosis was primarily localized to adipocytes in the hypodermis and the dermis/hypodermis junction. There were no adverse side effects in the animals.

Conclusions: The degree of apoptosis following a 1064 nm laser treatment was proportional to the treatment duration. The 25 min treatment produced significantly more apoptosis than the 15 min treatment. The process of apoptosis continued over several weeks.

Level of evidence 4 therapeutic:

背景:使用1064纳米二极管激光进行非侵入性治疗,产生42至47摄氏度的皮下温度,诱导脂肪细胞死亡,为减少问题部位的脂肪提供了一种解决方案:本研究作者的目的是确定 15 分钟的治疗是否与标准的 25 分钟治疗具有相似的疗效:方法:对猪腹部皮肤 6 × 6 厘米的区域进行 15 或 25 分钟的 1064 nm 激光治疗。单次治疗在活检前 14 天或 28 天进行,而双重治疗则在活检前 14 天和 28 天进行。采用苏木精和 TUNEL 染色法检测采集皮肤组织的组织学变化和凋亡情况:结果:接受 25 分钟二极管激光治疗的猪皮肤在治疗后 28 天时,皮下组织的凋亡数量几乎是接受 15 分钟治疗时的两倍(10.5 对 5.7)。凋亡程度随治疗后时间的延长而增加,单次 25 分钟治疗后 28 天的凋亡计数是 14 天的近两倍(10.5 对 5.8)。在测试 1 次处理与 2 次处理时,2 次处理(收获组织前 28 天和 14 天)的凋亡率并未显著高于收获组织前 28 天的 1 次处理。凋亡主要发生在真皮下和真皮/真皮交界处的脂肪细胞。动物没有出现不良副作用:结论:1064 nm 激光治疗后的细胞凋亡程度与治疗持续时间成正比。治疗 25 分钟产生的细胞凋亡明显多于治疗 15 分钟产生的细胞凋亡。凋亡过程持续了数周:
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引用次数: 0
Does the Webster's Triangle Preservation Really Matter? A Retrospective Analysis of the Low-to-Low Osteotomies in the Head of the Inferior Turbinates. 韦氏三角保留真的重要吗?下鼻甲头部低对低截骨术的回顾性分析。
Pub Date : 2024-09-20 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae079
Luis C Ishida, Matheus Guedes, Guilherme F F Alves, Julia O da Fonseca, Eduardo L Fonesca, Giulia G Takahashi, Rolf Gemperli

Background: Osteotomies are important maneuvers in the plastic surgeon's arsenal for the nasal dorsum treatment. However, there is a concern regarding a possible medialization of the inferior turbinate's heads and narrowing of the internal nasal valve if the Webster's triangle is not preserved.

Objectives: To analyze the mobilization of the inferior turbinates during primary rhinoplasty after lateral osteotomies.

Methods: This is a retrospective study in which we analyzed 37 patients who underwent very low-to-low osteotomies in our service, during primary rhinoplasties. Axial and coronal computed tomography scans were obtained, and preoperative and 6 months postoperative images were compared with Radiant DICOM Viewer software (Medixant, Poznan, Poland) in 3-dimensional multiplanar reconstruction.

Results: There were no statistically significant differences between preoperative and postoperative measurements of the lower turbinate's osseous bases, both in axial (P = .305) and coronal (P = .08) images.

Conclusions: Low-to-low osteotomies showed no medialization of the inferior turbinate's heads or narrowing of the internal nasal valve in this study.

Level of evidence 4 therapeutic:

背景:截骨术是整形外科医生治疗鼻背的重要手段。然而,如果不保留韦氏三角,下鼻甲头可能会内侧化,鼻内瓣也可能会变窄,这一点令人担忧:方法:这是一项回顾性研究:这是一项回顾性研究,我们分析了 37 名在我们的服务范围内接受过非常低至低截骨术的患者,他们都是在初级鼻整形术中接受过截骨术的。通过 Radiant DICOM Viewer 软件(波兰波兹南 Medixant 公司)进行三维多平面重建,对术前和术后 6 个月的图像进行比较:结果:下鼻甲骨基的术前和术后测量值在轴向图像(P = .305)和冠状图像(P = .08)上均无统计学差异:结论:在本研究中,低对低截骨术未显示下鼻甲头内侧化或鼻内瓣狭窄:
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引用次数: 0
New Insights Into Breast and Chest Wall Asymmetry in the Aesthetic Patient. 美容患者乳房胸壁不对称的新认识。
Pub Date : 2024-09-14 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae080
Farhad Hafezi, Abbas Kazemi Ashtiani, Mahdokht Azarbakhsh, Jaafari Ali, Soheila Naderi Gharegheshlagh

Background: Asymmetry, a prevalent phenomenon throughout the human body, prompts this retrospective study, in which the authors aim at discerning potential patterns in its manifestation. Building upon our previous investigations in which left-sided chest wall and pelvic bone width surpassed their right-sided counterparts, a hypothesis is formulated suggesting the likelihood of the right breast being narrower and longer compared with the left.

Objectives: Our objective in this study is to investigate the correlation between the left-sidedness phenomenon in the chest wall and breast shape and appearance, with the aim of understanding its potential impact on outcomes in breast aesthetic surgery.

Methods: A random selection of pictures from 600 female patients undergoing various aesthetic breast procedures formed the basis of this study. Exclusion criteria involved the elimination of 254 pictures with nonstandard photography. Horizontal and vertical parameters of breasts and chest walls were measured, and the results on both sides were systematically compared to validate our hypothesis.

Results: On the left side, the chest wall, the distance between the nipple and the midline, and that of the nipple and the anterior axillary line were significantly wider. Vertical measurements, including the sternal notch to the nipple, the clavicle to the nipple, and the clavicle to inferior breast distance, although longer, did not exhibit statistical significance.

Conclusions: Approximately 77% of patients displayed wider breasts and chest walls on the left side. However, this observed asymmetry did not yield a statistically significant impact on the length of the breasts.

Level of evidence 3 diagnostic:

背景:不对称,在整个人体普遍存在的现象,促使这一回顾性研究,其中作者旨在辨别其表现的潜在模式。根据我们之前的研究,左侧胸壁和骨盆骨宽度超过右侧胸壁和骨盆骨宽度,我们提出了一个假设,表明右侧乳房比左侧乳房更窄更长。目的:本研究的目的是探讨胸壁左侧现象与乳房形状和外观之间的关系,以了解其对乳房美容手术结果的潜在影响。方法:随机选取600名接受不同乳房美容手术的女性患者的照片作为本研究的基础。排除标准包括剔除254张非标准摄影照片。测量了乳房和胸壁的水平和垂直参数,并系统地比较了两侧的结果,以验证我们的假设。结果:左侧胸壁、乳头距中线、乳头距腋前线明显变宽。纵向测量,包括胸骨切迹到乳头,锁骨到乳头,锁骨到下乳房的距离,虽然更长,但没有统计学意义。结论:约77%的患者显示左侧乳房和胸壁较宽。然而,这种观察到的不对称并没有对乳房的长度产生统计学上的显著影响。3级诊断证据:
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引用次数: 0
Case Series: Therapeutic Combination of VoluDerm Radiofrequency Microneedling and Glycolic Acid Peel in Scaled-Up Concentrations. 病例系列:体积射频微针和按比例浓度的乙醇酸剥离的治疗组合。
Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae075
Alex Levenberg, Yuri Vinshtok, Amikam Gershonowitz

Background: Glycolic acid (GA) is an α-hydroxy peeling agent that causes controlled removal of the epidermis, with or without the dermis. Studies have shown the ability of GA to stimulate fibroblast proliferation, induce collagen synthesis, and decrease collagen degradation. The VoluDerm radiofrequency microneedling (RFMN; Pollogen, Tel Aviv, Israel) utilizes an array of microelectrodes to penetrate the epidermis and deliver energy to the skin. The controlled fractional thermal injury promotes neocollagenesis in the correction of skin laxity and wrinkle reduction. It was theorized that GA and VoluDerm could synergistically boost collagen production in combined treatment.

Objectives: Safety and efficacy of the combination treatment were investigated in patients seeking corrections of the age-related skin deteriorations.

Methods: Seven female patients (aged 42-70 years, Fitzpatrick II-IV) with photo- and chrono-damaged skin received 5 treatments of VoluDerm followed by the GA peel at increasing 30% to 70% concentrations.

Results: Clinical photography taken 6 months after the treatment demonstrated improvement in elasticity, wrinkling, roughness, pigmentation, erythema, and pore size across the entire treated group. Efficacy quantified by the physician and patients per 1 to 5 Global Aesthetic Improvement Scale was average 4.3 and 4.5, respectively. The treatments were tolerated well without preprocedural anesthesia. Skin phenomena observed after GA application were suggestive of the acid passing to deeper layers.

Conclusions: A novel combination of VoluDerm RFMN and GA at increased concentrations provided safe and effective synergy in the treatment of aging facial skin. Visible results demonstrated skin tightening, reduction of rhytidids, and improvement of the skin texture which may be a result of the combination.

Level of evidence 4:

背景:乙醇酸(GA)是一种α-羟基去皮剂,可有控制地去除表皮,也可不去除真皮。研究表明,GA 能刺激成纤维细胞增殖,诱导胶原蛋白合成,减少胶原蛋白降解。VoluDerm 射频微针疗法(RFMN;Pollogen,以色列特拉维夫)利用微电极阵列穿透表皮,向皮肤输送能量。受控的点阵热损伤可促进新胶原生成,从而矫正皮肤松弛和减少皱纹。据推测,在联合治疗中,GA 和 VoluDerm 能协同促进胶原蛋白的生成:目的:研究联合治疗的安全性和有效性:七名女性患者(年龄 42-70 岁,菲茨帕特里克 II-IV)的皮肤受到了光损伤和慢性损伤,她们在接受了 5 次 VoluDerm 治疗后,又接受了浓度从 30% 增加到 70% 的 GA 脱皮疗法:结果:治疗 6 个月后的临床照片显示,整个治疗组的皮肤弹性、皱纹、粗糙度、色素沉着、红斑和毛孔大小均有所改善。医生和患者按 1 至 5 分的全球美学改善量表量化的疗效分别为平均 4.3 分和 4.5 分。治疗过程无需术前麻醉,耐受性良好。使用 GA 后观察到的皮肤现象表明,酸性物质进入了深层:结论:VoluDerm RFMN 和 GA 的高浓度新组合在治疗面部皮肤老化方面提供了安全有效的协同作用。肉眼可见的结果表明皮肤收紧、皱纹减少、肤质改善,这可能是联合使用的结果:
{"title":"Case Series: Therapeutic Combination of VoluDerm Radiofrequency Microneedling and Glycolic Acid Peel in Scaled-Up Concentrations.","authors":"Alex Levenberg, Yuri Vinshtok, Amikam Gershonowitz","doi":"10.1093/asjof/ojae075","DOIUrl":"10.1093/asjof/ojae075","url":null,"abstract":"<p><strong>Background: </strong>Glycolic acid (GA) is an α-hydroxy peeling agent that causes controlled removal of the epidermis, with or without the dermis. Studies have shown the ability of GA to stimulate fibroblast proliferation, induce collagen synthesis, and decrease collagen degradation. The VoluDerm radiofrequency microneedling (RFMN; Pollogen, Tel Aviv, Israel) utilizes an array of microelectrodes to penetrate the epidermis and deliver energy to the skin. The controlled fractional thermal injury promotes neocollagenesis in the correction of skin laxity and wrinkle reduction. It was theorized that GA and VoluDerm could synergistically boost collagen production in combined treatment.</p><p><strong>Objectives: </strong>Safety and efficacy of the combination treatment were investigated in patients seeking corrections of the age-related skin deteriorations.</p><p><strong>Methods: </strong>Seven female patients (aged 42-70 years, Fitzpatrick II-IV) with photo- and chrono-damaged skin received 5 treatments of VoluDerm followed by the GA peel at increasing 30% to 70% concentrations.</p><p><strong>Results: </strong>Clinical photography taken 6 months after the treatment demonstrated improvement in elasticity, wrinkling, roughness, pigmentation, erythema, and pore size across the entire treated group. Efficacy quantified by the physician and patients per 1 to 5 Global Aesthetic Improvement Scale was average 4.3 and 4.5, respectively. The treatments were tolerated well without preprocedural anesthesia. Skin phenomena observed after GA application were suggestive of the acid passing to deeper layers.</p><p><strong>Conclusions: </strong>A novel combination of VoluDerm RFMN and GA at increased concentrations provided safe and effective synergy in the treatment of aging facial skin. Visible results demonstrated skin tightening, reduction of rhytidids, and improvement of the skin texture which may be a result of the combination.</p><p><strong>Level of evidence 4: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"6 ","pages":"ojae075"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Tranexamic Acid in Breast Reduction and Abdominoplasty: A Review of a Multicenter Federated Electronic Health Record Database. 氨甲环酸在乳房缩小术和腹壁成形术中的应用:多中心联合电子病历数据库回顾。
Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae077
Theodore E Habarth-Morales, Emily Isch, Alexander P Zavitsanos, Wesley M Wride, Harrison D Davis, Arturo J Rios-Diaz, Robyn B Broach, John P Fischer, Joseph M Serletti, Said C Azoury, Matthew Jenkins

Background: Tranexamic acid (TXA), a fibrinolysis inhibitor, is widely used in various surgical fields to minimize blood loss. However, its efficacy and safety in plastic surgery, especially in reduction mammaplasty and abdominoplasty, remain underexplored. This study investigates the utility of intravenous (IV) TXA in these procedures, focusing on reducing postoperative complications and evaluating its safety in the context of venous thromboembolism (VTE).

Objectives: To evaluate the efficacy and safety of TXA in reduction mammaplasty and abdominoplasty.

Methods: Using data from the TriNetX LLC (Cambridge, MA) National Health Research Network database, this retrospective study compared adult patients undergoing reduction mammaplasty or abdominoplasty who received intraoperative IV TXA against those who did not. Primary outcomes included postoperative seroma and hematoma incidences, whereas secondary outcomes assessed the necessity for procedural drainage and the occurrence of VTE within 1-year postsurgery.

Results: No significant differences in the rates or risks of hematoma, seroma, or the need for procedural drainage between patients administered IV TXA and those who were not, for both reduction mammaplasty and abdominoplasty. Additionally, IV TXA did not increase the risk of VTE in either patient group.

Conclusions: IV TXA application in reduction mammaplasty and abdominoplasty does not provide added benefits in reducing postoperative complications such as seroma, hematoma, or the necessity for procedural drainage. Furthermore, it does not alter the risk of thromboembolic events. These findings highlight the need for further research, particularly through randomized control trials, to understand TXA's efficacy in plastic surgery.

Level of evidence 3 therapeutic:

背景:氨甲环酸(TXA)是一种纤维蛋白溶解抑制剂,被广泛应用于各种外科领域以减少失血。然而,氨甲环酸在整形外科,尤其是乳房缩小整形术和腹部整形术中的有效性和安全性仍未得到充分探索。本研究调查了静脉注射 TXA 在这些手术中的作用,重点是减少术后并发症和评估其在静脉血栓栓塞(VTE)方面的安全性:评估TXA在乳房缩小整形术和腹部整形术中的有效性和安全性:这项回顾性研究利用 TriNetX LLC(马萨诸塞州剑桥市)国家健康研究网络数据库中的数据,比较了接受乳房缩小整形术或腹部整形术的成年患者术中静脉注射 TXA 的情况和未接受 TXA 的情况。主要结果包括术后血清肿和血肿发生率,次要结果评估术后引流的必要性和术后一年内 VTE 的发生率:在乳房缩小整形术和腹部整形术中,使用静脉注射 TXA 的患者和未使用静脉注射 TXA 的患者在血肿、血清肿和手术引流的发生率或风险方面没有明显差异。此外,静脉注射 TXA 不会增加两组患者发生 VTE 的风险:在乳房缩小成形术和腹部成形术中使用静脉注射 TXA 不会增加减少术后并发症(如血清肿、血肿或手术引流的必要性)的益处。此外,它也不会改变血栓栓塞事件的风险。这些发现强调了进一步研究的必要性,尤其是通过随机对照试验来了解TXA在整形手术中的疗效:
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引用次数: 0
Changes in Volume of Lips in 3-Dimensional Analysis and Projection of Lips in Sonography After Injection of Particle-Type Hyaluronic Acid Filler Utilizing a 9-Point Injection Technique. 利用9点注射技术注射颗粒型透明质酸填充剂后嘴唇三维分析和超声显像中体积的变化。
Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae076
Jong Seo Kim

Background: Lip augmentation procedure with hyaluronic acid (HA) fillers can make patients younger with more attractive. After the injection on the lips, the result is temporary. Physicians and patients wonder how long the HA filler last on the lips.

Objectives: The main goal of this study is to determine how much volume of HA is reduced after injection on the lips utilizing a "9-point" injection technique.

Methods: In this prospective study, 25 females were injected using HA filler and evaluated using noninvasive 3-dimensional-scanner analysis before, 1 h, 1 week, 1 month, 6 months, and 9 months after injection. The changes in projection of lips were evaluated using sonography. The patients were treated as usual manner in a single clinic. Using 29-gauge needle, 20 mg/mL of HA filler was injected into the lips. Default injection amount was 1 cc. HA filler was injected submucosally using linear thread and fanning technique.

Results: Twenty-three patients were followed up. The mean age was 34.8 years (range, 20-48 years). The volume of lips became 181.34% (±61.14) at 1 h, 91.18% (±10.12) at 1 week, 75.09% (±11.02) at 1 month, 55.36% (±10.48) at 6 months, and 39.21% (±4.54) at 9 months. The projection of upper lip areas increased 25.3% at 1 h, 22.8% at 1 week, 17.7% at 1 month, 14.8% at 6 months, 11.5% at 9 months in sonography. The projection of lower lip areas increased 23.1% at 1 h, 20.7% at 1 week, 15.9% at 1 month, 13.9% at 6 months, and 10.6% at 9 months in sonography.

Conclusions: Lip augmentation with HA showed improved shape during 9 months. The volume of HA decreased at a constant rate after injection, except for the first week. Injected HA was absorbed at a constant rate, and more than half was absorbed after 9 months utilizing a "9-point" injection technique.

Level of evidence 4 therapeutic:

背景:透明质酸(HA)填充的丰唇手术可以使患者更年轻,更有吸引力。在嘴唇上注射后,效果是暂时的。医生和病人都想知道HA填充物在嘴唇上能维持多久。目的:本研究的主要目的是确定使用“9点”注射技术在唇部注射后HA的体积减少了多少。方法:在这项前瞻性研究中,25名女性在注射前、注射后1小时、1周、1个月、6个月和9个月使用无创三维扫描仪分析注射HA填充剂并进行评估。用超声检查评价唇部投影的变化。患者在同一诊所接受常规治疗。用29号针将HA填充剂20 mg/mL注射到唇部。默认注射量为1cc。采用线性螺纹和扇形技术粘膜下注射HA填充剂。结果:23例患者随访。平均年龄34.8岁(20 ~ 48岁)。1 h时唇部体积为181.34%(±61.14),1周时为91.18%(±10.12),1个月时为75.09%(±11.02),6个月时为55.36%(±10.48),9个月时为39.21%(±4.54)。超声显示上唇面积在1小时、1周、1个月、6个月、9个月分别增加了25.3%、22.8%、17.7%、14.8%和11.5%。超声检查显示,下唇面积在1小时、1周、1个月、6个月和9个月时分别增加23.1%、20.7%、15.9%、13.9%和10.6%。结论:透明质酸丰唇术9个月后,唇形得到改善。除第一周外,注射后HA的体积均以恒定速率下降。注射的HA以恒定的速率被吸收,使用“9点”注射技术,9个月后吸收了一半以上。证据等级4:治疗性:
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引用次数: 0
A Preliminary Qualitative Analysis of women's Experiences With Vaginal Fractional CO2 Laser Treatments. 对女性阴道二氧化碳点阵激光治疗体验的初步定性分析。
Pub Date : 2024-09-03 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae074
Anne Nileshni Fernando, Christine Hamori, Jayson Oates, Gemma Sharp

Background: Menopause involves a range of bodily changes, with impacts on physical and psychological well-being. Around half of the postmenopausal women experience genitourinary syndrome of menopause (GSM). Fractional CO2 laser treatment can promote tissue regeneration in the vaginal wall to potentially assist with managing GSM. However, the results from clinical trials of this treatment have been mixed, and the personal perceptions and experiences of women receiving this treatment have been largely unexplored.

Objectives: To qualitatively explore the motivations and outcomes of women who have undergone vaginal fractional CO2 laser treatment.

Methods: Fourteen postmenopausal women were involved in the study. These women had undergone vaginal fractional CO2 laser treatment between 2 and 48 months earlier (M = 32.1, standard deviation = 14.9 months). Telephone interviews were conducted to explore women's motivations and their experiences after treatment. Interviews were recorded and transcribed verbatim. Deductive and inductive thematic analysis was conducted to analyze interviews.

Results: Analyses produced 4 major themes. First, motivations mostly revolved around participants seeking relief from menopausal symptoms. Second, some participants noted positive sexual outcomes, including improved sexual pleasure after treatment. Third, participants noted positive physical and psychological effects, including improvements in incontinence and overall confidence. Lastly, a subset of participants reported no discernible changes.

Conclusions: This novel qualitative exploration of women's motivations and outcomes of fractional CO2 laser therapy demonstrates the multifaceted impact of treatment. These findings highlight the importance of considering the holistic effects of fractional CO2 laser therapy on women's health during midlife, particularly amid menopausal changes.

Level of evidence 4:

背景:更年期涉及一系列身体变化,对生理和心理健康都有影响。大约一半的绝经后妇女会出现更年期泌尿生殖系统综合征(GSM)。点阵式二氧化碳激光治疗可促进阴道壁组织再生,从而有可能帮助控制更年期生殖泌尿综合症。然而,这种治疗方法的临床试验结果参差不齐,而接受这种治疗的妇女的个人看法和经历在很大程度上也未得到探讨:方法:14 位绝经后妇女接受了阴道点阵 CO2 激光治疗:14名绝经后妇女参与了研究。这些妇女在2至48个月前接受过阴道点阵二氧化碳激光治疗(中=32.1,标准差=14.9个月)。研究人员进行了电话访谈,以了解妇女接受治疗的动机和治疗后的感受。对访谈进行了录音和逐字记录。对访谈进行了演绎和归纳主题分析:分析产生了 4 大主题。首先,治疗动机主要是为了缓解更年期症状。第二,一些参与者注意到了积极的性结果,包括治疗后性快感的改善。第三,参与者注意到了积极的生理和心理影响,包括尿失禁和整体自信心的改善。最后,一部分参与者表示没有明显的变化:这项对女性接受点阵式 CO2 激光治疗的动机和结果进行的新颖定性探索表明了治疗的多方面影响。这些发现强调了考虑二氧化碳点阵激光疗法对中年女性健康的整体影响的重要性,尤其是在更年期变化中:
{"title":"A Preliminary Qualitative Analysis of women's Experiences With Vaginal Fractional CO<sub>2</sub> Laser Treatments.","authors":"Anne Nileshni Fernando, Christine Hamori, Jayson Oates, Gemma Sharp","doi":"10.1093/asjof/ojae074","DOIUrl":"https://doi.org/10.1093/asjof/ojae074","url":null,"abstract":"<p><strong>Background: </strong>Menopause involves a range of bodily changes, with impacts on physical and psychological well-being. Around half of the postmenopausal women experience genitourinary syndrome of menopause (GSM). Fractional CO<sub>2</sub> laser treatment can promote tissue regeneration in the vaginal wall to potentially assist with managing GSM. However, the results from clinical trials of this treatment have been mixed, and the personal perceptions and experiences of women receiving this treatment have been largely unexplored.</p><p><strong>Objectives: </strong>To qualitatively explore the motivations and outcomes of women who have undergone vaginal fractional CO<sub>2</sub> laser treatment.</p><p><strong>Methods: </strong>Fourteen postmenopausal women were involved in the study. These women had undergone vaginal fractional CO<sub>2</sub> laser treatment between 2 and 48 months earlier (<i>M</i> = 32.1, standard deviation = 14.9 months). Telephone interviews were conducted to explore women's motivations and their experiences after treatment. Interviews were recorded and transcribed verbatim. Deductive and inductive thematic analysis was conducted to analyze interviews.</p><p><strong>Results: </strong>Analyses produced 4 major themes. First, motivations mostly revolved around participants seeking relief from menopausal symptoms. Second, some participants noted positive sexual outcomes, including improved sexual pleasure after treatment. Third, participants noted positive physical and psychological effects, including improvements in incontinence and overall confidence. Lastly, a subset of participants reported no discernible changes.</p><p><strong>Conclusions: </strong>This novel qualitative exploration of women's motivations and outcomes of fractional CO<sub>2</sub> laser therapy demonstrates the multifaceted impact of treatment. These findings highlight the importance of considering the holistic effects of fractional CO<sub>2</sub> laser therapy on women's health during midlife, particularly amid menopausal changes.</p><p><strong>Level of evidence 4: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"6 ","pages":"ojae074"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Closed-Incision Negative Pressure Wound Therapy in Reducing Postoperative Complications in Breast Reconstruction After Radiotherapy: A Propensity Score Analysis. 闭合切口负压伤口疗法对减少放疗后乳房再造术后并发症的疗效:倾向得分分析
Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae073
Khaled O Alameddine, Cristina A Salinas, Maria Yan, Jorys Martinez-Jorge, Aparna Vijayasekaran, Nho V Tran, Christin A Harless

Background: Implant-based breast reconstruction following radiotherapy can lead to significant postoperative complications. Closed-incision negative pressure wound therapy (ciNPWT) has emerged as a potential intervention to reduce these complications.

Objectives: To assess the effectiveness of ciNPWT in reducing postoperative complications in patients undergoing implant-based breast reconstruction after radiotherapy.

Methods: A retrospective single-center cohort study was conducted, including patients who underwent implant-based breast reconstruction after mastectomy and radiotherapy between January 1, 2015, and December 31, 2022. We utilized a procedure-level analysis model with patients contributing distinct observations for multiple procedures. Our primary outcome measures included fluid collection, infection, and wound complications. Propensity score analysis was employed to adjust for potential confounders, such as BMI, smoking history, and diabetes history, creating a balanced comparison between the ciNPWT-treated and untreated groups.

Results: In our study of 301 breast reconstructions postradiotherapy from 2015 to 2022, encompassing 218 unique patients, we found significant benefits of ciNPWT. During an average of 2.2-year follow-up, the ciNPWT group demonstrated no infections, contrasting with a 10.4% rate in the non-ciNPWT group (P < .0001). Wound complications were also significantly lower in the ciNPWT group (1.9% vs 11.2%; P = .00848). Demographic differences were adjusted using inverse probability of treatment weights. The findings suggest ciNPWT's promising role in enhancing postoperative outcomes in breast reconstruction postradiotherapy.

Conclusions: Our study suggests that the use of ciNPWT in implant-based breast reconstruction postradiotherapy can potentially reduce postoperative complications. This intervention can improve patient outcomes and may offer cost-saving benefits in the long run.

Level of evidence 3 therapeutic:

背景:放疗后以植入物为基础的乳房重建可能导致严重的术后并发症。闭切口负压伤口疗法(ciNPWT)已成为减少这些并发症的潜在干预措施:评估闭切口负压伤口疗法在减少放疗后植入物乳房重建患者术后并发症方面的效果:我们进行了一项回顾性单中心队列研究,研究对象包括在 2015 年 1 月 1 日至 2022 年 12 月 31 日期间接受乳房切除术和放疗后植入式乳房重建术的患者。我们采用了一个程序级分析模型,患者可对多个程序提供不同的观察结果。我们的主要结果指标包括积液、感染和伤口并发症。我们采用倾向评分分析来调整潜在的混杂因素,如体重指数、吸烟史和糖尿病史,从而在接受 ciNPWT 治疗组和未接受治疗组之间进行平衡比较:从2015年到2022年,我们对301名放疗后乳房再造患者进行了研究,其中包括218名患者,我们发现ciNPWT具有显著疗效。在平均 2.2 年的随访期间,ciNPWT 组未发生感染,而非 ciNPWT 组的感染率为 10.4%(P < .0001)。ciNPWT 组的伤口并发症也明显较低(1.9% 对 11.2%;P = .00848)。人口统计学差异采用治疗权重的逆概率进行调整。研究结果表明,ciNPWT 有助于提高放疗后乳房再造的术后效果:我们的研究表明,在放疗后假体乳房重建中使用 ciNPWT 有可能减少术后并发症。从长远来看,这种干预措施可改善患者的预后,并可节约成本:
{"title":"Efficacy of Closed-Incision Negative Pressure Wound Therapy in Reducing Postoperative Complications in Breast Reconstruction After Radiotherapy: A Propensity Score Analysis.","authors":"Khaled O Alameddine, Cristina A Salinas, Maria Yan, Jorys Martinez-Jorge, Aparna Vijayasekaran, Nho V Tran, Christin A Harless","doi":"10.1093/asjof/ojae073","DOIUrl":"https://doi.org/10.1093/asjof/ojae073","url":null,"abstract":"<p><strong>Background: </strong>Implant-based breast reconstruction following radiotherapy can lead to significant postoperative complications. Closed-incision negative pressure wound therapy (ciNPWT) has emerged as a potential intervention to reduce these complications.</p><p><strong>Objectives: </strong>To assess the effectiveness of ciNPWT in reducing postoperative complications in patients undergoing implant-based breast reconstruction after radiotherapy.</p><p><strong>Methods: </strong>A retrospective single-center cohort study was conducted, including patients who underwent implant-based breast reconstruction after mastectomy and radiotherapy between January 1, 2015, and December 31, 2022. We utilized a procedure-level analysis model with patients contributing distinct observations for multiple procedures. Our primary outcome measures included fluid collection, infection, and wound complications. Propensity score analysis was employed to adjust for potential confounders, such as BMI, smoking history, and diabetes history, creating a balanced comparison between the ciNPWT-treated and untreated groups.</p><p><strong>Results: </strong>In our study of 301 breast reconstructions postradiotherapy from 2015 to 2022, encompassing 218 unique patients, we found significant benefits of ciNPWT. During an average of 2.2-year follow-up, the ciNPWT group demonstrated no infections, contrasting with a 10.4% rate in the non-ciNPWT group (<i>P</i> < .0001). Wound complications were also significantly lower in the ciNPWT group (1.9% vs 11.2%; <i>P</i> = .00848). Demographic differences were adjusted using inverse probability of treatment weights. The findings suggest ciNPWT's promising role in enhancing postoperative outcomes in breast reconstruction postradiotherapy.</p><p><strong>Conclusions: </strong>Our study suggests that the use of ciNPWT in implant-based breast reconstruction postradiotherapy can potentially reduce postoperative complications. This intervention can improve patient outcomes and may offer cost-saving benefits in the long run.</p><p><strong>Level of evidence 3 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"6 ","pages":"ojae073"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement in Early Scar Maturation by Nanofat Infiltration: Histological and Spectrophotometric Preliminary Results From a Split Scar-Controlled, Randomized, Double-Blinded Clinical Trial. 纳米脂肪渗透改善早期疤痕成熟:疤痕分割对照、随机、双盲临床试验的组织学和分光光度法初步结果。
Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.1093/asjof/ojae072
Lisa Ramaut, Linde Moonen, Maxim Geeroms, Gaelle Leemans, Ellen Peters, Ramses Forsyth, Jan Gutermuth, Moustapha Hamdi

Background: The regenerative properties of stromal vascular fraction (SVF) in wound healing and scar formation are a subject of increasing clinical interest.

Objectives: Although preclinical studies have confirmed the angiogenetic, proliferative, and antifibrotic properties of SVF, there is limited clinical evidence from randomized controlled clinical trials.

Methods: Twelve patients who underwent abdominoplasty were included in this clinical study. Nanofat was mechanically obtained intraoperatively and infiltrated intradermally in the sutured surgical wound, randomly assigned to either the left or the right side. The abdominal scar was evaluated with the Patient and Observer Scar Assessment Scale, whereas erythema and pigmentation were measured with a reflectance spectrophotometry device (Mexameter, Courage + Khazaka electronic GmbH, Köln,Germany). Histological analysis and electron scan microscopy of tissue biopsies were performed at 8 months.

Results: The treated side of the scar showed significantly less erythema at 3- and 6-month follow-ups, but this difference reduced after 12 months. Patients reported better scar scores at the 6-month follow-up with a significantly better color at the treated side. Observers reported better overall scar scores at the treated side at 3-, 6-, and 12-month follow-ups, with better vascularization, pigmentation, and thickness. There was no statistically significant difference in terms of histological analysis between the 2 groups. There was no difference in the occurrence of adverse events between both sides.

Conclusions: Infiltration of nanofat exhibited promising results in surgical scar maturation characterized by less erythema and better texture. More clinical trials with a larger sample size are warranted to better elucidate the possible benefits of SVF on surgical scar formation.

Level of evidence 5:

背景:基质血管成分(SVF)在伤口愈合和疤痕形成中的再生特性越来越受到临床关注:尽管临床前研究证实了 SVF 的血管生成、增殖和抗纤维化特性,但来自随机对照临床试验的临床证据却很有限:本临床研究纳入了 12 名接受腹部整形手术的患者。术中机械获取纳米脂肪,并在缝合的手术伤口处皮内浸润,随机分配到左侧或右侧。腹部疤痕采用患者和观察者疤痕评估量表进行评估,红斑和色素沉着则采用反射分光光度计(Mexameter,Courage + Khazaka electronic GmbH,德国科伦)进行测量。8 个月后对组织活检进行组织学分析和电子扫描显微镜检查:结果:在 3 个月和 6 个月的随访中,接受治疗的一侧疤痕红斑明显减少,但在 12 个月后这种差异缩小。在 6 个月的随访中,患者的疤痕评分较好,治疗侧的疤痕颜色明显更好。在 3 个月、6 个月和 12 个月的随访中,观察者报告治疗侧的疤痕总体评分更好,血管化、色素沉着和厚度也更好。在组织学分析方面,两组之间没有明显的统计学差异。结论:结论:纳米脂肪的渗入对手术疤痕的成熟具有良好的效果,其特点是红斑更少、质地更好。为了更好地阐明 SVF 对手术瘢痕形成可能带来的益处,有必要进行更多样本量更大的临床试验:
{"title":"Improvement in Early Scar Maturation by Nanofat Infiltration: Histological and Spectrophotometric Preliminary Results From a Split Scar-Controlled, Randomized, Double-Blinded Clinical Trial.","authors":"Lisa Ramaut, Linde Moonen, Maxim Geeroms, Gaelle Leemans, Ellen Peters, Ramses Forsyth, Jan Gutermuth, Moustapha Hamdi","doi":"10.1093/asjof/ojae072","DOIUrl":"10.1093/asjof/ojae072","url":null,"abstract":"<p><strong>Background: </strong>The regenerative properties of stromal vascular fraction (SVF) in wound healing and scar formation are a subject of increasing clinical interest.</p><p><strong>Objectives: </strong>Although preclinical studies have confirmed the angiogenetic, proliferative, and antifibrotic properties of SVF, there is limited clinical evidence from randomized controlled clinical trials.</p><p><strong>Methods: </strong>Twelve patients who underwent abdominoplasty were included in this clinical study. Nanofat was mechanically obtained intraoperatively and infiltrated intradermally in the sutured surgical wound, randomly assigned to either the left or the right side. The abdominal scar was evaluated with the Patient and Observer Scar Assessment Scale, whereas erythema and pigmentation were measured with a reflectance spectrophotometry device (Mexameter, Courage + Khazaka electronic GmbH, Köln,Germany). Histological analysis and electron scan microscopy of tissue biopsies were performed at 8 months.</p><p><strong>Results: </strong>The treated side of the scar showed significantly less erythema at 3- and 6-month follow-ups, but this difference reduced after 12 months. Patients reported better scar scores at the 6-month follow-up with a significantly better color at the treated side. Observers reported better overall scar scores at the treated side at 3-, 6-, and 12-month follow-ups, with better vascularization, pigmentation, and thickness. There was no statistically significant difference in terms of histological analysis between the 2 groups. There was no difference in the occurrence of adverse events between both sides.</p><p><strong>Conclusions: </strong>Infiltration of nanofat exhibited promising results in surgical scar maturation characterized by less erythema and better texture. More clinical trials with a larger sample size are warranted to better elucidate the possible benefits of SVF on surgical scar formation.</p><p><strong>Level of evidence 5: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"6 ","pages":"ojae072"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Aesthetic surgery journal. Open forum
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