B. Mańkowski, A. Osmola-Mańkowska, R. Olszański, A. Bielecki, P. Grala, K. Slowinski
In the past, vascular anomalies were divided into vascular malformations and vascular tumors. Radiotherapy was one of the leading methods of treatment for vascular malformations and infantile haemangiomas in the past and considered as harmless in those days. Many years later it turned out that management was not necessary and dan - gerous, even responsible for possible skin cancers appeared within areas exposed to radiotherapy in the future. The case report shows the presence of squamous cell carcinoma within the irradiated vascular malformation of the frontotemporal area in early childhood. The lesion was surgically removed, the defect was covered by split thick - ness skin graft. The histopathological evaluation confirmed the carcinoma as well as its complete resection. Assess - ing the adult patients with vascular anomaly one should be aware of possible radiation therapy for that malformation in the past, then the evaluation of the skin must be careful and focused on possible neoplasmatic lesions.
{"title":"Case report Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy","authors":"B. Mańkowski, A. Osmola-Mańkowska, R. Olszański, A. Bielecki, P. Grala, K. Slowinski","doi":"10.5114/PDIA.2012.32397","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32397","url":null,"abstract":"In the past, vascular anomalies were divided into vascular malformations and vascular tumors. Radiotherapy was one of the leading methods of treatment for vascular malformations and infantile haemangiomas in the past and considered as harmless in those days. Many years later it turned out that management was not necessary and dan - gerous, even responsible for possible skin cancers appeared within areas exposed to radiotherapy in the future. The case report shows the presence of squamous cell carcinoma within the irradiated vascular malformation of the frontotemporal area in early childhood. The lesion was surgically removed, the defect was covered by split thick - ness skin graft. The histopathological evaluation confirmed the carcinoma as well as its complete resection. Assess - ing the adult patients with vascular anomaly one should be aware of possible radiation therapy for that malformation in the past, then the evaluation of the skin must be careful and focused on possible neoplasmatic lesions.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88982767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Type A behavior (TAB) pattern is a complex of behavioral characteristics or a life style expressing exces sive vigilance, aggressiveness, excitability, inclination to compete and a feeling of time pressure and excessive respon sibility. It is known to be a risk parameter of somatic illnesses and affects the course of disease. Aim: To qualify the relation between TAB and acceptance of illness (AI) in a group of individuals with psoriasis. Material and methods: The sample included 60 patients with psoriasis. Patients were subjected to three testing meth ods: Framingham Type A Behavior Pattern Measure, Acceptance of Illness Scale and a personal survey. Results: The results show differences in the intensity of a typical subcomponent of TAB pattern, time urgency, between healthy women and diseased men and between women and men in the diseased group of people. Women, in com parison to men, are predisposed to time urgency regardless of their health condition. The clinical state of diseased people does not differentiate the level of TAB. In the group of women with psoriasis there is a negative correlation between a tendency to follow the TAB pattern and its subcomponent time urgency and AI. Diseased women with a lower AI have a higher predisposition to functioning according to TAB. Type A is related to functioning in the state of illness by AI. Conclusions: Type A behavior plays the role of a risk predictor in the investigated group, but its role as a risk pre dictor of psoriasis requires further research.
A型行为模式(Type A behavior, TAB)是一种行为特征或生活方式的综合体，表现为过度的警惕、攻击性、兴奋性、竞争倾向以及时间压力和过度的责任感。已知它是躯体疾病的一个危险参数，并影响疾病的进程。目的:探讨银屑病患者TAB与疾病接受度(AI)的关系。材料与方法:研究对象为60例银屑病患者。采用Framingham A型行为模式量表、疾病接受度量表和个人问卷三种测试方法对患者进行测试。结果:结果显示TAB模式的一个典型子成分，时间紧迫性的强度在健康女性和患病男性之间以及患病人群中女性和男性之间存在差异。与男子相比，无论健康状况如何，妇女都倾向于时间紧迫。患者的临床状态不能区分TAB的水平。在银屑病妇女组中，遵循TAB模式的倾向及其子成分时间紧迫性和AI之间存在负相关。根据TAB，低AI的患病女性有更高的功能倾向。A型与人工智能在疾病状态下的功能有关。结论:A型行为在被调查人群中具有风险预测因子的作用，但其对银屑病风险的预测作用有待进一步研究。
{"title":"Original paper Type A behavior in individuals with psoriasis as a determinant of acceptance of illness","authors":"M. Basińska, M. Drozdowska","doi":"10.5114/PDIA.2012.32390","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32390","url":null,"abstract":"Introduction: Type A behavior (TAB) pattern is a complex of behavioral characteristics or a life style expressing exces sive vigilance, aggressiveness, excitability, inclination to compete and a feeling of time pressure and excessive respon sibility. It is known to be a risk parameter of somatic illnesses and affects the course of disease. Aim: To qualify the relation between TAB and acceptance of illness (AI) in a group of individuals with psoriasis. Material and methods: The sample included 60 patients with psoriasis. Patients were subjected to three testing meth ods: Framingham Type A Behavior Pattern Measure, Acceptance of Illness Scale and a personal survey. Results: The results show differences in the intensity of a typical subcomponent of TAB pattern, time urgency, between healthy women and diseased men and between women and men in the diseased group of people. Women, in com parison to men, are predisposed to time urgency regardless of their health condition. The clinical state of diseased people does not differentiate the level of TAB. In the group of women with psoriasis there is a negative correlation between a tendency to follow the TAB pattern and its subcomponent time urgency and AI. Diseased women with a lower AI have a higher predisposition to functioning according to TAB. Type A is related to functioning in the state of illness by AI. Conclusions: Type A behavior plays the role of a risk predictor in the investigated group, but its role as a risk pre dictor of psoriasis requires further research.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84240545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sobjanek, I. Michajłowski, M. Malek, M. Zabłotna, A. Włodarkiewicz, R. Nowicki
Introduction: The incidence of non-melanoma skin cancer (NMSC) and melanoma is increasing rapidly in the Euro pean population. There are only a few reports about cutaneous malignancy in the elderly population. Aim: Epidemiological, clinical, histopathological and surgical treatment result analysis of skin cancers in patients over 75 years old. Material and methods: A group of 254 patients over 75 years old operated on during 2002-2006 in the Department of Dermatology, Venerology and Allergology of the Medical University of Gdansk was included in the study. Sex ratio F/M was 1.2. The average age was 81.1 years old. Results: Patients over 75 years old comprised 40% of all operated patients because of malignancy in the analyzed period. Non-melanoma skin cancer were diagnosed in 92.5% of cases, melanoma in 5.9%. Basal cell carcinoma (BCC) was the most common malignancy, diagnosed in 72% of the patients. The incidence of squamous cell carcinoma (SCC) was statistically significantly higher compared to the general population (20.5% vs. 10.9%; p = 0.0002). BCC/SCC ratio was 3.5. In 39 patients (16.6%) multiple NMSC were observed. Exposure to UV radiation was the most com mon (52%) risk factor of cutaneous malignancy. The local recurrence rate of NMSC was 5.51%. Conclusions: The incidence of skin cancers in the northern Polish population over 75 years old is increasing. The clin ical and histopathological profile of skin cancer in the elderly differs from the general population. Surgical treatment is safe and effective management in these cases.
简介:在欧洲人群中，非黑色素瘤皮肤癌(NMSC)和黑色素瘤的发病率正在迅速增加。关于老年人群皮肤恶性肿瘤的报道很少。目的:分析75岁以上皮肤癌患者的流行病学、临床、组织病理学及手术治疗结果。材料和方法:研究纳入格但斯克医科大学皮肤、性病和过敏症科2002-2006年间接受手术的75岁以上患者254例。性别比率F/M为1.2。平均年龄为81.1岁。结果:75岁以上患者占分析期内因恶性肿瘤手术患者的40%。非黑色素瘤皮肤癌确诊率为92.5%，黑色素瘤确诊率为5.9%。基底细胞癌(BCC)是最常见的恶性肿瘤，诊断率为72%。与普通人群相比，鳞状细胞癌(SCC)的发病率有统计学意义(20.5% vs. 10.9%;P = 0.0002)。BCC/SCC比值为3.5。39例(16.6%)患者出现多发性NMSC。紫外线照射是皮肤恶性肿瘤最常见的危险因素(52%)。局部复发率为5.51%。结论:波兰北部75岁以上人群皮肤癌发病率呈上升趋势。老年人皮肤癌的临床和组织病理学特征不同于一般人群。手术治疗是安全有效的治疗方法。
{"title":"Original paper Skin cancer in the elderly – epidemiological, clinical and surgical treatment analysis of 254 patients","authors":"M. Sobjanek, I. Michajłowski, M. Malek, M. Zabłotna, A. Włodarkiewicz, R. Nowicki","doi":"10.5114/PDIA.2012.32386","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32386","url":null,"abstract":"Introduction: The incidence of non-melanoma skin cancer (NMSC) and melanoma is increasing rapidly in the Euro pean population. There are only a few reports about cutaneous malignancy in the elderly population. Aim: Epidemiological, clinical, histopathological and surgical treatment result analysis of skin cancers in patients over 75 years old. Material and methods: A group of 254 patients over 75 years old operated on during 2002-2006 in the Department of Dermatology, Venerology and Allergology of the Medical University of Gdansk was included in the study. Sex ratio F/M was 1.2. The average age was 81.1 years old. Results: Patients over 75 years old comprised 40% of all operated patients because of malignancy in the analyzed period. Non-melanoma skin cancer were diagnosed in 92.5% of cases, melanoma in 5.9%. Basal cell carcinoma (BCC) was the most common malignancy, diagnosed in 72% of the patients. The incidence of squamous cell carcinoma (SCC) was statistically significantly higher compared to the general population (20.5% vs. 10.9%; p = 0.0002). BCC/SCC ratio was 3.5. In 39 patients (16.6%) multiple NMSC were observed. Exposure to UV radiation was the most com mon (52%) risk factor of cutaneous malignancy. The local recurrence rate of NMSC was 5.51%. Conclusions: The incidence of skin cancers in the northern Polish population over 75 years old is increasing. The clin ical and histopathological profile of skin cancer in the elderly differs from the general population. Surgical treatment is safe and effective management in these cases.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79876804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In the recent years the number of children with cow’s milk protein allergy (CMPA) presenting with aller gies to extensively hydrolyzed whey (eHF-W) and casein formulae (eHF-C) respectively has increased. Aim: To present the patient characteristics of children with CMPA who presented with allergic reactions to eHF-W and/or eHF-C used as part of an elimination diet. Material and methods: A retrospective study was carried out for a group of 65 selected from of 359 children (3 to 12 months) affected with CMPA and allergy to eHF. Results: 18.1% (65/359) and 7.8% (28/359) from the group presented with allergic reactions to eHF-W and eHF-C, respectively. An allergic reaction to eHF-C occurred in 43% of the patients from the group (28/65). IgE-mediated CMPA presented with one of the following clinical manifestations: atopic dermatitis (AD) 94%, gastrointestinal symptoms (GI) 47%, respiratory symptoms (RS) 44%, anaphylactic reactions (AR) 26%. Non-IgE-mediated CMPA, on the other hand, manifested with: AD 97%, GI 22%, RS 10% .The observations showed that all 31 from the non-IgE mediated CMPA group with GI and AD manifestations presented with symptoms of eHF-C allergy ( p = 0.001). In the IgE-medi ated CMPA ( n = 34) the following factors were statistically significant with relation to eHF-C allergy: CMPA mani festing with GI ( p = 0.014) and AD. The occurrence of AR in response to cow’s milk protein (CMP) decreased the prob ability of an eHF-C allergy ( p = 0.028) in a statistically significant way. Conclusions: Children with CMPA who presented with allergies to eHF-W and eHF-C had a higher frequency of clin ical manifestation with GI and AD.
{"title":"Original paper Patient characteristics of children with cow’s milk allergy presenting with an allergy to extensively hydrolyzed whey and/or casein formulae used as part of an elimination diet","authors":"Z. Nowacki","doi":"10.5114/PDIA.2012.32389","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32389","url":null,"abstract":"Introduction: In the recent years the number of children with cow’s milk protein allergy (CMPA) presenting with aller gies to extensively hydrolyzed whey (eHF-W) and casein formulae (eHF-C) respectively has increased. Aim: To present the patient characteristics of children with CMPA who presented with allergic reactions to eHF-W and/or eHF-C used as part of an elimination diet. Material and methods: A retrospective study was carried out for a group of 65 selected from of 359 children (3 to 12 months) affected with CMPA and allergy to eHF. Results: 18.1% (65/359) and 7.8% (28/359) from the group presented with allergic reactions to eHF-W and eHF-C, respectively. An allergic reaction to eHF-C occurred in 43% of the patients from the group (28/65). IgE-mediated CMPA presented with one of the following clinical manifestations: atopic dermatitis (AD) 94%, gastrointestinal symptoms (GI) 47%, respiratory symptoms (RS) 44%, anaphylactic reactions (AR) 26%. Non-IgE-mediated CMPA, on the other hand, manifested with: AD 97%, GI 22%, RS 10% .The observations showed that all 31 from the non-IgE mediated CMPA group with GI and AD manifestations presented with symptoms of eHF-C allergy ( p = 0.001). In the IgE-medi ated CMPA ( n = 34) the following factors were statistically significant with relation to eHF-C allergy: CMPA mani festing with GI ( p = 0.014) and AD. The occurrence of AR in response to cow’s milk protein (CMP) decreased the prob ability of an eHF-C allergy ( p = 0.028) in a statistically significant way. Conclusions: Children with CMPA who presented with allergies to eHF-W and eHF-C had a higher frequency of clin ical manifestation with GI and AD.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73548948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Witmanowski, E. Lewandowicz, Daria Sobieszek, Magdalena Łuczkowska, J. Rykala
Introduction: Tuberosity of the nose is a slow, progressive, gentle process, leading to distortion and dysfunction of the nose. Underlying the change is perifollicular hypertrophy of the sebaceous glands, fibrous tissue proliferation and vascular changes of telangiectasia type. It is believed that it is the final stage of rosacea. Aim: To evaluate the effectiveness of surgical treatment using the method of tangential shear, based on a medical examination and subjective assessment of the effects of treatment by the patient. Material and methods: In the years 1998 to 2008 nine patients with moderate degree of rhinophyma were treated surgically by tangential shear, followed by electrocoagulation. The results were assessed according to a 4-point scale as very good, good, fair and poor. We evaluated the presence of postoperative complications (bleeding, infection, or other), healing time, the shape of the nose (size and symmetry), improved patency, reduction in the number of inflammatory conditions, widening of the field of view and long-term effects of treatment: disfiguring scars, uneven surface of the nose, nasal deformity and recurrence. Results: Among the 9 patients studied in 2 cases a very good result was achieved, in 5 good and in 2 satisfactory; no poor result was observed. Healing took an average of 6 weeks (1-15 weeks). None of the patients had postoper ative complications. Seven patients were satisfied with both the size and symmetry of the nose, one unsatisfied with the size and 1 dissatisfied with the symmetry. Following the operation, 1 patient had disfiguring scars, 3 uneven sur face of the nose, nasal deformity was observed in 2 cases and there was 1 recurrence. Of the 2 patients with a sat isfactory result, 1 has been re-operated on, while the other was set an additional term of treatment. Conclusions: Surgical treatment of nasal tuberosity by tangential shear followed by electrocoagulation is effective, and burdened by low rates of complications. To achieve a good aesthetic and functional effect, a very experienced operator is recommended.
{"title":"Original paper Evaluation of surgical treatment of rhinophyma with tangential shear of the lesion","authors":"H. Witmanowski, E. Lewandowicz, Daria Sobieszek, Magdalena Łuczkowska, J. Rykala","doi":"10.5114/PDIA.2012.32387","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32387","url":null,"abstract":"Introduction: Tuberosity of the nose is a slow, progressive, gentle process, leading to distortion and dysfunction of the nose. Underlying the change is perifollicular hypertrophy of the sebaceous glands, fibrous tissue proliferation and vascular changes of telangiectasia type. It is believed that it is the final stage of rosacea. Aim: To evaluate the effectiveness of surgical treatment using the method of tangential shear, based on a medical examination and subjective assessment of the effects of treatment by the patient. Material and methods: In the years 1998 to 2008 nine patients with moderate degree of rhinophyma were treated surgically by tangential shear, followed by electrocoagulation. The results were assessed according to a 4-point scale as very good, good, fair and poor. We evaluated the presence of postoperative complications (bleeding, infection, or other), healing time, the shape of the nose (size and symmetry), improved patency, reduction in the number of inflammatory conditions, widening of the field of view and long-term effects of treatment: disfiguring scars, uneven surface of the nose, nasal deformity and recurrence. Results: Among the 9 patients studied in 2 cases a very good result was achieved, in 5 good and in 2 satisfactory; no poor result was observed. Healing took an average of 6 weeks (1-15 weeks). None of the patients had postoper ative complications. Seven patients were satisfied with both the size and symmetry of the nose, one unsatisfied with the size and 1 dissatisfied with the symmetry. Following the operation, 1 patient had disfiguring scars, 3 uneven sur face of the nose, nasal deformity was observed in 2 cases and there was 1 recurrence. Of the 2 patients with a sat isfactory result, 1 has been re-operated on, while the other was set an additional term of treatment. Conclusions: Surgical treatment of nasal tuberosity by tangential shear followed by electrocoagulation is effective, and burdened by low rates of complications. To achieve a good aesthetic and functional effect, a very experienced operator is recommended.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81527553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Malek, H. Majewska, R. Nowicki, J. Roszkiewicz, W. Biernat
Acquired ichthyosis is a known paraneoplastic sign of lymphoproliferative malignancies, but ichthyosiform eruption can also constitute a rare atypical variant of mycosis fungoides. Ichthyosiform mycosis fungoides differs from acquired ichthyosis associated with mycosis fungoides in histopathology. Histological pictures of paraneoplastic ichthyosis usually do not show any aspect related to malignancy in the skin. In both cases thinning of the granular layer and decrease of filaggrin in that layer are observed. We describe here 2 patients with mycosis fungoides, who were treat ed in the Department of Dermatology, the first one with ichthyosiform mycosis fungoides and the other one with acquired ichthyosis with coexisting mycosis fungoides.
{"title":"Ichthyosis as a paraneoplastic syndrome and atypical variant of mycosis fungoides: two cases report","authors":"M. Malek, H. Majewska, R. Nowicki, J. Roszkiewicz, W. Biernat","doi":"10.5114/PDIA.2012.32396","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32396","url":null,"abstract":"Acquired ichthyosis is a known paraneoplastic sign of lymphoproliferative malignancies, but ichthyosiform eruption can also constitute a rare atypical variant of mycosis fungoides. Ichthyosiform mycosis fungoides differs from acquired ichthyosis associated with mycosis fungoides in histopathology. Histological pictures of paraneoplastic ichthyosis usually do not show any aspect related to malignancy in the skin. In both cases thinning of the granular layer and decrease of filaggrin in that layer are observed. We describe here 2 patients with mycosis fungoides, who were treat ed in the Department of Dermatology, the first one with ichthyosiform mycosis fungoides and the other one with acquired ichthyosis with coexisting mycosis fungoides.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88341297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rutkowski, K. Rutkowski, Joanna Rutkowska-Talipska, P. Sowa, S. Sułkowski
A b s t r a c t Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Syn thetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. There fore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, aller gic rhinitis and atopic dermatitis.
{"title":"Review paper Vitamin C: is it time to re-evaluate its role in health and disease?","authors":"R. Rutkowski, K. Rutkowski, Joanna Rutkowska-Talipska, P. Sowa, S. Sułkowski","doi":"10.5114/PDIA.2012.32394","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32394","url":null,"abstract":"A b s t r a c t Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Syn thetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. There fore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, aller gic rhinitis and atopic dermatitis.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89038872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Żukiewicz-Sobczak, E. Krasowska, J. Zwoliński, P. Sobczak, J. Chmielewska-Badora, P. Wróblewska, J. Piątek, A. Wojtyła
Allergic diseases are very common in developed countries, particularly among children, adolescents and young adults. Currently, allergies are being considered as an epidemic of the 21 st century. According to the Polish Society of Aller - gology, the percentage of adults suffering from asthma in our country is 5.4%, and in children 10%. The authors describe current knowledge regarding the pathomechanism, incidence, epidemiology and diagnostics of the most common sig - nificant allergic diseases, including allergic rhinitis, asthma, allergic conjunctivitis, atopic dermatitis and urticaria. One of the most common allergic diseases is allergic rhinitis, which is the result of an allergic inflammation of the nasal mucosa mediated by immunoglobulin E. Asthma is a lifelong chronic inflammatory disorder of the airways associat - ed with a variety of structural changes occurring in children and adults of all ages. This disease is characterized by bronchial hyperreactivity and obstruction which often disappear either spontaneously or with treatment. Atopic der - matitis is a chronic and relapsing inflammatory skin disease with a varying clinical spectrum, and may often play the role of the first stage of the atopic march. Urticaria is a heterogeneous group of diseases, characterized by the pres - ence of wheals and/or angioedema. The mainstay of allergy diagnosis is in vivo and in vitro testing. In vivo testing includes skin prick tests, prick-by-prick tests, atopy patch tests and also skin application skin test. In vitro testing includes mea - surement of serum total and antigen-specific IgE using various methods. During the last years, also component-resolved diagnostics have gained growing importance as a useful tool in clinical investigation of IgE-mediated allergies.
{"title":"Review paper Allergic diseases – current state of knowledge","authors":"W. Żukiewicz-Sobczak, E. Krasowska, J. Zwoliński, P. Sobczak, J. Chmielewska-Badora, P. Wróblewska, J. Piątek, A. Wojtyła","doi":"10.5114/PDIA.2012.32393","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32393","url":null,"abstract":"Allergic diseases are very common in developed countries, particularly among children, adolescents and young adults. Currently, allergies are being considered as an epidemic of the 21 st century. According to the Polish Society of Aller - gology, the percentage of adults suffering from asthma in our country is 5.4%, and in children 10%. The authors describe current knowledge regarding the pathomechanism, incidence, epidemiology and diagnostics of the most common sig - nificant allergic diseases, including allergic rhinitis, asthma, allergic conjunctivitis, atopic dermatitis and urticaria. One of the most common allergic diseases is allergic rhinitis, which is the result of an allergic inflammation of the nasal mucosa mediated by immunoglobulin E. Asthma is a lifelong chronic inflammatory disorder of the airways associat - ed with a variety of structural changes occurring in children and adults of all ages. This disease is characterized by bronchial hyperreactivity and obstruction which often disappear either spontaneously or with treatment. Atopic der - matitis is a chronic and relapsing inflammatory skin disease with a varying clinical spectrum, and may often play the role of the first stage of the atopic march. Urticaria is a heterogeneous group of diseases, characterized by the pres - ence of wheals and/or angioedema. The mainstay of allergy diagnosis is in vivo and in vitro testing. In vivo testing includes skin prick tests, prick-by-prick tests, atopy patch tests and also skin application skin test. In vitro testing includes mea - surement of serum total and antigen-specific IgE using various methods. During the last years, also component-resolved diagnostics have gained growing importance as a useful tool in clinical investigation of IgE-mediated allergies.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83668132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prophylaxis and therapy of keloids present a big challenge for medicine, despite the increasing knowledge about their pathogenesis. There are a lot of therapeutic methods but their effectiveness is still limited and unsatisfacto ry. These methods are divided into surgical, pharmacological and physical ones as well as the most frequently applied combined therapy, which is the most effective one. A surgical way of removing keloids is becoming less common and the method of intralesional application of steroids still remains the treatment of choice. In addition to the above there are cryotherapy, laser therapy, pressure therapy, X-ray irradiation and silicone products in a form of gels and dressings. Relatively new methods are intralesional injections of verapamil and 5-fluorouracil. Enalapril and trogli tazone, which are currently used in the treatment of hypertension and diabetes, are expected to be of use as well. Biological drugs like monoclonal antibodies against tumor growth factor (TGF)- β1, TGF- β2 and vascular endothelial growth factor and analogues of TGF- β3 are also potential solutions in the treatment of keloids. Further studies on the treatment of keloids should result in more efficient therapies.
{"title":"Review paper Keloids: current prophylactic and therapeutic methods","authors":"Wojciech Bienias, A. Kaszuba","doi":"10.5114/PDIA.2012.32392","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32392","url":null,"abstract":"Prophylaxis and therapy of keloids present a big challenge for medicine, despite the increasing knowledge about their pathogenesis. There are a lot of therapeutic methods but their effectiveness is still limited and unsatisfacto ry. These methods are divided into surgical, pharmacological and physical ones as well as the most frequently applied combined therapy, which is the most effective one. A surgical way of removing keloids is becoming less common and the method of intralesional application of steroids still remains the treatment of choice. In addition to the above there are cryotherapy, laser therapy, pressure therapy, X-ray irradiation and silicone products in a form of gels and dressings. Relatively new methods are intralesional injections of verapamil and 5-fluorouracil. Enalapril and trogli tazone, which are currently used in the treatment of hypertension and diabetes, are expected to be of use as well. Biological drugs like monoclonal antibodies against tumor growth factor (TGF)- β1, TGF- β2 and vascular endothelial growth factor and analogues of TGF- β3 are also potential solutions in the treatment of keloids. Further studies on the treatment of keloids should result in more efficient therapies.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75930087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Shahneh, Zohreh Babalo, B. Baradaran, Koushan Sineh Sepehr
Behcet’s disease is a chronic relapsing multi-organ inflammatory disorder characterized as a triad of oral and gen ital ulcers, uveitis. Characteristic manifestations of Behcet’s disease are joints, skin, central nervous system and gas trointestinal tract involvement. Behcet’s disease has a complicated genetic etiology. However, epidemiological stud ies recommend that genetic factors have a significant role in its pathogenesis, the same as other autoinflammatory disorders. Antigenic stimuli, antigen-presenting cells, T cells, monocyte, neutrophil and endothelial cells are most important parts of the pathology of the disease. Inflammatory response was triggered by an infectious agent in a genetically susceptible host. Understanding the pathogenesis based on the molecular mechanism of the disease highlights the new therapeutic modalities. Enhanced inflammatory activity and over-expression of proinflammato ry cytokines are the striking features of Behcet’s disease, and they are accordant with the result in other auto inflam matory disorders. Moreover, there is evidence of antigen-driven immune response in Behcet’s disease, but it prob ably advances in further innate immune reactivity. New therapeutic modalities target specific and nonspecific suppression of the immune system. The diagnosis is a clinical one, and although there is no single laboratory test enough for the diagnosis of Behcet’s disease. In this paper, a new aspect of the studies on genetic susceptibility, immunopathogenesis of Behcet’s disease and novel treatment modalities will be discussed.
{"title":"Review paper Insights into Behçet’s disease","authors":"Fatemeh Shahneh, Zohreh Babalo, B. Baradaran, Koushan Sineh Sepehr","doi":"10.5114/PDIA.2012.32395","DOIUrl":"https://doi.org/10.5114/PDIA.2012.32395","url":null,"abstract":"Behcet’s disease is a chronic relapsing multi-organ inflammatory disorder characterized as a triad of oral and gen ital ulcers, uveitis. Characteristic manifestations of Behcet’s disease are joints, skin, central nervous system and gas trointestinal tract involvement. Behcet’s disease has a complicated genetic etiology. However, epidemiological stud ies recommend that genetic factors have a significant role in its pathogenesis, the same as other autoinflammatory disorders. Antigenic stimuli, antigen-presenting cells, T cells, monocyte, neutrophil and endothelial cells are most important parts of the pathology of the disease. Inflammatory response was triggered by an infectious agent in a genetically susceptible host. Understanding the pathogenesis based on the molecular mechanism of the disease highlights the new therapeutic modalities. Enhanced inflammatory activity and over-expression of proinflammato ry cytokines are the striking features of Behcet’s disease, and they are accordant with the result in other auto inflam matory disorders. Moreover, there is evidence of antigen-driven immune response in Behcet’s disease, but it prob ably advances in further innate immune reactivity. New therapeutic modalities target specific and nonspecific suppression of the immune system. The diagnosis is a clinical one, and although there is no single laboratory test enough for the diagnosis of Behcet’s disease. In this paper, a new aspect of the studies on genetic susceptibility, immunopathogenesis of Behcet’s disease and novel treatment modalities will be discussed.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81971281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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