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Rare skin tumours in organ transplant recipients 器官移植受者罕见的皮肤肿瘤
Pub Date : 2020-01-01 DOI: 10.5114/ADA.2020.102100
B. Imko‐Walczuk, Joanna Renczyńska-Matysko, D. Kadylak, A. Dębska-Ślizień
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引用次数: 0
Mutation in the KRT1 gene causing epidermolysis bullosa simplex KRT1基因突变引起单纯大疱性表皮松解症
Pub Date : 2020-01-01 DOI: 10.5114/ada.2020.93443
Katarzyna Osipowicz, K. Wertheim-Tysarowska, E. Jankowska, M. Gos, A. Charzewska, K. Woźniak, C. Kowalewski
{"title":"Mutation in the KRT1 gene causing epidermolysis bullosa simplex","authors":"Katarzyna Osipowicz, K. Wertheim-Tysarowska, E. Jankowska, M. Gos, A. Charzewska, K. Woźniak, C. Kowalewski","doi":"10.5114/ada.2020.93443","DOIUrl":"https://doi.org/10.5114/ada.2020.93443","url":null,"abstract":"","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77616782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7 B7家族分子在口腔鳞状细胞癌中的作用:系统综述。第二部分:B7-1、B7-2、B7-H2、B7-H3、B7-H4、B7-H5 (VISTA)、B7-H6和B7-H7
Pub Date : 2020-01-01 DOI: 10.5114/ada.2020.98523
A. Starzyńska, A. Sejda, Ł. Adamski, P. Adamska, R. Pęksa, M. Sakowicz-Burkiewicz, P. Wychowański, B. Jereczek-Fossa
Introduction: The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases. Aim: To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression. Material and methods: A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review. Results: The biggest study group consisted of 201 patients and the smallest – 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies. Conclusions: The data presented indicate the complexity of cellular and molecular processes related to the forma-tion, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma. -1722C/T, -1661A/G, -1661G/G, -1661A/A and -318C/T the promoter region, 49A/G in exon 1, and CT60A/G in the 3’untrans-lated Genotypes:
口腔最常见的恶性肿瘤是鳞状细胞癌。它占该地区恶性病变的95%以上,其特点是迅速扩散和远处转移。目的:收集和回顾B7家族蛋白在口腔鳞状细胞癌中作为预后因素的数据,并描述其在侵袭性疾病进展中的作用。材料和方法:按照系统评价和荟萃分析(PRISMA)指南,对B7-1、B7-2、B7-H2、B7-H3、B7-H4、B7-H5 (VISTA)、B7-H6和B7-H7的文献进行系统综述。在2020年5月22日之前发表的9篇文章被纳入系统评价。结果:最大研究组201例,最小研究组40例。B7-1、B7-H3、B7-H4、B7-H5、B7-H6、B7-H7蛋白表达是影响预后的因素。总生存率与B7-H3、B7-H5、B7-H6、B7-H7显著相关。所有研究均采用免疫组织化学诊断方法。结论:这些数据表明,与口腔癌的形成、发展和侵袭相关的细胞和分子过程是复杂的。B7家族编码基因的突变和B7蛋白通路的改变可能影响口腔鳞状细胞癌患者的生存预后。-1722C/T, -1661A/G, -1661G/G, -1661A/A和-318C/T启动子区域,1外显子49A/G和3 '非翻译基因型的CT60A/G:
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引用次数: 1
Relationship between quality of life and anxiety aspects in chronic spontaneous urticaria 慢性自发性荨麻疹患者生活质量与焦虑的关系
Pub Date : 2019-01-01 DOI: 10.5114/ADA.2019.85811
A. Oles-Krykowska, K. Badura-Brzoza, Z. Brzoza
Abst rac t Introduction: Clinical experience indicates the role of the psychological component in chronic spontaneous urticaria (CSU). The CSU can lead to psychological disturbances. This phenomenon results in a possible quality of life impairment among CSU patients. Aim: To analyse in detail the quality of life parameters and anxiety aspects in relation to CSU duration and symptom intensity. Material and methods: The patient sample was composed of 67 CSU subjects. For the quality of life and mental status assessment, all subjects were questionnaired with CU-Q 2oL and State and Trait Anxiety Inventory (STAI). In the control group, 42 healthy volunteers were enrolled to fill in the STAI questionnaire. The Urticaria Activity Score (UAS) was used to assess disease activity. Results: We observed greater intensity of anxiety as a state and as a trait in CSU patients and greater intensity of anxiety as a state due to increasing patients’ age. The CU-Q 2oL Itching subscale was significantly impaired as a result of the intensity of the UAS scale. The Swelling/Mental status subscale was related to anxiety as a state and as a trait. Additionally, we noticed a greater quality of life impairment in subjects with longer disease duration. Conclusions: Our results prove that CSU results in a significant quality of life impairment. This phenomenon particularly concerns patients with longer disease duration time. As anxiety is a relatively frequent disturbance and negatively influences quality of life, we should identify these patients and monitor this parameter especially in older patients.
摘要:临床经验表明心理因素在慢性自发性荨麻疹(CSU)中的作用。犯罪现场调查组会导致心理障碍。这种现象可能导致CSU患者的生活质量受损。目的:详细分析CSU病程和症状强度与生活质量参数和焦虑方面的关系。材料和方法:患者样本由67名CSU受试者组成。采用cu - q2ol和状态与特质焦虑量表(STAI)对所有被试进行生活质量和心理状态评估。对照组选取42名健康志愿者填写STAI问卷。使用荨麻疹活动性评分(UAS)来评估疾病活动性。结果:我们观察到CSU患者作为一种状态和特征的焦虑强度更大,并且随着患者年龄的增加,焦虑作为一种状态的强度更大。由于UAS量表的强度,cu - q2ol瘙痒亚量表明显受损。膨胀/精神状态子量表作为一种状态和一种特征与焦虑有关。此外,我们注意到疾病持续时间越长,受试者的生活质量受损程度越高。结论:我们的研究结果证明,CSU导致显著的生活质量损害。这种现象尤其涉及病程较长的患者。由于焦虑是一种相对常见的干扰,并对生活质量产生负面影响,我们应该识别这些患者并监测这一参数,特别是在老年患者中。
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引用次数: 0
Behçet’s syndrome and relationship with the ratio of insulin-like growth factor-1 (IGF-1)/IGF-binding protein-3 (IGFBP-3) behet综合征及其与胰岛素样生长因子-1 (IGF-1)/ igf结合蛋白-3 (IGFBP-3)比值的关系
Pub Date : 2019-01-01 DOI: 10.5114/ADA.2019.85640
Özlem Doğan, Emine Ünal, U. Kisa, Nurkan Aksoy
Abst rac t Introduction: Behçet’s syndrome (BS) is a chronic inflammatory disease with unknown aetiology. Insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) have important metabolic properties such as anabolic, cytoprotective and anti-inflammatory effects. Circulating IGF-1 and IGF-1/IGFBP-3 concentrations are associated with adiposity and insulin resistance. Aim: To determine whether serum IGF-1 and IGFBP-3 levels or IGF-1/IGFBP-3 ratio were associated with the presence or activity of BS. Material and methods: Forty patients with BS (mean age: 39.6 ±10), and 20 healthy volunteers (mean age: 37 ±10.4) were enrolled. Serum IGF-1, IGFBP-3, and high sensitive C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) levels were measured in all subjects. Results: Mean IGF-1 levels were low in both active BS and remission BS compared to the control group and mean IGF-1 levels were similar in active BS and remission BS. In active BS, mean IGFBP-3 levels were higher than in the control group and remission BS. There were positive correlations between these inflammatory cytokines and IGFBP-3 levels. IGF-1/IGFBP-3 ratio was lower in patients with BS compared to the healthy volunteer group, which was statistically significant. IGF-1/IGFBP-3 ratio was lower in BS than in the control group independently of ESR and hs-CRP. Conclusions: IGF-1 may play a diagnostic role to present itself in BS. IGF-1/IGFBP-3 ratio is not useful as an activation or remission criterion. The ratio may be a useful marker to predict the risk of BS presence in the critical population.
摘要/ abstract简介:behet综合征(BS)是一种病因不明的慢性炎症性疾病。胰岛素样生长因子-1 (IGF-1)和igf结合蛋白-3 (IGFBP-3)具有重要的代谢特性,如合成代谢、细胞保护和抗炎作用。循环IGF-1和IGF-1/IGFBP-3浓度与肥胖和胰岛素抵抗有关。目的:探讨血清IGF-1和IGFBP-3水平或IGF-1/IGFBP-3比值是否与BS的存在或活动相关。材料与方法:选取40例BS患者(平均年龄39.6±10岁)和20例健康志愿者(平均年龄37±10.4岁)。测定所有受试者血清IGF-1、IGFBP-3、高敏c反应蛋白(hs-CRP)和红细胞沉降率(ESR)水平。结果:与对照组相比,活动性BS和缓解性BS的平均IGF-1水平较低,活动性BS和缓解性BS的平均IGF-1水平相似。活动性BS患者的平均IGFBP-3水平高于对照组和缓解性BS患者。这些炎性因子与IGFBP-3水平呈正相关。与健康志愿者组相比,BS患者IGF-1/IGFBP-3比值较低,差异有统计学意义。与ESR和hs-CRP无关,BS组IGF-1/IGFBP-3比值低于对照组。结论:IGF-1可能在BS中发挥诊断作用。IGF-1/IGFBP-3比值不能作为激活或缓解标准。该比率可能是预测临界人群中BS存在风险的有用标记。
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引用次数: 0
Skin allergic reaction to SCS – analysis of world literature and case report 皮肤对SCS的过敏反应——世界文献分析及病例报告
Pub Date : 2018-01-01 DOI: 10.5114/ADA.2018.78781
Kamila Woźniak-Dąbrowska, A. Nowacka, Wojciech Smuczyński, M. Śniegocki
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引用次数: 0
IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children IgA缺乏:婴幼儿食物过敏相关特应性皮炎的危险因素
Pub Date : 2016-10-21 DOI: 10.5114/ADA.2016.62844
Aleksandra Szczawińka-Popłonyk, Paulina Komasińska, A. Bręborowicz
Address for correspondence: Assoc. Prof. Aleksandra Szczawińska-Popłonyk MD, PhD, Department of Pediatric Pneumonology, Allergology and Clinical Immunology, Poznan University of Medical Sciences, 27/33 Szpitalna St, 60-572 Poznan, Poland, phone: +48 61 848 01 11, e-mail: ola@malwa.com.pl Received: 24.08.2015, accepted: 22.10.2015. IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children
通信地址:协会。Aleksandra教授Szczawińska-Popłonyk医学博士,波兹南医科大学儿科肺炎学、过敏症学和临床免疫学学系博士,波兰波兹南60-572 Szpitalna St 27/33,电话:+48 61 848 01 11,电子邮件:ola@malwa.com.pl收件时间:24.08.2015,接受时间:22.10.2015。IgA缺乏:婴幼儿食物过敏相关特应性皮炎的危险因素
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引用次数: 3
Original paper Allergy to propolis in Polish beekeepers 波兰养蜂人对蜂胶过敏
Pub Date : 2012-12-21 DOI: 10.5114/PDIA.2012.32391
K. Basista, B. Filipek
Introduction: According to the literature propolis is a non-toxic and safe substance. However, propolis can induce allergy. Beekeepers may be the group most affected by contact allergy and propolis is an occupational contact aller gen for them. Aim: To determine the prevalence of propolis contact allergy in beekeepers and theirs families and its possible asso ciation with other coexistent conditions. Material and methods: The questionnaire ‘Allergy to propolis among beekeepers’ was distributed to beekeepers by hand through the Beekeepers Associations, especially the Provincial Association of Apiarists in Krakow. The study was conducted on adults of both genders who had given informed consent to participate in the study. The program Statistica was used for data management and statistical analysis. Results: A total of 2540 questionnaires were distributed, including 1360 questionnaires from Malopolska region. Five hundred and fifty-eight questionnaires were returned, including 345 from Malopolska region. The response rate was 21.97% (25.4% Malopolska region). Among 558 beekeepers propolis contact allergy occurred in 17 cases (3.05%). Four hundred anf four of 558 beekeepers used propolis as a therapeutic agent. Eleven of 404 (2.72%) beekeepers report ed propolis allergy. Only 5 beekeepers reported concomitant propolis allergy after contact with this substance dur ing beekeeping and using propolis as a therapeutic agent. Among 2205 members of families who were using propo lis only 14 patients (0.63%) reported propolis allergy. Conclusions: Allergy to propolis in Polish beekeepers does not seem to be a common phenomenon.
文献介绍:蜂胶是一种无毒、安全的物质。然而,蜂胶会引起过敏。养蜂人可能是受接触性过敏影响最大的群体,蜂胶对他们来说是一种职业性接触过敏原。目的:了解养蜂人及其家庭中蜂胶接触性过敏的发生率及其与其他共存疾病的关系。材料和方法:通过养蜂人协会,特别是克拉科夫省养蜂人协会,向养蜂人手工分发了“养蜂人对蜂胶过敏”问卷。这项研究是在知情同意参加研究的成年人中进行的。使用Statistica程序进行数据管理和统计分析。结果:共发放问卷2540份,其中Malopolska地区共发放问卷1360份。共收到558份问卷,其中345份来自马洛波尔斯卡地区。应答率为21.97% (Malopolska地区为25.4%)。558名养蜂人中发生蜂胶接触性过敏17例(3.05%)。558名养蜂人中有400人使用蜂胶作为治疗剂。404名养蜂人中有11人(2.72%)报告对蜂胶过敏。只有5名养蜂人报告在养蜂期间接触这种物质并使用蜂胶作为治疗剂后伴随蜂胶过敏。在2205例使用蜂胶的家庭成员中,仅有14例(0.63%)报告蜂胶过敏。结论:蜂胶过敏在波兰养蜂人似乎不是一个普遍现象。
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引用次数: 11
Case report Pointillist melanotic macules: a new clinical entity? 点状黑斑:一种新的临床实体?
Pub Date : 2012-12-21 DOI: 10.5114/PDIA.2012.32398
Cheng Tan, Wen‐yuan Zhu
A Chinese male and his father both presented disseminated, variably-sized and pigmented spots as well as stellate macules in their adulthood. No signs indicated a systemic involvement after extensive evaluation. Skin examina tion revealed that most macules were stellate or claw-like that differ from each other in shape and size. However, as a whole, these discrete lesions were interspersed regularly. Pathological changes included remarkable basilar lay er hyperpigmentation (black eye line sign) without proliferation of the melanocytes. Melanophages were noted in the dermis. We proposed the diagnosis of pointillist melanotic macules, and believe this is a new clinical entity.
一名中国男性及其父亲成年后均出现弥散性大小不一的色斑和星状斑。经过广泛的评估,没有迹象表明系统性的介入。皮肤检查显示,大多数斑点呈星状或爪状,形状和大小各不相同。然而,作为一个整体,这些分散的病变有规律地穿插。病理改变包括明显的基底层色素沉着(黑眼线征),无黑色素细胞增生。真皮中可见噬黑细胞。我们提出了点状黑斑的诊断,并相信这是一个新的临床实体。
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引用次数: 0
Original paper Evaluation of knowledge about acne vulgaris among a selected population of adolescents of Tricity schools 三联体学校青少年对寻常性痤疮知识的评价
Pub Date : 2012-12-21 DOI: 10.5114/PDIA.2012.32388
K. Tałasiewicz, A. Ołdakowska, A. Szczerkowska-Dobosz
Introduction: It is estimated that approximately 80% of adolescents have different forms of acne vulgaris. Due to the high prevalence of the disease and its psycho-emotional impact on the quality of life, it is important to prevent the spread of misconceptions. Aim:To analyze the basic knowledge and misconceptions concerning acne vulgaris among adolescents. Material and methods: The study included 900 adolescents aged 15-19 years (mean age: 17.47 years), 401 females, 493 males attending high schools ( n= 481) or technical colleges ( n= 419). The study was based on a direct anony mous questionnaire that consisted of fourteen multiple choice questions. Results: On average, 50.3% of questions were answered correctly. 57.8% of participants stated that they had suf fered from acne. As regards the causes, more than half (59.5%) of participants stated that acne is connected to eat ing and hygiene habits. 40.5% of students considered acne infectious. The study revealed that many “false beliefs” exist. 26.4% of adolescents believe that starting sexual activity can influence healing. Considering the effectiveness of curing acne in adolescence, 24.2% of participants do not see a point in early treatment. Regarding the sources of knowledge about acne, most adolescents use the internet, teenage newspapers and friends' opinions. Only 41.2% want to learn more, and almost 90% consider their knowledge sufficient. Conclusions:The results from a large population-based study indicate that the knowledge about acne is insufficient, which reveals the need for introducing educational programs in schools.
简介:据估计,大约80%的青少年有不同形式的寻常性痤疮。由于该病的高患病率及其对生活质量的心理和情绪影响,预防误解的传播非常重要。目的:分析青少年对寻常痤疮的基本认识和误解。材料与方法:本研究纳入900名15-19岁青少年(平均年龄17.47岁)、401名女性、493名高中或技校学生(n= 481)。这项研究是基于一份由14道选择题组成的直接匿名问卷。结果:平均答对率为50.3%。57.8%的参与者表示他们患有痤疮。至于原因,超过一半(59.5%)的参与者表示痤疮与饮食和卫生习惯有关。40.5%的学生认为痤疮具有传染性。这项研究揭示了许多“错误信念”的存在。26.4%的青少年认为开始性行为会影响康复。考虑到治疗青春期痤疮的有效性,24.2%的参与者认为早期治疗没有意义。关于痤疮知识的来源,大多数青少年使用互联网,青少年报纸和朋友的意见。只有41.2%的人想要学习更多,几乎90%的人认为他们的知识已经足够了。结论:一项基于大量人群的研究结果表明,关于痤疮的知识不足,这表明需要在学校引入教育计划。
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引用次数: 6
期刊
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
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