Aging brain最新文献_第2页

No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population 在老年记忆临床人群中，区域脑结构异常和认知功能之间的关联没有性别差异

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100137

A. Lamé , E.G. Thomas , S.A.J. van de Schraaf , C. Groot , C.H. Sudre , F. Barkhof , M. Muller , R. Ossenkoppele , H.F.M. Rhodius-Meester

Differences between men and women in cognitive impairment and neurodegeneration are not yet well understood. Although sex differences in brain structure abnormalities, including white matter hyperintensities (WMH) and grey matter (GM) atrophy, have been associated with cognitive decline in the ageing population, the evidence is limited and inconclusive. Therefore, we explored sex differences in brain structure abnormalities and in the association between brain structure abnormalities and cognitive functioning. We analyzed global and regional volumetric measures of WMH and GM of 475 patients visiting an academic geriatric memory clinic in the Netherlands with multiple linear regression analyses. For both global and regional WMH and GM, we found no sex differences in brain structure abnormalities. We also found no interaction of sex on the association between brain structure abnormalities and cognitive functioning. We reflect on using a binary classification of men and women based on sex in this study, which might overlook individual differences and does not elucidate gender-related factors that influence health and risk of pathology. Future studies should focus on exploring the relationship between sex and gender on brain structure and cognitive functioning beyond this binary model, by including more data on social context, more diverse populations and using intersectional approaches.

男性和女性在认知障碍和神经退行性变方面的差异尚不清楚。尽管脑结构异常（包括白质高强度（WMH）和灰质（GM）萎缩）的性别差异与老龄化人口的认知能力下降有关，但证据有限且不确定。因此，我们探讨了脑结构异常的性别差异以及脑结构异常与认知功能之间的关系。我们用多元线性回归分析分析了荷兰一家学术老年记忆诊所的475名患者的WMH和GM的全球和区域体积测量。对于全球和地区的WMH和GM，我们没有发现大脑结构异常的性别差异。我们还发现，性别对大脑结构异常和认知功能之间的关系没有影响。我们考虑在本研究中使用基于性别的男性和女性二元分类，这可能会忽略个体差异，并且无法阐明影响健康和病理风险的性别相关因素。未来的研究应通过纳入更多的社会背景数据、更多样化的人群和使用交叉方法，探索性别和社会性别在大脑结构和认知功能方面的关系，超越这种二元模型。

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引用次数: 0

Complex span measures of working memory do not mediate the effects of age on the P3 and N400 ERPs 工作记忆的复杂广度测量不介导年龄对P3和N400 erp的影响

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100140

Jasmin Joshi, Chandlyr M. Denaro, Alan A. Hartley, Catherine L. Reed

Working memory (WM), the temporary maintenance of a limited amount of information in an accessible state, is required for the performance of many tasks. Studies have shown that WM demands are related to the neural processing of tasks requiring attention: Age affects the ERP components associated with WM context updating processes in the visual oddball task (P3) and semantic processing in the word-pair judgment task (N400). This study investigated whether WM capacity measured by complex span tasks mediates the effects of age on these ERPs. Younger adults (YA, n = 44, ages 18–23 yr) and older adults (OA, n = 41, ages 69–89 yr) completed operation, reading, and symmetry complex span tasks and two ERP tasks (P3/visual oddball; N400/word-pair judgment). Results showed age-related differences for all complex span tests. Principal components analysis of these tests showed a single factor for both groups, so a combined WM capacity factor score was created. Regressions of age group and WM factor score on P3 and N400 amplitudes and latencies showed that OAs had relatively lower amplitudes and longer latencies. However complex span was not related to P3 or N400 amplitudes or latencies and that result was the same for younger and older adults; that is, complex span did not mediate the age effects. WM processes indexed by the P3 and N400 components appear to be different from those elicited by complex span tasks. Attentional control processes of WM influence oddball and semantic judgement tasks more than storage components.

工作记忆（WM）是在可访问状态下对有限数量信息的临时维护，是许多任务的执行所必需的。研究表明，WM需求与需要注意的任务的神经加工有关：年龄影响与视觉怪球任务（P3）和词对判断任务（N400）中WM上下文更新过程相关的ERP成分。本研究探讨了由复杂跨度任务测量的脑记忆能力是否介导了年龄对这些erp的影响。年轻人（YA, n = 44，年龄18-23岁）和老年人（OA, n = 41，年龄69-89岁）完成了操作、阅读和对称复杂跨度任务和两个ERP任务(P3/视觉怪球；N400 /一对词组的判断)。结果显示所有复杂跨度测试的年龄相关差异。这些测试的主成分分析显示两组都有一个单一因素，因此创建了一个综合WM能力因素评分。各年龄组和WM因子评分对P3和N400波幅和潜伏期的回归表明，oa的波幅较低，潜伏期较长。而复杂跨幅与P3、N400的振幅和潜伏期无显著相关性，在年轻人和老年人中结果相同；即复合跨度对年龄的影响没有中介作用。P3和N400组件索引的WM过程似乎与复杂跨任务引发的WM过程不同。WM的注意控制过程对古怪判断和语义判断任务的影响大于存储成分。

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引用次数: 0

Evaluation of candidate RT-qPCR reference genes in the aging African turquoise killifish brain 老化非洲绿松石鳉脑中候选RT-qPCR内参基因的评价

IF 2.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100151

Emily Whisenant, Arne C. Lekven

Reference genes (RGs) are typically used to normalize gene expression from RT-qPCR experiments. However, the expression of commonly used RGs can vary across different physiological conditions, such as aging, and potentially lead to inaccurate interpretations of results. In African turquoise killifish (Nothobranchius furzeri), the stability of reference genes has not been evaluated during aging. Here, we evaluate six candidate reference genes used in other models of aging (actb, cyc1, gapdh, gusb, oaz1a, and tbp) and examine their brain expression stability in adult males and females from young (10 weeks post-hatching) to old (25 weeks post-hatching). To examine RG stability, we used a combination of summary statistics based on analyses of Cq values, normalized fold change of tyrosine hydroxylase (th), and available computational programs. Overall, we found that cyc1, oaz1a, and gusb were the most stable reference genes during aging across both sexes, with specific rankings reflecting sex-dependent differences, while gapdh and actb were the least reliable. Importantly, when th expression was normalized to our selected RGs, we found that only female samples had an age-related decrease in expression, and expression analysis was highly dependent on the choice of reference gene. Taken together, our findings provide the first systematic evaluation of RG stability in the killifish brain and highlight cyc1, oaz1a, and gusb as reliable RGs for studies of aging. We recommend that future studies use at least two of these RGs in combination for accurate normalization and evaluate RGs for selected experimental conditions within the framework established in this study.

参考基因（RGs）通常用于规范RT-qPCR实验中的基因表达。然而，常用RGs的表达可能因不同的生理条件而异，如衰老，并可能导致对结果的不准确解释。在非洲绿松石鳉（Nothobranchius furzeri）中，内参基因在衰老过程中的稳定性尚未得到评估。在这里，我们评估了其他衰老模型中使用的六个候选内参基因（actb, cyc1, gapdh, gusb， oaz1a和tbp），并检查了它们在成年雄性和雌性从幼年（孵化后10周）到老年（孵化后25周）的大脑表达稳定性。为了检验RG的稳定性，我们结合了基于Cq值分析的汇总统计、酪氨酸羟化酶（th）的归一化折叠变化和可用的计算程序。总体而言，我们发现cyc1， oaz1a和gusb是两性衰老过程中最稳定的参考基因，其具体排名反映了性别依赖性差异，而gapdh和actb是最不可靠的。重要的是，当表达归一化到我们选择的RGs时，我们发现只有女性样本的表达与年龄相关，表达分析高度依赖于内参基因的选择。综上所述，我们的研究结果首次系统地评估了鳉鱼大脑中RG的稳定性，并强调了cyc1、oaz1a和gusb是衰老研究中可靠的RG。我们建议未来的研究至少使用其中两种RGs进行精确归一化，并在本研究建立的框架内评估RGs在选定实验条件下的效果。

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引用次数: 0

Sex differences in the association between episodic memory residual reserve index and change in executive function 情景记忆剩余储备指数与执行功能变化相关性的性别差异

IF 2.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100146

Cheyenne Chooi , Brandon E. Gavett , David Ames , Paul Maruff , Vincent Doré , Victor L. Villemagne , Pierrick Bourgeat , Ying Xia , Colin L. Masters , Ralph N. Martins , Kevin Taddei , Christopher C. Rowe , Michael Weinborn , Stephanie R. Rainey-Smith

Sex differences in cognitive reserve might contribute to females being disproportionately affected by Alzheimer’s disease (AD). We investigated sex differences in the protective effects of cognitive reserve, and whether brain beta-amyloid accounts for differences. Older adults (n = 997 from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing) diagnosed as Cognitively Normal, Mild Cognitive Impairment, or AD at baseline were assessed every 18 months for up to a maximum of seven visits. Cognitive reserve was calculated from the variance in episodic memory not explained by demographic or brain measures. Executive functioning (EF) intercept and slope were regressed onto the main and interaction effects of cognitive reserve x brain integrity x sex, plus covariates (age, number of APOE ε4 alleles). A three-way interaction was observed between cognitive reserve, brain integrity, and sex on the EF slope. Females benefitted more than males from the protective effects of cognitive reserve at low levels of brain integrity. Sex differences in the protective effect of cognitive reserve were not moderated by brain beta-amyloid burden.

认知储备的性别差异可能导致女性患阿尔茨海默病（AD）的比例失调。我们研究了认知储备保护作用的性别差异，以及大脑β -淀粉样蛋白是否解释了差异。来自澳大利亚老龄化成像、生物标志物和生活方式研究的997名老年人（n = 997）在基线时被诊断为认知正常、轻度认知障碍或AD，每18个月评估一次，最多7次。认知储备是根据情景记忆的差异来计算的，不能用人口统计学或大脑测量来解释。执行功能（EF）截距和斜率回归到认知储备、脑完整性、性别以及协变量（年龄、APOE ε4等位基因数量）的主效应和交互效应。在EF斜率上，认知储备、脑完整性和性别之间存在三方交互作用。女性比男性更受益于认知储备在低水平大脑完整性下的保护作用。认知储备保护作用的性别差异不受脑β -淀粉样蛋白负荷的影响。

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引用次数: 0

Influence of aging and task-related activation on descending cortical modulation of spinal sensorimotor circuitry 衰老和任务相关激活对脊髓感觉运动回路下行皮质调节的影响

IF 2.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100153

Alejandro J. Lopez , Terrence J. Glover , Taylor M. Leone , Catherine F. Mason , Camille Guzman , Lena H. Ting , Michael R. Borich , Trisha M. Kesar

The objective of this study was to evaluate the effects of aging on descending modulation of spinal reflexes across different task conditions. In healthy young (YA; age 27 ± 4 years) and older (OA; age 63 ± 10 years) adults, we utilized paired subthreshold transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) to elicit unconditioned (PNS only) and conditioned (TMS paired with PNS) soleus Hoffmann (H-)reflexes at 3 inter-stimulus intervals (ISIs) (−1.5, +10 ms, +40 ms) and during 3 task conditions − sit rest (SR), sit active (SA), and quiet stance (QS). Our results showed that at the + 40 ms ISI, compared to YA, the OA group showed significant differences in modulation (and reversal from facilitation to inhibition) of soleus H-reflexes during both SA and QS tasks (p < 0.0001). Correlation analysis showed a significant negative relationship between age and the magnitude of H-reflex modulation at the + 40 ms ISI, such that older individuals showed a larger magnitude of H-reflex inhibition. In conclusion, altered task-related modulation of spinal reflexes at the + 40 ms ISI may reflect specific aging-related effects on spinal sensorimotor integration, likely mediated via complex interactions between the influence of polysynaptic slower-conducting descending pathways, sensory afferents, and local spinal circuits, on spinal reflex activity during motor task performance.

本研究的目的是评估年龄对不同任务条件下脊髓反射下行调节的影响。在健康青年（年龄27±4岁）和老年人（年龄63±10岁）中，我们采用阈下经颅磁刺激（TMS）和外周神经刺激（PNS）配对，在3个刺激间隔（- 1.5、+10 ms、+40 ms）和3个任务条件下——坐着休息（SR）、坐着活动（SA）和安静姿势（QS）下诱发非条件（仅PNS）和条件（TMS与PNS配对）比目鱼霍夫曼（H-）反射。我们的研究结果显示，在+ 40 ms ISI时，与YA相比，OA组在SA和QS任务中对比目鱼h -反射的调节（以及从促进到抑制的逆转）表现出显著差异（p < 0.0001）。相关分析显示，年龄与+ 40 ms ISI时h -反射调制强度呈显著负相关，即年龄越大的个体h -反射抑制强度越大。综上所述，在ISI + 40 ms时，脊髓反射的任务相关调节的改变可能反映了与年龄相关的脊髓感觉运动整合的特定影响，这可能是通过多突触传导较慢的下行通路、感觉传入和局部脊髓回路对运动任务中脊髓反射活动的影响之间的复杂相互作用介导的。

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引用次数: 0

Identification of novel candidate loci for Alzheimer’s disease and related dementias by leveraging the shared genetic basis with hippocampal volume 利用与海马体积共享的遗传基础，鉴定阿尔茨海默病和相关痴呆的新候选基因座

IF 2.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100147

Chenyang Jiang , Sven J. van der Lee , Niccolò Tesi , Wiesje M. van der Flier , Betty M. Tijms , Lianne M. Reus

Alzheimer’s disease and related dementias (ADRD) are complex neurodegenerative disorders of which the genetic basis remains incompletely understood. Hippocampal volume loss is a core hallmark of AD. Hippocampal volume also has a strong heritable component and its genetic underpinnings may help us to understand the complex biological mechanism underlying ADRD. To identify shared genetic risk loci across late-onset ADRD and bilateral hippocampal volumes, we conducted a cross-trait analysis of existing GWAS data on the two traits using the conjunctional false discovery rate (conjFDR) framework. Functional annotation and phenome-wide association studies (PheWAS) were performed on the identified shared loci to characterize their biological relevance. We identified 11 unique lead genetic loci, of which 7 loci showed discordant directional effects (loci associated with increased risk for ADRD and smaller hippocampal volumes). We found that SHARPIN and TNIP1 genes play a role in ADRD by affecting hippocampal volumes. In addition, we observed 9 novel ADRD-hippocampus loci in genes previously implicated in AD (IGIP and ACE) and novel ADRD-genes (KCTD13, HINT1, SH3TC2, FAM53B, TPM1, IL34 and SSH2). PheWAS results show that most shared loci associated with neuroimaging measurements, white blood cell markers, red blood cell markers, and lipids. This study shows a shared genetic basis between ADRD and bilateral hippocampal volumes. By integrating summary statistics for these two traits, we identified both novel and previously reported ADRD-hippocampus loci. Functional analysis highlights the role of immune cells and lipid markers in the shared loci, suggesting a shared neurobiological basis for ADRD and bilateral hippocampal volumes.

阿尔茨海默病和相关痴呆（ADRD）是复杂的神经退行性疾病，其遗传基础仍未完全了解。海马体积损失是阿尔茨海默病的核心标志。海马体体积也具有很强的遗传成分，其遗传基础可能有助于我们理解ADRD背后复杂的生物学机制。为了确定迟发性ADRD和双侧海马体积之间的共同遗传风险位点，我们使用联合错误发现率（conjunctional false discovery rate，简称conjFDR）框架对现有的GWAS数据进行了跨性状分析。对鉴定的共享位点进行功能注释和全现象关联研究（PheWAS），以表征其生物学相关性。我们确定了11个独特的先导基因位点，其中7个位点表现出不一致的定向效应（与ADRD风险增加和海马体积较小相关的位点）。我们发现SHARPIN和TNIP1基因通过影响海马体积在ADRD中发挥作用。此外，我们在先前与AD相关的基因（IGIP和ACE）和新的adrd基因（KCTD13、HINT1、SH3TC2、FAM53B、TPM1、IL34和SSH2）中发现了9个新的adrd -海马位点。PheWAS结果显示，大多数共享位点与神经成像测量、白细胞标记物、红细胞标记物和脂质相关。这项研究表明，ADRD与双侧海马体积之间存在共同的遗传基础。通过整合这两个特征的汇总统计数据，我们确定了新的和先前报道的adrd -海马位点。功能分析强调了免疫细胞和脂质标记物在共享位点中的作用，表明ADRD和双侧海马体积具有共同的神经生物学基础。

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引用次数: 0

Cellular senescence, neuroinflammation, and microRNAs: Possible interactions driving aging and neurodegeneration in the hippocampal neurogenic niche 细胞衰老、神经炎症和microrna：海马神经源性生态位中驱动衰老和神经变性的可能相互作用

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100141

O. Polzer , E. Kinloch , C.P. Fitzsimons

Cellular senescence influences normal physiology and ageing-related diseases, including neurodegeneration. Senescent cells accumulate with age in the brain, secreting pro-inflammatory factors that promote neuroinflammation, which has been linked to disorders like Alzheimer’s and Parkinson’s. Neurons and other brain cells such as microglia, astrocytes, and neural stem/progenitor cells (NSPCs), exhibit senescence in aged brains. NSPCs, essential for neurogenesis, may enter senescence due to inflammatory signals and other factors and microRNAs may regulate this process. Here we discuss senescence mechanisms, neuroinflammation, and potential therapeutic targets, proposing that modulating senescence by microRNA-mediated pathways could help combat neurodegenerative diseases.

细胞衰老影响正常生理和衰老相关疾病，包括神经变性。随着年龄的增长，衰老细胞在大脑中积累，分泌促炎因子，促进神经炎症，这与阿尔茨海默氏症和帕金森症等疾病有关。神经元和其他脑细胞，如小胶质细胞、星形胶质细胞和神经干/祖细胞（NSPCs），在衰老的大脑中表现出衰老。NSPCs作为神经发生所必需的细胞，可能会受到炎症信号等因素的影响而进入衰老，而microrna可能调控这一过程。在这里，我们讨论了衰老机制，神经炎症和潜在的治疗靶点，提出通过微rna介导的途径调节衰老可以帮助对抗神经退行性疾病。

引用次数: 0

Selenium deficiency negatively affects survival and integrity of human hippocampal progenitor cells 缺硒对人海马祖细胞的存活和完整性有负面影响

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100138

Sahand Farmand, Emaan Ahmed, Hadisa Azizi Zawar, Sandrine Thuret

Selenium has been shown to be a key regulatory element in the health, survival and proliferation of neural stem and progenitor cells, with various studies underlining its anti-aging properties. However, most of this knowledge is derived from rodent models, leaving its effects on human hippocampal progenitor cells unclear. In this study, we utilized a human hippocampal progenitor cell (HPC) line to examine the effects of varying concentrations of sodium selenite, an inorganic form of selenium (0 µM, 0.1 µM, 0.23 µM, 0.5 µM, and 1.0 µM), on the proliferation, apoptosis, and progenitor integrity of these cells. To do this, HPCs were exposed to these concentrations for 48 h, followed by immunocytochemistry to quantify, cell number (DAPI-positive cells), proliferation (KI67-positve cells), apoptosis (CC3-positve cells), and progenitor integrity (SOX2- and Nestin-positive cells). While our results indicated no significant effects of selenium concentrations on proliferation or apoptosis, we demonstrated that absence of selenium (0 μM) in the culture media significantly reduced both cell number and percentage of Nestin-positive cells, but only when compared to the condition with the highest selenium concentration (1.0 μM). Our findings underscore the role of selenium in regulating the survival and integrity of human HPCs. Lastly, we emphasize the need for further research to uncover the mechanisms underlying these observed changes.

硒已被证明是神经干细胞和祖细胞健康、存活和增殖的关键调控元素，各种研究都强调了它的抗衰老特性。然而，这些知识大多来自啮齿动物模型，其对人类海马祖细胞的影响尚不清楚。在这项研究中，我们利用人类海马祖细胞（HPC）系来检测不同浓度亚硒酸钠（无机形式的硒）（0µM, 0.1µM, 0.23µM， 0.5µM和1.0µM）对这些细胞的增殖、凋亡和祖细胞完整性的影响。为此，将HPCs暴露在这些浓度下48小时，然后通过免疫细胞化学来量化细胞数量（dapi阳性细胞）、增殖（ki67阳性细胞）、凋亡（cc3阳性细胞）和祖细胞完整性（SOX2-和nesting阳性细胞）。虽然我们的研究结果表明硒浓度对细胞增殖或凋亡没有显著影响，但我们发现培养基中缺乏硒（0 μM）显著减少了巢蛋白阳性细胞的数量和百分比，但仅与硒浓度最高（1.0 μM）的情况相比。我们的研究结果强调了硒在调节人类HPCs存活和完整性中的作用。最后，我们强调需要进一步研究以揭示这些观察到的变化的机制。

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引用次数: 0

Nigrostriatal dopaminergic neurotransmission and resilience to peripheral systemic risk factors for gait slowing upon transition to uneven surfaces in older adult 黑质纹状体多巴胺能神经传递和对周围系统危险因素的恢复能力在老年人过渡到不平整的表面时步态减慢

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100143

Lana M. Chahine , Andrea Rosso , Ian Troidl , Mary Ganguli , Anne Newman , Steven Cummings , Stephanie Studenski , Brian Lopresti , Sarah Royse , Theodore Huppert , Mark Redfern , Patrick J. Sparto , Nico I. Bohnen , Caterina Rosano

Identifying mechanisms that compensate for slow gait speed in older adults is crucial. Dopaminergic neurotransmission curbs deleterious associations of cerebrovascular disease with gait, but whether it compensates for peripheral systemic risk factors (PSRF) for gait slowing has not been studied. In this cross-sectional study of community-dwelling older adults, we examined the relationship between nigrostriatal dopaminergic terminal integrity and gait speed in individuals with and without ≥ 1 PSRF for gait slowing: obesity, joint pain, or reduced muscle strength. The primary outcome was gait speed cost (%GSC) on transition from even to uneven surface. Participants underwent dopaminergic imaging with dihydrotetrabenazine [¹¹C]DTBZ positron emission tomography. Among 197 individuals, (mean (SD) age 74.92 (4.53) years; 61.93 % female; 90.86 % White), 130 (65.99 %) had ≥ 1 PSRF. Relationship between posterior putamen [¹¹C]DTBZ binding and %GSC was modified by PSRF; in those with ≥ 1 PSRF (but not in those with no PSRF), posterior putamen [¹¹C]DTBZ binding was associated with %GSC (β = 0.198, p = 0.03) independent of potential confounders. This cross-sectional study indicates that higher striatal dopaminergic neurotransmission may compensate for the effects of PSRF on gait slowing.

确定补偿老年人慢速步态的机制至关重要。多巴胺能神经传递抑制了脑血管疾病与步态的有害关联，但它是否补偿了周围系统危险因素（PSRF）对步态减慢的影响尚未得到研究。在这项社区老年人的横断面研究中，我们研究了黑质纹状体多巴胺能末端完整性与步态速度之间的关系，这些个体有或没有≥1个PSRF导致步态减慢：肥胖、关节疼痛或肌肉力量下降。主要结局是步态速度成本（%GSC）从平坦的表面过渡到不平坦的表面。参与者使用二氢四苯那嗪[11C]DTBZ正电子发射断层扫描进行多巴胺能成像。197例个体中，平均（SD）年龄74.92（4.53）岁；女性占61.93%；90.86%（白人），130例（65.99%）PSRF≥1。PSRF改变后壳核[11C]DTBZ结合与%GSC的关系；在PSRF≥1的患者中（而非无PSRF的患者），后壳核[11C]DTBZ结合与%GSC相关（β = 0.198, p = 0.03），独立于潜在的混杂因素。这项横断面研究表明，较高的纹状体多巴胺能神经传递可能补偿PSRF对步态减慢的影响。

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引用次数: 0

The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study 老年抑郁症状与脑淀粉样蛋白-β沉积的关系：ARIC-PET研究

IF 2.7 Q3 CLINICAL NEUROLOGY

Aging brain

Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100152

Sylee Kanetkar , Valerie N. Morrill , Marco T. Egle , Keenan A. Walker , Dean F. Wong , Rebecca F. Gottesman

Late-life depression is associated with an increased risk of developing dementia related to Alzheimer’s disease, yet the mechanism underlying this relationship remains poorly understood. This study investigated the association of late-life depressive symptoms (LLDS) with brain amyloid deposition by PET. 334 dementia-free individuals from the Atherosclerosis Risk in Communities Study had Florbetapir-PET scans in late-life (ages 67–89). Elevated global and regional brain amyloid deposition was defined as a Florbetapir standardized uptake value ratio (SUVR) > 1.2. LLDS was assessed using the 11-item Center for Epidemiological Studies Depression Scale (CES-D) and defined as late-life CES-D ≥ 9. Several secondary depression measures (e.g., antidepressant use) were also explored. Stratified analyses across race, sex, and cognitive status groups were conducted. Participants (median age 76 years; 57.2 % female; 42.5 % Black; 26.9 % mild cognitive impairment) showed no association of LLDS with global amyloid deposition. Although antidepressant use was not associated with global amyloid overall, antidepressant use was associated with elevated global amyloid in individuals with normal cognition but not mild cognitive impairment. There was no effect modification by race and sex. Overall, our findings suggest that LLDS are generally not associated with global amyloid deposition, but further investigation of this relationship in larger sample sizes is warranted.

老年抑郁症与阿尔茨海默病相关的痴呆风险增加有关，但这种关系背后的机制尚不清楚。本研究通过PET研究了老年抑郁症状（LLDS）与脑淀粉样蛋白沉积的关系。来自社区动脉粥样硬化风险研究的334名无痴呆患者在晚年（67-89岁）进行了Florbetapir-PET扫描。升高的整体和区域脑淀粉样蛋白沉积被定义为Florbetapir标准化摄取值比（SUVR） > 1.2。LLDS采用11项流行病学研究中心抑郁量表（CES-D）进行评估，并定义为晚年CES-D≥9。还探讨了几种继发性抑郁措施（例如，使用抗抑郁药）。进行了跨种族、性别和认知状态组的分层分析。参与者（中位年龄76岁；57.2%女性；42.5%黑人；26.9%轻度认知障碍）显示LLDS与整体淀粉样蛋白沉积没有关联。虽然抗抑郁药的使用与总体淀粉样蛋白无关，但在认知正常而非轻度认知障碍的个体中，抗抑郁药的使用与总体淀粉样蛋白升高有关。没有种族和性别的影响。总的来说，我们的研究结果表明，LLDS通常与整体淀粉样蛋白沉积无关，但需要在更大的样本量中进一步研究这种关系。

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引用次数: 0