V. Gojković–Cvjetković, R. Grujić, Ž. Marjanović-Balaban, V. Kalaba
Gluten refers to a complex mixture of gliadins and glutenins. It can cause numerous foodborne disorders. In sensitive individuals gluten can lead to celiac disease (CD), wheat sensitivity and allergy. Gliadin proteins are one of the gluten fractions. The aim of this paper was to examine how different conditions, mixing time (2.5, 5, 7.5, and 10 min) of the sample with the most commonly solvent 70% (v/v) ethanol and 70% (v/v) isopropanol and incubation time (15, 20, 25, and 30 min) affect the efficiency of gliadin determination with the ELISA method. A commercial kit was used to determine gliadin concentrations, and absorbance was measured at 450 nm, using the ELISA reader. Based on the obtained results, the optimal mixing time of the sample with the solvents was 5 minutes and the incubation time was 25 minutes. Under these conditions, the extraction efficiency is the best, i.e., the highest gliadin concentration is obtained. The results of research can be of fundamental importance in the study of gluten proteins and the impact of technological procedures on their change and the possibility of reducing the allergic effect.
{"title":"Investigation of different extraction conditions on the efficiency of gliadin extraction and determination by ELISA method","authors":"V. Gojković–Cvjetković, R. Grujić, Ž. Marjanović-Balaban, V. Kalaba","doi":"10.5937/savteh2102009g","DOIUrl":"https://doi.org/10.5937/savteh2102009g","url":null,"abstract":"Gluten refers to a complex mixture of gliadins and glutenins. It can cause numerous foodborne disorders. In sensitive individuals gluten can lead to celiac disease (CD), wheat sensitivity and allergy. Gliadin proteins are one of the gluten fractions. The aim of this paper was to examine how different conditions, mixing time (2.5, 5, 7.5, and 10 min) of the sample with the most commonly solvent 70% (v/v) ethanol and 70% (v/v) isopropanol and incubation time (15, 20, 25, and 30 min) affect the efficiency of gliadin determination with the ELISA method. A commercial kit was used to determine gliadin concentrations, and absorbance was measured at 450 nm, using the ELISA reader. Based on the obtained results, the optimal mixing time of the sample with the solvents was 5 minutes and the incubation time was 25 minutes. Under these conditions, the extraction efficiency is the best, i.e., the highest gliadin concentration is obtained. The results of research can be of fundamental importance in the study of gluten proteins and the impact of technological procedures on their change and the possibility of reducing the allergic effect.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82626933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Petrović, S. Savić, J. Zvezdanović, L. Nikolić, S. Stojiljković
Benzoic acid has a wide use primarily in food but it is also used in cosmetic, pharmaceutical and other products. Because of noted carcinogenic and toxic characteristics under certain concentration it is considered a pollutant that becomes an important environmental problem. In this study, commercial activated charcoal was tested for the removal of benzoic acid from aqueous solutions. Removal of benzoic acid was investigated in a batch and column system under various values of pH, temperature, activated charcoal granulation and mass. The analysis of all samples was performed by visible absorption spectrometry. The optimum conditions for benzoic acid removal in a batch system were found to be pH 3, contact time of 60 min, the temperature of 273.65 K and adsorbent dose of 10 g L-1. The benzoic acid removal can be performed in a column system as well in which the highest quantity of benzoic acid is removed during the first 20 min (70%) and saturation occurs after 70 min. The used benzoic acid removing methods can be characterized as simple, economical and fast and requiring no chemical treatment.
苯甲酸主要在食品中有广泛的用途，但它也用于化妆品、药品和其他产品。由于它在一定浓度下具有显著的致癌性和毒性，被认为是一种污染物，已成为一个重要的环境问题。在本研究中，测试了商用活性炭对水溶液中苯甲酸的去除效果。在不同的pH值、温度、活性炭造粒和质量条件下，采用间歇式和柱式系统对苯甲酸的去除进行了研究。所有样品均采用可见吸收光谱法进行分析。间歇式体系中苯甲酸脱除的最佳条件为pH为3，接触时间为60 min，温度为273.65 K，吸附剂用量为10 g L-1。苯甲酸的去除也可以在柱式系统中进行，在柱式系统中，苯甲酸的去除率在前20 min达到最高(70%)，70 min后达到饱和。所采用的苯甲酸去除方法具有简单、经济、快速和不需要化学处理的特点。
{"title":"Benzoic acid removal from aqueous solutions by activated charcoal","authors":"S. Petrović, S. Savić, J. Zvezdanović, L. Nikolić, S. Stojiljković","doi":"10.5937/savteh2101005p","DOIUrl":"https://doi.org/10.5937/savteh2101005p","url":null,"abstract":"Benzoic acid has a wide use primarily in food but it is also used in cosmetic, pharmaceutical and other products. Because of noted carcinogenic and toxic characteristics under certain concentration it is considered a pollutant that becomes an important environmental problem. In this study, commercial activated charcoal was tested for the removal of benzoic acid from aqueous solutions. Removal of benzoic acid was investigated in a batch and column system under various values of pH, temperature, activated charcoal granulation and mass. The analysis of all samples was performed by visible absorption spectrometry. The optimum conditions for benzoic acid removal in a batch system were found to be pH 3, contact time of 60 min, the temperature of 273.65 K and adsorbent dose of 10 g L-1. The benzoic acid removal can be performed in a column system as well in which the highest quantity of benzoic acid is removed during the first 20 min (70%) and saturation occurs after 70 min. The used benzoic acid removing methods can be characterized as simple, economical and fast and requiring no chemical treatment.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84270231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Black pepper (Piper nigrum L.) is a tropical plant, best known for its fruit, used as a spice all around the world. The fruits of black pepper can be processed in various ways, so there are end products such as white, black, red, and green pepper. Black pepper contains many substances such as terpenes, alkaloids, lignans, phenylpropanoids, etc., which are responsible for some of the most important biological activities: antioxidant, antimicrobial, anticancer, anti-inflammatory, analgesic, antipyretic, hepatoprotective, bio-enhancing and enzyme inhibitory activities. These activities have also been proven in clinical studies, and probably the future of black pepper research should be based on discovering the most effective way to use the active compounds of pepper for the development of herbal drugs with fewer contraindications than standard drugs. Further preclinical and clinical studies are needed to prepare and apply phytoformulations based on the black pepper isolates.
{"title":"Black pepper: Chemical composition and biological activities","authors":"A. Milenković, L. Stanojević","doi":"10.5937/savteh2102040m","DOIUrl":"https://doi.org/10.5937/savteh2102040m","url":null,"abstract":"Black pepper (Piper nigrum L.) is a tropical plant, best known for its fruit, used as a spice all around the world. The fruits of black pepper can be processed in various ways, so there are end products such as white, black, red, and green pepper. Black pepper contains many substances such as terpenes, alkaloids, lignans, phenylpropanoids, etc., which are responsible for some of the most important biological activities: antioxidant, antimicrobial, anticancer, anti-inflammatory, analgesic, antipyretic, hepatoprotective, bio-enhancing and enzyme inhibitory activities. These activities have also been proven in clinical studies, and probably the future of black pepper research should be based on discovering the most effective way to use the active compounds of pepper for the development of herbal drugs with fewer contraindications than standard drugs. Further preclinical and clinical studies are needed to prepare and apply phytoformulations based on the black pepper isolates.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84172981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milan Kostic, Olivera S. Stamenković, V. Veljković
The base-catalyzed methanolysis of roadside pennycress, olive, melon, grapeseed, hempseed, sunflower, and plum kernel oils was performed in the presence of KOH (1% to the oil weight) at the temperature of 60° C and the methanol/oil molar ratio of 6:1. The aim of this work was to reveal the influence of the fatty acid composition of the oils on the kinetics of these methanolysis reactions. The irreversible pseudo-first-order reaction was used for modeling the kinetics of the methanolysis reactions, and the reaction rate constant was correlated with the content of unsaturated fatty acids in the oil. The value of the reaction rate constant increases linearly with increasing the unsaturated fatty acids content in the oil. The applicability and reliability of the model were confirmed by high values of the coefficient of determination and low values of the mean relative percentage deviation between the calculated and experimental triacylglycerols conversion degree.
{"title":"The influence of fatty acid composition on the kinetics of the vegetable oil methanolysis reaction","authors":"Milan Kostic, Olivera S. Stamenković, V. Veljković","doi":"10.5937/savteh2102024k","DOIUrl":"https://doi.org/10.5937/savteh2102024k","url":null,"abstract":"The base-catalyzed methanolysis of roadside pennycress, olive, melon, grapeseed, hempseed, sunflower, and plum kernel oils was performed in the presence of KOH (1% to the oil weight) at the temperature of 60° C and the methanol/oil molar ratio of 6:1. The aim of this work was to reveal the influence of the fatty acid composition of the oils on the kinetics of these methanolysis reactions. The irreversible pseudo-first-order reaction was used for modeling the kinetics of the methanolysis reactions, and the reaction rate constant was correlated with the content of unsaturated fatty acids in the oil. The value of the reaction rate constant increases linearly with increasing the unsaturated fatty acids content in the oil. The applicability and reliability of the model were confirmed by high values of the coefficient of determination and low values of the mean relative percentage deviation between the calculated and experimental triacylglycerols conversion degree.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77002140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Botteri, Tihana Dekanić, A. Tarbuk, D. Đorđević
It is well known that the optimal concentration of fluorescent whitening agent (FWA) in the bath results in high whiteness of single component textiles. At the same time, due to fluorescence of FWA, the higher UV protection is achieved as well. However, for the textile blends it is not so easy to achieve. Depending on the fabric chemical composition, different FWAs must be applied. Therefore, the influence of FWA chemical constitution to the whiteness and UV protection of cotton and cotton/polyester blend were researched in this paper. For that purpose, cotton and cotton/polyester blended (50%/50%) fabrics was treated with four different FWAs by Huntsman, Uvitex® brand: BHT, RSB, NFW and EBF. Spectral remission before and after FWA treatment was measured on a remission spectrophotometer Spectraflash SF 300, Datacolor. Whiteness degree was calculated according to ISO 105-J02:1997, and the Tint Deviations and its coloristic meanings were determined according to Griesser. The UV protection of cotton and cotton/polyester fabrics treated with FWA was determined according to AS/NZS 4399:2017 using transmission spectrophotometer Cary 50/Solascreen, Varian. Based on the results obtained,the stilbene disulphonic acid triazine derivative (Uvitex® RSB) can be recommended for use on a cotton/polyester blend.
众所周知，荧光增白剂在浴液中的最佳浓度可以提高单组分纺织品的白度。同时，由于FWA的荧光性，也达到了更高的紫外线防护。然而，对于纺织混纺织物来说，这就不那么容易实现了。根据织物的化学成分，必须使用不同的FWAs。因此，本文研究了FWA化学成分对棉和棉/涤纶混纺织物白度和防紫外线性能的影响。为此，用亨斯迈、Uvitex®品牌的四种不同的FWAs处理棉和棉/聚酯混纺(50%/50%)织物:BHT、RSB、NFW和EBF。用Datacolor公司的光谱缓解分光光度计Spectraflash SF 300测量FWA治疗前后的光谱缓解。根据ISO 105-J02:1997计算白度，根据Griesser确定色度偏差及其色彩含义。根据AS/NZS 4399:2017，使用透射分光光度计Cary 50/Solascreen, Varian测定经FWA处理的棉和棉/涤纶织物的紫外线防护性能。根据获得的结果，二苯乙烯二磺酸三嗪衍生物(Uvitex®RSB)可以推荐用于棉/聚酯混纺。
{"title":"The influence of FWA chemical constitution to the whiteness and UV protection of cotton and cotton/polyester blend","authors":"L. Botteri, Tihana Dekanić, A. Tarbuk, D. Đorđević","doi":"10.5937/savteh2102066b","DOIUrl":"https://doi.org/10.5937/savteh2102066b","url":null,"abstract":"It is well known that the optimal concentration of fluorescent whitening agent (FWA) in the bath results in high whiteness of single component textiles. At the same time, due to fluorescence of FWA, the higher UV protection is achieved as well. However, for the textile blends it is not so easy to achieve. Depending on the fabric chemical composition, different FWAs must be applied. Therefore, the influence of FWA chemical constitution to the whiteness and UV protection of cotton and cotton/polyester blend were researched in this paper. For that purpose, cotton and cotton/polyester blended (50%/50%) fabrics was treated with four different FWAs by Huntsman, Uvitex® brand: BHT, RSB, NFW and EBF. Spectral remission before and after FWA treatment was measured on a remission spectrophotometer Spectraflash SF 300, Datacolor. Whiteness degree was calculated according to ISO 105-J02:1997, and the Tint Deviations and its coloristic meanings were determined according to Griesser. The UV protection of cotton and cotton/polyester fabrics treated with FWA was determined according to AS/NZS 4399:2017 using transmission spectrophotometer Cary 50/Solascreen, Varian. Based on the results obtained,the stilbene disulphonic acid triazine derivative (Uvitex® RSB) can be recommended for use on a cotton/polyester blend.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88130097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miloš Đukić, J. Jovanović, G. Stojanović, S. Jovanovic
There are many motives to study alkaloids within Crassulaceae family, such as chemotaxonomic consideration of alkaloid distribution and evaluation of their biological potential. Data on alkaloids from Sedum telephium (syn. H. telephium) aroused interest for further alkaloid investigation within the genus Hylotelephium H. Ohba. Thus, the aim of this study was to investigate and characterize other plant sources of alkaloids from the same genus. An alkaloid extract (AE-HS) was isolated from fresh aerial parts of a cultivated hybrid H. spectabile x telephium. The chemical composition of AE-HS was determined by GC-MS (gas chromatography - mass spectrometry) method. Eight components were identified, which made up 91.8% of the sample. The most present component of AE-HS was g-crotonolactone (78.6%) followed by 3-methyl-2-butenal (8.6%) and (E)-coniferyl alcohol (2.8%). Nicotine was identified as the only alkaloid in the AE-HS (0.4%). Along with many non-alkaloid compounds, a previous study found six alkaloids in AE of S. telephium (~7%), suggesting differences from our results. Additionally, alkaloid distribution is limited within other genera of the family and belonging to the same genus does not mean a uniform qualitative composition. Further analyzes of AEs of Hylotelephium taxa would certainly shed light on the pattern of alkaloid distribution.
{"title":"Chemical composition of the alkaloid extract isolated from Hylotelephium spectabile (Boreau) H. Ohba x telephium (L.) H. Ohba aerial parts","authors":"Miloš Đukić, J. Jovanović, G. Stojanović, S. Jovanovic","doi":"10.5937/savteh2102005d","DOIUrl":"https://doi.org/10.5937/savteh2102005d","url":null,"abstract":"There are many motives to study alkaloids within Crassulaceae family, such as chemotaxonomic consideration of alkaloid distribution and evaluation of their biological potential. Data on alkaloids from Sedum telephium (syn. H. telephium) aroused interest for further alkaloid investigation within the genus Hylotelephium H. Ohba. Thus, the aim of this study was to investigate and characterize other plant sources of alkaloids from the same genus. An alkaloid extract (AE-HS) was isolated from fresh aerial parts of a cultivated hybrid H. spectabile x telephium. The chemical composition of AE-HS was determined by GC-MS (gas chromatography - mass spectrometry) method. Eight components were identified, which made up 91.8% of the sample. The most present component of AE-HS was g-crotonolactone (78.6%) followed by 3-methyl-2-butenal (8.6%) and (E)-coniferyl alcohol (2.8%). Nicotine was identified as the only alkaloid in the AE-HS (0.4%). Along with many non-alkaloid compounds, a previous study found six alkaloids in AE of S. telephium (~7%), suggesting differences from our results. Additionally, alkaloid distribution is limited within other genera of the family and belonging to the same genus does not mean a uniform qualitative composition. Further analyzes of AEs of Hylotelephium taxa would certainly shed light on the pattern of alkaloid distribution.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80313765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nowadays, functional materials based on renewable bioresources and environmentally friendly processes have attracted increased attention of both the industrial and the scientific community. Cellulose, the structural material of all plants, is the most abundant natural and renewable polymer possessing some promising properties, such as mechanical robustness, hydrophilicity, biocompatibility, and biodegradability. This paper gives an overview of the current cellulose research directed towards an advanced understanding and application of this most important bioresource. Emphasis is placed on cellulose functionalization and its conversion into novel high-performance cellulose materials with tailored properties (such as fibers, films, membranes, composites, and biomedical materials). Various physical and chemical treatments (alkalis, oxidizing agents, acetylation, ultrasound treatment, plasma treatment, and many other single or combined methods) used for cellulose modification to adjust its properties for different purposes, have been concisely reviewed. Furthermore, the unique hierarchical architecture of natural cellulose consisting of nanoscale fibrils and crystallites allows the extraction of the nanocrystals, and micro- and nanofibrilated cellulose via mechanical and chemical methods or their combination. These nanocellulose materials offer great opportunities in the field of advanced and functional materials. Finally, a novel platform to prepare various cellulose-based materials through more efficient and environmentally friendly processes based on recently developed new and "green" solvents for cellulose has also been discussed.
{"title":"Development of novel cellulose-based functional materials","authors":"M. Kostić","doi":"10.5937/savteh2102073k","DOIUrl":"https://doi.org/10.5937/savteh2102073k","url":null,"abstract":"Nowadays, functional materials based on renewable bioresources and environmentally friendly processes have attracted increased attention of both the industrial and the scientific community. Cellulose, the structural material of all plants, is the most abundant natural and renewable polymer possessing some promising properties, such as mechanical robustness, hydrophilicity, biocompatibility, and biodegradability. This paper gives an overview of the current cellulose research directed towards an advanced understanding and application of this most important bioresource. Emphasis is placed on cellulose functionalization and its conversion into novel high-performance cellulose materials with tailored properties (such as fibers, films, membranes, composites, and biomedical materials). Various physical and chemical treatments (alkalis, oxidizing agents, acetylation, ultrasound treatment, plasma treatment, and many other single or combined methods) used for cellulose modification to adjust its properties for different purposes, have been concisely reviewed. Furthermore, the unique hierarchical architecture of natural cellulose consisting of nanoscale fibrils and crystallites allows the extraction of the nanocrystals, and micro- and nanofibrilated cellulose via mechanical and chemical methods or their combination. These nanocellulose materials offer great opportunities in the field of advanced and functional materials. Finally, a novel platform to prepare various cellulose-based materials through more efficient and environmentally friendly processes based on recently developed new and \"green\" solvents for cellulose has also been discussed.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82022075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanja B. Kokanov, M. Nikolic, I. Novaković, Tamara R. Todorović, N. Filipović
(Thiazolyl-2-yl)hydrazones (THs) are a group of organic compounds containing both hydrazone and 1,3-thiazole pharmacophores present in many approved drugs. They have been investigated greatly in recent years due to potent anticancer, antibacterial, antifungal, antituberculosis, anti-inflammatory, and antiparasitic activities. In this study, one pyridine-based and two quinoline-based, novel THs were synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (NMR). The antimicrobial activity of the compounds was tested against five Gram-positive and five Gram-negative bacteria, as well as against three fungi. The antioxidant capacity of the compounds was tested in six antioxidative assays. The results showed that quinoline-based THs were more active against tested Gram-negative bacteria and fungi strains than pyridine-based compounds. All the compounds showed excellent antioxidative activity comparable to or greater than the used standards (vitamin C and Trolox). Absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were calculated in-silico. Results pointed to promising good pharmacokinetics profiles of investigated compounds, especially 2-quinoline carboxaldehyde-based compound, which can be a lead drug candidate.
{"title":"Synthesis, characterization, and evaluation of antioxidant and antimicrobial activity of three novel n-heteroaromatic hydrazonyl-thiazoles","authors":"Sanja B. Kokanov, M. Nikolic, I. Novaković, Tamara R. Todorović, N. Filipović","doi":"10.5937/savteh2102014k","DOIUrl":"https://doi.org/10.5937/savteh2102014k","url":null,"abstract":"(Thiazolyl-2-yl)hydrazones (THs) are a group of organic compounds containing both hydrazone and 1,3-thiazole pharmacophores present in many approved drugs. They have been investigated greatly in recent years due to potent anticancer, antibacterial, antifungal, antituberculosis, anti-inflammatory, and antiparasitic activities. In this study, one pyridine-based and two quinoline-based, novel THs were synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (NMR). The antimicrobial activity of the compounds was tested against five Gram-positive and five Gram-negative bacteria, as well as against three fungi. The antioxidant capacity of the compounds was tested in six antioxidative assays. The results showed that quinoline-based THs were more active against tested Gram-negative bacteria and fungi strains than pyridine-based compounds. All the compounds showed excellent antioxidative activity comparable to or greater than the used standards (vitamin C and Trolox). Absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were calculated in-silico. Results pointed to promising good pharmacokinetics profiles of investigated compounds, especially 2-quinoline carboxaldehyde-based compound, which can be a lead drug candidate.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82120805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Angjusheva, V. Ducman, Monika Fidancevska, V. Jovanov
Construction and demolition waste produced in the Republic of North Macedonia remains a major economic and environmental problem because all construction and demolition waste ends up in local dumps or is disposed of in a landfill. The objective of this study was to investigate the influence of the process parameters on the physical and mechanical properties of clay-based ceramics with partial replacement of clay with construction and demolition waste. Determination of the chemical composition of the waste demolition brick using X-ray fluorescence showed that it consisted of different oxides such as SiO2, Al2O3, Fe2O3 and CaO and minor contents of alkaline and earth alkaline oxides. Production of these ceramics was conducted through the consolidation of clay and waste demolition brick with the evaluation of the main process parameters such as sintering temperature [ST], the content of waste demolition brick [WDB] and isothermal period at the final temperature [IP]. The final model equations for density and bending strength dependence of the main process parameters were obtained and presented. The microstructure of the ceramics determined by SEM shows that the waste material is homogeneously dispersed in the clay matrix.
{"title":"Optimizing process parameters of clay-based ceramics with addition of construction and demolition waste","authors":"B. Angjusheva, V. Ducman, Monika Fidancevska, V. Jovanov","doi":"10.5937/savteh2102061a","DOIUrl":"https://doi.org/10.5937/savteh2102061a","url":null,"abstract":"Construction and demolition waste produced in the Republic of North Macedonia remains a major economic and environmental problem because all construction and demolition waste ends up in local dumps or is disposed of in a landfill. The objective of this study was to investigate the influence of the process parameters on the physical and mechanical properties of clay-based ceramics with partial replacement of clay with construction and demolition waste. Determination of the chemical composition of the waste demolition brick using X-ray fluorescence showed that it consisted of different oxides such as SiO2, Al2O3, Fe2O3 and CaO and minor contents of alkaline and earth alkaline oxides. Production of these ceramics was conducted through the consolidation of clay and waste demolition brick with the evaluation of the main process parameters such as sintering temperature [ST], the content of waste demolition brick [WDB] and isothermal period at the final temperature [IP]. The final model equations for density and bending strength dependence of the main process parameters were obtained and presented. The microstructure of the ceramics determined by SEM shows that the waste material is homogeneously dispersed in the clay matrix.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80784770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Nikolić, T. Stojanović, V. Nikolić, M. Urošević, S. Ilić-Stojanović, Ana Tačić, I. Gajić, V. Savic, Aleksandar Zdravković
In this study, two series of hydrogels were synthesised with different molar ratio of glucose units of starch and citric acid. The advantage of using natural raw materials (starch and citric acid) for the synthesis of hydrogels lies in the fact that these raw materials are synthesised in nature, beneficial to human beings, easily degradable after use and harmless. The generated hydrogels and starting reactants were structurally characterised by applying the method of Fourier transform infrared spectroscopy (FTIR). FTIR analysis shows that the synthesis reaction of hydrogels based on starch and citric acid rests upon the esterification reaction of carboxyl groups in citric acid with hydroxyl groups in starch. The residual amount of citric acid in synthesised hydrogels was determined under high pressure with high-performance liquid chromatography (HPLC). The values of unreacted citric acid range between 9.85 and 16.08%.The scanning electron microscopy was applied in the analysis of hydrogel morphology. The swelling of hydrogel was monitored at 25 °C in the solutions of pH values of 5, 7 and 9. The highest swelling degree (a=8.55) was achieved in water at pH 7 for the hydrogel synthesised with the smallest amount of citric acid as the cross-linker at the ratio of glucose units of starch and citric acid being 72. Hydrogels synthesised from such monomers are environmentally friendly and fully biodegradable.
{"title":"Synthesis and characterisation of hydrogels based on starch and citric acid","authors":"L. Nikolić, T. Stojanović, V. Nikolić, M. Urošević, S. Ilić-Stojanović, Ana Tačić, I. Gajić, V. Savic, Aleksandar Zdravković","doi":"10.5937/savteh2001050n","DOIUrl":"https://doi.org/10.5937/savteh2001050n","url":null,"abstract":"In this study, two series of hydrogels were synthesised with different molar ratio of glucose units of starch and citric acid. The advantage of using natural raw materials (starch and citric acid) for the synthesis of hydrogels lies in the fact that these raw materials are synthesised in nature, beneficial to human beings, easily degradable after use and harmless. The generated hydrogels and starting reactants were structurally characterised by applying the method of Fourier transform infrared spectroscopy (FTIR). FTIR analysis shows that the synthesis reaction of hydrogels based on starch and citric acid rests upon the esterification reaction of carboxyl groups in citric acid with hydroxyl groups in starch. The residual amount of citric acid in synthesised hydrogels was determined under high pressure with high-performance liquid chromatography (HPLC). The values of unreacted citric acid range between 9.85 and 16.08%.The scanning electron microscopy was applied in the analysis of hydrogel morphology. The swelling of hydrogel was monitored at 25 °C in the solutions of pH values of 5, 7 and 9. The highest swelling degree (a=8.55) was achieved in water at pH 7 for the hydrogel synthesised with the smallest amount of citric acid as the cross-linker at the ratio of glucose units of starch and citric acid being 72. Hydrogels synthesised from such monomers are environmentally friendly and fully biodegradable.","PeriodicalId":7216,"journal":{"name":"Advanced Technologies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89262410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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