Pub Date : 2025-01-01Epub Date: 2025-06-09DOI: 10.29011/2574-7754.102316
Pascal J Goldschmidt-Clermont, Robert Montenegro, Kate Rojas, Alexander J P Goldschmidt, Ian A White
The face and hands are among the most exposed areas of the human body. Maintaining healthy facial skin is particularly challenging due to its continuous exposure to environmental stressors. Factors such as ultraviolet (UV) radiation, air pollution, and adverse weather conditions, including humidity, wind, cold, and heat can all negatively impact the skin. UV radiation contributes to skin aging by inducing dermal thinning and hyperpigmentation, while pollution can lead to pore obstruction and the formation of comedones. Hormonal fluctuations, particularly in estrogen, testosterone, and cortisol play a significant role in modulating sebum production, comedogenesis, and cutaneous inflammation, all of which can contribute to the development of acne. Consequently, physiological stages such as puberty, menstruation, pregnancy, and menopause can markedly influence skin tone, texture, and overall clarity. Genetic predisposition plays a significant role in the susceptibility to dermatological conditions such as comedonal acne, inflammatory acne, rosacea, and hyperpigmentation. While topical and systemic acne therapies can be effective, their efficacy is often contingent upon appropriate selection based on individual skin type and acne phenotype. In some cases, treatments may be ineffective or associated with adverse effects, including irritation, scarring, or post-inflammatory hyperpigmentation. Additionally, mechanical trauma or incidental abrasions to the facial skin pose further challenges to maintaining cutaneous integrity and appearance. Here we provide evidence that a new therapeutic countermeasure, ViX001, can heal recalcitrant acne and sizeable abrasions.
{"title":"First Applications of Purified and Sterile Human Amniotic Fluid for the Successful Healing of Abrasion and Acne Lesions of the Face.","authors":"Pascal J Goldschmidt-Clermont, Robert Montenegro, Kate Rojas, Alexander J P Goldschmidt, Ian A White","doi":"10.29011/2574-7754.102316","DOIUrl":"10.29011/2574-7754.102316","url":null,"abstract":"<p><p>The face and hands are among the most exposed areas of the human body. Maintaining healthy facial skin is particularly challenging due to its continuous exposure to environmental stressors. Factors such as ultraviolet (UV) radiation, air pollution, and adverse weather conditions, including humidity, wind, cold, and heat can all negatively impact the skin. UV radiation contributes to skin aging by inducing dermal thinning and hyperpigmentation, while pollution can lead to pore obstruction and the formation of comedones. Hormonal fluctuations, particularly in estrogen, testosterone, and cortisol play a significant role in modulating sebum production, comedogenesis, and cutaneous inflammation, all of which can contribute to the development of acne. Consequently, physiological stages such as puberty, menstruation, pregnancy, and menopause can markedly influence skin tone, texture, and overall clarity. Genetic predisposition plays a significant role in the susceptibility to dermatological conditions such as comedonal acne, inflammatory acne, rosacea, and hyperpigmentation. While topical and systemic acne therapies can be effective, their efficacy is often contingent upon appropriate selection based on individual skin type and acne phenotype. In some cases, treatments may be ineffective or associated with adverse effects, including irritation, scarring, or post-inflammatory hyperpigmentation. Additionally, mechanical trauma or incidental abrasions to the facial skin pose further challenges to maintaining cutaneous integrity and appearance. Here we provide evidence that a new therapeutic countermeasure, ViX001, can heal recalcitrant acne and sizeable abrasions.</p>","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.29011/2574-7754.101904
{"title":"The Danger of Diagnostic Overshadowing in Primary Care: A Case Report of Delayed Diagnosis of Inflammatory Bowel Disease","authors":"","doi":"10.29011/2574-7754.101904","DOIUrl":"https://doi.org/10.29011/2574-7754.101904","url":null,"abstract":"","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.29011/2574-7754.101900
{"title":"Retrospective Review of Patients Presenting for Daytime, Evening, Weekday, and Weekend Breast Cancer Screening and Diagnostic Imaging Appointments","authors":"","doi":"10.29011/2574-7754.101900","DOIUrl":"https://doi.org/10.29011/2574-7754.101900","url":null,"abstract":"","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.29011/2574-7754.101891
{"title":"Outcome of Patients with Delayed Brain Metastases Following Initial Ipilimumab plus Nivolumab Treatment of Disseminated Melanoma","authors":"","doi":"10.29011/2574-7754.101891","DOIUrl":"https://doi.org/10.29011/2574-7754.101891","url":null,"abstract":"","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":" 75","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.29011/2574-7754.101893
Daniele Speciale, Alberto Pagnamenta, Filippo Tami, Paolo Maino, Sabrina Bettoni
Major road trauma in the prone position, when the victim cannot be released or retrieved due to intense pain, is a rare event. We present a case of a young patient who was incarcerated with his right lower limb in the prone position in a bulldozer. The impossibility of being able to extract him in a short time and the very intense pain, not responsive to high doses of analgesics, led us to perform an induction and intubation in the prone position with video laryngoscope. The success of the maneuver allowed us to release the patient in a short time with excellent outcome in terms of recovery of the lower limb
{"title":"Intubation of a Patient in Prone Position with the Videolaryngoscope in a Street Trauma","authors":"Daniele Speciale, Alberto Pagnamenta, Filippo Tami, Paolo Maino, Sabrina Bettoni","doi":"10.29011/2574-7754.101893","DOIUrl":"https://doi.org/10.29011/2574-7754.101893","url":null,"abstract":"Major road trauma in the prone position, when the victim cannot be released or retrieved due to intense pain, is a rare event. We present a case of a young patient who was incarcerated with his right lower limb in the prone position in a bulldozer. The impossibility of being able to extract him in a short time and the very intense pain, not responsive to high doses of analgesics, led us to perform an induction and intubation in the prone position with video laryngoscope. The success of the maneuver allowed us to release the patient in a short time with excellent outcome in terms of recovery of the lower limb","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":" 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.29011/2574-7754.101882
{"title":"Case Report: Pulmonary Aplasia in Pregnant Women","authors":"","doi":"10.29011/2574-7754.101882","DOIUrl":"https://doi.org/10.29011/2574-7754.101882","url":null,"abstract":"","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"78 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.29011/2574-7754.101881
Ivan Rektor, M. Fňašková, Sofia Berezka, M. Gajdoš, Pavel Říha, Tetyana Evmenova, Marek Preiss
Purpose: We raised the question whether the neurobiological and psychological impact of war stress could be observed in Ukrainian refugees during an ongoing war. Ukrainian refugee women (UG, n=43) from the war-torn regions were investigated and were compared to Czech women control group without stress (CG, n=21). Men were not allowed to leave Ukraine due to the war conditions. Method: Psychological testing was performed using tests available in Ukrainian language: Posttraumatic stress disorder Check List; Zung Self-Rating Depression Scale; The State-Trait Anxiety Inventory; Test of Intellectual Potential and Digit Span - WAIS III. Magnetic Resonance Imaging included voxel-based morphometry, functional MR, seed-based connectivity. Finding: UG scored significantly higher than CG in stress (p<0.001), depression (p=0.019) and anxiety (p=0.001) and lower than CG in an abstract reasoning task (p<0.030). The groups did not differ significantly in memory and intellectual tasks. MRI showed an enlargement of the posterior and central parts of the thalamus that were related to the frontal orbital gyrus and insula indicating a connectivity with limbic system regions. Conclusion: The data show the impact of acute and ongoing war-related stress on psychological features as well as on the thalamus and connectivity of stress-related cortical areas. Acute and ongoing war stress had a significant neurobiological impact on refugees from war-torn Ukraine.
{"title":"Acute War Stress in Ukrainian Refugees: Neurobiological and Psychological Impact","authors":"Ivan Rektor, M. Fňašková, Sofia Berezka, M. Gajdoš, Pavel Říha, Tetyana Evmenova, Marek Preiss","doi":"10.29011/2574-7754.101881","DOIUrl":"https://doi.org/10.29011/2574-7754.101881","url":null,"abstract":"Purpose: We raised the question whether the neurobiological and psychological impact of war stress could be observed in Ukrainian refugees during an ongoing war. Ukrainian refugee women (UG, n=43) from the war-torn regions were investigated and were compared to Czech women control group without stress (CG, n=21). Men were not allowed to leave Ukraine due to the war conditions. Method: Psychological testing was performed using tests available in Ukrainian language: Posttraumatic stress disorder Check List; Zung Self-Rating Depression Scale; The State-Trait Anxiety Inventory; Test of Intellectual Potential and Digit Span - WAIS III. Magnetic Resonance Imaging included voxel-based morphometry, functional MR, seed-based connectivity. Finding: UG scored significantly higher than CG in stress (p<0.001), depression (p=0.019) and anxiety (p=0.001) and lower than CG in an abstract reasoning task (p<0.030). The groups did not differ significantly in memory and intellectual tasks. MRI showed an enlargement of the posterior and central parts of the thalamus that were related to the frontal orbital gyrus and insula indicating a connectivity with limbic system regions. Conclusion: The data show the impact of acute and ongoing war-related stress on psychological features as well as on the thalamus and connectivity of stress-related cortical areas. Acute and ongoing war stress had a significant neurobiological impact on refugees from war-torn Ukraine.","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"138 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.29011/2574-7754.101875
{"title":"An Emerging Problem: Multidisciplinary Treatment of Liver Transplant-Associated Biliary Complica- tions in Patients with Roux-En-Y Gastric Bypass","authors":"","doi":"10.29011/2574-7754.101875","DOIUrl":"https://doi.org/10.29011/2574-7754.101875","url":null,"abstract":"","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141836410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.29011/2574-7754.101872
A. Chuansumrit, S. Jaovisidha, N. Sirachainan, Tachit Jiravichitchai, P. Kadegasem, Ketsuda Kempka, Monratta Pitakcharoen, Wannaphorn Rotchanpanya
Dose Emicizumab, and Sequential Monthly Low Dose Emicizumab and Factor VIII Concentrate Prophylaxis among Patients with Hemophilia A: A Case Series Report of 3-Year Follow-Up.
血友病 A 患者中的小剂量埃米珠单抗和每月序贯小剂量埃米珠单抗及因子 VIII 浓缩物预防治疗：3 年随访病例系列报告。
{"title":"Effectiveness of Monthly Low Dose Emicizumab, and Sequential Monthly Low Dose Emicizumab and Factor VIII Concentrate Prophylaxis among Patients with Hemophilia A: A Case Series Report of 3-Year Follow-Up","authors":"A. Chuansumrit, S. Jaovisidha, N. Sirachainan, Tachit Jiravichitchai, P. Kadegasem, Ketsuda Kempka, Monratta Pitakcharoen, Wannaphorn Rotchanpanya","doi":"10.29011/2574-7754.101872","DOIUrl":"https://doi.org/10.29011/2574-7754.101872","url":null,"abstract":"Dose Emicizumab, and Sequential Monthly Low Dose Emicizumab and Factor VIII Concentrate Prophylaxis among Patients with Hemophilia A: A Case Series Report of 3-Year Follow-Up.","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"103 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.29011/2574-7754.101876
Emira Hysa, Eugerta Dilka, Laert Gjati, D. Xhemalaj, Olvis Petre, E. Tashi, Franc Rrumbullaku, Marsel Broqi, Valentina Hima, Alma Tefereci, Esmeralda Nushi, Ada Shehaj, Justi Shestani, Klara Ziu, F. Gradica, P. Kapisyzi
The increasing use of lung ultrasound has consistently shown its high sensitivity compared to stethoscopes and radiographs for acute inflammatory and cardiovascular pathologies. It saves time, is relatively cost-effective, bedside, and provides information on adjacent systems to the respiratory system while avoiding radiation exposure [1-6]. Lung ultrasound holds particular value not only in detecting abnormal lung conditions but often plays a decisive role in diagnosis or further diagnostic steps. Lesions near the thoracic wall can be identified using lung ultrasound, which provides good imaging for diagnosing lung diseases. Ultrasound examination of the liver may reveal concurrent liver involvement in up to 15% of individuals with lung echinococcus cyst [7,8]. In rare cases, the presence of fluid in the thoracic cavity is mistakenly identified through lung ultrasound as simple parapneumonic pleural effusion [9]. In this study, we aim to demonstrate the importance of lung ultrasound in resolving diagnostic dilemmas: plankton sign, hailstorm, snowstorm, or snowball [10-13] in a case of lung echinococcus cyst. The video image of the presentation of lung echinococcus cyst is nearly unique in our knowledge.
{"title":"Challenging Dilemma: Is it Rainstorm, Hailstorm, Snowstorm, or Snowball?","authors":"Emira Hysa, Eugerta Dilka, Laert Gjati, D. Xhemalaj, Olvis Petre, E. Tashi, Franc Rrumbullaku, Marsel Broqi, Valentina Hima, Alma Tefereci, Esmeralda Nushi, Ada Shehaj, Justi Shestani, Klara Ziu, F. Gradica, P. Kapisyzi","doi":"10.29011/2574-7754.101876","DOIUrl":"https://doi.org/10.29011/2574-7754.101876","url":null,"abstract":"The increasing use of lung ultrasound has consistently shown its high sensitivity compared to stethoscopes and radiographs for acute inflammatory and cardiovascular pathologies. It saves time, is relatively cost-effective, bedside, and provides information on adjacent systems to the respiratory system while avoiding radiation exposure [1-6]. Lung ultrasound holds particular value not only in detecting abnormal lung conditions but often plays a decisive role in diagnosis or further diagnostic steps. Lesions near the thoracic wall can be identified using lung ultrasound, which provides good imaging for diagnosing lung diseases. Ultrasound examination of the liver may reveal concurrent liver involvement in up to 15% of individuals with lung echinococcus cyst [7,8]. In rare cases, the presence of fluid in the thoracic cavity is mistakenly identified through lung ultrasound as simple parapneumonic pleural effusion [9]. In this study, we aim to demonstrate the importance of lung ultrasound in resolving diagnostic dilemmas: plankton sign, hailstorm, snowstorm, or snowball [10-13] in a case of lung echinococcus cyst. The video image of the presentation of lung echinococcus cyst is nearly unique in our knowledge.","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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