Brianna Conte, D. Casey, N. Gerber, L. Wexler, K. Alektiar, S. Berry, S. Wolden
{"title":"Whole-Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases: Single-Institution Prospective Clinical Trial","authors":"Brianna Conte, D. Casey, N. Gerber, L. Wexler, K. Alektiar, S. Berry, S. Wolden","doi":"10.37549/aro1344","DOIUrl":"https://doi.org/10.37549/aro1344","url":null,"abstract":"","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45757660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Opportunities Are Knocking, Are You Listening?","authors":"K. McComas","doi":"10.37549/aro1341","DOIUrl":"https://doi.org/10.37549/aro1341","url":null,"abstract":"","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44635334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Razavian, Alexis N. Schutz, L.-T. Chang, Cecil Benitez, M. Sandoval, Y. Sharifzadeh, M. Sherer, E. Merfeld, C. Washington, G. McKenzie, Q. Khan, C. Hassanzadeh, Mona Arbab
{"title":"Evaluating the Utility of Webinars on the Radiation Oncology Residency Application Process in the COVID-19 Era","authors":"N. Razavian, Alexis N. Schutz, L.-T. Chang, Cecil Benitez, M. Sandoval, Y. Sharifzadeh, M. Sherer, E. Merfeld, C. Washington, G. McKenzie, Q. Khan, C. Hassanzadeh, Mona Arbab","doi":"10.37549/aro1339","DOIUrl":"https://doi.org/10.37549/aro1339","url":null,"abstract":"","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47712709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. K. Sandstrom, David B. Mansur, M. L. Morgan, Serah Choi
region. The patient underwent a near total resection of the tumor and pathology showed a CNS WHO grade 2 meningioma. One month following surgery, she completed conventionally fractionated radiation therapy to the residual tumor and surrounding high-risk region using proton beam therapy to a total dose of 50.4 cobalt gray equivalents (CGE) in 28 fractions (1.8 CGE per fraction) (Figure 1) . In the absence of an established dose response and given the proximity of the optic apparatus and the emerging uncertainty about proton relative biological effectiveness (RBE) and radiation injury, a dose of 50.4 CGE was used. The maximum (to 0.03 cc volume) and mean doses to the optic nerves and chiasm were: right Abstract Radiation-induced optic neuropathy (RION) is a rare late effect following radiation caused by damage to the optic nerves or chiasm. It is a profound and devastating complication of radiation therapy with no effective treatment and is irreversible. Charles Bonnet syndrome (CBS) is a rare phenomenon characterized by complex visual hallucinations that occur concurrently with visual field loss or visual acuity loss. This case describes a woman with a CNS WHO grade 2 meningioma who received conventionally fractionated radiation therapy with a proton beam to the residual tumor and resection cavity after near total resection. She subsequently developed RION with vision loss and hallucinations and was diagnosed with CBS. We recommend that even though the incidence of RION is rare, patients should be counseled by providers for potential late effects of radiation treatment with surveillance routinely after treatment.
{"title":"A Case of Vision Loss From Radiation-Induced Optic Neuropathy Resulting in Charles Bonnet Syndrome","authors":"S. K. Sandstrom, David B. Mansur, M. L. Morgan, Serah Choi","doi":"10.37549/aro1340","DOIUrl":"https://doi.org/10.37549/aro1340","url":null,"abstract":"region. The patient underwent a near total resection of the tumor and pathology showed a CNS WHO grade 2 meningioma. One month following surgery, she completed conventionally fractionated radiation therapy to the residual tumor and surrounding high-risk region using proton beam therapy to a total dose of 50.4 cobalt gray equivalents (CGE) in 28 fractions (1.8 CGE per fraction) (Figure 1) . In the absence of an established dose response and given the proximity of the optic apparatus and the emerging uncertainty about proton relative biological effectiveness (RBE) and radiation injury, a dose of 50.4 CGE was used. The maximum (to 0.03 cc volume) and mean doses to the optic nerves and chiasm were: right Abstract Radiation-induced optic neuropathy (RION) is a rare late effect following radiation caused by damage to the optic nerves or chiasm. It is a profound and devastating complication of radiation therapy with no effective treatment and is irreversible. Charles Bonnet syndrome (CBS) is a rare phenomenon characterized by complex visual hallucinations that occur concurrently with visual field loss or visual acuity loss. This case describes a woman with a CNS WHO grade 2 meningioma who received conventionally fractionated radiation therapy with a proton beam to the residual tumor and resection cavity after near total resection. She subsequently developed RION with vision loss and hallucinations and was diagnosed with CBS. We recommend that even though the incidence of RION is rare, patients should be counseled by providers for potential late effects of radiation treatment with surveillance routinely after treatment.","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47787188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
appropriate for SRS over WBRT techniques? What is the best sequencing of
适用于SRS而非WBRT技术？什么是最好的排序
{"title":"Stereotactic Radiosurgery for Brain Metastases: Review of Existing Data and Future Directions","authors":"E. Rahimy, S. Soltys","doi":"10.37549/aro1338","DOIUrl":"https://doi.org/10.37549/aro1338","url":null,"abstract":"appropriate for SRS over WBRT techniques? What is the best sequencing of","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48641654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Han, N. Kovalchuk, M. Gensheimer, L. Vitzthum, L. Xing, M. Surucu
formed by all MLC leaves retracted is 40 cm. The jaw pairs open 1 or 2 cm at the isocenter in the longitudinal direction. The nominal beam dose rate is 850 monitor units (MU)/min for the original IMRT/SBRT version of the machine. With the BgRT upgrade, the dose rate is 1000 MU/ min. The kVCT scanner is located on a plane 61.4 cm superior to the room laser. The X1 machine consists of 2 symmetrically opposing 90-degree arcs of PET detectors incorporated into the architecture of a ring-gantry at the same plane to the linac 100 cm superior to the room laser. The treatment delivery with the X1 system is achieved axially with the couch advancing at discrete intervals of 2.1 mm, making 1 or 4 passes through the treated region Abstract Biology-guided radiation therapy (BgRT) is an emerging technology that integrates real-time PET imaging with radiation therapy to improve tumor targeting and treatment outcomes. This systematic review aims to summarize the Stanford experience on the current state of knowledge on machine commissioning, quality assurance, treat-ment planning, clinical applications, safety, and efficacy of BgRT in cancer treatment. The review underscores advancements in the clinical implementation of intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) technologies, facilitated by the introduction of the novel BgRT machine. It also highlights challenges related to improving workflow efficiency and validating tracking accuracy in real-world patient situations. This document serves as a valuable resource for researchers, clinicians, and decision-makers within the realm of radiation oncology, providing insights into the status of the PET-based BgRT machine and guiding the trajectory of future research.
{"title":"Stanford Experience With Commissioning, Quality Assurance and IMRT/ SBRT Treatment of the First Biology-Guided Radiation Therapy Machine","authors":"B. Han, N. Kovalchuk, M. Gensheimer, L. Vitzthum, L. Xing, M. Surucu","doi":"10.37549/aro1343","DOIUrl":"https://doi.org/10.37549/aro1343","url":null,"abstract":"formed by all MLC leaves retracted is 40 cm. The jaw pairs open 1 or 2 cm at the isocenter in the longitudinal direction. The nominal beam dose rate is 850 monitor units (MU)/min for the original IMRT/SBRT version of the machine. With the BgRT upgrade, the dose rate is 1000 MU/ min. The kVCT scanner is located on a plane 61.4 cm superior to the room laser. The X1 machine consists of 2 symmetrically opposing 90-degree arcs of PET detectors incorporated into the architecture of a ring-gantry at the same plane to the linac 100 cm superior to the room laser. The treatment delivery with the X1 system is achieved axially with the couch advancing at discrete intervals of 2.1 mm, making 1 or 4 passes through the treated region Abstract Biology-guided radiation therapy (BgRT) is an emerging technology that integrates real-time PET imaging with radiation therapy to improve tumor targeting and treatment outcomes. This systematic review aims to summarize the Stanford experience on the current state of knowledge on machine commissioning, quality assurance, treat-ment planning, clinical applications, safety, and efficacy of BgRT in cancer treatment. The review underscores advancements in the clinical implementation of intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) technologies, facilitated by the introduction of the novel BgRT machine. It also highlights challenges related to improving workflow efficiency and validating tracking accuracy in real-world patient situations. This document serves as a valuable resource for researchers, clinicians, and decision-makers within the realm of radiation oncology, providing insights into the status of the PET-based BgRT machine and guiding the trajectory of future research.","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48066937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Saraf, G. Boyd, A. D. De Leo, P. Gawu, C. Pinnix, Steve E. Braunstein, R. Jimenez, I. Franco, L. Singer
{"title":"Future of Radiation Oncology Education: Transforming Scholarly Teaching Into Medical Education Scholarship","authors":"A. Saraf, G. Boyd, A. D. De Leo, P. Gawu, C. Pinnix, Steve E. Braunstein, R. Jimenez, I. Franco, L. Singer","doi":"10.37549/aro1334","DOIUrl":"https://doi.org/10.37549/aro1334","url":null,"abstract":"","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43514000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pranit Singh, Jacob Adams, Sylvia Choo, M. Adams, J. McDonald, Laura Barton, R. Levine, D. W. Kim, R. Palm, J. Frakes, Sarah Hoffe
{"title":"Locoregional Chemoradiation for a Patient with BRCA1 Stage IV Pancreatic Adenocarcinoma","authors":"Pranit Singh, Jacob Adams, Sylvia Choo, M. Adams, J. McDonald, Laura Barton, R. Levine, D. W. Kim, R. Palm, J. Frakes, Sarah Hoffe","doi":"10.37549/aro1335","DOIUrl":"https://doi.org/10.37549/aro1335","url":null,"abstract":"","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41952232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Upadhyay, H. Perlow, Evan M. Thomas, S. Beyer, R. Raval, J. Grecula, D. Blakaj, A. Chakravarti, W. Slone, P. Giglio, J. Elder
no other distant metastases. She underwent video-assisted thoracoscopic surgery (VATS) biopsy of parietal pleural nodules, which confirmed metastatic renal cell carcinoma. Baseline contrast-enhanced MRI of brain was negative for intracranial metastases. She was started on first-line systemic therapy with pembrolizumab and axitinib. Restaging scans revealed good response with improvement in small pulmonary nodules with minimal residual pleural thickening in the right lung base. About 6 months after initial diagnosis, the patient presented with headaches and left-sided neck pain. A brain MRI with and without contrast revealed interval development of a 1.5 × 1.4-cm enhancing nodule in the left frontal lobe with mild to moderate surrounding vasogenic edema and mass effect. She also had an MRI of the cervical spine, which demonstrated multilevel degenerative changes but no metastatic disease. She was started on a short course of tapering Abstract Radiation necrosis (RN) is a concerning late toxicity after radiation therapy for brain metastases. The management of RN primarily depends on the extent of edema on imaging and presence of symptoms. Oral corticosteroids are the mainstay of management; however, they are not optimal for long-term management because of multiple side effects and drug interactions. Boswellia serrata is an extract derived from Indian frankincense, which is available as an over-the-counter supplement, and has been traditionally used in the treatment of asthma, arthritis and colitis due to its anti-inflammatory properties. Recent data have reported the benefits of Boswellia on reducing cerebral edema. We discuss a case report involving a patient with brain metastases treated with stereotactic radiosurgery who developed early RN and had a good response with resolution of postradiation edema with the use of Boswellia.
{"title":"Role of Boswellia Serrata in Management of CNS Radiation Necrosis After Radiosurgery for Brain Metastases","authors":"R. Upadhyay, H. Perlow, Evan M. Thomas, S. Beyer, R. Raval, J. Grecula, D. Blakaj, A. Chakravarti, W. Slone, P. Giglio, J. Elder","doi":"10.37549/aro1337","DOIUrl":"https://doi.org/10.37549/aro1337","url":null,"abstract":"no other distant metastases. She underwent video-assisted thoracoscopic surgery (VATS) biopsy of parietal pleural nodules, which confirmed metastatic renal cell carcinoma. Baseline contrast-enhanced MRI of brain was negative for intracranial metastases. She was started on first-line systemic therapy with pembrolizumab and axitinib. Restaging scans revealed good response with improvement in small pulmonary nodules with minimal residual pleural thickening in the right lung base. About 6 months after initial diagnosis, the patient presented with headaches and left-sided neck pain. A brain MRI with and without contrast revealed interval development of a 1.5 × 1.4-cm enhancing nodule in the left frontal lobe with mild to moderate surrounding vasogenic edema and mass effect. She also had an MRI of the cervical spine, which demonstrated multilevel degenerative changes but no metastatic disease. She was started on a short course of tapering Abstract Radiation necrosis (RN) is a concerning late toxicity after radiation therapy for brain metastases. The management of RN primarily depends on the extent of edema on imaging and presence of symptoms. Oral corticosteroids are the mainstay of management; however, they are not optimal for long-term management because of multiple side effects and drug interactions. Boswellia serrata is an extract derived from Indian frankincense, which is available as an over-the-counter supplement, and has been traditionally used in the treatment of asthma, arthritis and colitis due to its anti-inflammatory properties. Recent data have reported the benefits of Boswellia on reducing cerebral edema. We discuss a case report involving a patient with brain metastases treated with stereotactic radiosurgery who developed early RN and had a good response with resolution of postradiation edema with the use of Boswellia.","PeriodicalId":72265,"journal":{"name":"Applied radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42930062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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