Pub Date : 2024-07-18DOI: 10.1080/27694127.2024.2370728
Elisabetta Bartolini, Kris van Moer, B. Janji
{"title":"Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy","authors":"Elisabetta Bartolini, Kris van Moer, B. Janji","doi":"10.1080/27694127.2024.2370728","DOIUrl":"https://doi.org/10.1080/27694127.2024.2370728","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.1080/27694127.2024.2371736
Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak
{"title":"A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during\u0000 C. elegans\u0000 post-embryonic development and identifies compounds that modulate autophagy","authors":"Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak","doi":"10.1080/27694127.2024.2371736","DOIUrl":"https://doi.org/10.1080/27694127.2024.2371736","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24eCollection Date: 2024-12-31DOI: 10.1080/27694127.2024.2358648
Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti
Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a critical role in tumor initiation, progression, and therapy resistance. The tumor microenvironment (TME) is a complex area where diverse cancer cells reside creating a highly interactive environment with secreted factors, and the extracellular matrix. Autophagy, a cellular self-digestion process, influences dynamic cellular processes in the tumor TME integrating diverse signals that regulate tumor development and heterogeneity. Autophagy acts as a double-edged sword in the breast TME, with both tumor-promoting and tumor-suppressing roles. Autophagy promotes breast tumorigenesis by regulating tumor cell survival, migration and invasion, metabolic reprogramming, and epithelial-mesenchymal transition (EMT). BCSCs harness autophagy to maintain stemness properties, evade immune surveillance, and resist therapeutic interventions. Conversely, excessive, or dysregulated autophagy may lead to BCSC differentiation or cell death, offering a potential avenue for therapeutic exploration. The molecular mechanisms that regulate autophagy in BCSCs including the mammalian target of rapamycin (mTOR), AMPK, and Beclin-1 signaling pathways may be potential targets for pharmacological intervention in breast cancer. This review provides a comprehensive overview of the relationship between autophagy and BCSCs, highlighting recent advancements in our understanding of their interplay. We also discuss the current state of autophagy-targeting agents and their preclinical and clinical development in BCSCs.
{"title":"Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective.","authors":"Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti","doi":"10.1080/27694127.2024.2358648","DOIUrl":"10.1080/27694127.2024.2358648","url":null,"abstract":"<p><p>Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a critical role in tumor initiation, progression, and therapy resistance. The tumor microenvironment (TME) is a complex area where diverse cancer cells reside creating a highly interactive environment with secreted factors, and the extracellular matrix. Autophagy, a cellular self-digestion process, influences dynamic cellular processes in the tumor TME integrating diverse signals that regulate tumor development and heterogeneity. Autophagy acts as a double-edged sword in the breast TME, with both tumor-promoting and tumor-suppressing roles. Autophagy promotes breast tumorigenesis by regulating tumor cell survival, migration and invasion, metabolic reprogramming, and epithelial-mesenchymal transition (EMT). BCSCs harness autophagy to maintain stemness properties, evade immune surveillance, and resist therapeutic interventions. Conversely, excessive, or dysregulated autophagy may lead to BCSC differentiation or cell death, offering a potential avenue for therapeutic exploration. The molecular mechanisms that regulate autophagy in BCSCs including the mammalian target of rapamycin (mTOR), AMPK, and Beclin-1 signaling pathways may be potential targets for pharmacological intervention in breast cancer. This review provides a comprehensive overview of the relationship between autophagy and BCSCs, highlighting recent advancements in our understanding of their interplay. We also discuss the current state of autophagy-targeting agents and their preclinical and clinical development in BCSCs.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.1080/27694127.2024.2348899
Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold
{"title":"Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells","authors":"Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold","doi":"10.1080/27694127.2024.2348899","DOIUrl":"https://doi.org/10.1080/27694127.2024.2348899","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1080/27694127.2024.2346064
Aleksandra Janusz-Kamińska, Jacek Jaworski
{"title":"Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning","authors":"Aleksandra Janusz-Kamińska, Jacek Jaworski","doi":"10.1080/27694127.2024.2346064","DOIUrl":"https://doi.org/10.1080/27694127.2024.2346064","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"18 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1080/27694127.2024.2342129
F. D. Naso, F. Strappazzon
{"title":"Combining doxorubicin and miR-218-5p: a new strategy to fight breast cancer?","authors":"F. D. Naso, F. Strappazzon","doi":"10.1080/27694127.2024.2342129","DOIUrl":"https://doi.org/10.1080/27694127.2024.2342129","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"30 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.1080/27694127.2024.2326241
Hala Shalhoub, Patrick Gonzalez, Alexandre Dos Santos, Julie Guillermet-Guibert, Nicolas Moniaux, Nicolas Dupont, J. Faivre
{"title":"Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma","authors":"Hala Shalhoub, Patrick Gonzalez, Alexandre Dos Santos, Julie Guillermet-Guibert, Nicolas Moniaux, Nicolas Dupont, J. Faivre","doi":"10.1080/27694127.2024.2326241","DOIUrl":"https://doi.org/10.1080/27694127.2024.2326241","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"27 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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