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PINK1 regulated mitophagy is evident in skeletal muscles. PINK1 对有丝分裂的调控在骨骼肌中非常明显。
Autophagy reports
Pub Date : 2024-03-11 DOI: 10.1080/27694127.2024.2326402
Francois Singh, Lea Wilhelm, Alan R Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H Ogmundsdottir, Ian G Ganley

PINK1, mutated in familial forms of Parkinson's disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most tissues. To further characterize this pathway in vivo, we used mito-QC mice in which loss of PINK1 was combined with the mitochondrial-associated POLGD257A mutation. We focused on skeletal muscle as gene expression data indicates that this tissue has the highest PINK1 levels. We found that loss of PINK1 in oxidative hindlimb muscle significantly reduced mitophagy. Of interest, the presence of the POLGD257A mutation, while having a minor effect in most tissues, restored levels of muscle mitophagy caused by the loss of PINK1. Although our observations highlight that multiple mitophagy pathways operate within a single tissue, we identify skeletal muscle as a tissue of choice for the study of PINK1-dependant mitophagy under basal conditions.

家族性帕金森病中突变的 PINK1 可在线粒体去极化后启动有丝分裂。然而，由于 PINK1 的缺失不会改变大多数组织的基础有丝分裂水平，因此很难在小鼠体内对这一途径进行生理学监测。为了进一步确定这一途径的体内特征，我们使用了丝裂QC小鼠，在这种小鼠中，PINK1的缺失与线粒体相关的POLGD257A突变相结合。我们重点研究了骨骼肌，因为基因表达数据表明该组织的 PINK1 水平最高。我们发现，氧化性后肢肌肉中 PINK1 的缺失会显著降低有丝分裂。值得注意的是，POLGD257A 突变虽然在大多数组织中影响较小，但却能恢复因 PINK1 缺失而导致的肌肉有丝分裂水平。尽管我们的观察结果突显了多种有丝分裂途径在单个组织中的作用，但我们认为骨骼肌是在基础条件下研究 PINK1 依赖性有丝分裂的首选组织。
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引用次数: 0
GRB2, a protein known for a long time with a new autophagy-regulating function GRB2，一种具有新的自噬调节功能的已知蛋白质
Autophagy reports
Pub Date : 2024-03-06 DOI: 10.1080/27694127.2024.2325265
S. Vega-Rubín-de-Celis
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引用次数: 0
Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy α-突触核蛋白聚集体引发心磷脂外化和有丝分裂
Autophagy reports
Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2314361
Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain
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引用次数: 0
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure 心肌自噬与无菌性炎症在心力衰竭发病过程中的相互影响
Autophagy reports
Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2320605
Jialing Tang, Eddie Tam, Erfei Song, Aimin Xu, Gary Sweeney
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引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports
Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
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引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports
Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
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引用次数: 0
ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses ATG3 受氧化还原调节，以确保 ATG8 在产生 ROS 的压力下脂化
Autophagy reports
Pub Date : 2024-01-08 DOI: 10.1080/27694127.2023.2300622
Manuel J. Mallén-Ponce, M. Pérez-Pérez
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引用次数: 0
Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes 龙胆草素抑制葡萄糖转运，诱导 PRKAA1 介导的自噬，清除原发性星形胶质细胞中的β淀粉样蛋白和相关炎症
Autophagy reports
Pub Date : 2024-01-05 DOI: 10.1080/27694127.2023.2296209
Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar
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引用次数: 0
Molecular structures and function of the autophagosome-lysosome fusion machinery. 自噬体-溶酶体融合机制的分子结构和功能。
Autophagy reports
Pub Date : 2024-01-01 Epub Date: 2024-02-04 DOI: 10.1080/27694127.2024.2305594
Jiajie Diao, Calvin K Yip, Qing Zhong

Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome and the lytic organelle lysosome/vacuole. Over the past decade, various core components of the molecular machinery that execute this critical terminal autophagy event have been identified. This review highlights recent advances in understanding the molecular structures, biochemical functions, and regulatory mechanisms of key components of this highly sophisticated machinery including the SNARE fusogens, tethering factors, Rab GTPases and associated guanine nucleotide exchange factors, and other accessory factors.

大自噬（又称自噬）在维持细胞平衡方面发挥着关键作用。多步骤自噬降解途径的终极步骤涉及载货的双膜自噬体与溶酶体/囊泡之间的融合。在过去的十年中，执行这一关键的终端自噬事件的分子机制的各种核心成分已被确定。这篇综述重点介绍了最近在了解这一高度复杂的机制的主要成分的分子结构、生化功能和调控机制方面取得的进展，这些成分包括 SNARE fusogens、系留因子、Rab GTPases 和相关的鸟嘌呤核苷酸交换因子以及其他附属因子。
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引用次数: 0
Et tu, Brute? TFEB promotes virus replication before being cleaved by a viral protease. 你呢，布鲁特？TFEB 在被病毒蛋白酶分解之前会促进病毒复制。
Autophagy reports
Pub Date : 2024-01-01 Epub Date: 2024-09-16 DOI: 10.1080/27694127.2024.2402675
Alagie Jassey, William T Jackson
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引用次数: 0
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