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Discovery of small-molecule inhibitors for the protein-protein interactions involving ATG5 ATG5蛋白-蛋白质相互作用小分子抑制剂的发现
Pub Date : 2023-05-27 DOI: 10.1080/27694127.2023.2215617
Honggang Xiang, Renxiao Wang
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引用次数: 0
Cargo-interacting regions (CIR) of CCPG1 capture ER luminal cargos for reticulophagy CCPG1的货物相互作用区(CIR)捕获内质网吞噬的管腔货物
Pub Date : 2023-05-16 DOI: 10.1080/27694127.2023.2213560
Haruka Chino, S. Ishii, N. Mizushima, Eisuke Itakura
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引用次数: 0
Conserved regulation of autophagosome-lysosome fusion through YKT6 phosphorylation YKT6磷酸化对自噬体-溶酶体融合的调控作用
Pub Date : 2023-05-10 DOI: 10.1080/27694127.2023.2210946
Pablo Sánchez-Martín, C. Kraft
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引用次数: 0
Autophagy safeguards conidial environmental persistence in filamentous fungi 自噬保护丝状真菌分生孢子环境的持久性
Pub Date : 2023-04-25 DOI: 10.1080/27694127.2023.2205343
Jin-Li Ding, M. Feng, S. Ying
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引用次数: 0
Obesity-related proximal tubulopathy: an emerging threat to kidney health 肥胖相关的近端肾小管病变:对肾脏健康的新威胁
Pub Date : 2023-04-10 DOI: 10.1080/27694127.2023.2200341
Takeshi Yamamoto, Jun Nakamura, Yoshitsugu Takabatake, Y. Isaka
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引用次数: 0
A novel autophagy inhibitor, bTBT, disturbs autophagosome formation 一种新的自噬抑制剂,bTBT,干扰自噬体的形成
Pub Date : 2023-04-06 DOI: 10.1080/27694127.2023.2194620
Momoka Chiba, Mai Yanagawa, Yurika Oyama, Shingo Harada, T. Nemoto, Akira Matsuura, Eisuke Itakura
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引用次数: 0
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia BNIP3磷酸化和泛素化之间的相互作用调节低氧条件下的线粒体自噬
Pub Date : 2023-04-04 DOI: 10.1080/27694127.2023.2197637
Yun-Ling He, J. Li, Yan Cao, Haitao Wu, Li-Ying Wu
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引用次数: 0
Atg8 family proteins, LIR/AIM motifs and other interaction modes. Atg8家族蛋白、LIR/AIM基序和其他相互作用模式
Pub Date : 2023-03-19 eCollection Date: 2023-12-31 DOI: 10.1080/27694127.2023.2188523
Vladimir V Rogov, Ioannis P Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A Tooze, Ivan Dikic, Trond Lamark, Terje Johansen

The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, C. elegans and Drosophila to humans. Although varying in number of homologs, from one in yeast to seven in humans, and more than ten in some plants, there is a strong evolutionary conservation of structural features and interaction modes. The most prominent interaction mode is between the LC3 interacting region (LIR), also called Atg8 interacting motif (AIM), binding to the LIR docking site (LDS) in Atg8 homologs. There are variants of these motifs like "half-LIRs" and helical LIRs. We discuss details of the binding modes and how selectivity is achieved as well as the role of multivalent LIR-LDS interactions in selective autophagy. A number of LIR-LDS interactions are known to be regulated by phosphorylation. New methods to predict LIR motifs in proteins have emerged that will aid in discovery and analyses. There are also other interaction surfaces than the LDS becoming known where we presently lack detailed structural information, like the N-terminal arm region and the UIM-docking site (UDS). More interaction modes are likely to be discovered in future studies.

泛素样蛋白的Atg8家族在自噬和其他涉及囊泡融合和运输的过程中发挥着关键作用,其中溶酶体/液泡是终点站。Atg8蛋白的核作用也正在显现。在此,我们综述了Atg8家族蛋白的结构和功能特征,以及它们在酵母、拟南芥、秀丽隐杆线虫和果蝇等模式生物中与人类的蛋白质-蛋白质相互作用模式。尽管同源物的数量各不相同,从酵母中的一个到人类中的七个,以及一些植物中的十多个,但结构特征和
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引用次数: 0
Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy 细胞内病原体对mTORC1-或trpml1 - tfeb诱导的异种吞噬反应的存活
Pub Date : 2023-03-19 DOI: 10.1080/27694127.2023.2191918
M. Capurro, A. Prashar, Xiaodong Gao, N. Jones
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引用次数: 0
Does Exercise Regulate Autophagy in Humans? A Systematic Review and Meta-Analysis 运动能调节人类的自噬吗?系统综述与荟萃分析
Pub Date : 2023-03-17 DOI: 10.1080/27694127.2023.2190202
Xiang-Ke Chen, Chen Zheng, P. Siu, F. Sun, S. Wong, A. Ma
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引用次数: 0
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