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Association between polypharmacy and hypertension in the Iranian population aged 50 years or older: Iranian Multicenter Osteoporosis Study (IMOS-2021). 伊朗50岁及以上人群多药与高血压之间的关系:伊朗多中心骨质疏松症研究(IMOS-2021)。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-12-01 DOI: 10.1186/s12875-025-03094-4
Sanaz Bordbar, Neda Cheraghloo, Sarmad Salehi, Kazem Khalagi, Safoora Gharibzadeh, Pardis Zarepour, Mohanna Khojasteh, Ozra Tabatabaei-Malazy, Bagher Larijani
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引用次数: 0
The rural adolescent vaccine enterprise (RAVE): a cluster-randomized trial testing a multicomponent intervention to improve HPV vaccination in rural primary care settings. 农村青少年疫苗企业(RAVE):一项集群随机试验,测试了多成分干预措施,以改善农村初级保健机构的HPV疫苗接种。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-29 DOI: 10.1186/s12875-025-03076-6
Brigit A Hatch, Steele Valenzuela, Caitlin Dickinson, Chrystal Barnes, Nithya Ramalingam, Miguel Marino, Lyle J Fagnan, Sean Goodman, Patricia A Carney
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引用次数: 0
Clinical coordination between primary-level physicians and referral-level specialists in Morocco: a cross-sectional study. 摩洛哥初级医生和转诊专家之间的临床协调:一项横断面研究。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-29 DOI: 10.1186/s12875-025-03065-9
Rachid Moulki, Zakaria Belrhiti, Hanane Asri, Abdelghaffar El-Ammari, Asmae Khattabi

Background: As part of the ongoing overhaul of the Moroccan health-care system, clinical coordination between primary level physicians (PLP) and referral level specialists (RLS) remains crucial but under documented, especially in North Africa and the Eastern Mediterranean Region. This study aimed to assess clinical coordination levels in the Casablanca-Settat region and identify influencing factors.

Methods: An analytical cross-sectional survey was conducted from April to May 2024 among a random sample of 329 public-sector physicians (186 PLP; 143 RLS) from a pool of 1637 eligible practitioners. The COORDENA-CAT questionnaire, adapted from the original COORDENA instrument developed in Latin America and refined in Catalonia, was translated into French, culturally adapted, and psychometrically validated in four steps: forward-back translation, expert review, cognitive interviews, and a pilot study confirming construct validity and reliability. Fourteen items evaluated experiences of information-sharing and clinical-management coordination, whereas one summary item captured overall perception. Sociodemographic, organizational, and interactional data were collected. A multivariable logistic regression was performed to identify factors associated with a high perception of coordination (α = 0.05).

Results: Only 30.7% respondents (18.8% of PLP vs. 46.2% of RLS) reported regularly sharing clinical information. Therapeutic coherence was limited, with just 24.3% stating that care plans were jointly defined. While 97.3% of the PLP considered referrals appropriate, only 59.4% of the RLS agreed. Overall, 27.7% of the physicians (17.2% PLP and 41.3% RLS) judged coordination "often or always" satisfactory. Independent determinants of a high perception of coordination included working at the referral level (adjusted OR (aOR) = 3.34; 95% CI: 1.60-6.97), having personal ties with the other level (aOR = 3.05; 1.54-6.04), perceiving mutual influence on practice (aOR = 2.39; 1.24-4.58), and working in an institution that facilitates coordination (aOR = 2.66; 1.37-5.17).

Conclusion: Clinical coordination in the study region is limited, especially among PLP, due to inadequate feedback, weak formal mechanisms, and restricted specialist access. Strengthening local governance, providing secure digital tools (such as shared electronic health record and tele-expertise), organizing regular clinical meetings, and granting PLP formal recognition as care coordinators are priority strategies to enhance the continuity and efficiency of care pathways.

背景:作为摩洛哥正在进行的卫生保健系统改革的一部分,初级医生(PLP)和转诊级专家(RLS)之间的临床协调仍然至关重要,但没有记录,特别是在北非和东地中海地区。本研究旨在评估卡萨布兰卡-塞塔地区的临床协调水平,并确定影响因素。方法:于2024年4 - 5月在1637名符合条件的执业医师中随机抽取329名公共部门医师(PLP 186名,RLS 143名)进行分析性横断面调查。COORDENA- cat问卷改编自在拉丁美洲开发并在加泰罗尼亚改进的COORDENA原始工具,被翻译成法语,进行文化调整,并通过四个步骤进行心理测量学验证:前后翻译、专家评审、认知访谈和确认结构效度和信度的试点研究。14个项目评估了信息共享和临床管理协调的经验,而一个摘要项目捕获了总体感知。收集了社会人口学、组织和互动数据。采用多变量逻辑回归来确定与高协调感知相关的因素(α = 0.05)。结果:只有30.7%的受访者(PLP为18.8%,RLS为46.2%)报告定期分享临床信息。治疗一致性是有限的,只有24.3%的人说护理计划是共同定义的。97.3%的PLP认为转介合适,而只有59.4%的RLS同意。总体而言,27.7%的医生(17.2%的PLP和41.3%的RLS)认为协调“经常或总是”令人满意。高协调感知的独立决定因素包括在转诊水平工作(调整后OR = 3.34;95% CI: 1.60-6.97),与其他层次有个人联系(aOR = 3.05; 1.54-6.04),感知到对实践的相互影响(aOR = 2.39; 1.24-4.58),在一个有利于协调的机构工作(aOR = 2.66; 1.37-5.17)。结论:由于反馈不充分、正规机制薄弱和专家准入受限,研究区域的临床协调有限,特别是PLP之间的临床协调。加强地方治理、提供安全的数字工具(如共享电子健康记录和远程专业知识)、组织定期临床会议以及正式承认PLP为护理协调员是提高护理途径连续性和效率的优先战略。
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引用次数: 0
Defining quality indicators for atherosclerotic cardiovascular diseases in primary care, extractable from the electronic health record: a RAND-modified Delphi method. 定义初级保健中动脉粥样硬化性心血管疾病的质量指标,可从电子健康记录中提取:rand修改的德尔菲法
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-29 DOI: 10.1186/s12875-025-03087-3
Laura Christiaens, Willem Raat, Liesbeth Meel, Marijke Avonts, Marie Van de Putte, Bert Vaes, Steve Van den Bulck

Background: Atherosclerotic cardiovascular diseases (ASCVD) account for 85% of all cardiovascular diseases and put a substantial burden on healthcare systems. General practitioners play an important role in managing ASCVD. The management of ASCVD could be improved by audit and feedback (A&F) based on quality indicators (QIs) derived from the electronic health record (EHR) of the general practitioner. This study aimed to define a set of validated and EHR extractable QIs for ASCVD to support A&F in primary care.

Methods: A RAND-modified Delphi method was employed to define QIs. Recommendations were selected based on the SMART principle from international guidelines, selected following the AGREE II evaluation. After assessment by a multidisciplinary expert panel, the recommendations were analyzed using the median Likert Scale score, prioritization, and degree of agreement. They were preliminary classified as having high, uncertain or low potential to measure the quality of ASCVD care. These recommendations were further discussed in a consensus meeting. Upon final validation, high-potential recommendations were converted into QIs.

Results: A questionnaire composed of 92 recommendations, selected from 12 international guidelines, were presented to the panel, resulting in a set of 50 high-potential recommendations. These were merged and modified into 41 recommendations after the consensus meeting. This resulted in a final set of 41 QIs classified into four categories: follow-up (N = 4), pharmacological treatment (N = 22), patient education (N = 10), and referral (N = 5).

Conclusions: This study defines a set of 41 EHR extractable QIs for ASCVD in primary care, supporting A&F in primary care.

背景:动脉粥样硬化性心血管疾病(ASCVD)占所有心血管疾病的85%,给卫生保健系统带来了沉重的负担。全科医生在管理ASCVD方面发挥着重要作用。基于全科医生电子健康记录(EHR)质量指标的审计和反馈(A&F)可以改善ASCVD的管理。本研究旨在为ASCVD定义一套经过验证且可从电子病历中提取的QIs,以支持初级保健中的A&F。方法:采用改进rand的德尔菲法确定质量指标。建议是根据国际准则中的SMART原则选择的,这些准则是在AGREE II评估之后选择的。在多学科专家小组评估后,使用中位数李克特量表评分、优先级和一致程度对建议进行分析。他们被初步分为高、不确定或低潜力来衡量ASCVD护理的质量。在协商一致会议上进一步讨论了这些建议。在最终验证后,高潜力的建议被转换为QIs。结果:向专家组提交了一份由92项建议组成的问卷,这些建议是从12项国际指南中选出的,最终产生了50项高潜力建议。这些建议在协商一致会议后合并并修改为41项建议。最终41个QIs分为四类:随访(N = 4)、药物治疗(N = 22)、患者教育(N = 10)和转诊(N = 5)。结论:本研究定义了一套41个用于初级保健ASCVD的EHR可提取QIs,支持初级保健中的A&F。
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引用次数: 0
Invited commentary: does social concordance matter? 特邀评论:社会和谐重要吗?
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-28 DOI: 10.1186/s12875-025-03080-w
Janeane N Anderson

Social concordance is a facilitator of key dimensions of healthcare engagement and may mitigate effects of systemic oppression. Given social hierarchies disadvantage marginalized patients in medical encounters, social concordance can strengthen the patient-clinician therapeutic alliance and increase communication and epistemic justice, necessary precursors to patient empowerment and improved health outcomes.

社会和谐是促进医疗保健参与的关键因素,并可能减轻系统性压迫的影响。鉴于社会等级制度在医疗遭遇中对边缘化患者不利,社会和谐可以加强患者-临床医生治疗联盟,增加沟通和认识正义,这是患者赋权和改善健康结果的必要前兆。
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引用次数: 0
Analysing comfort with primary care discussions and openness to social prescribing as mediators of the associations between loneliness and wellbeing among Canadians aged 55 and older. 在55岁及以上的加拿大人中,分析初级保健讨论的舒适度和对社会处方的开放性作为孤独和幸福之间关联的中介。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-28 DOI: 10.1186/s12875-025-03067-7
Daniel R Y Gan, Vivian Welch, Paul Hébert, Michelle Nelson, Kate Mulligan, Adam S Hoverman, Sandra Allison, Grace Park, Kiffer G Card

Background: Addressing the complex health and wellbeing challenges of older adults is a critical public health priority as populations age. Social Prescribing (SP) represents a promising strategy, connecting patients to non-clinical, community-based resources to enhance physical, mental, and social wellbeing.

Methods: To develop a SP theory of change, this study used cross-sectional data from 2,450 community-dwelling older adults who participated in a population survey. Factor analyses identified four factors of comfort with primary care discussions (general, mental, physical, and social wellness) and three factors of openness to SP (effectiveness, meaningfulness, and supportiveness). Path analysis was conducted for each set of mediators separately.

Results: Path analyses revealed that comfort with primary care discussions about social wellness (β = 0.08**) is associated with better wellbeing. People who report social loneliness are most comfortable with primary care discussions about general wellness (β = - 0.17***) and least comfortable with primary care discussions about mental wellness (β = - 0.24***), whereas people who report emotional loneliness are more likely to have similar levels of comfort to discuss general wellness and mental wellness (β = - 0.18***; - 0.18***). In addition, social loneliness is associated with less comfort with primary care discussions about social wellness (β = - 0.19***) and mental wellness (β = - 0.19***), whereas association is not found for emotional loneliness. These suggest that addressing the SP needs of people who experience emotional loneliness requires a different strategy. Reporting emotional loneliness is associated with expressing support for SP (β = 0.14***), which may be key to improving wellbeing (β = 0.10***) among this population. Overall, social loneliness has a total effect size of βtotal = - 0.19, whereas emotional loneliness has a total effect size of βtotal = - 0.45, more than 2.3 times larger.

Conclusions: While SP may be acceptable to those who need it, some may experience greater difficulties accessing SP through primary care providers without interventions tailored to their loneliness status that could elicit buy-in and enrolment. Primary care providers may wish to pay closer attention to people with emotional loneliness. Other considerations, such as trust and motivational interviewing for positive self-beliefs may explain potential changes from loneliness to wellbeing.

背景:随着人口老龄化,解决老年人复杂的健康和福祉挑战是一个关键的公共卫生优先事项。社会处方(SP)代表了一种很有前途的策略,将患者与非临床的、基于社区的资源联系起来,以增强身体、精神和社会福祉。方法:为了建立SP变化理论,本研究使用了参与人口调查的2450名社区居住老年人的横断面数据。因素分析确定了对初级保健讨论感到舒适的四个因素(一般、心理、身体和社会健康)和对SP开放的三个因素(有效性、意义性和支持性)。对每组介质分别进行通径分析。结果:通径分析显示,与社会健康有关的初级保健讨论的舒适度(β = 0.08**)与更好的幸福感相关。报告社交孤独的人对一般健康的初级保健讨论最舒服(β = - 0.17***),对心理健康的初级保健讨论最不舒服(β = - 0.24***),而报告情感孤独的人更有可能对一般健康和心理健康有相似的舒适程度(β = - 0.18***; - 0.18***)。此外,社会孤独与初级保健中关于社会健康的讨论(β = - 0.19***)和心理健康(β = - 0.19***)的舒适感相关,而与情感孤独没有关联。这些表明,解决经历情感孤独的人的SP需求需要一种不同的策略。报告情感孤独与表达对SP的支持相关(β = 0.14***),这可能是改善该人群幸福感的关键(β = 0.10***)。总体而言,社交孤独的总效应量为βtotal = - 0.19,而情感孤独的总效应量为βtotal = - 0.45,是社交孤独的2.3倍以上。结论:虽然有需要的人可能会接受SP,但有些人可能会遇到更大的困难,无法通过初级保健提供者获得SP,而没有针对他们的孤独状况量身定制的干预措施,这可能会引发购买和注册。初级保健提供者可能希望更密切地关注情感孤独的人。其他考虑因素,如信任和积极自我信念的动机性访谈可能解释从孤独到幸福的潜在变化。
{"title":"Analysing comfort with primary care discussions and openness to social prescribing as mediators of the associations between loneliness and wellbeing among Canadians aged 55 and older.","authors":"Daniel R Y Gan, Vivian Welch, Paul Hébert, Michelle Nelson, Kate Mulligan, Adam S Hoverman, Sandra Allison, Grace Park, Kiffer G Card","doi":"10.1186/s12875-025-03067-7","DOIUrl":"10.1186/s12875-025-03067-7","url":null,"abstract":"<p><strong>Background: </strong>Addressing the complex health and wellbeing challenges of older adults is a critical public health priority as populations age. Social Prescribing (SP) represents a promising strategy, connecting patients to non-clinical, community-based resources to enhance physical, mental, and social wellbeing.</p><p><strong>Methods: </strong>To develop a SP theory of change, this study used cross-sectional data from 2,450 community-dwelling older adults who participated in a population survey. Factor analyses identified four factors of comfort with primary care discussions (general, mental, physical, and social wellness) and three factors of openness to SP (effectiveness, meaningfulness, and supportiveness). Path analysis was conducted for each set of mediators separately.</p><p><strong>Results: </strong>Path analyses revealed that comfort with primary care discussions about social wellness (β = 0.08**) is associated with better wellbeing. People who report social loneliness are most comfortable with primary care discussions about general wellness (β = - 0.17***) and least comfortable with primary care discussions about mental wellness (β = - 0.24***), whereas people who report emotional loneliness are more likely to have similar levels of comfort to discuss general wellness and mental wellness (β = - 0.18***; - 0.18***). In addition, social loneliness is associated with less comfort with primary care discussions about social wellness (β = - 0.19***) and mental wellness (β = - 0.19***), whereas association is not found for emotional loneliness. These suggest that addressing the SP needs of people who experience emotional loneliness requires a different strategy. Reporting emotional loneliness is associated with expressing support for SP (β = 0.14***), which may be key to improving wellbeing (β = 0.10***) among this population. Overall, social loneliness has a total effect size of β<sub>total</sub> = - 0.19, whereas emotional loneliness has a total effect size of β<sub>total</sub> = - 0.45, more than 2.3 times larger.</p><p><strong>Conclusions: </strong>While SP may be acceptable to those who need it, some may experience greater difficulties accessing SP through primary care providers without interventions tailored to their loneliness status that could elicit buy-in and enrolment. Primary care providers may wish to pay closer attention to people with emotional loneliness. Other considerations, such as trust and motivational interviewing for positive self-beliefs may explain potential changes from loneliness to wellbeing.</p>","PeriodicalId":72428,"journal":{"name":"BMC primary care","volume":"26 1","pages":"382"},"PeriodicalIF":2.6,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12661800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building self-determination through the lens of the Circle of Courage: a qualitative evaluation of a social prescribing program for children and youth in Canada. 通过勇气圈的镜头建立自决:对加拿大儿童和青年社会处方方案的定性评估。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-28 DOI: 10.1186/s12875-025-03066-8
Caitlin Muhl, Valeria Dimitrova, Ellen Song, Isobel Fishman, Ashley Buffone, Samantha Kempe, Nicole Racine, Susan Bennett

Background: Social prescribing is gaining traction globally as a means to achieve global goals for health and wellbeing. In 2023, we launched a social prescribing program in a comprehensive, pediatric integrated health and social service hub in an underserved inner city neighbourhood in Ottawa, Ontario, Canada. The program targeted children and youth with poor social health, including social isolation and loneliness. Program participants were paired with a connector, who worked with them to explore their individual needs, strengths, and interests. Together, they created a social prescription for a child and youth-friendly community activity. The connector then provided a supported referral to aid the program participant in successfully completing their social prescription. The program was piloted at the hub over a period of ten months, during which time a program evaluation took place. As part of our program evaluation, we sought to explore the concept of self-determination, which is thought to be one of the guiding principles of social prescribing. While self-determination has been explored in adult social prescribing, it has not yet been examined in child and youth social prescribing. Thus, the aim of this evaluation was to explore the ways in which our social prescribing program may foster self-determination in children and youth.

Methods: A qualitative descriptive design was employed. Between November 2023 and February 2024, semi-structured interviews were conducted with 33 program participants and 30 caregivers at the six-month mark of enrollment in the program. Interview questions centered around program participants' and caregivers' experiences of the program. Interviews were audio recorded, transcribed verbatim, and anonymized. Using the Circle of Courage - a child and youth-focused theory on self-determination, we conducted deductive thematic analysis.

Results: The findings indicated that the program may foster self-determination through each component of the Circle of Courage: (1) Independence: The child's free will is nurtured by increased responsibility; (2) Belonging: The universal longing for human bonds is nurtured by relationships of trust; (3) Mastery: The child's inborn thirst for learning is nurtured; and (4) Generosity: The child's character is nurtured by concern for others.

Conclusion: This evaluation has shed light on the ways in which social prescribing may foster self-determination in children and youth. The Circle of Courage may be a useful framework to explore the impact of other child and youth social prescribing programs.

背景:作为实现全球健康和福祉目标的一种手段,社会处方在全球范围内越来越受到关注。2023年,我们在加拿大安大略省渥太华一个服务不足的内城社区的综合性儿科综合健康和社会服务中心启动了一项社会处方计划。该方案针对的是社会健康状况不佳的儿童和青年,包括社会孤立和孤独。项目参与者与一名联络人配对,联络人与他们一起探索他们的个人需求、优势和兴趣。他们一起为儿童和青年友好的社区活动制定了社会处方。然后,连接者提供了一个支持转介,以帮助项目参与者成功完成他们的社会处方。该项目在该中心进行了为期10个月的试点,在此期间进行了项目评估。作为项目评估的一部分,我们试图探索自我决定的概念,这被认为是社会处方的指导原则之一。虽然自我决定在成人社会处方中得到了探讨,但在儿童和青少年社会处方中尚未得到研究。因此,这次评估的目的是探索我们的社会处方计划可以促进儿童和青少年自决的方式。方法:采用定性描述设计。在2023年11月至2024年2月期间,对33名项目参与者和30名护理人员进行了半结构化访谈。访谈问题主要围绕项目参与者和护理人员对项目的体验展开。采访录音,逐字抄录,并匿名。我们运用以儿童和青年为中心的自我决定理论“勇气圈”进行了演绎主题分析。结果:研究结果表明,该计划可以通过勇气圈的每个组成部分培养自我决定:(1)独立性:儿童的自由意志是通过增加责任来培养的;(2)归属感:信任关系孕育了对人类纽带的普遍渴望;(3)精通:培养孩子天生的求知欲;(4)慷慨:孩子的性格是通过关心他人而培养的。结论:这一评价揭示了社会处方可能促进儿童和青年自决的方式。“勇气之圈”可能是一个有用的框架,可以用来探索其他儿童和青少年社会处方项目的影响。
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引用次数: 0
Collaboration between general practitioners and psychiatrists via digital platforms in the Netherlands: advantages and specific limiting factors. 荷兰全科医生和精神科医生通过数字平台的合作:优势和特定限制因素。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-28 DOI: 10.1186/s12875-025-03088-2
Isabel Meusel, Maarten Wagenaar, Huibert Burger, Marcus Hendrikus Blanker
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引用次数: 0
Diagnostic accuracy of artificial intelligence compared to family physicians and dermatologists for skin conditions: a systematic review and meta-analysis. 与家庭医生和皮肤科医生相比,人工智能对皮肤病的诊断准确性:一项系统综述和荟萃分析。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-28 DOI: 10.1186/s12875-025-03073-9
Norhane Nadour, Théo Duguet, Sophie Zahedi, Hugo Figoni, Roxane Liard

Context: Artificial intelligence (AI) technologies are increasingly used for image recognition, especially for skin lesions. Due to what may be long wait times for dermatology appointments, general practitioners (GPs) are the gatekeepers when it comes to skin diseases requiring rapid treatments.

Objective: This study aims to examine the diagnostic accuracy of AI in diagnosing skin lesions encountered in primary care and to perform a meta-analysis of AI's in diagnostic accuracy for melanoma detection.

Methodology: This systematic review and meta-analysis, conducted according to the 2020 PRISMA guidelines, included diagnostic accuracy studies using any type of AI applied to photographs or dermoscopy images to diagnose skin lesions encountered in primary care settings. The reference standard was dermatologist consensus or histopathological examination. Searches were conducted in PubMed, Web of Science and Cochrane in December 2023. Risk of bias and concerns of applicability were assessed using the QUADAS-2 tool. Data extraction was conducted by two investigators and meta-analysis was performed using a bivariate random effects model.

Results: Between 2013 and 2023, 382 studies were found and 38 met the inclusion criteria.AI's accuracy was reported as non-inferior or superior to that of dermatologists in 30 studies, while 4 studies reported that AI was less accurate than dermatologists. Similarly, AI's accuracy was reported as non-inferior or superior to that of GPs in 8 studies, and one study indicated that AI was less accurate than GPs. The meta-analysis showed that AI for the diagnosis of melanoma had a pooled sensitivity of 0.86 (95% CI: 0.80-0.90) and a specificity of 0.94 (95% CI: 0.89-0.97). The diagnostic odds ratio was 44.36 (95% CI: 29.28; 67.1), with an AUC of 0.922 for the SROC curve. Of the 38 included studies, 25 were at high risk of bias, primarily due to patient selection. Datasets were frequently not representative of the outpatient population, as malignant conditions were often overestimated.

Conclusion: AI appears to perform at a similar level to dermatologists, and the same is true when comparing AI to GPs. This is especially true for serious conditions like melanoma, suggesting that AI could be a valuable tool for GPs in improving patient care.

背景:人工智能(AI)技术越来越多地用于图像识别,尤其是皮肤病变。由于皮肤科预约的等待时间可能很长,当涉及到需要快速治疗的皮肤病时,全科医生(gp)是守门人。目的:本研究旨在检验人工智能诊断初级保健中遇到的皮肤病变的准确性,并对人工智能在黑色素瘤检测中的诊断准确性进行荟萃分析。方法:本系统综述和荟萃分析根据2020年PRISMA指南进行,包括使用任何类型的人工智能应用于照片或皮肤镜检查图像来诊断初级保健机构遇到的皮肤病变的诊断准确性研究。参照标准为皮肤科医师共识或组织病理学检查。检索于2023年12月在PubMed, Web of Science和Cochrane进行。使用QUADAS-2工具评估偏倚风险和适用性问题。数据提取由两名研究者进行,采用双变量随机效应模型进行meta分析。结果:2013 - 2023年共纳入382项研究,38项符合纳入标准。在30项研究中,人工智能的准确性不低于或优于皮肤科医生,而4项研究报告人工智能的准确性低于皮肤科医生。同样,在8项研究中,人工智能的准确性被报道为不低于或优于全科医生,一项研究表明人工智能的准确性低于全科医生。荟萃分析显示,人工智能诊断黑色素瘤的总敏感性为0.86 (95% CI: 0.80-0.90),特异性为0.94 (95% CI: 0.89-0.97)。诊断优势比为44.36 (95% CI: 29.28; 67.1), SROC曲线的AUC为0.922。在纳入的38项研究中,25项存在高偏倚风险,主要是由于患者选择。数据集往往不能代表门诊人口,因为恶性疾病往往被高估。结论:人工智能的表现似乎与皮肤科医生相当,与全科医生相比也是如此。对于像黑色素瘤这样的严重疾病来说尤其如此,这表明人工智能可以成为全科医生改善患者护理的宝贵工具。
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引用次数: 0
How do pharmacists navigate clinical uncertainty when reviewing polypharmacy? A critical literature review. 在审查多种药物时,药剂师如何应对临床不确定性?一篇批判性的文献综述。
IF 2.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-27 DOI: 10.1186/s12875-025-03122-3
Tomazo J Kallis, Karen Mattick, Jenny Scott, Rupert A Payne

Background: Clinical pharmacists are the principal profession reviewing polypharmacy in English general practice. Pharmacists reviewing polypharmacy can encounter clinical uncertainty, thus affecting decision-making and the utility of medication reviews. Understanding factors and interventions that mitigate clinical uncertainty could improve polypharmacy medication reviews. This review's objective was to explore how primary care clinical pharmacist decision-making can be improved when reviewing polypharmacy in the context of clinical uncertainty.

Methods: A critical literature review was undertaken in key databases. Included articles explored polypharmacy, clinical uncertainty and medication review by primary care clinical pharmacists. Exclusion criteria included community pharmacy and monotherapy management. Quality assurance was conducted using Lincoln and Guba's evaluative criteria. Contents of included papers were thematically analysed and conceptual models produced.

Results: 647 titles/abstracts were screened and 11 full-text articles included, encompassing focus group, interview, ethnography and intervention-development studies. Pharmacists expressed feelings of self-competence occurring alongside apprehension when reviewing polypharmacy. Relationships with patients, including shared decision-making, continuity of care and engagement can support medication reviews. Decision-making is impacted by environmental factors, with poor working relationships within organisations, working across several sites and time pressures hindering deprescribing. The absence of clinical and deprescribing guidelines for multimorbid patients contributes to clinical uncertainty. Multidisciplinary working mitigates clinical uncertainty and training interventions can support pharmacists to proactively deprescribe.

Conclusion: Pharmacist, patient and environmental factors can influence pharmacists' decision-making when experiencing clinical uncertainty during polypharmacy review. Clinical education, peer support and multidisciplinary working have roles in reducing clinical uncertainty and therefore optimising pharmacists' reviews of polypharmacy.

背景:临床药师是英国全科医学中综合药学的主要职业。药师审查多药会遇到临床不确定性,从而影响决策和药物审查的效用。了解减轻临床不确定性的因素和干预措施可以改善多种药物的药物评价。本综述的目的是探讨在临床不确定性的背景下,如何改进初级保健临床药师的决策。方法:在关键数据库中进行文献综述。纳入的文章探讨了综合用药、临床不确定性和初级保健临床药师的药物审查。排除标准包括社区药房和单一疗法管理。质量保证采用Lincoln和Guba的评估标准。纳入论文的内容进行了主题分析,并产生了概念模型。结果:筛选了647个标题/摘要,并纳入了11篇全文文章,包括焦点小组、访谈、民族志和干预发展研究。药剂师表达了自我能力的感觉,同时出现的担忧时,检讨多种药物。与患者的关系,包括共同决策、护理的连续性和参与,可以支持药物审查。决策受到环境因素的影响,组织内部的不良工作关系,跨多个站点的工作以及时间压力阻碍了处方的制定。缺乏针对多病患者的临床和处方指南导致临床不确定性。多学科工作减轻了临床的不确定性和培训干预可以支持药剂师主动开处方。结论:药师、患者和环境因素会影响药师在多药审评中遇到临床不确定性时的决策。临床教育、同伴支持和多学科工作在减少临床不确定性和优化药剂师对综合用药的评价方面发挥着作用。
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BMC primary care
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