Comprehensive psychoneuroendocrinology最新文献

{"title":"Effect of a multidisciplinary lifestyle intervention on stress-related parameters in people with rheumatoid arthritis and osteoarthritis: secondary analysis of the \"Plants for Joints\" randomized controlled trial","authors":"C.A. Wagenaar ,&nbsp;J. Christiaans ,&nbsp;V. Hermans ,&nbsp;W. Walrabenstein ,&nbsp;F.A. Koopman ,&nbsp;H. van Middendorp ,&nbsp;D. van Schaardenburg","doi":"10.1016/j.cpnec.2025.100298","DOIUrl":"10.1016/j.cpnec.2025.100298","url":null,"abstract":"<div><h3>Objective</h3><div>In two randomized controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. This secondary analysis aimed to evaluate the effect of the PFJ intervention on stress-related parameters.</div></div><div><h3>Methods</h3><div>In two PFJ observer-blind randomized controlled trials (RCT), people with (1) RA with low-moderate disease activity or (2) MSOA were randomized to receive the PFJ lifestyle intervention or usual care. The 16-week PFJ intervention consisted of a whole-food plant-based diet, physical activity, and sleep and stress management. This secondary analysis investigated stress-related outcomes including heart rate, heart rate variability (HRV: root square mean of successive differences (RMSSD) and normalised high frequency (HFnorm), salivary cortisol, perceived stress (Perceived Stress Scale 10; PSS-10), and time spent on stress-reducing activities. An intention-to-treat analysis with a linear regression model (HRV) or linear mixed model (cortisol and PSS-10), adjusted for baseline values, was used to analyse between-group differences.</div></div><div><h3>Results</h3><div>77 people with RA and 64 with MSOA completed the RCT. RA participants following the PFJ intervention showed a significant improvement in HFnorm (between-group difference: 6.6; 95 % CI 0.5, 12.6) and an improving trend in RMSSD (4.3; 95 % CI -1.5, 10.1) alongside non-significant reductions of heart rate (3.1; 95 % CI-3.9, 10.1), salivary cortisol (1.3; 95 % CI -0.6, 3.1) and perceived stress (−2.0; 95 % CI -4.4, 0.3), compared to usual care. In participants with MSOA, there were no differences in heart rate, HRV outcomes, cortisol, or perceived stress between the intervention and control group. Both RA and MSOA participants temporarily increased time spent on stress-reducing activities, yet no change from baseline was observed after 16 weeks. In RA participants increased time spent on stress-reducing activities was associated with increased HFnorm.</div></div><div><h3>Conclusion</h3><div>This secondary analysis suggests the PFJ program may have a positive influence on stress-related parameters in people with RA, but not MSOA, compared to usual care.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100298"},"PeriodicalIF":2.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a multimodal intervention on physical health factors and lifestyle in patients with affective disorders – results from a randomized controlled trial","authors":"Ida Schou Ipsen ,&nbsp;Rasmus Schwarz ,&nbsp;Lars Vedel Kessing ,&nbsp;Kamilla W. Miskowiak ,&nbsp;Maj Vinberg","doi":"10.1016/j.cpnec.2025.100295","DOIUrl":"10.1016/j.cpnec.2025.100295","url":null,"abstract":"<div><h3>Background</h3><div>Traditional treatment for affective disorders primarily focuses on symptom management through pharmacotherapy and psychotherapy and rarely addresses co-existing physical impairments.</div></div><div><h3>Methods</h3><div>This randomized controlled trial assessed the impact of a six-month multimodal intervention (AWARE) on physical health in patients with bipolar and unipolar depressive disorders. A total of 103 patients, median age 40.75 years (65 % female), were randomized into the AWARE group (n = 50) or treatment as usual (TAU) group (n = 53). The AWARE intervention included five modules focused on activities of daily living, mood management, social relations, physical health, and cognition, with participants receiving approximately 12 sessions. TAU involved standard psychiatric care, Health outcomes were evaluated on sleep, metabolic markers, substance use, medication side effects, and perceived physical health. Statistical analyses used logistic regression for group comparisons and analysis of covariance for continuous outcomes.</div></div><div><h3>Results</h3><div>The AWARE group had significant improvements in sleep onset latency and reported reduced physical pain affecting daily work compared to TAU. However, no statistically significant differences were found in other physical health outcomes, such as metabolic markers, substance use, medication side effects, or perceived physical health. Study limitations include a modest sample size and a relatively short intervention duration.</div></div><div><h3>Conclusion</h3><div>While the AWARE intervention improved sleep and pain management, it did not significantly affect other health markers. Future research should involve longer intervention periods, larger sample sizes, and a comprehensive approach to both mental and physical health.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100295"},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol awakening response in pregnant women with depressive disorders: a potential marker of recovery status from pregnancy to postpartum","authors":"Carlinde W. Broeks ,&nbsp;Babette Bais ,&nbsp;Rien Van ,&nbsp;Hilmar H. Bijma ,&nbsp;Elisabeth F.C. van Rossum ,&nbsp;Witte J.G. Hoogendijk ,&nbsp;Mijke P. Lambregtse-Van den Berg ,&nbsp;Astrid M. Kamperman","doi":"10.1016/j.cpnec.2025.100297","DOIUrl":"10.1016/j.cpnec.2025.100297","url":null,"abstract":"<div><h3>Introduction</h3><div>Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to peripartum depression, potentially contributing to symptom persistence. This study examines the relationship between the cortisol awakening response (CAR) during pregnancy and depressive symptom reduction postpartum.</div></div><div><h3>Methods</h3><div>Pregnant women with a current depressive episode were included in this study, part of a larger RCT on bright light therapy. At baseline (12–32 weeks of pregnancy), participants provided saliva samples at awakening, +30, and +60 min post-awakening. The CAR was assessed using three measures: area under the curve relative to ground (AUCg), area under the curve relative to increase (AUCi), and peak reactivity (difference between awakening and +30 min cortisol levels). Depressive symptoms were measured using the Hamilton Depression Rating Scale (HAM-D) at baseline and two months postpartum. Linear regression models assessed associations between CAR measures and depressive symptom change, adjusting for relevant covariates.</div></div><div><h3>Results</h3><div>The study included 55 pregnant women (mean age: 32.3 years, SD 4.8; mean gestational age: 19.7 weeks). Mean HAM-D scores decreased from 16.7 (SD 5.3) at baseline to 5.7 (SD 5.6) postpartum. Higher AUCi during pregnancy was associated with less symptom reduction postpartum (unadjusted β = 0.36, p = .02; adjusted β = 0.36, p = .02), as was peak cortisol reactivity (unadjusted β = 0.33, p = .03; adjusted β = 0.32, p = .03), while AUCg showed no significant association with symptom change (unadjusted p = .19; adjusted p = .28).</div></div><div><h3>Conclusion</h3><div>Higher AUCi and peak cortisol reactivity of the cortisol awakening response during pregnancy were linked to persistence of depressive symptoms postpartum, suggesting that heightened cortisol reactivity to awakening may indicate persistent stress vulnerability in peripartum depression. Total cortisol output (AUCg) was not predictive of recovery. These findings underscore the potential relevance of stress reactivity over basal cortisol levels in peripartum depression and highlight the need for further research in larger samples to elucidate the usefulness in clinical practice.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100297"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the metabolic signature of intermittent explosive disorder: Preliminary evidence and potential mechanisms for altered bilirubin metabolism","authors":"Jeffrey B. Schwimmer ,&nbsp;Murray B. Stein ,&nbsp;Emil F. Coccaro ,&nbsp;Alejandro D. Meruelo","doi":"10.1016/j.cpnec.2025.100294","DOIUrl":"10.1016/j.cpnec.2025.100294","url":null,"abstract":"<div><div>Intermittent Explosive Disorder (IED) is characterized by impulsive aggression and emotional dysregulation, yet its systemic biological underpinnings remain poorly understood. This study examined bilirubin metabolism and systemic biomarkers as indicators of metabolic vulnerability in individuals with IED. Laboratory data for total and indirect bilirubin and white blood cell (WBC) count were analyzed in individuals with IED and a demographically and clinically matched general population (GP) control group. A 10:1 nearest-neighbor propensity score matching procedure was used to balance covariates including age, sex, race, ethnicity, body mass index (BMI), and alcohol and tobacco use. Participants with hepatobiliary or inflammatory conditions were excluded to reduce heterogeneity and confounding. Group comparisons used unique individuals with biomarker values averaged across timepoints.</div><div>Individuals with IED showed lower total and indirect bilirubin levels compared to matched controls, with a moderate effect size for indirect bilirubin (d = −0.37) and a small effect for total bilirubin (d = −0.10). WBC differences were minimal (d = −0.12). Linear mixed-effects models incorporating repeated measures yielded consistent results, though none of the group differences reached statistical significance, likely due to limited sample size in the IED group. Sensitivity analyses suggested bilirubin findings were more robust to unmeasured confounding than WBC.</div><div>These results highlight a potential hepatobiliary or metabolic signature in IED, rather than a primary inflammatory process. Given the preliminary nature of the findings, absence of cytokine data, and limited statistical power, results should be interpreted cautiously and warrant replication in larger samples with broader inflammatory and lifestyle profiling.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100294"},"PeriodicalIF":2.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panic attack symptoms in patients with diabetic peripheral neuropathy","authors":"Nayden H. Manolov ,&nbsp;Arman Sh Postadzhiyan ,&nbsp;Sonya M. Karabeliova ,&nbsp;Peter M. Marinov","doi":"10.1016/j.cpnec.2025.100292","DOIUrl":"10.1016/j.cpnec.2025.100292","url":null,"abstract":"<div><div>Assessment of diabetic peripheral neuropathy (DPN) usually focuses on nerve damage resulting from hyperglycaemia. However, screening for common psychiatric disorders may improve the recognition of psychopathology in patients with DPN.</div><div>This epidemiological cohort study aimed to evaluate the prevalence of panic attack symptoms in patients with DPN compared toa control group of healthy individuals without type 2 diabetes mellitusorDPN.Additionally, this study sought to compare the severity of these symptoms between the two groups.The study was conducted via a survey over three years in an accredited practice of physicians at the Medical University-Sofia.</div><div>A total of267 participants were included, comprising 83 patients with DPN and 184healthy controls. Both groups completed the Prime-MD Patient Health Questionnaire. The results indicated significant differences between the two study groups(<em>t</em>[127.513] = 3.293; <em>p</em> &lt; 0.01), and patients with DPN had a higher prevalence of panic attack symptoms than those in the control group.Furthermore, significant differences were observed in the severity of panic attack symptoms within the DPN group (<em>t</em>[(81] = 2.017, <em>p</em> &lt; 0.05).Patients who had experienced DPN for more than one year reported more severe symptoms than those who had experienced it for less than oneyear. Our results indicate that the high prevalence of panic attack symptoms inpatients with DPN highlights the need for integrated screening for psychiatric disorders within the overall management plan for diabetes mellitus.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100292"},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-based discrimination and cortisol output: A systematic review","authors":"Maria A. Kalantzis ,&nbsp;Daniel M. Maitland ,&nbsp;Miranda Yannon ,&nbsp;Christina Gaggiano ,&nbsp;Jinbo He ,&nbsp;Aldo Barrita ,&nbsp;Lorelai Symmes ,&nbsp;William H. O'Brien","doi":"10.1016/j.cpnec.2025.100290","DOIUrl":"10.1016/j.cpnec.2025.100290","url":null,"abstract":"<div><div>Discrimination based on weight status (or weight-related discrimination/stigma) may be related to greater physical and mental health concerns via physiological and psychological phenotypes of stress. Cortisol output, a biomarker of stress, has been measured in relation to weight stigma and weight-related discrimination. This systematic review aims to synthesize existing research on the relationship between weight-related discrimination and cortisol output, evaluate methodological approaches for measuring these constructs, and identify research gaps regarding contextual factors influencing this relationship. A comprehensive search was conducted across multiple databases (PsycINFO, Scopus, ProQuest, and PubMed) from February 1 to July 1, 2024, resulting in 11 eligible studies that examined weight discrimination in relation to cortisol levels. Studies were assessed for quality using the NHLBI Study Quality Assessment Tool, and inter-rater reliability for coding was established at 90 %. The findings revealed a range of sample sizes (45–4341) and diverse participant characteristics, including variations in age, race, and body mass index (BMI). About half (N = 5) of the included studies reported a positive relation between weight stigma and cortisol output. The review also uncovered significant limitations in current methodologies, particularly concerning contextual factors and other marginalized identities, such as socioeconomic status and food insecurity, along with measuring other forms of discrimination in tandem with weight stigma, such as racial discrimination. These findings underscore the need for future research to adopt a more intersectional approach in examining the multifaceted nature of weight stigma and how it relates to a greater stress response in multiple marginalized identities, as well as including longitudinal modeling of weight stigma's impact on biomarkers for stress.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100290"},"PeriodicalIF":2.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical language lateralization in positive schizotypy and modulating effects of the menstrual cycle","authors":"Helene Hjelmervik ,&nbsp;Josef J. Bless ,&nbsp;Julien Laloyaux ,&nbsp;Kenneth Hugdahl ,&nbsp;Markus Hausmann","doi":"10.1016/j.cpnec.2025.100291","DOIUrl":"10.1016/j.cpnec.2025.100291","url":null,"abstract":"<div><div>Previous studies have shown atypical language asymmetry in male participants with high schizotypy traits, but in female participants the pattern is less clear. Such sex differences could suggest a role of sex hormones, especially since hemispheric asymmetries have been shown to change across the menstrual cycle. By modulating attention in a consonant-vowel dichotic listening test, the current study aimed to investigate language lateralization (ear advantage of non-forced condition) in high vs low positive-schizotypy and the role of the menstrual cycle. In addition, we aimed to replicate menstrual cycle effects on the left attention condition. Thirty-nine female participants were tested in the menstrual (low estradiol) or follicular (high estradiol) cycle phase. Women tested in the follicular phase were found to perform better on the left attention condition, indicating enhanced cognitive control. In the non-forced condition, the high positive-schizotypy group showed increased right hemispheric involvement during the follicular phase relative to the menstrual phase; whereas an increase in left hemispheric dominance was seen in the low positive-schizotypy group during this cycle phase. The results suggest an underlying difference in lateralization between low and high positive-schizotypy that is enhanced by gonadal hormones, perhaps through altered interhemispheric inhibition. Overall, the study suggests that the atypical language lateralization in high schizotypy individuals is highly flexible and dependent on the hormonal milieu, and could potentially be related to neuroprotective effects of estradiol.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100291"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workers’ well-being during viral pandemics and epidemics: A scoping review","authors":"Tyler Pacheco ,&nbsp;Simon Coulombe ,&nbsp;Nancy L. Kocovski ,&nbsp;Julia Carbone","doi":"10.1016/j.cpnec.2025.100286","DOIUrl":"10.1016/j.cpnec.2025.100286","url":null,"abstract":"<div><div>Studies have documented workers' well-being during individual pandemics and epidemics. However, there lies a need to summarize worker well-being <em>across</em> crises. Moreover, there is a scarcity of reviews exploring precarious workers' well-being during these crises. Adopting a multidisciplinary perspective via positive psychology's third wave, this scoping review examines positive and negative well-being across diverse occupational groups and situations (e.g., precarious employment) and across crises. Inspired by Ecological Systems Theory, factors at different ecological levels (self, social, workplace, pandemic) relevant to workers' well-being are reviewed. The following questions are addressed: 1) How are virus-related public health crises (i.e., epidemics, pandemics) related to workers' well-being? 2) What resilience and risk factors are associated with workers' well-being in these crises? And 2a) How is the well-being of precarious workers impacted during virus-related public health crises? Of the 2,395 potentially relevant articles published before October 23rd, 2020, 187 were retained. Overall, more research has been conducted on negative than positive well-being. Workers experienced: 1) positive well-being frequently or at moderately high levels overall during pandemics and epidemics, 2) mild to moderate negative well-being during SARS and COVID-19's beginning and high negative well-being during other crises, and 3) high work-related well-being during such crises. Factors at self- (age, gender), social- (social support), workplace- (occupation, frontline status), and pandemic-related (risk/exposure, knowing someone infected/killed by the virus, PPE access) levels were associated with workers' well-being. Although explored infrequently, precarious employment was typically associated with greater negative well-being. Practice- and policy-related recommendations are discussed.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100286"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using hair biomarkers to examine social-emotional resilience in adolescence: A feasibility study","authors":"Cynthia R. Rovnaghi ,&nbsp;Anjali Gupta ,&nbsp;Susan Ramsundarsingh ,&nbsp;Ronnie I. Newman ,&nbsp;Sa Shen ,&nbsp;Jordan K.H. Vedelli ,&nbsp;Elizabeth L. Reichert ,&nbsp;Kanwaljeet J.S. Anand","doi":"10.1016/j.cpnec.2025.100287","DOIUrl":"10.1016/j.cpnec.2025.100287","url":null,"abstract":"<div><h3>Background</h3><div>The SKY Schools Program combines breath-based techniques and a social-emotional learning curriculum. We examined its effects on objective physiological biomarkers, including hair cortisol (HCC, chronic stress measure) and hair oxytocin (HOC, social affiliation measure), as well as behavioral (youth risk behaviors) and mental health outcomes (anxiety, depression).</div></div><div><h3>Methods</h3><div>The SKY Schools program was adapted for post-pandemic restrictions (i.e., staff shortages, no lessons requiring writing, limited weekly follow-ups) and implemented among 7th grade students (daily in-person 40-min sessions for three weeks during physical education classes). Longitudinal assessments were obtained at baseline (T1, February 2022, N = 21), post-intervention (T2, June 2022, N = 20), and follow-up (T3, December 2022, N = 18).</div></div><div><h3>Results</h3><div>Most of our sample was male (67 %), Hispanic (62 %), and lived in low-income (&lt;$100K) households (75 %). Students reported fewer poor mental health days at follow-up (Friedman test p &lt; 0.01). Log-normal (Ln)-HCC (p &lt; 0.01) were higher post-intervention vs. baseline (median 1.81 (IQR 1.63–2.46) vs. 1.60 (0.91–1.85)) and lower at follow-up (1.23; IQR: 0.64–1.50), with HCC in more students moving into the adaptive range (25th-75th percentile). Ln-HOC (p = 0.04) were higher post-intervention vs. baseline (1.78 (1.54–2.26) vs. 1.50 (0.81–1.70)).</div></div><div><h3>Conclusions</h3><div>This study uniquely evaluated the impact of the SKY intervention on hair cortisol (HCC) and hair oxytocin concentrations (HOC), which are objective, physiological measures of chronic stress and social affiliation. Results suggest that SKY may improve social affiliation and possibly HPA-axis regulation.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100287"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and the prefrontal-hippocampal pathway - A multimodal neuroimaging study in transgender women","authors":"Setthanan Jarukasemkit ,&nbsp;Karen M. Tam ,&nbsp;Seksan Yoadsanit ,&nbsp;Ty Easley ,&nbsp;Hailey Modi ,&nbsp;Lyn Stahl ,&nbsp;Adun Kampaengtip ,&nbsp;Thanissara Chansakul ,&nbsp;Rena Janamnuaysook ,&nbsp;Akarin Hiransuthikul ,&nbsp;Chaipat Chunharas ,&nbsp;Janine D. Bijsterbosch","doi":"10.1016/j.cpnec.2025.100288","DOIUrl":"10.1016/j.cpnec.2025.100288","url":null,"abstract":"<div><div>This study aims to investigate functional and neurotransmitter signaling in the prefrontal-hippocampal pathway in relation to depression in a cohort of Thai transgender women. Twenty participants completed mental health surveys and imaging between January and March 2024. Depression severity was measured by Patient Health Questionnaire-9 (PHQ-9) scores. Higher PHQ-9 scores were associated with lower GABA levels in the hippocampus, and with lower fractional amplitude of low-frequency fluctuations (fALFF) in the dorsolateral prefrontal cortex. However, removal of the hippocampal GABA outlier resulted in a non-significant relationship with PHQ-9. Therefore, future studies with larger datasets should further investigate the association between GABA and depression in a transgender cohort. These findings revealed interactions between neurotransmitter signaling and functional brain activity of the hippocampal-prefrontal circuit in depression.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100288"},"PeriodicalIF":2.1,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}