Comprehensive psychoneuroendocrinology最新文献

{"title":"Sleep disturbances linked to plasma orexin A levels in patients with bipolar disorder: A preliminary study","authors":"Carlota Moya-Lacasa ,&nbsp;Gonzalo Paniagua ,&nbsp;Manuel Couce-Sánchez ,&nbsp;Sergio Romero-Jiménez ,&nbsp;Ainoa García-Fernández ,&nbsp;Pilar Sáiz ,&nbsp;M. Paz García-Portilla ,&nbsp;Leticia González-Blanco","doi":"10.1016/j.cpnec.2025.100321","DOIUrl":"10.1016/j.cpnec.2025.100321","url":null,"abstract":"<div><div>Sleep disturbances are a core symptom of bipolar disorder (BD). Other sleep disturbances such as nightmares, sleep apnea and restless legs are also common in BD. Biomarkers related to the sleep-wake cycle, specifically orexins, have attracted research on their role in other psychiatric disorders, but have been less explored in BD. We aimed to analyze the relationship between orexin A levels and sleep characteristics in patients with BD.</div><div>This is a secondary analysis of a cross-sectional study including 113 outpatients during follow-up. The Oviedo Sleep Questionnaire was used to evaluate sleep characteristics. The Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Hamilton Anxiety Rating Scale were used to assess clinical status. Orexin A, Interleukin 1 receptor antagonist, and tumor necrosis factor alpha were measured in plasma. Sociodemographic and other clinical variables were collected. Statistical analysis using parametric tests and logistic regression were performed.</div><div>No differences between sexes (62 % women) were found for any sleep disturbances. Snoring, restless legs, and nightmares, but not insomnia, showed an association with orexin A. In logistic regression models, restless legs were associated with severity of depression (OR: 1.070, p = 0.015), Interleukin 1 receptor antagonist (OR: 1.004, p = 0.037), and orexin A (OR: 0.963, p = 0.022). As for nightmares, only severity of anxiety (OR: 1.113, p &lt; 0.001), and benzodiazepines (OR: 0.166, p = 0.006) showed an association.</div><div>This is one of the few studies analyzing the relationship of sleep quality and orexin A in BD. Evaluating sleep disturbances other than insomnia in BD is valuable, since they are often associated with worse clinical outcomes.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100321"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling the biopsychosocial effects of gender-affirming hormone therapy on social health: A protocol for a multi-arm prospective cohort study (AFFIRM Relationships)","authors":"Margot W.L. Morssinkhof ,&nbsp;Nessa Millet ,&nbsp;Giulia T. Zoppolat ,&nbsp;Sigsten K. Stieglitz ,&nbsp;Baudewijntje P.C. Kreukels ,&nbsp;David Matthew Doyle","doi":"10.1016/j.cpnec.2025.100329","DOIUrl":"10.1016/j.cpnec.2025.100329","url":null,"abstract":"<div><h3>Introduction</h3><div>Gender-affirming hormone therapy (GAHT) is associated with improvements in gender congruence and changes in psychosocial functioning, yet its effects on social health are not yet known. Social health, i.e., someone having adequate quantity and quality of relationships to meet their needs for meaningful connection, is a key determinant of quality of life. Understanding potential changes in social health during GAHT is therefore essential to information provision for trans and gender diverse (TGD) people. The study, <em>AFFIRM Relationships</em>, aims to prospectively examine how GAHT affects social health and to isolate the biological effects of hormonal intervention relative to other gender-affirming treatments (i.e., mastectomy and voice training).</div></div><div><h3>Methods</h3><div>We will conduct a multi-arm prospective longitudinal cohort study of TGD people who start GAHT, gender-affirming voice training, or gender-affirming mastectomy, prospectively following participants from before starting treatment to 3, 6, 12, and 24 months after starting treatment. We will examine changes in social health, including potential changes in social networks. We aim to disentangle the ways in which social health changes after GAHT by examining changes in psychosocial functioning and the potential roles of social stigma and gender congruence. Furthermore, we will compare the effects of GAHT, which induces a systemic biological change, to the effects of voice training and mastectomy, which are non-systemic interventions, to better understand the unique biological effects of GAHT.</div></div><div><h3>Ethics and dissemination</h3><div>Ethical approval for this study was granted by the Medical Ethical Committee of Amsterdam UMC (study no. 2024.0927). Results from this study will be disseminated via academic peer-reviewed publications, adapted into guidelines for clinical care, and we will co-design dissemination strategies for the TGD community together with a group of lived experienced experts (LEEs).</div></div><div><h3>Registration</h3><div>N/A.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100329"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting concerns about falling to modulate biological stress systems: Effects of a multicomponent randomized controlled trial in older adults","authors":"Anja Müller ,&nbsp;Robert Kob ,&nbsp;Cornel Christian Sieber ,&nbsp;Ellen Freiberger ,&nbsp;Nicolas Rohleder ,&nbsp;Sabine Britting","doi":"10.1016/j.cpnec.2025.100315","DOIUrl":"10.1016/j.cpnec.2025.100315","url":null,"abstract":"<div><h3>Introduction</h3><div>Concerns about falling (CaF) are common in older adults and may act as a chronic stressor affecting physical activity, psychological well-being and physiological regulation. This study examined the impact of a 16-week multimodal exercise intervention on CaF, stress pathways, and peripheral inflammation in older adults.</div></div><div><h3>Methods</h3><div>In the randomized, controlled FEARFALL study, 160 community-dwelling older adults (aged ≥70 years) were assigned to either an intervention group (IG) or a sham control group (SCG). The IG received a multimodal exercise program, while the SCG engaged in low-intensity activities. Three psychological questionnaires were used to assess CaF: Falls Efficacy Scale-International [FES-I] (fear of falling); Falls Efficacy Scale-International Avoidance Behavior [FES-IAB] (avoidance behavior); Updated Perceived Control of Falling Scale [UP-CoF] (perceived control). Hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) activity was determined using saliva samples (cortisol, alpha-amylase), inflammatory markers using blood samples (C-reactive protein [CRP], Interleukin 6 [IL-6]).</div></div><div><h3>Results</h3><div>There were significant improvements in CaF over time and perceived control in both groups (FES-I: <em>β</em> = −6.645, 95 %-CI [-10.56, −2.73], <em>p</em> = .001; UP-CoF: <em>β</em> = 3.911, 95 %-CI [1.24, 6.58], <em>p</em> = .004). Diurnal cortisol slope normalized after the intervention (<em>β</em> = −0.014, 95 %-CI [-0.03, 0.00], <em>p</em> = .014), while other neuroendocrine and inflammatory markers remained unchanged.</div></div><div><h3>Conclusion</h3><div>A multimodal short-term intervention reduced psychological aspects of CaF, while physiological stress and inflammatory parameters may require more intensive or longer-term interventions. Findings support CaF as a biopsychosocial stressor and highlight the efficacy of multimodal programs in enhancing coping in older adults.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100315"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A few degrees, a lot more stress: Associations between room temperature and reactivity to psychosocial stress","authors":"Kim Fricke ,&nbsp;Marie-Christin Barthel ,&nbsp;Nina Alexander ,&nbsp;Ulf Baumgärtner ,&nbsp;Markus Muehlhan ,&nbsp;Susanne Vogel","doi":"10.1016/j.cpnec.2025.100319","DOIUrl":"10.1016/j.cpnec.2025.100319","url":null,"abstract":"<div><div>Increases in ambient temperatures pose a potential risk to mental and physical health. Heat has already been associated with alterations in bodily stress systems, and stress in turn is another major risk factor for various diseases. Yet, the precise impact of moderate temperature rises on stress reactivity remains unclear. This study investigated associations between moderate room temperature variations (17°C–28 °C) and physiological (cortisol, alpha amylase, heart rate, and mean arterial pressure) and subjective stress reactivity in 73 healthy adult participants exposed to a psychosocial stressor, the Trier Social Stress Test. Higher room temperatures were associated with increased reactivity in both the hypothalamic-pituitary-adrenal axis (cortisol concentrations) and the autonomic nervous system (alpha amylase activity, heart rate, mean arterial pressure), but not subjective stress. These findings highlight a potential pathway through which rising temperatures could exacerbate stress-related health vulnerabilities, even in non-extreme conditions.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100319"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model","authors":"Hui Chen ,&nbsp;Jindong Mao ,&nbsp;Min Wang ,&nbsp;Qian Zhang ,&nbsp;Rui Zheng ,&nbsp;Yumei Wu ,&nbsp;Xue Ma ,&nbsp;Qingquan Liu","doi":"10.1016/j.cpnec.2025.100317","DOIUrl":"10.1016/j.cpnec.2025.100317","url":null,"abstract":"<div><div>Osteocalcin (OCN), an active substance produced by bone tissue, has demonstrated potential in alleviating depressive symptoms and exerting extensive regulatory effects on glial cells in animals by participating in the communication between bone and brain, while its precise mechanisms within the central nervous system (CNS) still not fully understood. In this study, we validated the antidepressant effects of OCN in depressive mice induced by chronic unpredictable mild stress (CUMS), and conducted a comprehensive assessment of the functional impacts of OCN in hippocampus using proteomic analysis. Additionally, the effects of OCN on astrocytes were investigated. Behavioral tests suggested that OCN significantly ameliorated the depressive - like behaviors of mice exposed to CUMS, manifesting by the reduced immobility time in the tail suspension test and forced swimming test. Results from the proteomic analysis showed that 117 differentially expressed proteins were found between the CUMS group and the CUMS + OCN group. The subcellular localization of these proteins was mostly enriched in the cytoplasm and cell membrane, involving in various cellular physiological processes. Importantly, we found that OCN influenced glycophagy in astrocytes in the hippocampus. These findings uncover the antidepressant efficacy of OCN, along with its target and mechanisms of action, providing a theoretical foundation for the in - depth exploration of the crucial physiological functions of OCN in the brain.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100317"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotics use increases the risk of breast cancer in Women: Findings from systematic review and meta-analysis of observational studies","authors":"Mehdi Karimi ,&nbsp;Fatemeh Ziyafati Kafi ,&nbsp;Samira Pirzad ,&nbsp;Seyed Morteza Ali Pourfaraji ,&nbsp;Sharareh Jahangiri","doi":"10.1016/j.cpnec.2025.100313","DOIUrl":"10.1016/j.cpnec.2025.100313","url":null,"abstract":"<div><h3>Background and objective</h3><div>Emerging evidence suggests Antipsychotics may influence cancer risk through prolactin elevation. While studies have explored the potential link between antipsychotic use and breast cancer risk, findings remain inconsistent. A comprehensive synthesis of existing data is needed to clarify this association. This meta-analysis aimed to discover the association between antipsychotic use and the risk of breast cancer in females.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across major online databases from inception to May 2025 to identify relevant studies. Data were extracted from eligible publications, and meta-analyses were performed to estimate the pooled effect sizes. Relative risks (RRs) were used for cohort studies, while odds ratios (ORs) were used for case-control studies.</div></div><div><h3>Results</h3><div>A pooled analysis of 13 observational studies (14 effect sizes from seven cohort and seven case-control studies) demonstrated a significant association between antipsychotic use and increased breast cancer risk (OR: 1.23; 95 % CI: 1.12–1.35; <em>p</em> &lt; 0.01). Subgroup analyses showed elevated risk in both cohort studies (OR: 1.25; 95 % CI: 1.00–1.56; <em>p</em> = 0.046) and case-control studies (OR: 1.21; 95 % CI: 1.11–1.32; <em>p</em> &lt; 0.001). First-generation antipsychotics were associated with a higher risk (OR: 1.22; 95 % CI: 1.03–1.45; <em>p</em> = 0.023) compared to second-generation agents (OR: 1.08; 95 % CI: 1.04–1.13; <em>p</em> &lt; 0.001). Geographically, the highest risk was observed in Asian populations (OR: 1.42; 95 % CI: 1.08–1.88; <em>p</em> = 0.011), followed by European (OR: 1.21; 95 % CI: 1.14–1.28; <em>p</em> &lt; 0.001) and North American populations (OR: 1.17; 95 % CI: 1.06–1.31; <em>p</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>This meta-analysis found that antipsychotic use is associated with a 23 % increased risk of breast cancer in females, with a higher risk observed for first-generation compared to second-generation antipsychotics, and particularly elevated in Asian populations. These findings emphasize the need for further research into the underlying mechanisms and regional disparities. Clinicians should carefully evaluate the risks when prescribing antipsychotics and consider regular breast health monitoring for patients undergoing long-term treatment.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100313"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does including multiple hormones and family context together clarify hormone-behavior associations? A systematic review","authors":"Kristine Marceau ,&nbsp;Jennifer Hu ,&nbsp;Sohee Lee ,&nbsp;Prudence Regacho ,&nbsp;Gina Canino-Quiñones","doi":"10.1016/j.cpnec.2025.100326","DOIUrl":"10.1016/j.cpnec.2025.100326","url":null,"abstract":"<div><div>The objective of this study was to review the literature to determine whether simultaneously considering the hormonal milieu and the parenting domain of family context clarifies hormone-behavior associations in children and adolescents. We conducted a systematic review of PubMed, Scopus, and Web of Science in May 2024 and PsycINFO in May 2025. Inclusion criteria: Studies included variable(s) assessing family context in the parenting domain, measures of multiple hormones in children/adolescents where at least one was from the hypothalamic-pituitary-adrenal (HPA) or hypothalamic-pituitary-gonadal (HPG) axis, and a child/adolescent behavioral outcome, and children/adolescents studied were under 18 years. Reviews and animal studies, studies that were not peer reviewed (e.g., dissertation/theses, chapters) or not written in English were excluded. Our search and screen yielded 27 articles. The Robins-E tool was used to assess risk of bias; we provide a narrative synthesis of results. Most studies examined multiple hormones, but independently. Fewer studies included measures of hormonal milieu, using ratios most often, but also data aggregation (e.g., factors, profiles), and/or by calculating interactions among hormones. Childhood maltreatment was the family context construct most often assessed, followed by parent psychopathology, and less often, measures of parent-child relationship quality. Results provided some evidence that 1) hormonal milieu-behavior associations differ in the context of family conflict than social evaluative threat. 2) Less positive family environments were associated with high cortisol-to-(low) DHEA ratios cross-sectionally, but to lower cortisol-to-DHEA ratio longitudinally, and cortisol-to-DHEA ratios can be associated with behavior problems, though inconsistently across studies. And, 3) maltreatment can strengthen single hormone-behavior associations but may not moderate the association of hormonal milieu with behavioral outcomes. There was a surprising lack of longitudinal studies, and very few replication opportunities across specific findings given the heterogeneity in which phenotypes were measured and the construction of models. We provide recommendations for future research including a framework for future work to build a more systematic literature base regarding the role of family context in multihormone-behavior associations.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100326"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The motivational drives of sickness: Acute changes in self-rated motivation during experimental endotoxemia assessed with the newly developed Motivation Scale of Sickness (MOSSick)","authors":"Rasmus Skarp ,&nbsp;Lina S. Hansson ,&nbsp;Tina Sundelin ,&nbsp;Sofie Paues ,&nbsp;Martin Janson ,&nbsp;Leonie JT. Balter ,&nbsp;Mats J. Olsson ,&nbsp;John Axelsson ,&nbsp;Mats Lekander ,&nbsp;Julie Lasselin","doi":"10.1016/j.cpnec.2025.100327","DOIUrl":"10.1016/j.cpnec.2025.100327","url":null,"abstract":"<div><div>While altered motivation is central in sickness behavior, previous research has mainly focused on motivation for rewards, rather than motivational changes in a broader perspective. In a larger study following a randomized within-subject placebo-controlled crossover design, we investigated the effects of systemic inflammatory activation on self-rated motivation in 21 healthy participants, using an intravenous injection of 2.0 ng/kg body weight lipopolysaccharide (LPS) compared to an intravenous injection of saline (placebo). Self-rated motivation was measured before, 3 h, and 7.5 h post-injection using the Motivation Scale of Sickness (MOSSick), a newly developed tool designed to assess motivational changes during sickness. It contains 26 items covering motivational drives related to hunger, thirst, and food preferences; resting, physical, and social activities; care seeking; and utilization of resources (i.e., willingness to ‘pay’ and ‘walk’) to be able to rest or to be healthy at once. At the peak of the sickness response (3 h post-LPS injection), there was an increased motivation to seek care, rest, and sleep, as compared to placebo, while motivation to partake in physical and social activities decreased. Several of these effects remained at 7.5 h post-injection. When in the LPS condition, participants were also willing to pay more money to rest and to be healthy compared to when in the placebo condition. Hunger increased over time in both conditions, but less after LPS administration. During the peak of the sickness response, higher sickness ratings were weakly associated with lower motivation for social activities and higher motivation for resting and sleeping. No further association was found between motivational drives and sickness ratings or other sickness measures, i.e. concentrations of cytokines and tympanic temperature, although sample size was limited for these analyses. These findings illustrate that motivational changes during acute sickness are not restricted to a general decrease in motivation. Instead, sick individuals are more motivated to take part in behaviors that enable energy preservation, care, and recovery, compared to when healthy.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100327"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, functional and salivary cortisol level changes in individuals with schizophrenia undergoing cognitive behavioral therapy for psychosis in addition to their usual antipsychotic medication","authors":"Felicia Iftene,&nbsp;Adriana Farcas,&nbsp;Simon O'Brien","doi":"10.1016/j.cpnec.2025.100312","DOIUrl":"10.1016/j.cpnec.2025.100312","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100312"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed-methods analysis of sickness behavior during a natural experiment: An integrative single-case study","authors":"Christian Schubert ,&nbsp;Lennart Seizer ,&nbsp;Nina Camille Sophia Lauby ,&nbsp;Dietmar Fuchs","doi":"10.1016/j.cpnec.2025.100301","DOIUrl":"10.1016/j.cpnec.2025.100301","url":null,"abstract":"<div><div>Sickness behavior is a coordinated set of psychological changes mediated by immune system activity, e.g., during infection and wounding. It is an adaptive response to conserve energy and resources in support of immune activity and to protect the community by signaling others that one is ill. In this integrative single-case study, a 27-year-old healthy woman collected her entire urine over a period of 63 days in continuous 12-h intervals (126 measurements in total). In addition, among other regular psychological assessments, she completed an emotional state questionnaire (EWL) each morning and evening, and had an in-depth psychological interview once a week. In the urine samples, neopterin, cortisol, and creatinine were measured. Coincidentally, the subject experienced a period of sickness during the study period, lasting two days (from 12-h interval 21 to 24), accompanied by fatigue, vomiting, diarrhea, low-grade fever, and increases in urinary neopterin and cortisol concentrations. During this sickness period, structural breaks occurred in the time-series of two positive emotional states, i.e., performance-related activity and general feeling of comfort, with significant drops in their mean levels lasting for over 50 days until the end of the study. The intensive longitudinal data set collected in this integrative single-case study makes it possible to adopt a biopsychosocial meta-perspective (bottom-up, top-down) when interpreting the results.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100301"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}