Comprehensive psychoneuroendocrinology最新文献

Association between anxiety symptoms on risky e-biking riding behavior among adolescents: based on gut-brain axis 青少年危险电动自行车骑行行为与焦虑症状之间的关系：基于肠-脑轴

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2026-01-13 DOI: 10.1016/j.cpnec.2026.100337

Liting Zhou , Jiayu Liu , Shuyi Li , Yujun Xiong , Feifeng Qin , Zhongyun Luo , Dongmei Huang , Huihe Chen , Xiaomin Wang

Objective

This study aimed to investigate the association between anxiety symptoms and risky e-bike riding behavior (RERB) among adolescents and to explore whether gut microbiota mediates this relationship.

Methods

Adolescents using e-bikes were recruited through a combined online and offline recruitment approach. Data collection involved supervised electronic questionnaire completion in face-to-face settings, with biological samples collected independently by participants. Anxiety symptoms were assessed using the Generalized Anxiety Disorder-7 scale. RERB were evaluated via a structured questionnaire, yielding separate scores for aggressive behaviors (ABS), violation behaviors (VBS), and negligent behaviors (NES), along with total behavior scores (TBS). Fecal samples were obtained for metagenomic sequencing to characterize gut microbiota composition. Multiple linear regression was employed to elucidate the associations between anxiety symptoms and RERB. Partial Least Squares Path Modeling (PLS-PM) was applied to evaluate the potential mediating role of gut microbiota in these associations.

Results

A total of 71 adolescents were included in this cross-sectional study. Anxiety symptoms were significantly associated with RERB, including TBS and VBS (both P < 0.05). Among the 15 microbial genera identified from fecal samples, 17 species showed significant association with both anxiety symptoms and RERB. PLS-PM modeling revealed a significant mediating effect of specific gut microbiota in the anxiety→behavior pathway, particularly for TBS and VBS. In contrast, for ABS, a reverse pathway—microbiota→anxiety→behavior—was found significant.

Conclusions

Anxiety symptoms were significantly associated with RERB among adolescents. Specific gut microbiota may mediate these associations, suggesting a potential microbiota–brain–behavior pathway.

目的探讨青少年焦虑症状与危险骑电动自行车行为（RERB）的关系，并探讨肠道菌群是否在其中起中介作用。方法采用线上线下结合的方式招募使用电动自行车的青少年。数据收集包括在面对面的环境下完成监督电子问卷，生物样本由参与者独立收集。使用广泛性焦虑障碍-7量表评估焦虑症状。通过结构化问卷对RERB进行评估，得出攻击行为（ABS）、违规行为（VBS）、疏忽行为（NES）以及总行为得分（TBS）。获得粪便样本进行宏基因组测序以表征肠道微生物群组成。采用多元线性回归分析焦虑症状与RERB的关系。应用偏最小二乘路径模型（PLS-PM）来评估肠道微生物群在这些关联中的潜在介导作用。结果本研究共纳入71名青少年。焦虑症状与RERB显著相关，包括TBS和VBS （P < 0.05）。在粪便样本中鉴定的15种微生物属中，17种与焦虑症状和RERB均有显著相关性。PLS-PM模型揭示了特定肠道微生物群在焦虑→行为通路中的显著中介作用，特别是对TBS和VBS。相反，对于ABS，反向途径-微生物群→焦虑→行为-被发现是显著的。结论青少年焦虑症状与RERB有显著相关性。特定的肠道微生物群可能介导这些关联，提示潜在的微生物群-脑-行为途径。

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引用次数: 0

The correlational study of the 24 solar terms and meteorological factors with the acute exacerbation of bipolar disorder 24节气及气象因素与双相情感障碍急性加重的相关性研究

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2026-01-09 DOI: 10.1016/j.cpnec.2025.100336

Jian Chen , Tingting Wu , Hongyu Wu , Jingying Zhou , Wenfei Li

Background

Bipolar disorder (BD) is a severe mood disorder, and increasing evidence suggests that acute episodes of BD may exhibit seasonal patterns. However, the relationship between acute BD episodes and meteorological factors remains a contentious issue in academia. This study aims to investigate the distribution of BD acute episodes across 24 solar terms, offering a fresh perspective on the link between BD acute episodes and meteorological factors.

Methods

This analysis was based on retrospectively collected hospitalization records from patients with acute BD episodes at Anhui Mental Health Center (2020–2022), and contemporaneous meteorological data.

Results

The two peaks of BD manic episodes occurred during Rainwater and Grain in Ear solar terms, whereas the peak of depressive episodes was observed during Rainwater and Summer Solstice solar terms. BD manic episodes were significantly correlated with temperature differences, interday temperature differences and interday wind speed differences. Depressive episodes were significantly correlated with the temperature difference, interday wind speed difference and atmospheric pressure. Linear regression analysis revealed that the interday atmospheric pressure difference and interday temperature difference were significantly associated with acute BD episodes.

Conclusion

This study conducted a large-scale survey on the distribution of acute BD episodes across 24 solar terms in the Chinese population and their correlations with meteorological factors and sociodemographic characteristics. The findings indicate that the distribution of BD acute episodes varies across the 24 solar terms and that there is a correlation between BD acute episodes and certain meteorological factors, particularly drastic changes in temperature and atmospheric pressure, which may account for the differences in the number of BD acute episodes across the solar terms.

背景：双相情感障碍（BD）是一种严重的情绪障碍，越来越多的证据表明，双相情感障碍的急性发作可能表现出季节性模式。然而，急性双相障碍发作与气象因素的关系在学术界仍是一个有争议的问题。本研究旨在研究24节气中双相障碍急性发作的分布，为双相障碍急性发作与气象因子的关系提供新的视角。方法回顾性收集安徽省精神卫生中心2020-2022年急性双相障碍患者住院记录，并结合同期气象资料进行分析。结果双相障碍躁狂发作的两个高峰出现在雨水节气和夏至节气，抑郁发作的高峰出现在雨水节气和夏至节气。BD躁狂发作与温差、日间温差和日间风速差异显著相关。抑郁发作与温差、日间风速差、气压显著相关。线性回归分析显示，日间气压差和日间温差与急性双相障碍发作显著相关。结论本研究对中国24节气人群急性BD发作的分布及其与气象因素和社会人口学特征的相关性进行了大规模调查。研究结果表明，24节气中BD急性发作的分布存在差异，并且与某些气象因素，特别是温度和气压的剧烈变化存在相关性，这可能解释了不同节气中BD急性发作次数的差异。

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引用次数: 0

Maternal thyroid function in the first half of pregnancy and neurodevelopmental outcomes in early adolescence in the Amsterdam Born Children and their Development (ABCD) cohort 在阿姆斯特丹出生的儿童及其发展（ABCD）队列中，怀孕前半期母亲甲状腺功能和青春期早期神经发育结局

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-12-22 DOI: 10.1016/j.cpnec.2025.100333

Sarai M. Keestra , Susanne R. de Rooij , Tessa J. Roseboom , Marsh Königs , Tanja GM. Vrijkotte , Martijn J.J. Finken

Maternal thyroid hormone levels in pregnancy have been implicated to play a role in brain development, but few observational studies have examined their relationship with neurodevelopmental outcomes beyond early childhood. We investigated associations between maternal thyroid function during the first 20 weeks of pregnancy and neurodevelopmental outcomes in 1824 children aged 10–13 years from the Amsterdam Born Children and their Development (ABCD) cohort. Outcomes included neurocognition (non-verbal intelligence [Raven's Progressive Matrices], executive working memory [SOPT]), behavioural organisation (behaviour regulation and metacognition [BRIEF], and internalizing behaviour and risk-seeking [SURPS]), and emotional, social, and behavioural problems (mother-, teacher-, and self-reported SDQ internalizing and externalizing problems). We fitted linear and quadratic multivariable regression models, as well as restricted cubic splines with three knots for the 10th, 50th and 90th percentiles, choosing the best model to assess associations across the continuous range of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) on the outcomes, both in pregnancies without overt thyroid disease and in the full cohort. Secondary analyses examined potential threshold effects (10th and 90th percentiles of TSH and FT4), and impact of clinical thyroid dysfunction based on cohort-specific reference ranges, anti-TPO positivity, and sex differences. We found a small but significant positive linear association between maternal log-transformed TSH in pregnancies free of overt thyroid disease and non-verbal intelligence in girls (estimate: 0.05, 95 % CI: 0.01 to 0.09, p = 0.02; SMD: 0.015), but not in boys, after correction for multiple testing. No other neurodevelopmental outcomes were associated with maternal thyroid function. These findings suggest that maternal thyroid function in early pregnancy, in the absence of overt thyroid disease, shows no consistent associations with child neurodevelopmental outcomes in adolescence, apart from a small association with non-verbal intelligence in girls that may not be clinically relevant.

怀孕期间母亲甲状腺激素水平与大脑发育有关，但很少有观察性研究考察其与儿童早期以外神经发育结果的关系。我们调查了1824名来自阿姆斯特丹出生儿童及其发展（ABCD）队列的10-13岁儿童在怀孕前20周的母亲甲状腺功能与神经发育结局之间的关系。结果包括神经认知（非语言智力[Raven's Progressive Matrices]、执行工作记忆[SOPT]）、行为组织（行为调节和元认知[BRIEF]、内化行为和风险寻求[SURPS]），以及情绪、社会和行为问题（母亲、教师和自我报告的SDQ内化和外化问题）。我们拟合了线性和二次多变量回归模型，以及第10、50和90百分位数的三节限制性三次样条，选择了最佳模型来评估促甲状腺激素（TSH）和游离甲状腺素（FT4）的连续范围对结局的影响，无论是在没有明显甲状腺疾病的妊娠中还是在整个队列中。二级分析检查了潜在阈值效应（TSH和FT4的第10和90百分位数），以及基于队列特定参考范围、抗tpo阳性和性别差异的临床甲状腺功能障碍的影响。我们发现，在没有明显甲状腺疾病的怀孕期间，母亲对数转化TSH与女孩的非语言智力之间存在微小但显著的正线性关联（估计：0.05,95% CI: 0.01至0.09,p = 0.02; SMD: 0.015），但在多次测试校正后，男孩没有。没有其他神经发育结果与母体甲状腺功能相关。这些发现表明，在没有明显甲状腺疾病的情况下，妊娠早期母亲的甲状腺功能与青春期儿童的神经发育结果没有一致的关联，除了与女孩的非语言智力有微小的关联，这可能与临床无关。

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引用次数: 0

Exploring the mediating roles of diet and physical activity in the association between different obesity phenotypes and risk of depression: A cox survival analysis approach 探讨饮食和身体活动在不同肥胖表型和抑郁风险之间的中介作用：cox生存分析方法

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-12-19 DOI: 10.1016/j.cpnec.2025.100332

Yang Liu , Yue Zheng , Mingfang Wang , Juan Liao , Lu Long

Although obesity has been linked to an increased risk of depression, the risk associated with different obesity phenotypes remain unclear, as does the role of lifestyle behaviors. Participants from the UK Biobank who were free of depression at the baseline and had complete data on body composition and metabolism-related measures were selected and followed up. Multivariable Cox models were employed to assess the risk of developing depression according to obesity phenotypes. Mediation analyses were conducted to evaluate the potential mediating effects of diet and physical activity in this association. Among 391,781 participants, a total of 20,027 incident depression was recorded after a median follow-up period of 13.39 years. Our study revealed that different obesity phenotypes increased the risk of depression to varying degrees. Compared with healthy non-obese individuals, those with BMI ≥30 kg/m² only had the lowest risk of depression (HR: 1.15, 95 %CI: 1.04, 1.28), and then followed by central obesity (HR: 1.60, 95 %CI: 1.51, 1.70), metabolically unhealthy obesity (HR: 1.63, 95 %CI: 1.56, 1.70). Sarcopenic obesity results in the highest risk of depression among these four phenotypes (HR: 1.86, 95 %CI: 1.40, 2.46). Both physical activity and diet mediated the effect of the four obesity phenotypes on the risk of depression. In the relationship between BMI ≥30 only and depression, physical activity mediated for 2.49 % and diet mediated for 1.60 %. Between metabolically unhealthy obesity and depression, physical activity mediated for 7.08 % and diet mediated for 1.86 %. This set of data was 5.29 % and 1.47 % in the relationship between central obesity and depression, and 6.22 % and 1.25 % in the relationship between sarcopenic obesity and depression. Subgroup analyses revealed that the female with obesity (including four types) had a higher risk of depression compared to the male, whereas individuals aged 60 years or older and those who were former or current smokers with obesity (except sarcopenic obesity) exhibited a lower risk of depression. These findings provide a basis for the prevention of obesity-depression comorbidity in obese patients.

尽管肥胖与抑郁风险增加有关，但不同肥胖表型的风险仍不清楚，生活方式行为的作用也不清楚。研究人员从英国生物银行（UK Biobank）中选择了基线时无抑郁症的参与者，并对他们的身体组成和代谢相关指标进行了随访。采用多变量Cox模型根据肥胖表型评估患抑郁症的风险。我们进行了中介分析，以评估饮食和身体活动在这一关联中的潜在中介作用。在391,781名参与者中，经过13.39年的中位随访期，总共记录了20027例抑郁症事件。我们的研究表明，不同的肥胖表型在不同程度上增加了患抑郁症的风险。与健康的非肥胖者相比，BMI≥30 kg/m2的人患抑郁症的风险最低（HR: 1.15, 95% CI: 1.04, 1.28），其次是中心性肥胖（HR: 1.60, 95% CI: 1.51, 1.70）和代谢不健康肥胖（HR: 1.63, 95% CI: 1.56, 1.70）。在这四种表型中，肌肉减少型肥胖导致抑郁症的风险最高（HR: 1.86, 95% CI: 1.40, 2.46）。运动和饮食均介导了四种肥胖表型对抑郁风险的影响。在BMI≥30与抑郁的关系中，体力活动介导2.49%，饮食介导1.60%。在代谢不健康的肥胖和抑郁之间，体育活动介导7.08%，饮食介导1.86%。中枢性肥胖与抑郁的关系分别为5.29%和1.47%，肌少性肥胖与抑郁的关系分别为6.22%和1.25%。亚组分析显示，与男性相比，女性肥胖（包括四种类型）患抑郁症的风险更高，而年龄在60岁或以上的个体以及曾经或现在吸烟的肥胖（肌肉减少性肥胖除外）患抑郁症的风险较低。这些发现为预防肥胖患者的肥胖-抑郁合并症提供了依据。

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引用次数: 0

Cortisol-to-DHEAS awakening response ratio in people with dementia and family caregivers: Associations with age, dementia severity and agitation 痴呆患者和家庭照顾者的皮质醇- dheas觉醒反应比：与年龄、痴呆严重程度和躁动的关系

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-12-19 DOI: 10.1016/j.cpnec.2025.100334

Wanrui Wei , Töres Theorell , Gabriella Engstrom , Azita Emami

Background

The ratio of cortisol to dehydroepiandrosterone sulfate (DHEAS) in the awakening response has emerged as a potential biomarker of stress-related dysregulation in neurodegenerative conditions. Whether this ratio differs between people with dementia (PWD) and family caregivers, and how it varies with age, sex, dementia severity and agitation, remains unclear.

Methods

We analyzed 1093 day-level saliva samples from 58 participants (PWD = 28; caregivers = 30). The primary outcome was the log-transformed awakening response ratio of cortisol to DHEAS. Linear mixed-effects models with a participant random intercept and natural splines for age estimated group contrasts as geometric mean ratios (GMRs) from estimated marginal means. Fixed-effect predictors included age, sex, dementia severity (Global Deterioration Scale, GDS), and agitation (Brief Agitation Rating Scale, BARS). Model comparisons were conducted. Within PWD, mean-centered models tested one interaction at a time (Sex × GDS, Sex × BARS, Age × GDS, Age × BARS).

Results

There was no between-group difference in the ratio after accounting for within-participant clustering and age (GMR = 0.97, 95 % CI 0.64–1.46; p = 0.87). Within PWD, interaction models indicated that the association between age and the ratio strengthened with higher dementia severity (β = 0.043, p = 0.04) and greater agitation (β = 0.011, p = 0.006). Marginal R² ranged 0.114–0.141; conditional R² 0.358–0.376.

Conclusions

Although average ratio did not differ between PWD and caregivers, it increased more steeply with age at higher dementia severity and agitation. These findings highlight the cortisol-to-DHEA(S) awakening response ratio as a non-invasive and clinically relevant biomarker reflecting symptom-linked neuroendocrine heterogeneity in dementia.

唤醒反应中皮质醇与脱氢表雄酮硫酸酯（DHEAS）的比例已成为神经退行性疾病中应激相关失调的潜在生物标志物。目前尚不清楚痴呆症患者（PWD）和家庭照顾者之间的这一比例是否不同，以及它如何随年龄、性别、痴呆症严重程度和躁动而变化。方法我们分析了58名参与者（PWD = 28，护理人员= 30）的1093份日水平唾液样本。主要结果是对数转换的皮质醇对DHEAS的觉醒反应比率。线性混合效应模型与参与者随机截距和自然样条的年龄估计组对比作为估计边际均值的几何平均比率（GMRs）。固定效应预测因子包括年龄、性别、痴呆严重程度（全球恶化量表，GDS）和躁动（短暂躁动评定量表，BARS）。进行模型比较。在PWD中，以均值为中心的模型一次测试一个交互作用（性别× GDS、性别× BARS、年龄× GDS、年龄× BARS）。结果考虑参与者内聚类和年龄因素后，GMR = 0.97, 95% CI 0.64-1.46; p = 0.87，组间无统计学差异。在PWD中，相互作用模型表明，年龄与该比率之间的相关性随着痴呆严重程度（β = 0.043, p = 0.04）和躁动程度（β = 0.011, p = 0.006）的增加而增强。边际R2范围为0.114-0.141；条件R2 0.358-0.376。结论老年痴呆患者与照护者的平均痴呆率无显著差异，但随着年龄的增长，痴呆严重程度和躁动程度越高，痴呆率上升越快。这些发现强调了皮质醇与脱氢表雄酮(S)唤醒反应比是反映痴呆症状相关神经内分泌异质性的非侵入性和临床相关生物标志物。

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引用次数: 0

Longitudinal trajectories of cancer-related cognitive impairment and influential factors among patients with lung cancer 肺癌患者癌症相关认知功能障碍的纵向轨迹及影响因素

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-12-11 DOI: 10.1016/j.cpnec.2025.100330

Xiaoju Zhu , Yalan Huang , Haiwei Fu , Sixiong Luo , Yuanjing Jiang , Zonghua Wang

Objective

This study aimed to investigate longitudinal cognitive changes and identify factors associated with cancer-related cognitive impairment (CRCI) among lung cancer survivors.

Methods

Cognitive function was assessed using the FACT-Cog (subjective) and TICS-M (objective). The baseline assessment was completed before the use of chemotherapy drugs and recorded as T0. After completing the first cycle of chemotherapy, it was recorded as T1; after the second cycle, as T2; after the third cycle, as T3; after the fourth cycle, as T4; and after the fifth cycle, as T5. Linear mixed-effect models evaluated associations between clinical/sociodemographic factors and cognitive outcomes.

Results

Higher education level and later treatment progression were correlated with increased TICS-M scores. In contrast, Rural residence (β = −1.89, p = 0.021) and more comorbidities (β = −2.15, p = 0.033) were associated with reduced FACT-Cog scores. Treatment progression correlated with improved TICS-M scores (β = 0.716, p = 0.001). No significant differences were observed between the chemotherapy and chemoimmunotherapy groups (p > 0.05). A key finding was the observed discordance between stable subjective reports and modestly improving objective scores over time. There was a discrepancy between subjective and objective cognitive evaluations, as FACT-Cog scores remained consistent over time (mean 129.8 ± 20.2), while TICS-M scores showed a slight improvement (from 23.4 ± 4.9 to 24.4 ± 3.7).

Discussion

The influence of education, residence, and comorbidities on CRCI trajectories in lung cancer patients highlights the need for integrated evaluation tools. This longitudinal analysis not only identifies distinct risk profiles for CRCI but also underscores the critical need for proactive screening and tailored supportive care programs. These priorities provide a guide for improving cognitive health outcomes in lung cancer survivorship care.

目的本研究旨在调查肺癌幸存者的纵向认知变化并确定与癌症相关认知障碍（CRCI）相关的因素。方法采用FACT-Cog（主观）和tic - m（客观）评价认知功能。基线评估在化疗药物使用前完成，记录为T0。完成第一个周期化疗后，记T1；第二个周期后，为T2；第三个周期后，为T3；第四个周期后，为T4；第五个周期之后，称为T5。线性混合效应模型评估临床/社会人口因素与认知结果之间的关系。结果受教育程度越高，治疗进展越晚，tic - m评分越高。相比之下，农村居住（β = - 1.89, p = 0.021）和更多合并症（β = - 2.15, p = 0.033）与FACT-Cog评分降低相关。治疗进展与改善的tic - m评分相关（β = 0.716, p = 0.001）。化疗组与化疗免疫组间无显著差异（p > 0.05）。一个关键的发现是观察到稳定的主观报告和随着时间的推移适度提高的客观分数之间的不一致。主观和客观认知评估之间存在差异，因为FACT-Cog评分随时间保持一致（平均129.8±20.2），而tic - m评分略有改善（从23.4±4.9到24.4±3.7）。教育程度、居住地和合并症对肺癌患者CRCI轨迹的影响突出了对综合评估工具的需求。这项纵向分析不仅确定了CRCI的不同风险概况，而且强调了积极筛查和量身定制的支持性护理计划的必要性。这些优先事项为改善肺癌生存护理中的认知健康结果提供了指导。

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引用次数: 0

Before pregnancy trauma primes oxytocin receptor expression in placenta during superstorm sandy 在超级风暴桑迪期间，怀孕前的创伤导致胎盘中催产素受体的表达

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-11-01 DOI: 10.1016/j.cpnec.2025.100328

Patricia M. Pehme , Wai M. Wong , Corina Lesseur , Joshua C. Brumberg , Yoko Nomura

Objective

Given the role of sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis in trauma transmission and oxytocin's stress buffering effects, this study examined whether placental oxytocin receptor (OXTR) gene expression differs by maternal trauma exposure status.

Methods

A sample (N = 152) was drawn from a longitudinal birth cohort. OXTR was quantified using nCounter platform as expressed or unexpressed. Maternal trauma exposure was assessed via validated questionnaire and categorized into four groups: before pregnancy trauma, Superstorm Sandy exposure during pregnancy, both, or neither (reference). Logistic regression and synergy index (SI) were calculated to examine individual and additive interaction effects.

Results

In the proportion of samples with detectable OXTR, neither individual exposure significantly altered placental OXTR expression. However, both traumas exposure group had an over a 6-fold increase (OR = 6.13, p = .01) compared to the reference. The SI was 2.17 suggesting that the combined effect of both traumas exceeded the sum of their individual effects on placental OXTR expression.

Conclusion

Given oxytocin linked placental adaptations to cope with consequences of stress, this greater-than-additive modification, as evidenced by the synergy index, suggests trauma exposure before pregnancy fundamentally changes how the placenta responds to disaster exposure during pregnancy in anticipation of harsh external conditions.

目的通过探讨交感神经系统和下丘脑-垂体-肾上腺（HPA）轴在创伤传递和催产素应激缓冲中的作用，探讨胎盘催产素受体（OXTR）基因表达是否因母体创伤暴露状态而异。方法从纵向出生队列中抽取样本152例。使用nCounter平台定量OXTR，分为表达或未表达。通过有效的问卷对产妇的创伤暴露进行评估，并将其分为四组：怀孕前的创伤、怀孕期间的飓风桑迪暴露、两者都暴露或两者都不暴露（参考文献）。计算逻辑回归和协同指数（SI）来检验个体和加性相互作用效应。结果在可检测到OXTR的样本中，个体暴露均未显著改变胎盘OXTR的表达。然而，与参考组相比，两个创伤暴露组都增加了6倍以上（OR = 6.13, p = 0.01）。SI为2.17，表明两种创伤对胎盘OXTR表达的综合影响超过其单独影响的总和。综上所述，鉴于催产素与胎盘适应应激有关，这种大于添加剂的改变表明，怀孕前的创伤暴露从根本上改变了胎盘在怀孕期间对恶劣外部条件的灾难暴露的反应。

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引用次数: 0

Thirty-three years of editorial work. A lifetime adventure 33年的编辑工作。一生的冒险

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-11-01 DOI: 10.1016/j.cpnec.2025.100331

Rose-Marie Bluthe

引用次数: 0

Changes in hair cortisol during retirement transition: the Finnish retirement and aging study 退休过渡期毛发皮质醇的变化：芬兰退休与老龄化研究

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-11-01 DOI: 10.1016/j.cpnec.2025.100325

Konsta Kuusento , Susanna Kortesluoma , Saana Myllyntausta , Jussi Vahtera , Linnea Karlsson , Sari Stenholm

Objectives

Retirement is a significant life event involving removal of work stress and changes in other psychological factors. These changes may induce physiological responses in the body, such as changes in levels of the stress hormone cortisol, but no previous studies exist on the topic. The aim of this study was to examine changes in hair cortisol concentration and the associated work-related factors during the retirement transition.

Methods

One hundred and ninety-nine workers from the Finnish Retirement and Aging study participated in annual hair sampling before and after the retirement transition. Hair cortisol concentration was measured using mass spectrometry. Work-related factors were examined through survey measures. Latent trajectory analysis was used to investigate the heterogeneity of the changes in hair cortisol concentration during the retirement transition.

Results

The study population had a mean age of 63.1 (SD 1.1) years and 92 % were women. Three trajectory groups for hair cortisol changes were identified: ”stable low” (79 %), “fluctuating” (6 %) and “post-retirement increase” (15 %). ”Post-retirement increase” group consisted of older participants compared to the “stable low” and “fluctuating” groups. No significant differences in exposure to work-related stressors were found between the groups.

Conclusion

For the majority of the participants, the levels of hair cortisol remained relatively low and stable during the retirement transition, but for subgroups of individuals annual fluctuation and post-retirement increase in levels of hair cortisol were observed. Work-related stressors were not found to explain the variability, thus further research on changes in hair cortisol changes during retirement is warranted.

退休是一件重要的生活事件，涉及工作压力的消除和其他心理因素的变化。这些变化可能会引起身体的生理反应，比如应激激素皮质醇水平的变化，但此前没有关于这一主题的研究。本研究的目的是检查在退休过渡期间头发皮质醇浓度的变化和相关的工作相关因素。方法来自芬兰退休与老龄化研究的199名工人在退休过渡前后每年进行一次头发取样。用质谱法测定毛发皮质醇浓度。通过调查手段对工作相关因素进行考察。潜在轨迹分析用于研究退休过渡期间毛发皮质醇浓度变化的异质性。结果研究人群平均年龄为63.1岁（SD 1.1），其中92%为女性。毛发皮质醇变化的三个轨迹组被确定为：“稳定低”（79%），“波动”（6%）和“退休后增加”（15%）。与“稳定低”和“波动”组相比，“退休后增加”组由年龄较大的参与者组成。在与工作有关的压力源暴露方面，两组之间没有发现显著差异。结论：对于大多数参与者来说，在退休过渡期间，毛发皮质醇水平保持相对较低和稳定，但对于个体亚组来说，毛发皮质醇水平的年度波动和退休后的增加是观察到的。没有发现与工作相关的压力因素可以解释这种差异，因此对退休期间头发皮质醇变化的进一步研究是有必要的。

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引用次数: 0

Disentangling the biopsychosocial effects of gender-affirming hormone therapy on social health: A protocol for a multi-arm prospective cohort study (AFFIRM Relationships) 性别肯定激素治疗对社会健康的生物心理社会效应：一项多臂前瞻性队列研究方案（AFFIRM Relationships）

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology

Pub Date : 2025-11-01 DOI: 10.1016/j.cpnec.2025.100329

Margot W.L. Morssinkhof , Nessa Millet , Giulia T. Zoppolat , Sigsten K. Stieglitz , Baudewijntje P.C. Kreukels , David Matthew Doyle

Introduction

Gender-affirming hormone therapy (GAHT) is associated with improvements in gender congruence and changes in psychosocial functioning, yet its effects on social health are not yet known. Social health, i.e., someone having adequate quantity and quality of relationships to meet their needs for meaningful connection, is a key determinant of quality of life. Understanding potential changes in social health during GAHT is therefore essential to information provision for trans and gender diverse (TGD) people. The study, AFFIRM Relationships, aims to prospectively examine how GAHT affects social health and to isolate the biological effects of hormonal intervention relative to other gender-affirming treatments (i.e., mastectomy and voice training).

Methods

We will conduct a multi-arm prospective longitudinal cohort study of TGD people who start GAHT, gender-affirming voice training, or gender-affirming mastectomy, prospectively following participants from before starting treatment to 3, 6, 12, and 24 months after starting treatment. We will examine changes in social health, including potential changes in social networks. We aim to disentangle the ways in which social health changes after GAHT by examining changes in psychosocial functioning and the potential roles of social stigma and gender congruence. Furthermore, we will compare the effects of GAHT, which induces a systemic biological change, to the effects of voice training and mastectomy, which are non-systemic interventions, to better understand the unique biological effects of GAHT.

Ethics and dissemination

Ethical approval for this study was granted by the Medical Ethical Committee of Amsterdam UMC (study no. 2024.0927). Results from this study will be disseminated via academic peer-reviewed publications, adapted into guidelines for clinical care, and we will co-design dissemination strategies for the TGD community together with a group of lived experienced experts (LEEs).

Registration

N/A.

性别确认激素治疗（GAHT）与性别一致性的改善和社会心理功能的改变有关，但其对社会健康的影响尚不清楚。社会健康，即某人拥有足够数量和质量的关系来满足他们对有意义的联系的需求，是生活质量的关键决定因素。因此，了解GAHT期间社会健康的潜在变化对于向跨性别和性别多样化（TGD）人群提供信息至关重要。这项名为“确认关系”的研究旨在前瞻性地研究GAHT如何影响社会健康，并分离激素干预相对于其他性别确认治疗（即乳房切除术和声音训练）的生物效应。方法：我们将对接受GAHT、性别确认声音训练或性别确认乳房切除术的TGD患者进行一项多臂前瞻性纵向队列研究，从开始治疗前到开始治疗后3、6、12和24个月进行前瞻性随访。我们将研究社会健康的变化，包括社会网络的潜在变化。我们的目标是通过检查社会心理功能的变化以及社会耻辱和性别一致的潜在作用，来解开GAHT后社会健康变化的方式。此外，为了更好地了解GAHT的独特生物学效应，我们将比较GAHT的效果（它会引起全身生物学变化）与声音训练和乳房切除术（非全身干预）的效果。伦理和传播本研究的伦理批准由阿姆斯特丹UMC医学伦理委员会授予(研究号：2024.0927)。本研究的结果将通过同行评审的学术出版物进行传播，并纳入临床护理指南，我们将与一组生活经验丰富的专家（LEEs）共同设计TGD社区的传播策略。

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