Critical care science最新文献

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The relevance of including delirium in the assessment of sepsis-associated neurological disorders that cause changes in consciousness or confusion. 在评估引起意识或意识混乱改变的败血症相关神经系统疾病时包括谵妄的相关性。

Critical care science

Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250211

Roberta Esteves Vieira de Castro, Yu Kawai, Daniela Nasu Monteiro Medeiros, Arnaldo Prata-Barbosa, Neelima Marupudi

引用次数: 0

Target trial emulation on dexmedetomidine for critically ill patients: all that glitters is not gold. 右美托咪定用于危重病人的靶试验模拟：闪光的并不都是金子。

Critical care science

Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250118

Bruna Brandao Barreto, Lisa Burry, Dimitri Gusmao-Flores

引用次数: 0

Artificial intelligence for the prediction of postoperative complications in the critically ill. 人工智能在危重病人术后并发症预测中的应用。

Critical care science

Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250025

Vanessa Moll, Ashish K Khanna, Piyush Mathur

引用次数: 0

Brazilian Research in Intensive Care Network (BRICNet): shaping the landscape of critical care research in Brazil and beyond. 巴西重症监护研究网络（BRICNet）：塑造巴西及其他地区重症监护研究的景观。

Critical care science

Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250284

Juliana Carvalho Ferreira, Adriano José Pereira, Alexandre Biasi Cavalcanti, Antonio Paulo Nassar Junior, Ary Serpa Neto, Bruno Adler Maccagnan Pinheiro Besen, Bruno Martins Tomazini, Cassiano Teixeira, Felipe Dal-Pizzol, Fernando Augusto Bozza, Fernando Godinho Zampieri, Flávia Ribeiro Machado, Glauco Adrieno Westphal, Israel Silva Maia, Leandro Utino Taniguchi, Luciano Cesar Pontes Azevedo, Marcio Soares, Otavio Ranzani, Pedro Vitale Mendes, Rafael Barberena Moraes, Regis Goulart Rosa, Rodrigo Santos Biondi, Suzana Margarete Lobo, Thiago Costa Lisboa, Viviane Cordeiro Veiga, Wagner Luis Nedel, Jorge Ibrain Figueira Salluh, André Miguel Japiassú, Bruno do Valle Pinheiro, Cássia Righy, Cíntia Magalhães Carvalho Grion, Eduardo Leite Vieira Costa, Fernando José da Silva Ramos, Flávio Geraldo Rezende de Freitas, João Gabriel Rosa Ramos, Luiz Marcelo Sá Malbouisson, Márcio Manozzo Boniatti, Pedro Kurtz, Roberta Muriel Longo Roepke, Thiago Domingos Corrêa, Vandack Alencar Nobre Júnior

Critical illnesses such as sepsis and acute respiratory distress syndrome lead to millions of deaths globally, with a higher burden in low- and middle-income countries. Conducting multicentric clinical studies is essential to help minimize the burden of critical illnesses, particularly in areas where their impact is greater. However, conducting large-scale multicentric studies is challenging, and most large multicentric studies in critical care are from high-income countries, which limits their relevance in other contexts. This highlights the need for collaborative research networks in low- and middle-income countries to better address local needs. The Brazilian Research in Intensive Care Network (BRICNet) was created by a group of intensivists and researchers in 2007 and is dedicated to being the leading organization in Brazil for conducting collaborative clinical research to improve care for critically ill patients. BRICNet focuses on investigator-initiated and collaborative studies relevant to global intensive care, with a special emphasis on Brazilian context. Its mission includes advancing research methodology, scientific writing, and conducting large-scale multicenter studies to fill knowledge gaps in critical care. Since its creation, the network has published 71 articles, including 15 randomized controlled trials and 14 observational studies, many of them in collaboration with major Brazilian institutions and international networks. This review aims to critically assess the achievements of BRICNet, highlighting its high-impact publications, international partnerships, and capacity building, which have significantly contributed to the field of intensive care. Looking ahead, we also identify barriers and solutions for sustainable growth.

脓毒症和急性呼吸窘迫综合征等严重疾病导致全球数百万人死亡，低收入和中等收入国家的负担更高。开展多中心临床研究对于帮助尽量减少严重疾病的负担至关重要，特别是在其影响较大的地区。然而，开展大规模多中心研究具有挑战性，而且大多数重症监护的大型多中心研究来自高收入国家，这限制了它们在其他情况下的相关性。这突出了在低收入和中等收入国家建立合作研究网络以更好地满足当地需求的必要性。巴西重症监护研究网络（BRICNet）由一群重症医师和研究人员于2007年创建，致力于成为巴西开展合作临床研究以改善危重患者护理的领先组织。BRICNet侧重于研究者发起的与全球重症监护相关的合作研究，特别强调巴西的情况。其使命包括推进研究方法、科学写作和开展大规模多中心研究，以填补重症监护方面的知识空白。自创建以来，该网络已发表了71篇文章，其中包括15项随机对照试验和14项观察性研究，其中许多是与巴西主要机构和国际网络合作进行的。本综述旨在批判性地评估金砖网络的成就，强调其高影响力的出版物、国际伙伴关系和能力建设，这些对重症监护领域做出了重大贡献。展望未来，我们还将确定可持续增长的障碍和解决方案。

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引用次数: 0

The legacy of Prof Rinaldo Bellomo for critical care and scientific publication: an editorial tribute from Critical Care Science. 里纳尔多·贝洛莫教授对重症监护和科学出版的遗产：《重症监护科学》的社论致敬。

Critical care science

Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250179

Ary Serpa Neto, Jorge Ibrain Figueira Salluh

引用次数: 0

Improving the outcomes of sepsis in Brazil: strategies and initiatives. 改善巴西败血症的结果：战略和举措。

Critical care science

Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250313

Daniela Carla de Souza, Regis Goulart Rosa, Reinaldo Salomão, Flávia Ribeiro Machado

引用次数: 0

To: Science over language: a plea to consider language bias in scientific publishing. 致：科学重于语言：呼吁考虑科学出版中的语言偏见。

Critical care science

Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250027

Rohan Magoon

引用次数: 0

Cardiopulmonary resuscitation in Brazilian medical television shows: a descriptive and quality assessment study. 巴西医疗电视节目中的心肺复苏：描述性和质量评估研究。

Critical care science

Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250228

Eduardo Messias Hirano Padrao, Fernando Onuchic, Monaliza de Almeida Castro, Ariadne Peres Silva Swarovsky, Augusto Barreto do Amaral Neto, Felippe Lazar Neto, Luciano César Pontes Azevedo, Fernando Godinho Zampieri, Caio de Assis Moura Tavares

Objective: To assess the accuracy of Brazilian television depictions of cardiopulmonary arrest, their management, and outcomes and to compare the observed outcomes with prior data from observational studies.

Methods: Investigators screened episodes, identified cardiac arrest scenes, collected relevant information, and assessed outcomes. Cardiac arrest scenes were then analyzed using the American Heart Association guidelines. The primary outcome was survival with favorable neurologic outcomes. Secondary outcomes were the return of spontaneous circulation and the number of Advanced Cardiovascular Life Support deviations in each event.

Results: Fifty-nine cardiac arrests were included in the study. Death occurred in 55.9% of patients, and return of spontaneous circulation was obtained in 54.2%. Survival rate was 44.1%, and 42.4% of the patients had favorable neurologic outcomes. Adherence to Advanced Cardiovascular Life Support guidelines did not demonstrate a significant impact on survival with favorable neurological outcomes, as evidenced by comparable odds ratios (0.86 [95%CI 0.22 - 2.36] for 3 - 5 deviations and 0.69 [95%CI 0.07 - 5.93] for ≥ 6 deviations using 0 - 2 deviations as reference). Television shows depicted a significantly higher proportion of favorable outcomes than real-world Brazilian cohorts for out-of-hospital and in-hospital scenarios (50% versus 20.5%, p = 0.107; and 43.3% versus 17.4%, p < 0.0001, respectively).

Conclusion: In Brazilian television shows, the portrayal of cardiopulmonary resuscitation is inaccurate and tends to overstate the likelihood of favorable outcomes following cardiac arrests.

目的：评估巴西电视对心肺骤停、处理和结果的描述的准确性，并将观察到的结果与观察性研究的先前数据进行比较。方法：研究人员筛选发作，确定心脏骤停场景，收集相关信息，并评估结果。然后使用美国心脏协会的指南对心脏骤停场景进行分析。主要终点是神经系统预后良好的生存期。次要结果是自发循环的恢复和每个事件中高级心血管生命支持偏差的数量。结果：59例心脏骤停纳入研究。55.9%的患者死亡，54.2%的患者恢复了自然循环。生存率为44.1%，42.4%的患者神经系统预后良好。坚持高级心血管生命支持指南并未显示出对神经系统预后有利的生存有显著影响，可比较的比值比（以0 - 2偏差为参考，3 - 5偏差为0.86 [95%CI 0.22 - 2.36]，≥6偏差为0.69 [95%CI 0.07 - 5.93]）证明了这一点。在院外和院内情况下，电视节目所描绘的有利结果比例明显高于现实世界中的巴西队列(50%对20.5%,p = 0.107；43.3% vs 17.4%, p < 0.0001)。结论：在巴西的电视节目中，心肺复苏的描述是不准确的，并且倾向于夸大心脏骤停后有利结果的可能性。

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引用次数: 0

To: Identification of distinct phenotypes and improving prognosis using metabolic biomarkers in COVID-19 patients. 目的：利用代谢生物标志物识别COVID-19患者的不同表型并改善预后。

Critical care science

Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250279

Carla Alexandra Scorza, Fulvio Alexandre Scorza, Josef Finsterer

引用次数: 0

To: Closing the critical care knowledge gap: the importance of publications from low-income and middle-income countries. 缩小重症监护知识差距：低收入和中等收入国家出版物的重要性。

Critical care science

Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.62675/2965-2774.20250026

Vanessa Soares Lanziotti, Lazaro Nelson Sanchez-Pinto

引用次数: 0

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