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Current treatment options in infectious diseases最新文献

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Monkeypox Outbreak: an Overview of Potential Therapeutic Options 猴痘爆发:潜在治疗方案概述
Current treatment options in infectious diseases
Pub Date : 2023-09-07 DOI: 10.1007/s40506-023-00266-7
Hamsa Hassan, Hamsa Ashraf Abdelhamid, Mayar Mohamed, M. Elsaid
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引用次数: 0
Hyperammonemia Syndrome Due to Ureaplasma and Mycoplasma Infections in Solid Organ Transplant Recipients: Treatment and Prophylaxis Strategies 固体器官移植受者因支原体和支原体感染引起的高氨血症综合征：治疗和预防策略
Current treatment options in infectious diseases
Pub Date : 2023-09-04 DOI: 10.1007/s40506-023-00265-8
Ashley H. Barnes, K. Saharia, Katya Prakash
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引用次数: 0
Looking at Sepsis in Patients with Terminal Illnesses 研究绝症患者的败血症
Current treatment options in infectious diseases
Pub Date : 2023-05-19 DOI: 10.1007/s40506-023-00264-9
P. Daniels, Meera Pahuja
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引用次数: 0
Listeriosis in Pregnancy 妊娠期李斯特菌病
Current treatment options in infectious diseases
Pub Date : 2023-02-27 DOI: 10.1007/s40506-023-00262-x
Theodora Germanopoulou, Angela Ishak, E. Hardy, Jennie E. Johnson, E. Mylonakis
{"title":"Listeriosis in Pregnancy","authors":"Theodora Germanopoulou, Angela Ishak, E. Hardy, Jennie E. Johnson, E. Mylonakis","doi":"10.1007/s40506-023-00262-x","DOIUrl":"https://doi.org/10.1007/s40506-023-00262-x","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42801215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in the Hospital Water System and Innovations to Prevent Healthcare-Associated Infections 医院供水系统面临的挑战和预防医疗相关感染的创新
Current treatment options in infectious diseases
Pub Date : 2023-02-15 DOI: 10.1007/s40506-023-00261-y
Erin B Gettler, Becky A. Smith, Sarah S. Lewis
{"title":"Challenges in the Hospital Water System and Innovations to Prevent Healthcare-Associated Infections","authors":"Erin B Gettler, Becky A. Smith, Sarah S. Lewis","doi":"10.1007/s40506-023-00261-y","DOIUrl":"https://doi.org/10.1007/s40506-023-00261-y","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 1","pages":"1 - 13"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49127280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines. 登革热:临床相关治疗策略和疫苗的最新进展。
Current treatment options in infectious diseases
Pub Date : 2023-01-01 DOI: 10.1007/s40506-023-00263-w
Monica Palanichamy Kala, Ashley L St John, Abhay P S Rathore

Dengue viruses (DENV) continue to circulate worldwide, resulting in a significant burden on human health. There are four antigenically distinct serotypes of DENV, an infection of which could result in a potentially life-threatening disease. Current treatment options are limited and rely on supportive care. Although one dengue vaccine is approved for dengue-immune individuals and has modest efficacy, there is still a need for therapeutics and vaccines that can reduce dengue morbidities and lower the infection burden. There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies. There are also new vaccine candidates that are being evaluated for their safety and efficacy in preventing dengue disease. This review highlights nuances in the current standard-of-care treatment of dengue. We also discuss emerging treatment options, therapeutic drugs, and vaccines that are currently being pursued at various stages of preclinical and clinical development.

登革热病毒(DENV)继续在世界范围内传播，对人类健康造成重大负担。DENV有四种抗原性不同的血清型，其感染可能导致潜在的危及生命的疾病。目前的治疗方案有限，依赖于支持性护理。虽然有一种登革热疫苗已获批准用于登革热免疫个体，而且效果一般，但仍然需要能够降低登革热发病率和降低感染负担的治疗方法和疫苗。最近在开发治疗登革热的有希望的药物方面取得了进展。这些包括可以减少病毒复制的直接抗病毒药物，以及用于减少炎症和/或血管病变的靶向宿主药物。还有一些新的候选疫苗正在评估它们在预防登革热方面的安全性和有效性。这篇综述强调了目前登革热标准治疗的细微差别。我们还讨论了目前处于临床前和临床开发的各个阶段的新兴治疗方案、治疗药物和疫苗。
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引用次数: 6
Mpox: Special Considerations in the Immunocompromised Host m痘:免疫功能低下宿主的特殊考虑
Current treatment options in infectious diseases
Pub Date : 2022-12-01 DOI: 10.1007/s40506-022-00260-5
Ashley H. Barnes, Christopher K Smith, Aditee Dash, Akira A. Shishido
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引用次数: 2
Case Report and Review of Management of HIV/HCV Coinfection After Treatment Failure 治疗失败后HIV/HCV合并感染的病例报告与管理综述
Current treatment options in infectious diseases
Pub Date : 2022-06-07 DOI: 10.1007/s40506-022-00259-y
P. Mathur, S. Kottilil, E. Wilson
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引用次数: 0
Updates in the Pharmacologic Prophylaxis and Treatment of Invasive Candidiasis in the Pediatric and Neonatal Intensive Care Units: Updates in the Pharmacologic Prophylaxis. 儿科和新生儿重症监护病房侵袭性念珠菌病的药物预防和治疗的最新进展:药物预防的最新进展。
Current treatment options in infectious diseases
Pub Date : 2022-06-01 Epub Date: 2022-05-16 DOI: 10.1007/s40506-022-00258-z
James Hunter Fly, Seerat Kapoor, Kelly Bobo, Jeremy S Stultz

Purpose of review: The goal of this review was to provide an update on the prevention and treatment options for invasive candidiasis (IC) in the neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU).

Recent findings: Studies have further validated the use of fluconazole for IC prophylaxis among high-risk patients in the NICU. It remains unclear if prophylaxis leads to resistance development and the ideal dosage regimen is still not clear. Recent studies have been published comparing caspofungin and micafungin to amphotericin B and illustrated similar efficacy outcomes in the NICU. Micafungin now has approval from the United States Food and Drug Administration (FDA) for use in infants < 4 months of age. Prophylactic strategies in the PICU could include zinc and vitamin D. Anidulafungin has recent non-comparative data supporting use in pediatric patients older than 1 month of age and also has a recent FDA approval for use in children 1 month of age and older.

Summary: Fluconazole prophylaxis remains a reasonable strategy in select NICU patients, although further analyses of resistance and the optimal dosage regimen are needed. Echinocandins are potential therapeutic options for non-meningitis or urinary tract infections in both the neonatal and pediatric population.

综述目的:本综述的目的是为新生儿重症监护病房(NICU)和儿科重症监护病房(PICU)的侵袭性念珠菌病(IC)的预防和治疗提供最新的选择。最近的发现:研究进一步证实了氟康唑在新生儿重症监护室高危患者中预防IC的使用。目前尚不清楚预防是否会导致耐药性的发展，理想的给药方案也尚不清楚。最近发表的研究将caspofungin和micafungin与两性霉素B进行了比较，结果显示在新生儿重症监护室的疗效相似。Micafungin现已获得美国食品和药物管理局(FDA)批准，可用于4个月以下的婴儿。PICU的预防策略可能包括锌和维生素d。Anidulafungin最近有非比较数据支持在1个月以上的儿科患者中使用，并且最近FDA批准在1个月及以上的儿童中使用。总结:氟康唑预防仍然是选择新生儿重症监护病房患者的合理策略，尽管需要进一步分析耐药性和最佳给药方案。棘白菌素是新生儿和儿童非脑膜炎或尿路感染的潜在治疗选择。
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引用次数: 3
Global Travel and Antimicrobial Resistance: a Challenge for Stewardship 全球旅行与抗菌药物耐药性：管理面临的挑战
Current treatment options in infectious diseases
Pub Date : 2022-01-26 DOI: 10.1007/s40506-021-00257-6
Franklin Mikell, William M. Wooten, S. Manandhar, J. Emberger
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引用次数: 1
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