Pub Date : 2020-01-01DOI: 10.35248/2379-1764.20.8.268
Pengbo Yang, L. Ying, Hexin Li, Xiaoxia Wang, Xiaofan Jia, L. Zou, Q. Pan, Xiangyi Liu
Background: Oxidative stress is closely related to many diseases, especially autoimmune diseases. Many previous studies have shown that there is a close relationship between oxidative stress and the development of hyperthyroidism, but the oxidative stress indicators in patients with hyperthyroidism and the correlation between oxidative indicators and lipid metabolism remain controversial. The aim of this study was to investigate the levels of three oxidative stress indicators Diacron Reactive Oxygen Metabolites, Biological Antioxidant Potential and Superoxide Dismutase (DROM, BAP and SOD) in hyperthyroidism patients and healthy controls, and their relationship with the severity of hyperthyroidism and lipid metabolism. Methods: 119 healthy individuals and 78 hyperthyroidism patients were included in this study. Automatic biochemical analyzer was used to detect three indicators of oxidative stress (BAP, SOD and DROM), three indicators of thyroid function (TSH, FT3 and FT4) and four indicators of lipid metabolism (TG, TC, LDL, HDL and fasting blood glucose) in patients with hyperthyroidism and healthy controls. Results: The basic levels of BAP and SOD in peripheral blood were significantly lower in hyperthyroidism patients compared to healthy controls (Pi¼0.001), while the level of DROM was significantly higher in patients with hyperthyroidism compared with control subjects (Pi¼0.05). There was no significant correlation between the three oxidative stress indicators and metabolites of glucose and lipid. The level of DROM was negative correlated with TSH and positive correlated with FT3 and FT4. Conclusion: Oxidative stress and antioxidant system play an important role in the pathogenesis of hyperthyroidism. In patients with hyperthyroidism, the level of oxidative stress products (DROM) was increased and the levels of antioxidant capacities (SOD and BAP) were decreased. BAP tend to be a better biomarker of antioxidant level in hyperthyroidism patients compared with SOD.
{"title":"Three Indicators of Oxidative Stress in the Evaluation of Hyperthyroidism","authors":"Pengbo Yang, L. Ying, Hexin Li, Xiaoxia Wang, Xiaofan Jia, L. Zou, Q. Pan, Xiangyi Liu","doi":"10.35248/2379-1764.20.8.268","DOIUrl":"https://doi.org/10.35248/2379-1764.20.8.268","url":null,"abstract":"Background: Oxidative stress is closely related to many diseases, especially autoimmune diseases. Many previous studies have shown that there is a close relationship between oxidative stress and the development of hyperthyroidism, but the oxidative stress indicators in patients with hyperthyroidism and the correlation between oxidative indicators and lipid metabolism remain controversial. The aim of this study was to investigate the levels of three oxidative stress indicators Diacron Reactive Oxygen Metabolites, Biological Antioxidant Potential and Superoxide Dismutase (DROM, BAP and SOD) in hyperthyroidism patients and healthy controls, and their relationship with the severity of hyperthyroidism and lipid metabolism. Methods: 119 healthy individuals and 78 hyperthyroidism patients were included in this study. Automatic biochemical analyzer was used to detect three indicators of oxidative stress (BAP, SOD and DROM), three indicators of thyroid function (TSH, FT3 and FT4) and four indicators of lipid metabolism (TG, TC, LDL, HDL and fasting blood glucose) in patients with hyperthyroidism and healthy controls. Results: The basic levels of BAP and SOD in peripheral blood were significantly lower in hyperthyroidism patients compared to healthy controls (Pi¼0.001), while the level of DROM was significantly higher in patients with hyperthyroidism compared with control subjects (Pi¼0.05). There was no significant correlation between the three oxidative stress indicators and metabolites of glucose and lipid. The level of DROM was negative correlated with TSH and positive correlated with FT3 and FT4. Conclusion: Oxidative stress and antioxidant system play an important role in the pathogenesis of hyperthyroidism. In patients with hyperthyroidism, the level of oxidative stress products (DROM) was increased and the levels of antioxidant capacities (SOD and BAP) were decreased. BAP tend to be a better biomarker of antioxidant level in hyperthyroidism patients compared with SOD.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"31 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75067688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2379-1764.1000E116
Jyoti Rawat
Biopharmaceutical medicines speak to a developing portion of the worldwide drug market, and with a large number of these biopharmaceutical items confronting loss of eliteness rights, likewise biosimilars may now enter the biopharmaceutical market. This investigation means to recognize and report which speculation and advancement methodologies are received by modern parts in the worldwide biopharmaceutical market
{"title":"The Market of Biopharmaceutical Medicines","authors":"Jyoti Rawat","doi":"10.35248/2379-1764.1000E116","DOIUrl":"https://doi.org/10.35248/2379-1764.1000E116","url":null,"abstract":"Biopharmaceutical medicines speak to a developing portion of the worldwide drug market, and with a large number of these biopharmaceutical items confronting loss of eliteness rights, likewise biosimilars may now enter the biopharmaceutical market. This investigation means to recognize and report which speculation and advancement methodologies are received by modern parts in the worldwide biopharmaceutical market","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"21 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84468811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2379-1764.20.8.274
Ling Xue, Jiao Li, Lin Wei, Cuiqing Ma, Suiyi Tan
Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 infection, has spread all over the world as an emerging infectious disease, causing a very serious impact on the global economy and public health. To date, there is no specific treatment or vaccines against coronaviruses. To prevent the infection and stop the pandemic, the research and development of effective SARS-CoV-2 vaccines has become an urgent matter. It is worth mentioning that appropriate adjuvants could enhance the strength and speed of the immune responses to vaccination. However, it takes time to customize different adjuvants with distinct targets (cellular or humoral immunity) and action intensity according to different antigens. In this review, we summarize the mechanism, advantages and disadvantages of adjuvants commonly used in licensed vaccines, as well as some novel adjuvants under development, hoping to provide information and increase the chances of success in developing effective SARS-CoV-2 vaccines in a short time frame.
{"title":"Adjuvant Option for Effective SARS-CoV-2 Vaccine","authors":"Ling Xue, Jiao Li, Lin Wei, Cuiqing Ma, Suiyi Tan","doi":"10.35248/2379-1764.20.8.274","DOIUrl":"https://doi.org/10.35248/2379-1764.20.8.274","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 infection, has spread all over the world as an emerging infectious disease, causing a very serious impact on the global economy and public health. To date, there is no specific treatment or vaccines against coronaviruses. To prevent the infection and stop the pandemic, the research and development of effective SARS-CoV-2 vaccines has become an urgent matter. It is worth mentioning that appropriate adjuvants could enhance the strength and speed of the immune responses to vaccination. However, it takes time to customize different adjuvants with distinct targets (cellular or humoral immunity) and action intensity according to different antigens. In this review, we summarize the mechanism, advantages and disadvantages of adjuvants commonly used in licensed vaccines, as well as some novel adjuvants under development, hoping to provide information and increase the chances of success in developing effective SARS-CoV-2 vaccines in a short time frame.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"79 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76097537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2379-1764.20.8.270
D. Lu, Ying Shen, Sha Cao
Human suicide study currently is unable to show close associations between pathogenic stages and therapeutic outcomes. A wide variety of factors coming from both insiders (human genetic predispositions, plasma levels of hormones and concentrations of neural transmitters) and outsiders (social, culture, environmental, cognitive, habitual and physical handicaps and so on) may equally determine suicide ideation and human mortality. This Editorial emphasizes these items of environmental and biological factors in suicide prediction, preventions and therapeutics.
{"title":"High Quality Treatments for Human Suicidal Events and Mortality","authors":"D. Lu, Ying Shen, Sha Cao","doi":"10.35248/2379-1764.20.8.270","DOIUrl":"https://doi.org/10.35248/2379-1764.20.8.270","url":null,"abstract":"Human suicide study currently is unable to show close associations between pathogenic stages and therapeutic outcomes. A wide variety of factors coming from both insiders (human genetic predispositions, plasma levels of hormones and concentrations of neural transmitters) and outsiders (social, culture, environmental, cognitive, habitual and physical handicaps and so on) may equally determine suicide ideation and human mortality. This Editorial emphasizes these items of environmental and biological factors in suicide prediction, preventions and therapeutics.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"9 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82370930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2379-1764.20.8.269
Habibat Mohammed, Tsegaye Gaddisa, Arega Bedasso Tsegaye, A. Neme, G. Bekele
Introduction: Geohelmenthes infections cause serious public health problem in Ethiopia. They were more prevalent among population with low income, poor personal hygiene and environmental sanitation, overcrowding and limited access to clean water. Objective: The Study Was aimed to estimating the prevalence of geohelmenthes infection and its predisposing factors among treatments seeking patients at Jimma health centers. Methods and Materials: Cross sectional study was carried out to determine the prevalence of geohelmenthes infection and predisposing factors among treatments seeking patients from June to August 2018 at Jimma health centers Data collected analyzed by SPSS statistical software was used to analysis data. Association between variables was analyzed using uni-variation and multi-variation logistic regression and p-values. The result was presented with odd ratio. P-value
{"title":"Prevalence of Geohelminthes Infection and its Predisposing Factors among Treatments Seeking Patients at Jimma Town Health Centers Jimma Zone South West Ethiopia","authors":"Habibat Mohammed, Tsegaye Gaddisa, Arega Bedasso Tsegaye, A. Neme, G. Bekele","doi":"10.35248/2379-1764.20.8.269","DOIUrl":"https://doi.org/10.35248/2379-1764.20.8.269","url":null,"abstract":"Introduction: Geohelmenthes infections cause serious public health problem in Ethiopia. They were more prevalent among population with low income, poor personal hygiene and environmental sanitation, overcrowding and limited access to clean water. Objective: The Study Was aimed to estimating the prevalence of geohelmenthes infection and its predisposing factors among treatments seeking patients at Jimma health centers. Methods and Materials: Cross sectional study was carried out to determine the prevalence of geohelmenthes infection and predisposing factors among treatments seeking patients from June to August 2018 at Jimma health centers Data collected analyzed by SPSS statistical software was used to analysis data. Association between variables was analyzed using uni-variation and multi-variation logistic regression and p-values. The result was presented with odd ratio. P-value <or=0.05 would take as the acceptable level significance. Results: Regarding to respondents residential area, patients living in urban area had 2.290 times higher prevalence of geohelmenthes infection as compared to patients living in rural area. Respondents who had dirty materials in fingernails were 63.256 times highly contribute for geohelmenthes infection as compared to do not having dirty materials in fingernails .Regarding to unwashed or uncooked vegetable or fruit eating habits, respondents uses unwashed or uncooked vegetable or fruit had 79.16 times highly contribute for geohelmenthes infections as compared those do not uses unwashed or un cooked vegetable or fruit.The overall prevalence of geohelmenthes 21.8% such as Ascaris lumbricoides 55 (14.3%), T. trichiura 16 (4.2%), Hookworm 10 (2.6%) and strongyloides 3 (0.8%). Conclusion and recommendation: The prevalence of geohelminthic infection was 21.8% in this study. Different between geohelminthes infection and poor hand washing practice before meal and after latrine, eating uncooked or unwashed vegetables and fruit, Trimming finger nails, Place of residence, and shoe wearing practice, and all associated factors were statically significant. Therefore, health education and development in sanitary infrastructure could achieve long-term and sustainable reductions in helminthes prevalence.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"41 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74055969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2379-1764.1000E115
Jyoti Rawat
An expanding number of patients are taking home grown drugs, for example, echinacea, garlic, ginkgo biloba, ginseng, St John's Wort, valerian, ephedra, kava, grapefruit squeeze and ginger. In spite of the fact that these home grown prescriptions are considered 'normal' items that may have a few advantages, unfavorable impacts, for example, expanded draining inclinations and medication communications are related with their utilization. Surgeons and anesthetists might be uninformed of their patients' utilization of these drugs since it is normal for patients not to uncover their utilization of this type of prescription, and the two specialists and anaesthetists regularly neglect to enquire about their utilization. Anesthetists and specialists must be comfortable with the impacts of home grown meds and ought to explicitly enquire about the utilization of natural meds during pre�?�operative evaluation. Presently accessible information proposes that all natural medications ought to be stopped 2 weeks before medical procedure.
{"title":"The Peri-Operative Implications of Natural Medications","authors":"Jyoti Rawat","doi":"10.35248/2379-1764.1000E115","DOIUrl":"https://doi.org/10.35248/2379-1764.1000E115","url":null,"abstract":"An expanding number of patients are taking home grown drugs, for example, echinacea, garlic, ginkgo biloba, ginseng, St John's Wort, valerian, ephedra, kava, grapefruit squeeze and ginger. In spite of the fact that these home grown prescriptions are considered 'normal' items that may have a few advantages, unfavorable impacts, for example, expanded draining inclinations and medication communications are related with their utilization. Surgeons and anesthetists might be uninformed of their patients' utilization of these drugs since it is normal for patients not to uncover their utilization of this type of prescription, and the two specialists and anaesthetists regularly neglect to enquire about their utilization. Anesthetists and specialists must be comfortable with the impacts of home grown meds and ought to explicitly enquire about the utilization of natural meds during pre�?�operative evaluation. Presently accessible information proposes that all natural medications ought to be stopped 2 weeks before medical procedure.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"103 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76709748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.4172/2379-1764.1000271
K. Shachi, Sanjeev Kumar, N. K. Prasad
In the present study an effort has been made to assess the hypoglycemic and anti–cholesterolmic activity of better gourd juice in alloxan monohydrate induced experimental animal model. Rats were acclimatized for 7 days in lab temperature. All animals were given standard water and pellet diet. Diabetes was induced in rats with the help of alloxan monohydrate (120 mg/kg body weight). After alloxan monohydrate injection rats were separated and treatment started with fresh better gourd juice and insulin. A marked rise in fasting blood glucose as well as serum cholesterol level were observed in diabetic control rats when compared to normal control rats. Antihyperglycemic and anti–cholesterolmic activity observed in bittergurd juice administered rats on 7th,14th,21th and 28th days post treatment.Anti–hyperglycemic and anti–cholesterolmic activity was found more effective than that of insulin treatment group. It is hope that present investigation will be helpful in establishing a scientific basis for anti–diabetic and Anticholesterolmic effects.
{"title":"Anti-diabetic and Anti-cholesterolmic effects of bittergourd(mommordica charantia Linn) fresh fruit juice metabolites to cure Alloxan Monohydrate induced Type-1 diabetes in Albino Rats","authors":"K. Shachi, Sanjeev Kumar, N. K. Prasad","doi":"10.4172/2379-1764.1000271","DOIUrl":"https://doi.org/10.4172/2379-1764.1000271","url":null,"abstract":"In the present study an effort has been made to assess the hypoglycemic and anti–cholesterolmic activity of better gourd juice in alloxan monohydrate induced experimental animal model. Rats were acclimatized for 7 days in lab temperature. All animals were given standard water and pellet diet. Diabetes was induced in rats with the help of alloxan monohydrate (120 mg/kg body weight). After alloxan monohydrate injection rats were separated and treatment started with fresh better gourd juice and insulin. A marked rise in fasting blood glucose as well as serum cholesterol level were observed in diabetic control rats when compared to normal control rats. Antihyperglycemic and anti–cholesterolmic activity observed in bittergurd juice administered rats on 7th,14th,21th and 28th days post treatment.Anti–hyperglycemic and anti–cholesterolmic activity was found more effective than that of insulin treatment group. It is hope that present investigation will be helpful in establishing a scientific basis for anti–diabetic and Anticholesterolmic effects.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"24 4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74448768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2379-1764.1000266
Bitsoev Vladimit Dodtievich
The paper considers one of the most important problems of modern medicine: corrective and guiding function of cardiovascular system in all manifestations of vital activity of an organism at the supramolecular level. A "thought" and its implementation "program" simultaneously appear in the left ventricle of the heart. In author's opinion, when a child is born, a place in the information bank of the biosphere is allocated for the constant receipt and storage of data on his or her vital activities, until the death. The author managed to discover a mechanism of information feedforward and feedback between an organism and the biosphere.
{"title":"Modern View on the Mechanism of andquot;thoughtandquot; Formation and Its Implementation andquot;programandquot; at the Supramolecular Level","authors":"Bitsoev Vladimit Dodtievich","doi":"10.4172/2379-1764.1000266","DOIUrl":"https://doi.org/10.4172/2379-1764.1000266","url":null,"abstract":"The paper considers one of the most important problems of modern medicine: corrective and guiding function of cardiovascular system in all manifestations of vital activity of an organism at the supramolecular level. A \"thought\" and its implementation \"program\" simultaneously appear in the left ventricle of the heart. In author's opinion, when a child is born, a place in the information bank of the biosphere is allocated for the constant receipt and storage of data on his or her vital activities, until the death. The author managed to discover a mechanism of information feedforward and feedback between an organism and the biosphere.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"51 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76622920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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