Duodecim; laaketieteellinen aikakauskirja最新文献

Ketamine infusions administered intravenously 1 to 3 times per week are the quickest and most effective treatment for depression. Short-course ketamine medication is established treatment both for unipolar depression and depressive episodes of bipolar affective disorder. Ketamine is suitable for initiating the treatment for treatment-resistant depression, alleviation of suicidal tendencies, and treatment of depressive patients suffering from simultaneous pain. The safety of prolonged treatment with ketamine is not known to sufficient degree. However, even long periods (up to 1.5 years) of ketamine treatment have not been associated with adverse effects. It would be appropriate to use short-course ketamine treatment more often than is currently done.

Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. In most cases it develops 2 to 3 weeks after the operation. An inflammatory reaction develops in the pericardium or pleural space with fever, chest pain and dyspnea as typical symptoms. The disease process is usually self-limiting. At present, the etiology is unknown, but an immunological mechanism is suspected as the cause of the disease. The incidence of PPS is essentially dependent on diagnostic criteria, patient group and type of operation. Treatment is carried out with anti-inflammatory analgesics, combined with colchicine in more severe cases.

Age-related macular degeneration (AMD) is the main cause of visual impairment in developed countries. Several improvements in the visualization of posterior segment of the eye together with the introduction of intravitreal anti-VEGF treatment have revolutionized the prognosis of the wet form of AMD (wAMD). Increasing incidence of wAMD together with the limited resources of the healthcare systems pose challenges for the provision and development of care. In context of these current aspects, we aim to set evidence-based guidelines for diagnosis, treatment and follow-up of patients with wAMD.

Traumatic hip dislocations constitute approximately 5% of all pediatric dislocations and typically result from high-energy trauma. However, pediatric hip dislocations can also occur as a result of minor energy due to flexibility of the joint structures of the immature hip. Children with a posteriorly dislocated hip present with the injured hip in flexion, adduction and internal rotation. Spontaneous relocation of hip dislocation is frequent and a thorough physical examination of the whole lower extremity is always required to reduce the chance of missing hip dislocation/subluxation. Dislocated hips should be emergently repositioned under general anesthesia. MRI is indicated after reduction and in patients after spontaneous relocation if labral interposition is suspected in plain radiographs.

Genomic data, i.e. measurement of variation in the complete genome has revolutionized genetic research and changed our understanding of the pathogenetic mechanisms of diseases. Genomic data in combination with Finnish special strengths - population history, the nation's comprehensive health records and a strong research tradition in genetic epidemiology - has made Finland a testing laboratory for diseases of public health importance. At the same time, genomic research has changed into statistical evaluation of large masses of data - big data. New research knowledge is now descending to the prevention and treatment of diseases, and this will affect future medical practices. In this reform, Finland has a chance to be a key player. The change is, however, global, and the world will not wait that Finland is ready, but instead we have to take care of it ourselves. When successful, new kind of research will help better allocate health care resources, provide more individualized care and stimulate businesses based on new technology.

Atypical hemolytic-uremic syndrome (aHUS) is a rare form of thrombotic microagiopathy caused dysregulation of the alternative pathway of the complement resulting in tissue. In aHUS, activation of the alternative pathway of the complement is in an aberrant way directed against endothelial cells and blood cells. This is either due to a mutation in a complement factor, most commonly factor H, or an autoantibody against a complement regulator. In some patients the underlying disorder is not identified despite thorough examinations. Typical aHUS-patients have acute kidney injury and microangiopathic hemolysis and, to a varying degree, disturbances of other organs. An effective inhibitor of the final product of complement, eculizumab, has revolutionized the treatment of these patients.

Laparoscopic appendectomy has practically replaced open surgery. Appendectomy, i.e. surgical excision of the appendix, is one of the most common procedures of a specializing surgeon, and serves to help learn the basics of laparoscopy - first by following and later independently performing the operation. Properative preparation, precise diagnosis, correct surgical technique and follow-up treatment are the cornerstones of successful care. The anatomy of the patient must be considered in the placement of trocars. The appendix is usually easily found, but its position and location may vary. In the operation, the base and the artery of the appendix are ligated, and the appendix removed in a plastic bag. Also a healthy appendix should be removed, but in this case other causes of the symptoms should be searched for. Surgical excision of a perforated appendix is considerably more challenging, and peritonitis should be operated without delay. Surgery of a periappendicular abscess requires experience and should be postponed until daytime. Most patients having undergone an excision of non-perforated appendix can be discharged within 23 hours after the operation.

Assessment and support of the work ability and function is an elementary responsibility of health care. The focus of assessment lies in the remaining functional capacity and its sufficiency with respect to occupational demands. Objective and subjective perspectives, personal resources and limitations, and the subject's relationship to the environment are taken into account according to biopsychosocial models of work ability. We recommend three useful self-report measurement tools for work ability and function. Return-to-Work-Readiness Questionnaire (RTW-RQ), Return-to-Work Self-Efficacy (RTW-SE) and Sheehan Disability Scale (SDS). These tools structure an interactive evaluation providing possibilities for follow-up. They provide means to discuss one's personal resources and limitations and to promote return-to-work.

The EU Clinical Trials Regulation will change the preliminary appraisal of trials and lighten the bureaucracy. Routines of the member states will be standardized, processing of applications provided with tighter time limits, and the licensing procedure made more flexible by using a common European portal. At the same time, definitions will be provided for low intervention trials subject to more flexible rules of follow-up, requirements of master file content, and traceability of test drugs. Implementation of the regulation depends on the completion of the EU portal, currently estimated to take place in the autumn of 2018. Preparations for execution in Finland are carried out by a working group appointed by the Ministry of Social Affairs and Health. On the national level, preparations are in progress to e.g. reorganize ethical evaluation, because the deadlines of evaluation of applications cannot be met with the current structure. Furthermore, regulations concerning insurances and collaterals, language requirements and possibilities of petitioning relating to the applications will also be decided on a national basis.

Modern invasive treatment of superficial venous insufficiency of the lower extremities is largely based on the use of intravenous procedures under ultrasound guidance. The first-line treatment is thermoablation, in which the insufficient superficial vein, typically vena saphena magna or parva, is constricted by using laser or radio frequency energy under ultrasound guidance. The procedure is nearly always successful under local anesthesia and can be performed as an outpatient operation. When necessary, visible collateral varices can be treated with foam sclerotherapy or by surgical excision. The need for associated medication or longer follow-up is limited and recovery is fast. The patients can be mobilized immediately, and only a couple of days of sick leave are usually required.