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The Hippo Pathway in Kidney Development. 肾脏发育中的Hippo通路。
Pub Date : 2025-03-01 Epub Date: 2025-01-26 DOI: 10.3390/encyclopedia5010015
Caroline M Lara, Toni Castro Torres, Usaid Mazhar, Dorrian G Cohen, Rebecca A Wingert

The kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to form functional nephron units. Understanding the mechanisms behind kidney development is paramount for elucidating the etiology of renal congenital disabilities and acquired diseases. The Hippo pathway is known for its involvement in various cellular functions, including cell fate determination and differentiation, and is a critical player in renal organogenesis. Here, we discuss research findings about the roles that Hippo signaling plays in kidney formation.

肾脏是一个复杂的器官,对多种体内平衡功能至关重要,包括维持液体和电解质平衡,清除各种代谢废物和激素的产生,经历复杂的发育过程形成功能性肾单位。了解肾脏发育背后的机制对于阐明肾脏先天性残疾和获得性疾病的病因至关重要。Hippo通路因其参与多种细胞功能而闻名,包括细胞命运决定和分化,并且在肾脏器官发生中起关键作用。在这里,我们讨论了有关Hippo信号在肾脏形成中的作用的研究结果。
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引用次数: 0
Interleukin-33 and Obesity-Related Inflammation and Cancer. 白细胞介素-33与肥胖相关炎症和癌症。
Pub Date : 2024-12-01 Epub Date: 2024-11-23 DOI: 10.3390/encyclopedia4040117
Cameron Kowitt, Qiuyang Zhang

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury. IL-33 is crucial in immune responses and is involved in various autoimmune and inflammatory diseases. Obesity is marked by chronic inflammation and is a known risk factor for several types of cancer. Recent studies have shown that IL-33 and its receptor complex are expressed in adipose (fat) tissue, suggesting they may play a role in obesity. While inflammation connects obesity and cancer, it is not yet clear whether IL-33 contributes to cancer associated with obesity. Depending on the cellular context, inflammatory environment, expression levels, and bioactivity, IL-33 can exhibit both protumorigenic and antitumorigenic effects. This review will explore the various functions of IL-33 in the inflammation linked to obesity and its relationship with cancer.

白细胞介素-33 (IL-33)是一种属于IL-1家族的细胞因子。它主要与2型免疫反应有关。它与免疫细胞上的受体复合物相互作用,对组织损伤或细胞损伤作出反应。IL-33在免疫应答中起关键作用,参与多种自身免疫性和炎症性疾病。肥胖以慢性炎症为特征,是几种癌症的已知风险因素。最近的研究表明,IL-33及其受体复合物在脂肪组织中表达,表明它们可能在肥胖中起作用。虽然炎症与肥胖和癌症有关,但目前尚不清楚IL-33是否与肥胖相关的癌症有关。根据细胞背景、炎症环境、表达水平和生物活性的不同,IL-33可以表现出致瘤和抗肿瘤的作用。本文将探讨IL-33在肥胖相关炎症及其与癌症的关系中的各种功能。
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引用次数: 0
High-Power Lasers 大功率激光器
Pub Date : 2024-08-09 DOI: 10.3390/encyclopedia4030080
Vladimir Chvykov
High-power lasers play an important role in modern science, industry, and medicine. A significant milestone was reached on 5 December 2022, when Inertial Confinement Nuclear Fusion (ICF) achieved scientific breakeven, releasing more energy than the input laser energy. Additionally, Extreme Ultraviolet Lithography (EUVL) has enabled the development of microchips with 3 nm process nodes, marking a leap in semiconductor technology. These examples, together with the recent achievement of 10 PW (1015 W) laser output, herald remarkable advancements in technology and science. Laser systems are broadly classified based on their operating regimes into two main categories: Continuous Wave (CW) operation, where the laser is continuously pumped and emits a steady beam of light, and the pulsed regime, in which the laser produces single or multiple pulses at various repetition rates. This review will primarily focus on pulsed laser systems, exploring their various types and recent technological advancements.
高功率激光器在现代科学、工业和医学中发挥着重要作用。2022 年 12 月 5 日,惯性约束核聚变(ICF)实现了科学盈亏平衡,释放的能量超过了输入的激光能量,这是一个重要的里程碑。此外,极紫外光刻技术(EUVL)实现了 3 纳米工艺节点的微芯片开发,标志着半导体技术的飞跃。这些例子以及最近实现的 10 PW (1015 W) 激光输出,都预示着技术和科学的显著进步。激光系统根据其工作状态大致分为两大类:连续波(CW)操作,即激光器持续泵浦并发出稳定的光束;脉冲操作,即激光器以不同的重复率产生单脉冲或多脉冲。本综述将主要关注脉冲激光系统,探讨其各种类型和最新技术进展。
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引用次数: 0
Soil as a Source of Fungi Pathogenic for Public Health 土壤作为公共卫生致病真菌的来源
Pub Date : 2024-07-25 DOI: 10.3390/encyclopedia4030075
Isabella Grishkan
Soil is an environment for huge diversity of fungi, which fulfill various tasks and support the maintaining of soil health. At the same time, varieties of soil fungal species, which produce numerous airborne spores and a range of mycotoxins, are known to be pathogenic for human health. The present review aims to summarize the current knowledge on soil fungi causing public health problems, including dermatoses, allergies, pulmonary diseases, wound infections, infections of the central nervous system, etc.
土壤是种类繁多的真菌生存的环境,它们承担着各种任务,为维护土壤健康提供支持。同时,众所周知,各种土壤真菌会产生大量空气传播的孢子和一系列真菌毒素,对人类健康具有致病性。本综述旨在总结目前有关土壤真菌导致公共健康问题的知识,包括皮肤病、过敏症、肺部疾病、伤口感染、中枢神经系统感染等。
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引用次数: 0
Ethical Issues in Researching Higher Education Teaching and Learning 高等教育教学研究中的伦理问题
Pub Date : 2024-07-17 DOI: 10.3390/encyclopedia4030074
Jennie Golding, Amanda Ince
Higher education here is taken to be education beyond school level: often at an institution (a university) that has degree-awarding powers, though some programmes may lead to a diploma, certificate or other award or qualification. Nomenclature around “research” in the associated teaching and learning is contested: professional enquiry, scholarship of teaching and learning, pedagogical research… are some of the terms used. Authors discuss and distinguish such terms. An ethical issue is a circumstance in which a moral conflict arises or is implicit and should be resolved in a morally acceptable way. These include privacy, informed consent, insider research and power relationships within higher education research; there are also fluid challenges around the use of digital contributions. Authors present a narrative exegesis of work in the associated areas, which authors argue will be of use to universities promoting such research, and of particular interest to two groups of academics wishing to systematically develop their practice in ways that contribute to the field: those on teaching-only contracts, who would also demonstrate their research credentials; and researchers from non-education-cognate fields. Authors identify directions for further work.
这里的高等教育是指超越学校水平的教育:通常是在拥有学位授予权的机构(大 学)进行,尽管有些课程可能会颁发文凭、证书或其他奖项或资格证书。与教学相关的 "研究 "术语是有争议的:专业探究、教学学术、教学研究......是其中的一些术语。作者对这些术语进行了讨论和区分。伦理问题是指出现或隐含道德冲突的情况,应以道德上可接受的方式加以解决。这些问题包括隐私、知情同意、内部研究和高等教育研究中的权力关系;在使用数字稿件方面也存在流动性挑战。作者对相关领域的工作进行了娓娓道来的诠释,作者认为这对促进此类研究的大学很有帮助,对希望以有助于该领域的方式系统地发展自己的实践的两类学者尤其有意义:一类是只签订教学合同的学者,他们也会展示自己的研究资历;另一类是来自非教育认可领域的研究人员。作者指出了进一步工作的方向。
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引用次数: 0
A Process Synthesis and Intensification Framework 流程综合与强化框架
Pub Date : 2024-07-03 DOI: 10.3390/encyclopedia4030072
J. R. Alcántara Avila, Cristopher Antonio Villegas Uribe, Josué Julián Herrera Velázquez, Julián Cabrera Ruiz
This Process Synthesis and Intensification (PS+I) framework uses a low-aggregation superstructure to solve the synthesis problem, and its solution is interpreted and translated into a task-integrated intensified process. Then, the process is post-optimized to find a better balance between operation and equipment costs. The solution leads to novel and counterintuitive intensified processes with low cost and energy requirements.
该流程合成与强化(PS+I)框架使用低聚集上层结构来解决合成问题,并将其解决方案解释和转化为任务集成强化流程。然后,对流程进行后期优化,以在运营和设备成本之间找到更好的平衡。该解决方案带来了低成本、低能耗的新颖且反直觉的强化工艺。
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引用次数: 0
A Systematic Review of Effects on ACL Injury of Soccer Shoe Outsoles, Soccer Playing Field Surfaces, and Outsole–Surface Interface 足球鞋外底、足球场表面和外底-表面界面对前交叉韧带损伤影响的系统性综述
Pub Date : 2024-05-24 DOI: 10.3390/encyclopedia4020057
A. Cicchella, Jierui He
Soccer is a sport with a high incidence of injuries. The most common injury occurs when the anterior cruciate ligament of the knee has undergone a sprain, strain, or partial or total rupture. Besides fitness factors (e.g., proprioception, balance and strength capabilities), a principal cause of ACL injuries is sport shoes and playing surfaces. Especially with the emergence of artificial surfaces (rubbers, turfs, concrete, asphalt, red turf), the ACL injuries dramatically increase. The cost of ACL injuries is high both in terms of career termination and in social and economic costs. Thus, it is necessary to understand the impact of sport shoes and playing surfaces on the ACL and how it can be mitigated. The present literature review followed the PRISMA methodology to identify the major biomechanical factors influencing the behavior of surfaces and shoes in relation to the ACL damage. Fifty-eight papers were identified. After reviewing the mechanism of injuries, we identified several distinct factors: type of outsole and mechanical arrangement of the outsoles; shear forces; characteristics of artificial turf surfaces; effect of weather on artificial surface aging and change in mechanical characteristics; outsole/ground interface; and the frictional, tractional and rotational forces in the pathogenesis of ACL injuries in soccer.
足球是一项受伤发生率很高的运动。最常见的损伤是膝关节前十字韧带扭伤、拉伤、部分或完全断裂。除了体能因素(如本体感觉、平衡和力量能力)外,运动鞋和比赛场地也是造成前交叉韧带损伤的主要原因。特别是随着人工场地(橡胶、草皮、混凝土、沥青、红色草皮)的出现,前交叉韧带损伤的情况急剧增加。前交叉韧带损伤的代价很高,既包括职业生涯的终止,也包括社会和经济成本。因此,有必要了解运动鞋和比赛场地对十字韧带的影响以及如何减轻这种影响。本次文献综述采用了 PRISMA 方法,以确定影响场地和运动鞋与前十字韧带损伤相关行为的主要生物力学因素。共发现了 58 篇论文。在回顾了损伤机制后,我们确定了几个不同的因素:外底类型和外底的机械排列;剪切力;人造草皮表面的特性;天气对人造表面老化和机械特性变化的影响;外底/地面界面;以及足球运动中前交叉韧带损伤发病机制中的摩擦力、牵引力和旋转力。
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引用次数: 0
An Overview of the Security of Programmable Logic Controllers in Industrial Control Systems 工业控制系统中可编程逻辑控制器的安全性概述
Pub Date : 2024-05-22 DOI: 10.3390/encyclopedia4020056
Hui Cui, JIN T. Hong, Rodney Louden
One key role in industrial control systems (ICSs) is known as Programmable Logic Controller (PLC). However, with the development of the Internet of Things (IoT), PLCs have become exposed to an increasing number of attacks, which may cause malfunctions of the whole ICS. Thus, it is necessary to identify potential attacks on PLCs and propose effective solutions to mitigate them. Unfortunately, to date, there have not been significant efforts made to provide a detailed overview of existing works on PLC security. With such a concern in mind, in this paper, we focus on summarising PLC security from different components running at different layers of a PLC architecture. We first review the framework of PLCs; then, we discuss several models when considering PLC security. After that, we provide an overview of existing attacks on PLCs and general solutions to those issues from different perspectives. Lastly, we conclude this paper with an overview of future research areas in PLC security.
可编程逻辑控制器(PLC)是工业控制系统(ICS)中的一个关键角色。然而,随着物联网(IoT)的发展,可编程逻辑控制器受到越来越多的攻击,可能导致整个 ICS 出现故障。因此,有必要识别针对 PLC 的潜在攻击,并提出有效的解决方案来缓解这些攻击。遗憾的是,迄今为止,还没有对 PLC 安全方面的现有工作进行详细概述。有鉴于此,在本文中,我们将重点从 PLC 架构的不同层级运行的不同组件来总结 PLC 的安全性。我们首先回顾了 PLC 的框架,然后讨论了考虑 PLC 安全性的几种模式。然后,我们从不同角度概述了针对 PLC 的现有攻击以及解决这些问题的一般方法。最后,我们概述了 PLC 安全的未来研究领域,以此结束本文。
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引用次数: 0
Social Aspects of Smart Urban Mobility 智能城市交通的社会方面
Pub Date : 2024-05-21 DOI: 10.3390/encyclopedia4020055
Łukasz Brzeziński
There is a growing interest in sustainable urban transport solutions in cities around the world. These changes, known as “smart urban mobility”, aim to reduce the negative effects of transport on the natural environment and enhance the standard of living for urban dwellers. It should be noted that in addition to this transformation’s technological aspects, modifying the city’s structure and architecture also has a social dimension. The transformation of urban mobility has a significant impact on social relations. Introducing new modes of transport, such as city bikes and electric scooters, creates new ways of moving around the city and can impact social interactions. This can increase social integration and a community’s sense of belonging. At the same time, it is necessary to consider the differences between social groups to ensure equal access to the benefits of these changes in addition to deeper social elements, such as changing the habits and expectations of residents and adapting solutions to the specific needs of each city. This paper aims to look at the social aspects of smart urban mobility, including the impact of these changes on the lives and relationships of city residents.
世界各地的城市对可持续的城市交通解决方案越来越感兴趣。这些变革被称为 "智能城市交通",旨在减少交通对自然环境的负面影响,提高城市居民的生活水平。值得注意的是,除了技术方面的变革,城市结构和建筑的改造也涉及到社会层面。城市交通的变革对社会关系有着重大影响。引入新的交通方式,如城市自行车和电动滑板车,创造了在城市中移动的新方式,并可能影响社会交往。这可以增强社会融合和社区归属感。同时,有必要考虑社会群体之间的差异,以确保平等享受这些变化带来的好处,此外还有更深层次的社会因素,如改变居民的习惯和期望,以及根据每个城市的具体需求调整解决方案。本文旨在探讨智能城市交通的社会方面,包括这些变化对城市居民生活和关系的影响。
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引用次数: 0
The Lower Paleolithic Engravings of Bilzingsleben, Germany 德国比尔辛格莱本旧石器时代下层雕刻
Pub Date : 2024-04-23 DOI: 10.3390/encyclopedia4020043
R. Bednarik
Some of the earliest known engravings are described, analyzed, and interpreted, following their microscopic examination. They are of significance in exploring the cognitive evolution of hominins several hundred thousand years ago and have not been described together before. The Steinrinne site near Bilzingsleben, north of Weimar, Germany, is one of Europe’s most important Lower Paleolithic occupation sites. Its extensive human habitation floor, excavated over 1000 square meters, comprises some of the world’s oldest evidence of dwellings, broadly matching or exceeding the age of examples proposed in Africa, India, and France. It has yielded numerous hominin remains, many wooden artefacts, other exquisitely preserved organic remains, and more portable engravings than any other Middle Pleistocene site. The latter are reviewed here, presenting the results of a detailed microscopic examination of the main finds. Bilzingsleben has so far produced the largest number of engraved Lower Paleolithic objects reported, which are particularly important to exploring the cognitive developments of hominins.
通过显微镜检查,对一些已知最早的雕刻进行了描述、分析和解释。它们对于探索几十万年前人类的认知进化具有重要意义,而且以前从未被一并描述过。德国魏玛北部比尔辛格莱本附近的斯坦林内遗址是欧洲最重要的旧石器时代下层人类居住遗址之一。该遗址发掘了 1000 多平方米的大面积人类居住地,包括一些世界上最古老的居住证据,其年代与非洲、印度和法国发现的实例大致相当或更久远。该遗址出土了大量类人猿遗骸、许多木制工艺品、其他保存完好的有机遗骸,以及比其他任何中更新世遗址都多的便携式雕刻。本文对后者进行了回顾,并介绍了对主要发现进行详细显微镜检查的结果。比林斯莱本迄今为止出土的旧石器时代下层雕刻品数量最多,这对探索人类认知能力的发展尤为重要。
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引用次数: 0
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