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Human Power Production and Energy Harvesting 人力生产和能源收集
Pub Date : 2023-06-07 DOI: 10.3390/encyclopedia3020050
A. Cicchella
This entry presents a holistic examination of the problem of harvesting energy from the human body. With the advent of the industrial revolution, in modern times, there is less and less need for physical human work; at the same time, motion is essential for health. Thus, sports and physical leisure activities have seen a dramatic increase in popularity. Until several decades ago, energy consumption was not an issue, at least in developed countries, but in recent years, it has become more and more evident that energy resources are finite and that there are limits to how much anthropic pressure the environment can sustain; one evident outcome is global warming. The repurposing of human energy also has psychological benefits, making people socially responsible and transforming otherwise wasted potential into a rewarding activity. Thus, on a small scale, over time, it has become evident that re-using and saving energy are vital. Humans can produce a large amount of energy through physical work, but over the past few decades, technologies have been developed to store and reuse energy that would otherwise be wasted. Some interesting applications and a critical review of the problem, which is linked to human metabolism and sport, are presented.
本条目提出了从人体收集能量问题的整体检查。随着工业革命的到来,现代社会对体力劳动的需求越来越少;同时,运动对健康也是必不可少的。因此,体育和体育休闲活动的受欢迎程度急剧增加。直到几十年前,能源消耗还不是一个问题,至少在发达国家是这样,但近年来,越来越明显的是,能源资源是有限的,环境所能承受的人为压力是有限的;一个明显的结果是全球变暖。人类能量的重新利用也有心理上的好处,使人们对社会负责,并将原本浪费的潜力转化为有益的活动。因此,在小范围内,随着时间的推移,再利用和节约能源的重要性已经变得很明显。人类可以通过体力劳动产生大量的能量,但在过去的几十年里,技术已经发展到储存和再利用能源,否则会被浪费。提出了一些有趣的应用和对该问题的批判性评述,该问题与人体代谢和运动有关。
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引用次数: 1
Large Language Models and Logical Reasoning 大型语言模型与逻辑推理
Pub Date : 2023-05-30 DOI: 10.3390/encyclopedia3020049
Robert Friedman
In deep learning, large language models are typically trained on data from a corpus as representative of current knowledge. However, natural language is not an ideal form for the reliable communication of concepts. Instead, formal logical statements are preferable since they are subject to verifiability, reliability, and applicability. Another reason for this preference is that natural language is not designed for an efficient and reliable flow of information and knowledge, but is instead designed as an evolutionary adaptation as formed from a prior set of natural constraints. As a formally structured language, logical statements are also more interpretable. They may be informally constructed in the form of a natural language statement, but a formalized logical statement is expected to follow a stricter set of rules, such as with the use of symbols for representing the logic-based operators that connect multiple simple statements and form verifiable propositions.
在深度学习中,大型语言模型通常根据语料库中的数据进行训练,作为当前知识的代表。然而,自然语言并不是可靠的概念交流的理想形式。相反,形式逻辑语句更可取,因为它们受可验证性、可靠性和适用性的约束。这种偏好的另一个原因是,自然语言不是为高效可靠的信息和知识流而设计的,而是由先前的一组自然约束形成的进化适应。作为一种形式结构化的语言,逻辑语句也更易于解释。它们可以以自然语言语句的形式非正式地构建,但形式化的逻辑语句应该遵循一套更严格的规则,例如使用符号来表示连接多个简单语句并形成可验证命题的基于逻辑的运算符。
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引用次数: 0
Depression in Elderly People 老年人的抑郁症
Pub Date : 2023-05-29 DOI: 10.3390/encyclopedia3020048
T. Paiva, Luísa Soares, A. L. Faria
Depression is not a sign of weakness, nor a lack of will or laziness. It is not a simple “being sad” or bored, but rather a pathology that needs intervention, treatment, and monitoring by professionals with expertise in mental health. It is a disorder that impacts the lives of people who do not receive timely help affecting not only the individual himself in his feelings, thoughts, and behaviors but also harming his relationships and daily life and is prevalent among elderly people. Depression manifests through multiple symptoms, is caused by numerous factors, and is preventable with specific practices. It is described as the “most frequent mental health problem worldwide,” has a higher prevalence in women, is different from mourning and sadness, and needs to be addressed to avoid extreme situations, such as suicide.
抑郁不是软弱的表现,也不是缺乏意志或懒惰。这不是一种简单的“悲伤”或无聊,而是一种需要心理健康专业人员干预、治疗和监测的病理学。它是一种影响没有得到及时帮助的人的生活的障碍,不仅影响个人的情感、思想和行为,还损害他的人际关系和日常生活,在老年人中普遍存在。抑郁症表现为多种症状,由多种因素引起,通过特定的实践是可以预防的。它被描述为“世界上最常见的心理健康问题”,在女性中的患病率更高,不同于哀悼和悲伤,需要解决以避免极端情况,如自杀。
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引用次数: 0
Fluorescence in Smart Textiles 智能纺织品中的荧光
Pub Date : 2023-05-27 DOI: 10.3390/encyclopedia3020047
A. Patti, D. Acierno
Fluorescence has been identified as an advantageous feature in smart fabrics, notably for the protection of humans during outdoor athletic activities, as well as for preventing counterfeiting and determining authenticity. Fluorescence in smart fabrics is achieved using dendrimers, rare earth metal compounds, and fluorescent dye. The principal method for producing fluorescent fabrics is to immerse the sample in a solution containing fluorescent agents. However, covalent connections between fluorophores and textile substates should be established to improve the stability and intensity of the fluorescent characteristics. Fabric can be fluorescent throughout, or fluorescent fibers can be woven directly into the textile structures, made of natural (cotton, silk) or synthetic (polyamide- and polyester-based) fibers, into a precise pathway that becomes visible under ultraviolet irradiation.
荧光已被确定为智能织物的一个有利特征,特别是在户外运动活动中保护人类,以及防止假冒和确定真实性。智能织物中的荧光是使用树枝状聚合物、稀土金属化合物和荧光染料实现的。生产荧光织物的主要方法是将样品浸入含有荧光剂的溶液中。然而,应在荧光团和纺织品亚态之间建立共价连接,以提高荧光特性的稳定性和强度。织物可以是荧光的,或者荧光纤维可以直接编织到由天然(棉、丝绸)或合成(聚酰胺和聚酯基)纤维制成的织物结构中,形成在紫外线照射下可见的精确路径。
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引用次数: 1
Chytrids in Soil Environments: Unique Adaptations and Distributions 土壤环境中的壶菌:独特的适应和分布
Pub Date : 2023-05-18 DOI: 10.3390/encyclopedia3020046
Deirdre G. Hanrahan-Tan, O. Lilje, L. Henderson
Chytridiomycota (zoosporic true fungi) have a consistent presence in soils and have been frequently identified within many diverse terrestrial environments. However, Chytridiomycota and other early-diverging fungi have low representation in whole-genome sequencing databases compared to Dikarya. New molecular techniques have provided insights into the diversity and abundance of chytrids in soils and the changes in their populations both spatially and temporally. Chytrids complete their life cycle within rapidly changing soil environments where they may be more common within micropores due to protection from predation, desiccation, and extreme temperatures. Reproductive and morphological changes occur in response to environmental changes including pH, fluctuating nutrient concentrations, and metals at levels above toxic thresholds. Rhizoids share some features of hyphae, including the spatial regulation of branching and the ability to attach, adapt to, and proliferate in different substrates, albeit on a microscale. Soil chytrids provide a pool of novel enzymes and proteins which enable a range of lifestyles as saprotrophs or parasites, but also can be utilised as alternative tools with some biotechnological applications. Thus, 3D live-cell imaging and micromodels such as MicroCT may provide insight into zoospore functions and rhizoid plasticity, respectively, in response to various conditions. A combination of classical techniques of soil chytrid baiting with simultaneous molecular and ecological data will provide insights into temporal population changes in response to environmental change. The authors emphasise the need to review and improve DNA-based methodologies for identifying and quantifying chytrids within the soil microbiome to expand our knowledge of their taxonomy, abundance, diversity, and functionality within soil environments.
壶菌科(游动孢子真真菌)在土壤中一直存在,并且在许多不同的陆地环境中经常被发现。然而,与Dikarya相比,壶菌科和其他早期分化真菌在全基因组测序数据库中的代表性较低。新的分子技术为了解土壤中壶菌的多样性和丰度及其种群的时空变化提供了新的思路。壶菌在快速变化的土壤环境中完成其生命周期,由于保护它们免受捕食,干燥和极端温度,它们可能在微孔中更常见。生殖和形态变化是对环境变化的反应,包括pH值、营养物质浓度波动和金属含量超过毒性阈值。尽管在微观尺度上,但类根具有菌丝的一些特征,包括分支的空间调节和在不同基质上的附着、适应和增殖能力。土壤壶菌提供了一种新的酶和蛋白质,使其作为腐养菌或寄生虫能够实现一系列的生活方式,但也可以作为一些生物技术应用的替代工具。因此,三维活细胞成像和微模型(如MicroCT)可以分别提供对各种条件下游动孢子功能和根状体可塑性的了解。将传统的土壤壶菌诱捕技术与同步的分子和生态数据相结合,将提供对环境变化响应的时间种群变化的见解。作者强调需要审查和改进基于dna的方法来鉴定和量化土壤微生物群中的壶菌,以扩大我们对土壤环境中壶菌的分类、丰度、多样性和功能的认识。
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引用次数: 2
Primary Chondroprogenitors: Standardized & Versatile Allogeneic Cytotherapeutics 原发性软骨祖细胞:标准化和通用的同种异体细胞疗法
Pub Date : 2023-05-17 DOI: 10.3390/encyclopedia3020045
A. Laurent, Annick Jeannerat, C. Peneveyre, C. Scaletta, V. Philippe, P. Abdel-Sayed, W. Raffoul, R. Martin, N. Hirt-Burri, L. Applegate
Primary chondroprogenitors obtained from standardized cell sources (e.g., FE002 clinical grade cell sources) may be cultured in vitro and may be cytotherapeutically applied in allogeneic musculoskeletal regenerative medicine. Multicentric translational research on FE002 human primary chondroprogenitors under the Swiss progenitor cell transplantation program has notably validated their robustness and high versatility for therapeutic formulation in clinically compatible prototypes, as well as a good safety profile in diverse in vivo preclinical models. Therein, stringently controlled primary cell source establishment and extensive cell manufacturing optimization have technically confirmed the adequation of FE002 primary chondroprogenitors with standard industrial biotechnology workflows for consistent diploid cell biobanking under GMP. Laboratory characterization studies and extensive qualification work on FE002 progenitor cell sources have elucidated the key and critical attributes of the cellular materials of interest for potential and diversified human cytotherapeutic uses. Multiple formulation studies (i.e., hydrogel-based standardized transplants, polymeric-scaffold-based tissue engineering products) have shown the high versatility of FE002 primary chondroprogenitors, for the obtention of functional allogeneic cytotherapeutics. Multiple in vivo preclinical studies (e.g., rodent models, GLP goat model) have robustly documented the safety of FE002 primary chondroprogenitors following implantation. Clinically, FE002 primary chondroprogenitors may potentially be used in various forms for volumetric tissue replacement (e.g., treatment of large chondral/osteochondral defects of the knee) or for the local management of chondral affections and pathologies (i.e., injection use in mild to moderate osteoarthritis cases). Overall, standardized FE002 primary chondroprogenitors as investigated under the Swiss progenitor cell transplantation program were shown to constitute tangible contenders in novel human musculoskeletal regenerative medicine approaches, for versatile and safe allogeneic clinical cytotherapeutic management.
从标准化细胞来源(例如,FE002临床级细胞来源)获得的原代软骨祖细胞可在体外培养,并可用于同种异体肌肉骨骼再生医学的细胞治疗。瑞士祖细胞移植项目对FE002人原代软骨祖细胞的多中心转化研究已经显著验证了其稳健性和高通用性,可用于临床相容原型的治疗配方,以及在多种体内临床前模型中的良好安全性。其中,严格控制原代细胞来源的建立和广泛的细胞制造优化,在技术上证实了FE002原代软骨祖细胞具有标准的工业生物技术工作流程,可以在GMP下实现二倍体细胞生物库的一致性。FE002祖细胞来源的实验室特性研究和广泛的鉴定工作已经阐明了潜在的和多样化的人类细胞治疗用途感兴趣的细胞材料的关键和关键属性。多种制剂研究(即基于水凝胶的标准化移植,基于聚合物支架的组织工程产品)表明FE002原代软骨祖细胞具有高通用性,可用于功能性异体细胞治疗。多项体内临床前研究(例如,啮齿动物模型,GLP山羊模型)已经有力地证明了FE002原代软骨祖细胞植入后的安全性。临床上,FE002原代软骨祖细胞可能以各种形式用于体积组织置换(例如,治疗膝关节的大软骨/骨软骨缺损)或局部治疗软骨病变和病理(例如,在轻中度骨关节炎病例中注射使用)。总的来说,在瑞士祖细胞移植项目下进行的标准化FE002原代软骨祖细胞研究表明,在新的人类肌肉骨骼再生医学方法中,对于多功能和安全的异体临床细胞治疗管理,FE002原代软骨祖细胞构成了有力的竞争者。
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引用次数: 0
Brazilian Urban Policy: Sustainability as a Driving Force 巴西城市政策:可持续性是驱动力
Pub Date : 2023-05-15 DOI: 10.3390/encyclopedia3020044
Felipe Teixeira Dias, M. E. Leite, Priscila Cembranel, J. B. S. O. de Andrade Guerra, R. S. Birch
Defining global themes such as Urban Policy, Urban Sustainability, and even the Right to the City (RTTC) is fundamental to stimulating and establishing a continuous dialogue with the scientific community, mainly in the social sciences. Thus, understanding the dynamics around the scope of urban sustainability requires an analysis that is focused on multiple global realities. Taking a holistic view of Brazilian Urban Policy, this entry looks at the historical contexts that make urban sustainability the driving force behind this policy. In addition, an interdisciplinary consideration of urban sustainability is proposed using an analysis that is based on the connection between urban policies and social functions that reflect the idea of a sustainable city. The results of this analysis also point to the need for a continuous debate on the subject that primarily promotes new discoveries; this is so that the driving force of urban policy can gain new meanings and new guidelines can be implemented.
定义诸如城市政策、城市可持续性甚至城市权利(RTTC)等全球主题对于促进和建立与科学界(主要是社会科学界)的持续对话至关重要。因此,理解围绕城市可持续性范围的动态需要对多个全球现实进行分析。从整体上看巴西的城市政策,本条目着眼于使城市可持续性成为这一政策背后驱动力的历史背景。此外,还建议对城市可持续性进行跨学科的考虑,使用一种基于反映可持续城市理念的城市政策和社会功能之间联系的分析。这一分析的结果还指出,需要对这个主要促进新发现的问题进行持续的辩论;这样,城市政策的驱动力才能获得新的意义,新的指导方针才能得以实施。
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引用次数: 1
Saccharomyces cerevisiae: Multifaceted Applications in One Health and the Achievement of Sustainable Development Goals 酿酒酵母:在一种健康和实现可持续发展目标中的多方面应用
Pub Date : 2023-05-13 DOI: 10.3390/encyclopedia3020043
N. Ballet, S. Renaud, Hugo Roume, Fanny George, P. Vandekerckove, Mickaël Boyer, Mickaël Durand-Dubief
Saccharomyces cerevisiae (SC), a yeast with an extensive history in food and beverage fermentations, is increasingly acknowledged for its multifaceted application in promoting and benefiting all aspects of a ‘One Health’ approach, including the prevention and control of zoonoses. For instance, SC contributes to environmentally sustainable agricultural practices through the reduced use of toxic agents, thus minimizing air and soil pollution while enhancing crop quality. Additionally, this versatile yeast can improve the health of domestic and farm animals, leading to more efficient and sustainable food production, while fostering synergistic impacts across environmental, animal, and human health spheres. Moreover, SC directly applies benefits to human health by promoting improved nutrition, improving gut health through probiotics, as an alternative to antibiotics, and treating gastric disorders. By aligning with several Sustainable Development Goals (SDGs), SC is vital in advancing global health and well-being, environmental sustainability, and responsible consumption and production. This entry illustrates the numerous benefits of SC and highlights its significant impact on a global ‘One Health’ scale, promoting the achievement of SDGs through its unique characteristics and deeper understanding of its contribution to the One Health concept.
酿酒酵母(Saccharomyces cerevisiae, SC)是一种在食品和饮料发酵方面有着悠久历史的酵母,它在促进和造福“同一个健康”方法的各个方面(包括预防和控制人畜共患病)方面的多方面应用越来越得到认可。例如,SC通过减少有毒物质的使用,促进环境可持续的农业实践,从而最大限度地减少空气和土壤污染,同时提高作物质量。此外,这种多功能酵母可以改善家畜和农场动物的健康,从而提高粮食生产的效率和可持续性,同时促进环境、动物和人类健康领域的协同影响。此外,SC通过促进改善营养,通过益生菌改善肠道健康,作为抗生素的替代品,以及治疗胃部疾病,直接将益处应用于人类健康。通过与多个可持续发展目标(sdg)保持一致,SC在促进全球健康和福祉、环境可持续性以及负责任的消费和生产方面至关重要。本条目说明了SC的众多好处,并强调了其对全球“同一个健康”规模的重大影响,通过其独特的特征和对其对同一个健康概念的贡献的更深入的理解,促进了可持续发展目标的实现。
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引用次数: 0
Predictive Modeling in Medicine 医学中的预测建模
Pub Date : 2023-05-11 DOI: 10.3390/encyclopedia3020042
Milan Toma, Ong Chi Wei
Predictive modeling is a complex methodology that involves leveraging advanced mathematical and computational techniques to forecast future occurrences or outcomes. This tool has numerous applications in medicine, yet its full potential remains untapped within this field. Therefore, it is imperative to delve deeper into the benefits and drawbacks associated with utilizing predictive modeling in medicine for a more comprehensive understanding of how this approach may be effectively leveraged for improved patient care. When implemented successfully, predictive modeling has yielded impressive results across various medical specialities. From predicting disease progression to identifying high-risk patients who require early intervention, there are countless examples of successful implementations of this approach within healthcare settings worldwide. However, despite these successes, significant challenges remain for practitioners when applying predictive models to real-world scenarios. These issues include concerns about data quality and availability as well as navigating regulatory requirements surrounding the use of sensitive patient information—all factors that can impede progress toward realizing the true potential impact of predictive modeling on improving health outcomes.
预测建模是一种复杂的方法,涉及利用先进的数学和计算技术来预测未来的事件或结果。该工具在医学上有许多应用,但其在该领域的全部潜力尚未开发。因此,有必要深入研究在医学中使用预测建模的好处和缺点,以便更全面地了解如何有效地利用这种方法来改善患者护理。如果成功实施,预测建模已经在各个医学专业产生了令人印象深刻的结果。从预测疾病进展到识别需要早期干预的高危患者,在世界各地的医疗保健机构中有无数成功实施这种方法的例子。然而,尽管取得了这些成功,从业者在将预测模型应用于实际场景时仍然面临着重大挑战。这些问题包括对数据质量和可用性的关注,以及围绕患者敏感信息使用的监管要求——所有这些因素都可能阻碍实现预测建模对改善健康结果的真正潜在影响。
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引用次数: 7
Human Resources Churning 人力资源流失
Pub Date : 2023-05-09 DOI: 10.3390/encyclopedia3020041
O. Pirrolas, P. Correia
The term churning is defined by a multifaceted approach and is quite a complex concept that has been gaining relevance in the field of human resources, due to the problematic loss of investment, originating from the voluntary exits of worker-associated costs. This phenomenon is a direct result of the rising competitive job market, causing employees to leave organizations and carry with them all the knowledge and experience acquired in the starting organization, an organization which invested in the development of its workers. Even though churning is aligned with human resource practices, it is considered a multifaceted concept because of the different contexts in which it interferes, such as economic context, per activity sector, clients, the type of organization, geographic location, etc. Although, despite its own complexity, churning is related to turnover; however, there are differences between these two concepts. While turnover is linked to the workers’ rotation within an organization, churning is mainly focused on the costs associated with voluntary exits from workers. It is simply linked to investment losses inside an organization, which has the main goal of creating mechanisms that allow the creation of awareness in organizations about the relevancy of action using strategic measurements of holding in order to minimize the churning rate, and in this way, reducing the unexpected costs, creating revenue, increasing proficiency, standing out in business activity, bettering nimbleness and expanding profits. This initial manuscript introduces the churning concept in human resources, the main causes of churning, as well as approaching how organizations take action in order to appease this event using literature, which lacks major advertising and given relevance to its pertinence in human resources. Through the analysis of the existing, this entry was guided with the objective of demystifying the subject of human resource churning.
“搅动”一词是由一种多方面的方法定义的,是一个相当复杂的概念,由于工人相关成本的自愿退出导致投资损失,这一概念在人力资源领域越来越重要。这种现象是竞争日益激烈的就业市场的直接结果,导致员工离开组织,随身携带在创业组织中获得的所有知识和经验,而创业组织是一个投资于员工发展的组织。尽管搅动与人力资源实践相一致,但它被认为是一个多方面的概念,因为它干扰的环境不同,如经济环境、每个活动部门、客户、组织类型、地理位置等。尽管搅动本身很复杂,但它与人员流动有关;然而,这两个概念之间存在差异。虽然流动性与组织内员工的轮换有关,但流失主要集中在员工自愿离职的相关成本上。它只是与组织内部的投资损失联系在一起,组织内部的主要目标是建立机制,通过持有的战略衡量标准,让组织意识到行动的相关性,以最大限度地降低波动率,从而降低意外成本,创造收入,提高熟练度,在商业活动中脱颖而出,提高灵活性和扩大利润。这篇最初的手稿介绍了人力资源中的翻腾概念,翻腾的主要原因,以及组织如何利用文献来采取行动来平息这一事件,这些文献缺乏主要的广告,并与人力资源的相关性有关。通过对现有的分析,本条目旨在解开人力资源流失的神秘面纱。
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引用次数: 1
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