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Monitoring, source apportionment, and health risk implications of potentially toxic element concentrations in canned fish products within Kumasi metropolis, Ghana 加纳库马西大都会内罐头鱼产品中潜在有毒元素浓度的监测、来源分析和健康风险影响
Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.focha.2026.101234
Gerheart Winfred Ashong , Wisdom Kwame Nyatuame , Flora Amerley Amarh , Dogbey Bright Agbeko , Ray Bright Voegborlo , Eric Selorm Agorku , Michael Yaw Peasah
Canned fish is widely consumed in Ghana due to its low cost, long shelf life, and nutritional value. However, concerns over potentially toxic elements (PTE) pose a growing public health risk. This study aimed to identify potential sources of enrichment, examine the PTE concentrations, and health implications of adults and children from consuming canned fish from the Ghanaian market. 100 canned fish samples obtained from Ayigya market in Kumasi were analysed for nine PTEs (As, Cd, Cu, Cr, Pb, Mn, Hg, Ni, and Zn). Multivariate statistical tools were employed to identify potential sources of enrichment for PTEs in canned fish. Human health risk was assessed using estimated dietary intake (EDI), noncarcinogenic (HI), and target carcinogenic (TCR). All PTE concentrations investigated were below safe permissible limits. Potential sources of PTEs enrichment were attributed to the fish ecosystem, processing equipment’s and canning material. The TCR < 10 -4 and HI < 1 were within tolerable intake levels, indicating less likelihood of cancer-related implications from the consumption of canned fish in adults and children. The findings reveal brand and source-dependent PTE contamination patterns, making it crucial for continuous surveillance and food safety awareness to ensure the safety of canned products in local markets.
罐头鱼因其成本低、保质期长、营养价值高而在加纳被广泛消费。然而,对潜在有毒元素(PTE)的关注构成了越来越大的公共健康风险。本研究旨在确定潜在的富集来源,检查PTE浓度,以及食用加纳市场罐装鱼对成人和儿童的健康影响。从库马西Ayigya市场获得的100个罐头鱼样本进行了9种pte(砷、镉、铜、铬、铅、锰、汞、镍和锌)分析。采用多元统计工具确定罐头鱼中pte的潜在富集来源。使用估计膳食摄入量(EDI)、非致癌物(HI)和目标致癌物(TCR)评估人类健康风险。所有调查的PTE浓度均低于安全允许限度。鱼类生态系统、加工设备和罐头材料是pte富集的潜在来源。TCR(10 -4)和HI(1)均在可耐受的摄入量范围内,表明食用罐头鱼对成人和儿童致癌的可能性较低。调查结果揭示了品牌和来源相关的PTE污染模式,因此对持续监测和食品安全意识至关重要,以确保当地市场罐装产品的安全。
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引用次数: 0
Correlation analysis of volatile compounds and sensory profiles in Indonesian palm sugar (Arenga pinnata) 印尼棕榈糖(Arenga pinnata)挥发性成分与感官特征的相关性分析
Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.focha.2026.101219
Siti Fatimah Kumala Dewi , Didah Nur Faridah , Nuri Andarwulan , Nancy Dewi Yuliana , Dede Robiatul Adawiyah , Ranna Nabiilah Az-Zahra
The production of palm sugar (Arenga pinnata) traditionally involves four main stages, including tapping, cooking, cooling and moulding. Regional differences in processing methods and the use of natural preservatives during sap tapping in Indonesia are expected to influence its chemical composition and sensory quality. This study investigated the volatile compound profiles and sensory attributes of palm sugar from Bangka, Central Bangka, West Bangka, and Pangkal Pinang, and examined their correlations. Volatiles were analyzed using headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME/GC–MS), and sensory attributes were evaluated through quantitative descriptive analysis (QDA). A total of seventy-six volatile compounds were identified, such as heterocyclics, aldehydes, ketones, alcohols, esters, phenols, acids, sulfur compounds, hydrocarbons, and amines. The use natural preservatives significantly affected pH and ash content, whereas moisture levels remained unaffected by processing conditions. Principal component analysis (PCA) revealed distinct regional sensory profiles. Palm sugar from Bangka (jackfruit wood, Ca(OH)2), Central Bangka (mangosteen leaves), and West Bangka (resak wood) was characterized by coconut flavor, coconut aroma, and sweetness. In contrast, Central Bangka samples prepared with ube-ube roots exhibited sweet potato and honey-like notes with smoky and woody characteristics, while Pangkal Pinang palm sugar was dominated by caramel flavor and bitterness. Partial least squares (PLS) regression demonstrated positive correlations between volatile compounds and sensory attributes of flavor, aroma, and taste, with the exception of sourness. These findings indicate that traditional processing and preservation practices greatly influence the chemical and sensory quality of palm sugar.
棕榈糖(Arenga pinnata)的生产传统上包括四个主要阶段,包括采摘、烹饪、冷却和成型。印度尼西亚在榨汁过程中加工方法和使用天然防腐剂方面的区域差异预计会影响其化学成分和感官质量。本文研究了邦卡、邦卡中部、邦卡西部和邦卡槟榔岛棕榈糖的挥发性化合物特征和感官属性,并分析了它们之间的相关性。采用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME/ GC-MS)分析挥发物,通过定量描述分析(QDA)评价感官属性。共鉴定出76种挥发性化合物,如杂环化合物、醛类、酮类、醇类、酯类、酚类、酸类、硫化合物、碳氢化合物和胺类。天然防腐剂的使用显著影响pH值和灰分含量,而水分水平不受加工条件的影响。主成分分析(PCA)显示了不同区域的感官分布。Bangka(菠萝蜜木,Ca(OH)2), Central Bangka(山竹叶)和West Bangka (resak木)的棕榈糖具有椰子味,椰子香气和甜味。相比之下,用管状根制备的中央邦卡样品表现出甘薯和蜂蜜样的烟熏和木质特征,而Pangkal Pinang棕榈糖则以焦糖味和苦味为主。偏最小二乘(PLS)回归表明,挥发性化合物与风味、香气和味觉的感官属性呈正相关,但酸味除外。这些发现表明,传统的加工和保存方法对棕榈糖的化学和感官品质有很大的影响。
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引用次数: 0
Effect of supercritical CO₂ extraction and the Soxhlet method on the content of curcuminoids, phenolic compounds, and antioxidant activity in Curcuma longa L 超临界co2萃取和索氏法对姜黄素、酚类化合物含量及抗氧化活性的影响
Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1016/j.focha.2025.101212
Evelyn Pelayo-Velásquez , Norma Gamarra-Mendoza , Carlos Seguil-Mirones , Moisés Mendoza-Álvarez , Mery Cusiche-Huamaní , Alex Pilco-Núñez
Turmeric roots from the tropical regions of Peru's Junín province were used. These roots are important in both gastronomy, due to their flavour and colour, and traditional medicine, due to their bioactive properties. This study involved a physicochemical analysis of fresh turmeric rhizomes to determine their degree of maturity. The study aimed to evaluate the effect of supercritical CO₂ (Sc-CO₂) pressure and temperature on the extraction of turmeric extract (TE), its curcuminoid content and its antioxidant activity. The rhizomes were prepared for extraction using both Sc-CO₂ and the Soxhlet method. The extracts were analysed by HPLC to quantify the curcuminoids, and by spectrophotometry to determine the total phenolic content (TPC) and the antioxidant activity (AA). Significant differences (p < 0.05) were observed in the extracts obtained with Sc-CO₂ at 50 °C and 25 MPa, which exhibited higher levels of demethoxycurcumin (DMC), curcumin (CC) and total curcuminoids (TC). Soxhlet extraction resulted in higher curcuminoid yields. The TPC and AA (DPPH method) of the Sc-CO₂ extracts at 50 °C and 25 MPa were higher than those of the Soxhlet extracts. These results highlight that supercritical CO₂ extraction is an environmentally friendly technology that prevents the degradation of curcuminoids, as demonstrated by higher DPPH free radical scavenging activity than that observed in Soxhlet extracts.
使用了秘鲁Junín省热带地区的姜黄根。由于其味道和颜色,这些根在烹饪和传统医学中都很重要,因为它们具有生物活性。本研究对新鲜姜黄根茎进行了理化分析,以确定其成熟程度。研究了超临界CO₂(Sc-CO₂)压力和温度对姜黄提取物(TE)提取、姜黄素含量及抗氧化活性的影响。用Sc-CO - 2和索氏法分别提取根状茎。采用高效液相色谱法测定姜黄素含量,分光光度法测定总酚含量(TPC)和抗氧化活性(AA)。在50°C和25 MPa条件下,用Sc-CO₂处理得到的提取物中去甲氧基姜黄素(DMC)、姜黄素(CC)和总姜黄素(TC)含量较高(p < 0.05)。索氏提取法提高了姜黄素的收率。在50℃和25 MPa条件下,Sc-CO₂提取物的TPC和AA (DPPH法)均高于Soxhlet提取物。这些结果表明,超临界CO 2萃取是一种环境友好的技术,可以防止姜黄素的降解,证明了比索氏提取物更高的DPPH自由基清除活性。
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引用次数: 0
Extraction of Jackfruit seed protein: Structural and functional analysis 菠萝蜜种子蛋白质的提取:结构和功能分析
Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.focha.2026.101245
Adharsh Ashok N , Manmath D. Sontakke , Kshirod Kumar Dash , N. Afzal Ali , Rafeeya Shams , Ayaz Mukarram shaikh , Kovács Béla
Jackfruit seeds, a by-product of the tropical fruit processing industry, are a rich protein source, with approximately 7% protein. The amino acids present in jackfruit seeds are histidine, threonine, valine, lysine, isoleucine, leucine, and phenylalanine. The study aimed to isolate the protein from jackfruit seeds and analyse its physicochemical, structural, and functional properties. In this study, the protein was isolated from jackfruit seed flour using acid-alkali precipitation and microwave-assisted extraction at 800 W. Protein solubility (81.48%) was improved for microwave-assisted extraction compared to the acid-alkali precipitation method (79.48%). The scanning electron microscope analysis showed compact, aggregated, irregular, and elongated flaky protein structure for microwave-assisted extraction compared to acid-alkali precipitation jackfruit seed protein isolate (JSPI). The differential scanning calorimetry study indicated a higher denaturation temperature for microwave-assisted extraction JSPI (106°C) than acid-alkali precipitation JSPI (95°C). FTIR spectra showed nine bands in the acid-alkali precipitation protein, indicating a more complex structure than the microwave-assisted extraction JSPI (6 bands). The XRD diffractogram showed that both isolated proteins were amorphous. Protein isolated by microwave-assisted extraction exhibited enhanced overall properties, making it better suited for a wide range of food applications.
菠萝蜜种子是热带水果加工业的副产品,含有丰富的蛋白质来源,蛋白质含量约为7%。菠萝蜜种子中的氨基酸有组氨酸、苏氨酸、缬氨酸、赖氨酸、异亮氨酸、亮氨酸和苯丙氨酸。本研究旨在从菠萝蜜种子中分离蛋白质,并对其理化、结构和功能特性进行分析。本研究以菠萝蜜籽粉为原料,采用酸碱沉淀和微波辅助萃取的方法,在800w下提取蛋白质。与酸碱沉淀法的蛋白溶解度(79.48%)相比,微波辅助提取提高了蛋白溶解度(81.48%)。扫描电镜分析结果显示,微波辅助提取的菠萝蜜籽分离蛋白(JSPI)结构紧凑、聚集、不规则、呈细长片状。差示扫描量热法研究表明,微波辅助提取JSPI的变性温度(106℃)高于酸碱沉淀JSPI(95℃)。FTIR光谱显示酸碱沉淀蛋白的9个波段,表明其结构比微波辅助提取的JSPI(6个波段)更为复杂。XRD衍射图显示两种分离蛋白均为无定形。通过微波辅助萃取分离出的蛋白质表现出增强的整体特性,使其更适合于广泛的食品应用。
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引用次数: 0
Microencapsulated fermented wild blueberries attenuate diet-induced lipid dysmetabolism 微胶囊化发酵野生蓝莓减轻饮食引起的脂质代谢紊乱
Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.focha.2026.101247
Dinushi Gamage , Petra Kienesberger , Christopher J. Sinal , H.P. Vasantha Rupasinghe
Dietary interventions, such as anthocyanins of wild blueberries, offer safer alternatives for the management of metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD). A novel process has been developed by using fermentation to enhance the bioactive diversity and efficacy, while microencapsulation improves their stability. Wild blueberries were sequentially fermented with Saccharomyces cerevisiae and Komagataeibacter spp., then microencapsulated with inulin and maltodextrin (1:1 w/w) by spray drying. Male C57BL/6J mice on a high-fat, high-sucrose diet received fermented, non-fermented, or microencapsulated fermented wild blueberries (416 mg gallic acid equivalents/kg body weight/day) for 22 weeks. Controls included chow-fed and high-fat, high-sucrose-fed non-supplemented groups. Microencapsulated fermented wild blueberries reduced food and energy intake, body weight gain, total body fat, liver weight, hepatic lipid accumulation, plasma total and free cholesterol, and hepatic triglycerides and preserved normal liver structure in high-fat, high-sucrose diet-fed mice. Western blots revealed that this encapsulated supplement upregulated hepatic phosphorylated adenosine monophosphate (AMP)-activated protein kinase-alpha ((p-AMPK)/AMPK ratio), reduced total acetyl-CoA carboxylase, fatty acid synthase, and cluster of differentiation 36 (CD36) protein levels, indicating suppressed lipogenesis and fatty acid uptake. Also, the supplement restored gut microbiota alpha diversity altered by the high-calorie diet and enriched beneficial species such as Akkermansia in the gut. Thus, this novel process can be utilized to develop a functional food ingredient or nutraceutical with potential applications in the prevention of MASLD among at-risk individuals, as well as serving as an adjunct therapeutic strategy for patients with established metabolic syndrome.
饮食干预,如野生蓝莓中的花青素,为代谢综合征和代谢功能障碍相关的脂肪变性肝病(MASLD)的治疗提供了更安全的选择。利用发酵提高其生物活性多样性和有效性,微胶囊化提高其稳定性。用酿酒酵母和komagataeibacterspp .对野生蓝莓进行连续发酵,然后用菊粉和麦芽糊精(1:1 w/w)进行微囊化喷雾干燥。高脂肪、高糖饮食的雄性C57BL/6J小鼠,连续22周食用发酵、不发酵或微胶囊发酵的野生蓝莓(416 mg没食子酸当量/kg体重/天)。对照组包括低脂喂养组和高脂肪、高蔗糖喂养的非补充组。微胶囊化的发酵野生蓝莓降低了高脂高糖饮食小鼠的食物和能量摄入、体重增加、总脂肪、肝脏重量、肝脏脂质积累、血浆总胆固醇和游离胆固醇以及肝脏甘油三酯,并保持了正常的肝脏结构。Western blot结果显示,这种包封补充剂上调了肝脏磷酸化腺苷单磷酸(AMP)活化蛋白激酶- α ((p-AMPK)/AMPK比值),降低了总乙酰辅酶a羧化酶、脂肪酸合成酶和分化簇36 (CD36)蛋白水平,表明抑制了脂肪生成和脂肪酸摄取。此外,这种补充剂恢复了因高热量饮食而改变的肠道微生物群α多样性,并丰富了肠道中的有益物种,如Akkermansia。因此,这一新的过程可以用来开发一种功能性食品成分或营养保健品,在预防高危人群的MASLD方面具有潜在的应用价值,也可以作为已建立代谢综合征患者的辅助治疗策略。
{"title":"Microencapsulated fermented wild blueberries attenuate diet-induced lipid dysmetabolism","authors":"Dinushi Gamage ,&nbsp;Petra Kienesberger ,&nbsp;Christopher J. Sinal ,&nbsp;H.P. Vasantha Rupasinghe","doi":"10.1016/j.focha.2026.101247","DOIUrl":"10.1016/j.focha.2026.101247","url":null,"abstract":"<div><div>Dietary interventions, such as anthocyanins of wild blueberries, offer safer alternatives for the management of metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD). A novel process has been developed by using fermentation to enhance the bioactive diversity and efficacy, while microencapsulation improves their stability. Wild blueberries were sequentially fermented with <em>Saccharomyces cerevisiae</em> and <em>Komagataeibacter</em> spp., then microencapsulated with inulin and maltodextrin (1:1 w/w) by spray drying. Male C57BL/6J mice on a high-fat, high-sucrose diet received fermented, non-fermented, or microencapsulated fermented wild blueberries (416 mg gallic acid equivalents/kg body weight/day) for 22 weeks. Controls included chow-fed and high-fat, high-sucrose-fed non-supplemented groups. Microencapsulated fermented wild blueberries reduced food and energy intake, body weight gain, total body fat, liver weight, hepatic lipid accumulation, plasma total and free cholesterol, and hepatic triglycerides and preserved normal liver structure in high-fat, high-sucrose diet-fed mice. Western blots revealed that this encapsulated supplement upregulated hepatic phosphorylated adenosine monophosphate (AMP)-activated protein kinase-alpha ((p-AMPK)/AMPK ratio), reduced total acetyl-CoA carboxylase, fatty acid synthase, and cluster of differentiation 36 (CD36) protein levels, indicating suppressed lipogenesis and fatty acid uptake. Also, the supplement restored gut microbiota alpha diversity altered by the high-calorie diet and enriched beneficial species such as <em>Akkermansia</em> in the gut. Thus, this novel process can be utilized to develop a functional food ingredient or nutraceutical with potential applications in the prevention of MASLD among at-risk individuals, as well as serving as an adjunct therapeutic strategy for patients with established metabolic syndrome.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"10 ","pages":"Article 101247"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of germination methods on the quality and physicochemical properties of rice 发芽方式对水稻品质及理化性质的影响
Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.focha.2025.101215
Andi Nur Faidah Rahman , Adiansyah Syarifuddin , Evina Vensia Nababan , Yuyun Adelin , Asmaul Husnah
Hydrolytic enzymes that degrade macromolecules and synthesise bioactive compounds are activated during germination. While BR and UDR require soaking to raise grain moisture and initiate growth, DTR germinates without soaking due to its naturally higher moisture content. These differences highlight the need to compare germination induced physicochemical alterations among BR, UDR, and DTR. Germination affected several quality parameters. Water content ranging from 11.49 % to 13.34 %. Significant increases were observed in GABA (1.41–14.49 mg/100 g), phosphorus (73.98–304.76 mg/100 g), magnesium (16.45–116.12 mg/100 g), crude fiber (6.77–7.85 %), fat (1.79–3.46 %), protein (8.24–8.92 %), and calories (348.80–366.70 Kcal/100 g), particularly in BR and DTR. Carbohydrates decreased from 76.28 % to 71.49 %. IC50 declined in UDR and BR but increased markedly in DTR (37253.20 mg/L). Milling yield decreased in all germinated samples, ranging from 65 % (UDR) to 74.67 % (BR). Sensory attributes also declined. Although DTR exhibited the highest GABA and IC50, BR demonstrated the most favorable nutritional changes overall; however, SEM analysis showed noticeable kernel cracking in BR. Overall, these results indicate that physicochemical and nutritional changes during germination are strongly influenced by the sequence of germination steps.
降解大分子和合成生物活性化合物的水解酶在萌发过程中被激活。BR和UDR需要浸水来提高籽粒水分,促进生长,而DTR由于其天然含水量较高,无需浸水即可发芽。这些差异突出了比较BR、UDR和DTR发芽诱导的理化变化的必要性。发芽影响了几个品质参数。含水量为11.49% ~ 13.34%。GABA (1.41-14.49 mg/100 g)、磷(73.98-304.76 mg/100 g)、镁(16.45-116.12 mg/100 g)、粗纤维(6.77 - 7.85%)、脂肪(1.79 - 3.46%)、蛋白质(8.24 - 8.92%)和热量(348.80-366.70 Kcal/100 g)显著增加,尤其是BR和DTR。碳水化合物从76.28%下降到71.49%。UDR和BR组IC50均降低,DTR组显著升高(37253.20 mg/L)。所有发芽样品的碾磨率均下降,UDR为65% ~ BR为74.67%。感官属性也下降了。虽然DTR表现出最高的GABA和IC50,但BR总体上表现出最有利的营养变化;然而,SEM分析显示BR中有明显的仁裂。总体而言,这些结果表明发芽过程中的理化和营养变化受发芽步骤顺序的强烈影响。
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引用次数: 0
Impact of agave fructans and agave syrup from Agave tequilana Weber var. Azul on the sensorial profile, glycemic index and insulinemic index of gummy candies 龙舌兰果聚糖和龙舌兰糖浆对软糖感官特征、血糖指数和胰岛素指数的影响
Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1016/j.focha.2026.101224
Rogelio Rodríguez-Rodríguez , Norma Morales-Hernández , Lorena-Vilet Moreno , Jorge Armando Jiménez-Avalos , Dante Guillermo Mejía Torres , Hugo Espinosa-Andrews
The regular consumption of candies, such as gummies, which are high in added sugars, can contribute to the development of metabolic disorders, including obesity and type 2 diabetes. Agave fructans from Agave tequila Weber var. azul and agave syrup may help reduce and control blood sugar levels and the insulin response. In this study, three gummy formulations (G1, G2, and G3) were prepared containing combinations of agave fructans, agave syrup, and sucrose. The total sugar content of gummy formulations was evaluated using via UHPLC. The results showed that the thermal manufacturing process did not alter the carbohydrate profile of the gummies. A hedonic test was subsequently used to evaluate the organoleptic characteristics of the samples by a group of untrained consumers. They reported differences in the taste, consistency, and overall preference of the formulations, which were related to the perceived sweetness and acidity level of the samples. Finally, a clinical study was conducted to assess the impact of consuming gummy formulations on the glycemic index and insulin index. The results showed that formulations G1 and G3 had low glycemic indices and low insulinemic indices, unlike G2 gummies, which had a medium glycemic index and a low insulinemic index.
经常食用糖,如软糖,添加糖含量高,会导致代谢紊乱,包括肥胖和2型糖尿病。从龙舌兰龙舌兰中提取的龙舌兰果聚糖和龙舌兰糖浆可能有助于降低和控制血糖水平和胰岛素反应。在本研究中,制备了含有龙舌兰果聚糖、龙舌兰糖浆和蔗糖的三种胶制剂(G1、G2和G3)。采用高效液相色谱法测定了胶制剂的总糖含量。结果表明,热加工过程没有改变糖的碳水化合物结构。随后,一组未经训练的消费者使用享乐测试来评估样品的感官特征。他们报告了配方的味道、稠度和总体偏好的差异,这些差异与样品的感知甜度和酸度水平有关。最后,进行了一项临床研究,以评估食用软糖制剂对血糖指数和胰岛素指数的影响。结果表明,配方G1和G3的血糖指数和胰岛素指数均较低,而配方G2的血糖指数和胰岛素指数均为中等。
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引用次数: 0
Upcycled sulfated glycosaminoglycan-rich hydrolysates from abalone (Haliotis spp.) viscera exhibit wide spectrum antioxidant and anti-inflammatory activities 从鲍鱼(Haliotis spp.)内脏中提取的升级回收的富含硫酸化糖胺聚糖的水解物具有广谱的抗氧化和抗炎活性
Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1016/j.focha.2025.101188
Wing H. Chung , Olav Muurlink , Nicholas Sheng Loong Tan , Ryu Takechi , Ranil Coorey , Janet Howieson
In commercial abalone processing, the viscera—comprising 25–42% of the animal—are typically discarded, presenting an opportunity to enhance sustainability by minimizing waste. Prior investigations have indicated that the viscera, particularly from Haliotis discus hannai, possess promising characteristics for therapeutic applications, notably as antioxidants and antiphlogistic agents, likely due to their abundant and unique sulfated glycosaminoglycans (sGAGs). However, fundamental mechanisms underlying its antiphlogistic potential remain poorly understood, especially regarding substrate shunting associated with inhibition of pro-inflammatory enzymes. Moreover, limited research has examined the interplay between antioxidant properties and phlogistic responses. Data on general sGAGs typology and the functionality of hydrolysates are similarly scarce. These gaps prompted the current study, which employed a hybrid heuristic and conventional scientific methodology to enhance understanding. Abalone viscera hydrolysates were exposed to pro-inflammatory enzymes (COX-1, COX-2, 5-LOX, 15-LOX), and their antioxidant activities were evaluated using stoichiometric: radical cation decolorization (ABTS), free radical scavenging (DPPH), ferric reducing ability (FRAP), and kinetic oxygen radical absorbance capacity (ORAC) assays. The content and typology of sGAGs, including N-/O-sulfation, were quantified alongside multiple statistical analyses. The findings indicate that hydrolysates from diverse Australian species inhibited the enzymes at similar IC50 values (0.59–5.44 mg d.b./mL), with one exception, suggesting their potential as wide-spectrum therapeutic agents. This study underscores the significant potential of repurposing abalone waste for novel therapeutics.
在商业鲍鱼加工中,内脏(占动物的25-42%)通常被丢弃,这为通过减少浪费来提高可持续性提供了机会。先前的研究表明,盘鱼的内脏,特别是盘鱼的内脏,具有很好的治疗应用特性,特别是作为抗氧化剂和消炎剂,可能是由于它们丰富而独特的硫代糖胺聚糖(sGAGs)。然而,其抗炎潜能的基本机制仍然知之甚少,特别是与促炎酶抑制相关的底物分流。此外,有限的研究已经检查了抗氧化性能和炎症反应之间的相互作用。关于sGAGs的一般类型和水解物的功能的数据同样很少。这些差距促使了当前的研究,该研究采用了启发式和传统科学方法的混合方法来加强理解。将鲍鱼内脏水解物暴露于促炎酶(COX-1, COX-2, 5-LOX, 15-LOX)中,并通过化学计量学:自由基阳离子脱色(ABTS),自由基清除(DPPH),铁还原能力(FRAP)和动态氧自由基吸收能力(ORAC)测定来评估其抗氧化活性。通过多种统计分析,量化了包括N-/ o -硫酸盐在内的sGAGs的含量和类型。研究结果表明,不同澳大利亚物种的水解物抑制酶的IC50值相似(0.59-5.44 mg d.b./mL),但有一个例外,表明它们有潜力成为广谱治疗药物。这项研究强调了鲍鱼废物用于新疗法的重大潜力。
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引用次数: 0
Characterisation of saffron floral bio-residues phenolic compounds under different drying treatments: from agricultural waste to bio-based ingredients 不同干燥处理下藏红花花残酚类化合物的特征:从农业废弃物到生物基成分
Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.1016/j.focha.2026.101262
Mariela Pontin , Luciana Poggi , Federico Berli , Leonardo Bolcato , Patricia Piccoli , Ariel Fontana
Saffron floral bio-residues are generally wasted due to their rapid deterioration. However, they are a source of nutrients and bioactive compounds with important nutraceutical properties. This study aimed to determine the optimal drying temperature to preserve phenolic compounds in saffron bio-residues, providing a low-cost conservation method for small-scale producers. The thermal stability of 37 phenolic compounds including anthocyanins, phenolic acids, flavonols, flavanols, stilbenes, flavanones, chalcones and phenyl-ethanol analogs was analyzed at 40, 60 and 80 °C. Anthocyanins were significantly affected by temperature, while the total concentration of phenolic acids, as well as that of most of the identified flavonols, flavanols and stilbenoids, remained stable at the different drying temperatures. This thermal stability ensured the dried bio-residues maintained similar antioxidant activity, as measured by ORAC assay, at all temperatures. Dehydration at temperatures no higher than 60 °C is suggested as an easy and economical method to preserve saffron floral bio-residues while maintaining the quality of their phenolic compounds.
藏红花花的生物残留物由于迅速变质而被浪费。然而,它们是营养素和具有重要营养成分的生物活性化合物的来源。本研究旨在确定藏红花生物残留物中酚类化合物的最佳干燥温度,为小规模生产者提供一种低成本的保存方法。研究了花青素、酚酸、黄酮醇、黄烷醇、二苯乙烯、黄酮、查尔酮和苯乙醇类似物等37种酚类化合物在40、60和80℃下的热稳定性。花青素受温度影响显著,而酚酸总浓度以及大多数已鉴定的黄酮醇、黄烷醇和茋类化合物的总浓度在不同干燥温度下保持稳定。这种热稳定性确保干燥的生物残留物在所有温度下都保持类似的抗氧化活性,正如ORAC测定的那样。在不高于60°C的温度下脱水是一种简单经济的方法,可以保存藏红花花的生物残留物,同时保持其酚类化合物的质量。
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引用次数: 0
Molecular insights into dietary hormetic phytochemicals in Olea europaea L. (Olive) and Nigella sativa L. (Black seed): Implications for human health 油橄榄(Olea europaea L.)和黑籽(Nigella sativa L.)中膳食致热植物化学物质的分子分析:对人类健康的影响
Pub Date : 2026-03-01 Epub Date: 2026-02-26 DOI: 10.1016/j.focha.2026.101266
Mirunalini Gobinath , Rania I.M. Almoselhy , Sathish Kumar Gunasekaran , Subhajit Dutta , Sagarika Mukherjee , Mohd Aftab Siddiqui , Afreen Usmani , Meghit Boumediene Khaled , Rajakumari Rajendran
Hormesis is defined as the biphasic dose response relationship which determines the dual activity of a phytochemical. In other words, when the same drug exhibits both beneficial and harmful effects at different concentrations. Phytochemicals present with considerable amounts in medicinal plants, especially Olea europaea L. (olive) and Nigella sativa L. (black seed) have multifaceted mechanisms which also demonstrate hormetic responses, as stated in various studies. Though these activities are known for decades, clinical implications of these mechanisms are less studied. Hence, a thorough understanding of hormetic responses at cellular and molecular level is essential for further research in the treatment of metabolic, chronic inflammation, and age-related disorders. Therefore, the aim of the current comprehensive review was to emphasize the importance of molecular hormetic mechanisms of bioactive compounds from Olea europaea L. (olive) and Nigella sativa L. (black seed) and focuses on their therapeutic potential for enhancing human health from disease prevention. Precise understanding of optimal dosage within hormetic zones is essential for ameliorated therapeutic effects that benefit various diseases and reduced off-target effects, adverse effects, etc., and improve the quality of life.
激效被定义为决定植物化学物质双重活性的双相剂量反应关系。换句话说,当同一种药物在不同浓度下同时表现出有益和有害的效果时。多种研究表明,药用植物中含有大量的植物化学物质,特别是橄榄和黑籽,具有多方面的机制,也显示出激效反应。虽然这些活动已经知道了几十年,但这些机制的临床意义却很少被研究。因此,深入了解细胞和分子水平上的激敏反应对于进一步研究代谢、慢性炎症和年龄相关疾病的治疗至关重要。因此,本文旨在强调橄榄和黑籽中生物活性化合物的分子致热机制的重要性,并重点介绍它们在预防疾病方面增强人类健康的治疗潜力。准确了解致效区内的最佳剂量对于改善各种疾病的治疗效果,减少脱靶效应、不良反应等,提高生活质量至关重要。
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Food chemistry advances
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