Pub Date : 2023-03-03DOI: 10.3389/fceng.2023.1066091
J. James, Leonie Lücking, H. V. van Dijk, J. Boon
Carbon monoxide (CO) is an important gas required for various industrial processes. Whether produced directly from syngas or as part of by-product gas streams, valorization of CO streams will play an important role in the decarbonization of industry. CO is often generated in mixtures with other gases such as H2, CO2, CH4, and N2 and therefore separation of CO from the other gases is required. In particular, separation of CO from N2 is difficult given their similar molecular properties. This paper summarizes the current state of knowledge on the four processes for separation of CO from gas mixtures: cryogenic purification, absorption, adsorption and membrane separation. Particular emphasis is placed on technical processes for industrial applications and separation of N2 and CO. Cryogenic processes are not suitable for separation of CO from N2. Absorption developments focus on the use of ionic liquids to replace solvents, with promising progress being made in the field of CO solubility in ionic liquids. Advancements in adsorption processes have focused on the development of new materials however future work is required to develop materials that do not require vacuum regeneration. Membrane processes are most promising in the form of solid state and mixed matrix membranes. In general, there is limited development beyond lab scale for new advancements in CO separation from gas streams. This highlights an opportunity and need to investigate and develop beyond state-of-the-art processes for CO separation at industrial scale, especially for separation of CO from N2.
{"title":"Review of technologies for carbon monoxide recovery from nitrogen- containing industrial streams","authors":"J. James, Leonie Lücking, H. V. van Dijk, J. Boon","doi":"10.3389/fceng.2023.1066091","DOIUrl":"https://doi.org/10.3389/fceng.2023.1066091","url":null,"abstract":"Carbon monoxide (CO) is an important gas required for various industrial processes. Whether produced directly from syngas or as part of by-product gas streams, valorization of CO streams will play an important role in the decarbonization of industry. CO is often generated in mixtures with other gases such as H2, CO2, CH4, and N2 and therefore separation of CO from the other gases is required. In particular, separation of CO from N2 is difficult given their similar molecular properties. This paper summarizes the current state of knowledge on the four processes for separation of CO from gas mixtures: cryogenic purification, absorption, adsorption and membrane separation. Particular emphasis is placed on technical processes for industrial applications and separation of N2 and CO. Cryogenic processes are not suitable for separation of CO from N2. Absorption developments focus on the use of ionic liquids to replace solvents, with promising progress being made in the field of CO solubility in ionic liquids. Advancements in adsorption processes have focused on the development of new materials however future work is required to develop materials that do not require vacuum regeneration. Membrane processes are most promising in the form of solid state and mixed matrix membranes. In general, there is limited development beyond lab scale for new advancements in CO separation from gas streams. This highlights an opportunity and need to investigate and develop beyond state-of-the-art processes for CO separation at industrial scale, especially for separation of CO from N2.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48014207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-22DOI: 10.3389/fceng.2023.1099010
C. Chotirotsukon, Kunlanis Jirachavala, Marisa Raita, Suchat Pongchaiphol, B. Hararak, N. Laosiripojana, V. Champreda
Organosolv lignin is an emerging bio-additive for creating functional properties in various products with its advantages in high-purity, sulfur-free, biocompatibility, and solubility in green solvents. In this study, effects of thermal and physical modification on alterations of functional properties and particle size distribution of isolated organosolv lignin from sugarcane bagasse (OLB) were studied. Thermal treatment of OLB at increasing temperatures from 170 to 230°C in 70%w/w aqueous ethanol led to alteration of phenolic hydroxyl content, while ultrasonication resulted in homogeneous size distribution of the modified OLB according to laser diffraction and scanning electron micrograph. The highest ultraviolet light absorbance and antioxidant activities were obtained at 190°C treatment which were correlated to the highest phenolic group content. Application of the modified OLB at 3% w/w in a base cream formulation resulted in enhancement of the anti-UV activity to exceed SPF 50 with increasing antioxidant activity in the product. The work provides basis on modification of organosolv lignin for application as a potent functional additive in cosmeceutical products.
{"title":"Effects of thermal and physical modification on functional properties of organosolv lignin from sugarcane bagasse and its application in cosmeceutical products","authors":"C. Chotirotsukon, Kunlanis Jirachavala, Marisa Raita, Suchat Pongchaiphol, B. Hararak, N. Laosiripojana, V. Champreda","doi":"10.3389/fceng.2023.1099010","DOIUrl":"https://doi.org/10.3389/fceng.2023.1099010","url":null,"abstract":"Organosolv lignin is an emerging bio-additive for creating functional properties in various products with its advantages in high-purity, sulfur-free, biocompatibility, and solubility in green solvents. In this study, effects of thermal and physical modification on alterations of functional properties and particle size distribution of isolated organosolv lignin from sugarcane bagasse (OLB) were studied. Thermal treatment of OLB at increasing temperatures from 170 to 230°C in 70%w/w aqueous ethanol led to alteration of phenolic hydroxyl content, while ultrasonication resulted in homogeneous size distribution of the modified OLB according to laser diffraction and scanning electron micrograph. The highest ultraviolet light absorbance and antioxidant activities were obtained at 190°C treatment which were correlated to the highest phenolic group content. Application of the modified OLB at 3% w/w in a base cream formulation resulted in enhancement of the anti-UV activity to exceed SPF 50 with increasing antioxidant activity in the product. The work provides basis on modification of organosolv lignin for application as a potent functional additive in cosmeceutical products.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49667851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-22DOI: 10.3389/fceng.2023.1130568
Asimina Marousi, Vassilis M. Charitopoulos
Game theory is a framework that has been used by various research fields in order to represent dynamic correlation among stakeholders. Traditionally, research within the process and energy systems engineering community has focused on the development of centralised decision making schemes. In the recent years, decentralised decision-making schemes have attracted increasing attention due to their ability to capture multi-stakeholder dynamics in a more accurate manner. In this article, we survey how centralised and decentralised decision making has been facilitated by game theoretic approaches. We focus on the deployment of such methods in process systems engineering problems and review applications related to supply chain optimisation problems, design and operations, and energy systems optimisation. Finally, we analyse different game structures based on the degree of cooperation and how fairness criteria can be employed to find fair payoff allocations.
{"title":"Game theoretic optimisation in process and energy systems engineering: A review","authors":"Asimina Marousi, Vassilis M. Charitopoulos","doi":"10.3389/fceng.2023.1130568","DOIUrl":"https://doi.org/10.3389/fceng.2023.1130568","url":null,"abstract":"Game theory is a framework that has been used by various research fields in order to represent dynamic correlation among stakeholders. Traditionally, research within the process and energy systems engineering community has focused on the development of centralised decision making schemes. In the recent years, decentralised decision-making schemes have attracted increasing attention due to their ability to capture multi-stakeholder dynamics in a more accurate manner. In this article, we survey how centralised and decentralised decision making has been facilitated by game theoretic approaches. We focus on the deployment of such methods in process systems engineering problems and review applications related to supply chain optimisation problems, design and operations, and energy systems optimisation. Finally, we analyse different game structures based on the degree of cooperation and how fairness criteria can be employed to find fair payoff allocations.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47475125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-20DOI: 10.3389/fceng.2023.1130127
Feifan Du, E. Shusta, S. Palecek
The blood-brain barrier (BBB) is a highly impermeable barrier separating circulating blood and brain tissue. A functional BBB is critical for brain health, and BBB dysfunction has been linked to the pathophysiology of diseases such as stroke and Alzheimer’s disease. A variety of models have been developed to study the formation and maintenance of the BBB, ranging from in vivo animal models to in vitro models consisting of primary cells or cells differentiated from human pluripotent stem cells (hPSCs). These models must consider the composition and source of the cellular components of the neurovascular unit (NVU), including brain microvascular endothelial cells (BMECs), brain pericytes, astrocytes, and neurons, and how these cell types interact. In addition, the non-cellular components of the BBB microenvironment, such as the brain vascular basement membrane (BM) that is in direct contact with the NVU, also play key roles in BBB function. Here, we review how extracellular matrix (ECM) proteins in the brain vascular BM affect the BBB, with a particular focus on studies using hPSC-derived in vitro BBB models, and discuss how future studies are needed to advance our understanding of how the ECM affects BBB models to improve model performance and expand our knowledge on the formation and maintenance of the BBB.
{"title":"Extracellular matrix proteins in construction and function of in vitro blood-brain barrier models","authors":"Feifan Du, E. Shusta, S. Palecek","doi":"10.3389/fceng.2023.1130127","DOIUrl":"https://doi.org/10.3389/fceng.2023.1130127","url":null,"abstract":"The blood-brain barrier (BBB) is a highly impermeable barrier separating circulating blood and brain tissue. A functional BBB is critical for brain health, and BBB dysfunction has been linked to the pathophysiology of diseases such as stroke and Alzheimer’s disease. A variety of models have been developed to study the formation and maintenance of the BBB, ranging from in vivo animal models to in vitro models consisting of primary cells or cells differentiated from human pluripotent stem cells (hPSCs). These models must consider the composition and source of the cellular components of the neurovascular unit (NVU), including brain microvascular endothelial cells (BMECs), brain pericytes, astrocytes, and neurons, and how these cell types interact. In addition, the non-cellular components of the BBB microenvironment, such as the brain vascular basement membrane (BM) that is in direct contact with the NVU, also play key roles in BBB function. Here, we review how extracellular matrix (ECM) proteins in the brain vascular BM affect the BBB, with a particular focus on studies using hPSC-derived in vitro BBB models, and discuss how future studies are needed to advance our understanding of how the ECM affects BBB models to improve model performance and expand our knowledge on the formation and maintenance of the BBB.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49318794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-14DOI: 10.3389/fceng.2023.1161913
P. Taboada-Serrano, S. Yiacoumi, C. Tsouris
Climate change and global environmental impacts are challenging humanity as a whole, and particularly the scientific community, to rethink our approaches towards energy harvesting, storage, and utilization, and to formulate processes geared to restoring compromised environments. A large task in these efforts involves developing technologies that have low or no carbon footprint, enable the use of renewable energy sources, and minimize or eliminate contamination of water resources and generation of untreatable waste. At the heart of many manufacturing technologies lie separation processes ranging from the purification of raw materials and consumables to the treatment or reutilization of waste. Therefore, revolutionizing these technologies involves developing novel separation processes that align perfectly with environmentally conscious goals. The goal of this Research Topic titled “Separations for Energy and Environmental Applications” is to provide an avenue to disseminate critical review on the state-of-the art and original research articles on emerging separation processes thatwill support the formulation of new, environmentally conscious chemical technologies that enable the migration to renewable energy sources. The first article (Murphy and Haji) presents a review of technologies for direct lithium extraction from low concentration, lithium-ion aqueous solutions. Lithium has become a significant player in the energy landscape, as it is the main component of lithium-ion batteries and of nuclear fusion technologies. Since lithium-ion batteries enable the utilization of intermittent, renewable energy sources as wind and solar, and the substation of fossil fuels in transportation, the demand for lithium increases exponentially as we migrate towards sustainable energy technologies. However, lithium land reserves are finite. According to the review article, lithium land reserves will be depleted within the next 60 years given the rate of exploitation required to satisfy the growing demand. It is imperative to develop technologies capable of separating and enriching lithium-ion from dilute solutions, from seawater to geothermal fluids and mine runoffs, and the review article in the Research Topic provides a much necessary foundation on the state-of-the-art for researchers to tackle this challenge. The second article (Lee and Chung) in this Research Topic presents original research on the separation of lithium from low concentration, lithium-ion aqueous solutions, specifically geothermal fluid. The article focusses on the effect of silicate ions, ubiquitous in thermal fluids, on the yield of lithium during separation. This Research Topic is of particular interest, as it aims to enable the recovery of a valuable resource from aqueous waste generated during renewable, geothermal energy production. OPEN ACCESS
{"title":"Editorial: Separations for Energy and Environmental Applications","authors":"P. Taboada-Serrano, S. Yiacoumi, C. Tsouris","doi":"10.3389/fceng.2023.1161913","DOIUrl":"https://doi.org/10.3389/fceng.2023.1161913","url":null,"abstract":"Climate change and global environmental impacts are challenging humanity as a whole, and particularly the scientific community, to rethink our approaches towards energy harvesting, storage, and utilization, and to formulate processes geared to restoring compromised environments. A large task in these efforts involves developing technologies that have low or no carbon footprint, enable the use of renewable energy sources, and minimize or eliminate contamination of water resources and generation of untreatable waste. At the heart of many manufacturing technologies lie separation processes ranging from the purification of raw materials and consumables to the treatment or reutilization of waste. Therefore, revolutionizing these technologies involves developing novel separation processes that align perfectly with environmentally conscious goals. The goal of this Research Topic titled “Separations for Energy and Environmental Applications” is to provide an avenue to disseminate critical review on the state-of-the art and original research articles on emerging separation processes thatwill support the formulation of new, environmentally conscious chemical technologies that enable the migration to renewable energy sources. The first article (Murphy and Haji) presents a review of technologies for direct lithium extraction from low concentration, lithium-ion aqueous solutions. Lithium has become a significant player in the energy landscape, as it is the main component of lithium-ion batteries and of nuclear fusion technologies. Since lithium-ion batteries enable the utilization of intermittent, renewable energy sources as wind and solar, and the substation of fossil fuels in transportation, the demand for lithium increases exponentially as we migrate towards sustainable energy technologies. However, lithium land reserves are finite. According to the review article, lithium land reserves will be depleted within the next 60 years given the rate of exploitation required to satisfy the growing demand. It is imperative to develop technologies capable of separating and enriching lithium-ion from dilute solutions, from seawater to geothermal fluids and mine runoffs, and the review article in the Research Topic provides a much necessary foundation on the state-of-the-art for researchers to tackle this challenge. The second article (Lee and Chung) in this Research Topic presents original research on the separation of lithium from low concentration, lithium-ion aqueous solutions, specifically geothermal fluid. The article focusses on the effect of silicate ions, ubiquitous in thermal fluids, on the yield of lithium during separation. This Research Topic is of particular interest, as it aims to enable the recovery of a valuable resource from aqueous waste generated during renewable, geothermal energy production. OPEN ACCESS","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44632045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-10DOI: 10.3389/fceng.2023.1055896
J. van Kampen, J. Overbeek, J. Boon, M. van Sint Annaland
In this work the continuous production of dimethyl ether (DME) by sorption-enhanced DME synthesis (SEDMES) technology has been demonstrated for the first time with a multi-column test-rig. A continuous single-pass carbon yield up to 95%, higher than ever reported before, has been achieved. The multi-column experiments have also shown that SEDMES can be operated at lower temperatures (220°C) than previously reported. This allows a higher temperature rise, making higher conversions possible while allowing even larger reactor tube diameters. Whereas the anticipated multi-tubular reactor concept is complex and costly, larger reactors could facilitate the economic valorisation. The SEDMES reactor model cannot only describe the transient behaviour of the process during the cyclic steady-state well, but also the dynamic approach towards the cyclic steady-state is adequately captured. Capturing the dynamic operation is of large interest with respect to process flexibility, especially for Power-to-X systems.
{"title":"Continuous multi-column sorption-enhanced dimethyl ether synthesis (SEDMES): Dynamic operation","authors":"J. van Kampen, J. Overbeek, J. Boon, M. van Sint Annaland","doi":"10.3389/fceng.2023.1055896","DOIUrl":"https://doi.org/10.3389/fceng.2023.1055896","url":null,"abstract":"In this work the continuous production of dimethyl ether (DME) by sorption-enhanced DME synthesis (SEDMES) technology has been demonstrated for the first time with a multi-column test-rig. A continuous single-pass carbon yield up to 95%, higher than ever reported before, has been achieved. The multi-column experiments have also shown that SEDMES can be operated at lower temperatures (220°C) than previously reported. This allows a higher temperature rise, making higher conversions possible while allowing even larger reactor tube diameters. Whereas the anticipated multi-tubular reactor concept is complex and costly, larger reactors could facilitate the economic valorisation. The SEDMES reactor model cannot only describe the transient behaviour of the process during the cyclic steady-state well, but also the dynamic approach towards the cyclic steady-state is adequately captured. Capturing the dynamic operation is of large interest with respect to process flexibility, especially for Power-to-X systems.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41819534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.3389/fceng.2022.1083180
Stefanie Kern, Rahel Lerner, N. Schork, H. Nirschl, M. Heijnen, G. Guthausen
Membrane ultrafiltration in new polymeric multi-channel membranes designed for in-out filtration was investigated to get insights into structure, flow and filtration properties. The apparent novelty of the membrane concerns the geometry and configuration of the feed channels. In-situ magnetic resonance imaging (MRI) allows non-invasive and non-destructive investigations with adequate spatial and time resolution. The structure of the new polymeric membrane was measured with an in-plane spatial resolution of 35 µm/pixel revealing first the polymer density distribution over the 19-channel membrane and second the wettability of the fiber and its cavities of different dimensions. MRI was also used to answer questions about flow and consequently feed distribution in the channels. Finally, in-situ filtration of an aqueous solution of sodium alginate was observed which led to deposit formation at the channel’s inner surfaces. The kinetics of this deposit formation was quantified. Backwashing and flushing gave insight into the cleanability of the channels.
{"title":"MRI on a new polymeric multichannel membrane for ultrafiltration","authors":"Stefanie Kern, Rahel Lerner, N. Schork, H. Nirschl, M. Heijnen, G. Guthausen","doi":"10.3389/fceng.2022.1083180","DOIUrl":"https://doi.org/10.3389/fceng.2022.1083180","url":null,"abstract":"Membrane ultrafiltration in new polymeric multi-channel membranes designed for in-out filtration was investigated to get insights into structure, flow and filtration properties. The apparent novelty of the membrane concerns the geometry and configuration of the feed channels. In-situ magnetic resonance imaging (MRI) allows non-invasive and non-destructive investigations with adequate spatial and time resolution. The structure of the new polymeric membrane was measured with an in-plane spatial resolution of 35 µm/pixel revealing first the polymer density distribution over the 19-channel membrane and second the wettability of the fiber and its cavities of different dimensions. MRI was also used to answer questions about flow and consequently feed distribution in the channels. Finally, in-situ filtration of an aqueous solution of sodium alginate was observed which led to deposit formation at the channel’s inner surfaces. The kinetics of this deposit formation was quantified. Backwashing and flushing gave insight into the cleanability of the channels.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46446347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-23DOI: 10.3389/fceng.2022.1116366
Zhongtian Du, Sen Zhang, S. Yang, Wenhao Yang, Jingjie Luo, Changhai Liang
We synthesized a series of modified Co-ZIF-67 materials with tunable morphology to support fine Au nanoparticles for the alkali-free aerobic oxidation of benzyl alcohol. Structure promotion was performed using Stöber silica as a hard template, which was subsequently removed by NaOH etching before gold immobilization. The texture structure of Au/(Si)C was greatly improved with increasing surface area and volume. CoOx was simultaneously introduced into the carbon shell from the Co-ZIF-67 precursor, which consequently facilitated the specific Au-support interaction via bimetallic synergy. XRD, XPS, and TEM images demonstrated the redispersion of both Au and CoOx as well as the electronic delivery between metals. Analysis of the chemical and surface composition suggested a surface rich in Auδ+ with abundant lattice oxygen contributed by CoOx in the final Au/(Si)C, which improved the transformation rate of benzyl alcohol even in an alkali-free condition. Au/(Si)C with finely dispersed Au particles showed excellent catalytic performance in the alkali-free environment, with 89.3% benzyl conversion and 74.5% benzaldehyde yield under very mild conditions.
{"title":"Promotion of Au nanoparticles on carbon frameworks for alkali-free aerobic oxidation of benzyl alcohol","authors":"Zhongtian Du, Sen Zhang, S. Yang, Wenhao Yang, Jingjie Luo, Changhai Liang","doi":"10.3389/fceng.2022.1116366","DOIUrl":"https://doi.org/10.3389/fceng.2022.1116366","url":null,"abstract":"We synthesized a series of modified Co-ZIF-67 materials with tunable morphology to support fine Au nanoparticles for the alkali-free aerobic oxidation of benzyl alcohol. Structure promotion was performed using Stöber silica as a hard template, which was subsequently removed by NaOH etching before gold immobilization. The texture structure of Au/(Si)C was greatly improved with increasing surface area and volume. CoOx was simultaneously introduced into the carbon shell from the Co-ZIF-67 precursor, which consequently facilitated the specific Au-support interaction via bimetallic synergy. XRD, XPS, and TEM images demonstrated the redispersion of both Au and CoOx as well as the electronic delivery between metals. Analysis of the chemical and surface composition suggested a surface rich in Auδ+ with abundant lattice oxygen contributed by CoOx in the final Au/(Si)C, which improved the transformation rate of benzyl alcohol even in an alkali-free condition. Au/(Si)C with finely dispersed Au particles showed excellent catalytic performance in the alkali-free environment, with 89.3% benzyl conversion and 74.5% benzaldehyde yield under very mild conditions.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46306431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-18DOI: 10.3389/fceng.2023.1076509
M. Kuschel, J. Wutz, Mustafa Salli, D. Monteil, T. Wucherpfennig
The robust scale up of perfusion systems requires comparable conditions over all scales to ensure equivalent cell culture performance. As cells in continuous processes circulate outside the bioreactor, performance losses may arise if jet flow and stirring cause a direct connection between perfusion feed and return. Computational fluid dynamics can be used to identify such short circuit flows, assess mixing efficiencies, and eventually adapt the perfusion setup. This study investigates the scale up from a 2 L glass bioreactor to 100 L and 500 L disposable pilot scale systems. Highly resolved Lattice Boltzmann Large Eddy simulations were performed in single phase and mixing efficiencies (Emix) furthermore experimentally validated in the 2 L system. This evaluation gives insight into the flow pattern, the mixing behavior and information on cell residence time inside the bioreactors. No geometric adaptations in the pilot scale systems were necessary as Emix was greater than 90% for all conditions tested. Two different setups were evaluated in 2 L scale where the direction of flow was changed, yielding a difference in mixing efficiency of 10%. Nevertheless, since Emix was confirmed to be >90% also for both 2 L setups and the determined mixing times were in a similar range for all scales, the 2 L system was deemed to be a suitable scale down model. The results demonstrate how computational fluid dynamic models can be used for rational process design of intensified production processes in the biopharmaceutical industry.
{"title":"CFD supported scale up of perfusion bioreactors in biopharma","authors":"M. Kuschel, J. Wutz, Mustafa Salli, D. Monteil, T. Wucherpfennig","doi":"10.3389/fceng.2023.1076509","DOIUrl":"https://doi.org/10.3389/fceng.2023.1076509","url":null,"abstract":"The robust scale up of perfusion systems requires comparable conditions over all scales to ensure equivalent cell culture performance. As cells in continuous processes circulate outside the bioreactor, performance losses may arise if jet flow and stirring cause a direct connection between perfusion feed and return. Computational fluid dynamics can be used to identify such short circuit flows, assess mixing efficiencies, and eventually adapt the perfusion setup. This study investigates the scale up from a 2 L glass bioreactor to 100 L and 500 L disposable pilot scale systems. Highly resolved Lattice Boltzmann Large Eddy simulations were performed in single phase and mixing efficiencies (Emix) furthermore experimentally validated in the 2 L system. This evaluation gives insight into the flow pattern, the mixing behavior and information on cell residence time inside the bioreactors. No geometric adaptations in the pilot scale systems were necessary as Emix was greater than 90% for all conditions tested. Two different setups were evaluated in 2 L scale where the direction of flow was changed, yielding a difference in mixing efficiency of 10%. Nevertheless, since Emix was confirmed to be >90% also for both 2 L setups and the determined mixing times were in a similar range for all scales, the 2 L system was deemed to be a suitable scale down model. The results demonstrate how computational fluid dynamic models can be used for rational process design of intensified production processes in the biopharmaceutical industry.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45848180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-17DOI: 10.3389/fceng.2023.1086881
Alberto Rodriguez, M. Hirakawa, Gina M. Geiselman, M. Tran-Gyamfi, Yooli K. Light, A. George, K. Sale
Naturally occurring microbial communities are able to decompose lignocellulosic biomass through the concerted production of a myriad of enzymes that degrade its polymeric components and assimilate the resulting breakdown compounds by members of the community. This process includes the conversion of lignin, the most recalcitrant component of lignocellulosic biomass and historically the most difficult to valorize in the context of a biorefinery. Although several fundamental questions on microbial conversion of lignin remain unanswered, it is known that some fungi and bacteria produce enzymes to break, internalize, and assimilate lignin-derived molecules. The interest in developing efficient biological lignin conversion approaches has led to a better understanding of the types of enzymes and organisms that can act on different types of lignin structures, the depolymerized compounds that can be released, and the products that can be generated through microbial biosynthetic pathways. It has become clear that the discovery and implementation of native or engineered microbial consortia could be a powerful tool to facilitate conversion and valorization of this underutilized polymer. Here we review recent approaches that employ isolated or synthetic microbial communities for lignin conversion to bioproducts, including the development of methods for tracking and predicting the behavior of these consortia, the most significant challenges that have been identified, and the possibilities that remain to be explored in this field.
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