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Data-driven structural synthesis of supercritical CO2 power cycles 超临界CO2动力循环的数据驱动结构合成
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-16 DOI: 10.3389/fceng.2023.1144115
Tahar Nabil, Mohamed Noaman, Tatiana Morosuk
With new materials, objectives or constraints, it becomes increasingly difficult to develop optimal processes using conventional heuristics-based or superstructure-based methods. Hence, data-driven alternatives have emerged recently, to increase creativity and accelerate the development of innovative technologies without requiring extensive industrial feedback. However, beyond these proof-of-concepts and the promise of automation they hold, a deeper understanding of the behaviour and use of these advanced algorithms by the process engineer is still needed. In this paper, we provide the first data-driven solution for designing supercritical CO 2 power cycle for waste heat recovery, a challenging industrial use case with lack of consensus on the optimal layout from the field literature. We then examine the issue of artificial intelligence acceptance by the process engineer, and formulate a set of basic requirements to foster user acceptance - robustness, control, understanding of the results, small time-to-solution. The numerical experiments confirm the robustness of the method, able to produce optimal designs performing as well as a set of selected expert layouts, yet only from the specification of the unit operations (turbomachinery and heat exchangers). We provide tools to exploit the vast amount of generated data, with pattern mining techniques to extract heuristic rules, thereby explaining the decision-making process. As a result, this paper shows how the process engineer can interact with the data-driven design approaches, by refocusing on the areas of domain expertise, namely, definition and analysis of the physical problem.
随着新材料、新目标或新限制的出现,使用传统的基于启发式或基于上层结构的方法开发最佳工艺变得越来越困难。因此,最近出现了数据驱动的替代方案,以增加创造力并加速创新技术的发展,而不需要广泛的工业反馈。然而,除了这些概念验证和它们所拥有的自动化承诺之外,流程工程师仍然需要对这些高级算法的行为和使用进行更深入的理解。在本文中,我们提供了第一个数据驱动的解决方案,用于设计用于废热回收的超临界二氧化碳动力循环,这是一个具有挑战性的工业用例,缺乏对现场文献中最佳布局的共识。然后,我们研究了过程工程师接受人工智能的问题,并制定了一套基本要求来促进用户接受——鲁棒性、控制、对结果的理解、短时间解决方案。数值实验证实了该方法的鲁棒性,能够产生最佳设计,以及一组选定的专家布局,但仅从单元操作规范(涡轮机械和热交换器)。我们提供工具来利用大量生成的数据,利用模式挖掘技术提取启发式规则,从而解释决策过程。因此,本文通过重新关注领域专业知识,即物理问题的定义和分析,展示了过程工程师如何与数据驱动的设计方法进行交互。
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引用次数: 0
Human gastro-intestinal organoid engineering: a state of the art 人类胃肠道类器官工程:最先进的技术
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-16 DOI: 10.3389/fceng.2023.1256334
Giada Benedetti, Beatriz Fournon Berodia, Paolo De Coppi, Giovanni Giuseppe Giobbe
Gastrointestinal organ failure, from congenital or postnatally acquired pathologies, is a major cause of death across countries of all income levels. Organoids and engineered tissues have been widely investigated as tools to model organ functions and treat pathologies. In this review we aim to describe the progress in human organoid engineering applied to the gastrointestinal tract (namely esophagus, stomach, and intestine). Starting from the onset of the organoid culture technique, we illustrate genetic engineering, stem cell niche engineering, bioprinting, and microfluidics approaches used to integrate mechano-physiological parameters with human organoids. Thanks to these improvements, organoid technology allows disease modelling of patient-specific pathologies, and personalized treatment screening, also offering a cell source for autologous transplantation. We further present an overview of the advances of tissue engineering in animal systems, concerning novel materials and scaffolds to be combined with a variety of cell types to reconstitute a viable surrogate for implantation. The effort in this field sets organoids as an important tool in personalized and regenerative medicine. Their application combined with the advances in tissue engineering holds great potential for translational application.
先天性或后天获得性病理导致的胃肠道器官衰竭是所有收入水平国家的一个主要死亡原因。类器官和工程组织作为模拟器官功能和治疗病理的工具已被广泛研究。本文综述了人体类器官工程在胃肠道(即食道、胃和肠)中的应用进展。从类器官培养技术开始,我们阐述了基因工程、干细胞生态位工程、生物打印和微流体方法,这些方法用于将机械生理参数与人类类器官相结合。由于这些改进,类器官技术允许对患者特异性病理进行疾病建模和个性化治疗筛选,也为自体移植提供了细胞来源。我们进一步概述了组织工程在动物系统中的进展,包括与各种细胞类型结合的新材料和支架,以重建可行的植入替代物。这一领域的努力使类器官成为个性化和再生医学的重要工具。它们的应用与组织工程的进展相结合,具有巨大的转化应用潜力。
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引用次数: 0
Circular economy-based multi-objective decentralized controller for activated sludge wastewater treatment plant 基于循环经济的活性污泥污水处理厂多目标分散控制器
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-02 DOI: 10.3389/fceng.2023.1235125
Sutha Subbian, Pappa Natarajan, Chitra Murugan
Introduction: Water scarcity and water pollution are two major issues in India. Circular economy-based wastewater treatment technology provides the most sustainable solutions for solving these issues. In this paper, a novel multi-objective decentralized controller (MODC) is proposed for benchmarking a multi-input multi-output (MIMO) activated sludge wastewater treatment plant (WWTP) to achieve maximum effluent quality with minimum cost. WWTPs with conventional control schemes consume more energy to achieve the desired effluent quality. Methods: In this study, a MIMO model is developed for the activated sludge process (ASP) from a physics-based model, and relative gain array (RGA) analysis are carried out to determine the interaction between the loops to identify a suitable control scheme for the MIMO process. In addition, a multi-objective decentralized control problem is formulated to achieve the conflicting multiple objectives of improving effluent quality and minimizing operational costs by efficient usage of energy. Results and discussion: The desired quality and cost reduction are verified by comparing the integral square error (ISE) and control effort (CE) values of a closed-loop WWTP. A multi-objective evolutionary algorithm (MOEA), namely, the non-dominated sorting genetic algorithm (NSGA)-II, successfully solves the multi-objective control problem. NSGA-II provides several optimal solutions in the Pareto front. In order to demonstrate the feasibility of the proposed controller, three optimal solutions are selected from the Pareto-optimal front, and their closed-loop performances are evaluated qualitatively and quantitatively for both servo and regulatory operations. Improving the quality of effluent enhances active sludge production, which in turn increases the methane production in the anaerobic digester.
水资源短缺和水污染是印度的两大问题。基于循环经济的废水处理技术为解决这些问题提供了最可持续的解决方案。本文提出了一种新的多目标分散控制器(MODC),用于多输入多输出(MIMO)活性污泥污水处理厂(WWTP)的基准控制,以最小的成本获得最大的出水质量。采用传统控制方案的污水处理厂需要消耗更多的能源才能达到所需的出水质量。方法:在本研究中,从基于物理的模型为活性污泥过程(ASP)建立了一个MIMO模型,并进行了相对增益阵列(RGA)分析,以确定回路之间的相互作用,从而确定适合MIMO过程的控制方案。此外,还制定了一个多目标分散控制问题,以实现提高出水质量和通过有效利用能源最小化运营成本的相互冲突的多个目标。结果和讨论:通过比较闭环污水处理厂的积分平方误差(ISE)和控制努力(CE)值,验证了期望的质量和成本降低。一种多目标进化算法(MOEA),即非支配排序遗传算法(NSGA)-II,成功地解决了多目标控制问题。NSGA-II在Pareto前沿提供了几种最优解决方案。为了证明所提出控制器的可行性,从pareto最优前选择了三个最优解,并对其伺服和调节操作的闭环性能进行了定性和定量评估。提高出水质量可以提高活性污泥的产量,从而增加厌氧消化池中的甲烷产量。
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引用次数: 1
Rescuing the Brazilian Agave breeding program: morphophysiological and molecular characterization of a new germplasm 拯救巴西龙舌兰育种计划:一种新种质的形态生理和分子特征
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-09-20 DOI: 10.3389/fceng.2023.1218668
Fabio Trigo Raya, Lucas Miguel de Carvalho, Juliana José, Larissa Prado da Cruz, Rafael Leonardo Almeida, Heliur Alves de Almeida Delevatti, Neidiquele Maria Silveira, Simone Ferreira da Silva, Maria Dolores Pissolato, Adriele Bárbara de Oliveira, Wagner José Villela dos Reis, Luís Guilherme Furlan de Abreu, Jesús Gutiérrez, Marcelo Falsarella Carazzolle, Ana Cristina Fermino Soares, Jorge Nieto Sotelo, Rafael Vasconcelos Ribeiro, Gonçalo Amarante Guimarães Pereira
Agaves have been a valuable resource in dryland areas for centuries, providing fibers (sisal), food, and beverages. However, the advent of synthetic fibers has led to a decrease in research on Agave , resulting in the cessation of breeding programs in Brazil. With the rise of climate change, there is renewed interest in Agave for its potential as a biofuel feedstock in semiarid regions. Since 2016, we have been collecting Agave accessions throughout the country and retrieving what is left of Brazil’s original breeding program to establish a new germplasm bank. Here, we evaluated 21 of those accessions growing in the field. We used molecular markers and morphophysiological traits to characterize the plants. Based on the Mayahuelin molecular marker, we were able to reconstruct a phylogeny for the Brazilian accessions. The morphophysiological traits explained 34.6% of the phenotypic variation in the dataset, with physiological traits such as leaf water content, effective quantum efficiency of photosystem II (Φ PSII ), and specific leaf mass (SLM) as the most significant traits. Specifically, we evaluated nine Agave species and found that the physiological traits, rather than the morphological ones, were the most significant. Leaf water content was negatively correlated with specific leaf mass, which could be used as a marker for selecting cultivars with higher biomass accumulation. Interestingly, Φ PSII and chlorophyll content were negatively correlated, suggesting photochemical adaptations throughout the rosette. Molecular and phenotypic data suggest that A. amaniensis , which is frequently considered a synonym of A. sisalana , is effectively another species. Overall, this study provides valuable information on the physiological traits of Brazilian Agave accessions and is a starting point for selecting more productive and climate-resilient cultivars for biorenewables production.
几个世纪以来,龙舌兰一直是干旱地区的宝贵资源,提供纤维(剑麻)、食品和饮料。然而,合成纤维的出现导致对龙舌兰的研究减少,导致巴西的育种计划停止。随着气候变化的加剧,人们对龙舌兰作为半干旱地区生物燃料原料的潜力重新产生了兴趣。自2016年以来,我们一直在全国范围内收集龙舌兰,并检索巴西原始育种计划的剩余资源,以建立一个新的种质资源库。在这里,我们评估了在该领域生长的21种植物。利用分子标记和形态生理特征对其进行了鉴定。基于Mayahuelin分子标记,我们能够重建巴西材料的系统发育。形态生理性状解释了34.6%的表型变异,其中叶片含水量、光系统II有效量子效率(Φ PSII)和比叶质量(SLM)等生理性状是最显著的性状。具体来说,我们对9种龙舌兰进行了评价,发现生理性状比形态性状更显著。叶片含水量与比叶质量呈负相关,可作为选择生物量积累较高品种的标志。有趣的是,Φ PSII与叶绿素含量呈负相关,表明整个莲座都具有光化学适应性。分子和表型数据表明,a . amaniensis通常被认为是a . sisalana的同义词,实际上是另一个物种。总的来说,本研究为巴西龙舌兰的生理特性提供了有价值的信息,并为生物可再生能源生产选择更具生产力和气候适应性的品种提供了起点。
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引用次数: 1
Editorial: Carbon-based catalytic engineering for sustainable industrial applications 社论:用于可持续工业应用的碳基催化工程
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-09-15 DOI: 10.3389/fceng.2023.1282418
Jingjie Luo, Wen Luo, Ning Wang, Kuang-Hsu Wu
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引用次数: 0
Outline of microbial fuel cells technology and their significant developments, challenges, and prospects of oxygen reduction electrocatalysts 概述了微生物燃料电池技术及其在氧还原电催化剂方面的重大进展、挑战和前景
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-09-07 DOI: 10.3389/fceng.2023.1228510
Kavery Elangovan, Prabhu Saravanan, Cristian H. Campos, Felipe Sanhueza-Gómez, Md. Maksudur Rahman Khan, Sim Yee Chin, Santhana Krishnan, Ramalinga Viswanathan Mangalaraja
The microbial fuel cells (MFCs) which demonstrates simultaneous production of electricity and wastewater treatment have been considered as one of the potential and greener energy production technology among the available bioelectrochemical systems. The air-cathode MFCs have gained additional benefits due to using air and avoiding any chemical substances as catholyte in the cathode chamber. The sluggish oxygen reduction reaction (ORR) kinetics at the cathode is one of the main obstacles to achieve high microbial fuel cell (MFC) performances. Platinum (Pt) is one of the most widely used efficient ORR electrocatalysts due to its high efficient and more stable in acidic media. Because of the high cost and easily poisoned nature of Pt, several attempts, such as a combination of Pt with other materials, and using non-precious metals and non-metals based electrocatalysts has been demonstrated. However, the efficient practical application of the MFC technology is not yet achieved mainly due to the slow ORR. Therefore, the review which draws attention to develop and choosing the suitable cathode materials should be urgent for the practical applications of the MFCs. In this review article, we present an overview of the present MFC technology, then some significant advancements of ORR electrocatalysts such as precious metals-based catalysts (very briefly), non-precious metals-based, non-metals and carbon-based, and biocatalysts with some significant remarks on the corresponding results for the MFC applications. Lastly, we also discussed the challenges and prospects of ORR electrocatalysts for the practical application of MFCs.
在现有的生物电化学系统中,微生物燃料电池(MFCs)具有同时发电和处理废水的特点,被认为是一种有潜力的绿色能源生产技术。空气阴极mfc由于在阴极室中使用空气和避免任何化学物质作为阴极电解质而获得了额外的好处。阴极氧还原反应(ORR)动力学缓慢是实现微生物燃料电池(MFC)高性能的主要障碍之一。铂(Pt)因其高效且在酸性介质中更稳定,是目前应用最广泛的高效ORR电催化剂之一。由于Pt的高成本和易中毒性质,人们已经进行了几种尝试,例如将Pt与其他材料结合,以及使用非贵金属和非金属基电催化剂。然而,MFC技术的高效实际应用尚未实现,主要原因是其ORR较慢。因此,研究开发和选择合适的阴极材料是mfc实际应用的迫切需要。本文综述了目前MFC技术的发展概况,介绍了ORR电催化剂的一些重要进展,如贵金属基催化剂、非贵金属基催化剂、非金属和碳基催化剂以及生物催化剂,并对MFC应用的相应结果进行了评述。最后,讨论了ORR电催化剂在mfc实际应用中的挑战和前景。
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引用次数: 1
Editorial: Saccharomyces cerevisiae as a model organism for biochemical engineering and bioprocesses 编辑:酿酒酵母菌作为生物化学工程和生物过程的模式生物
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-08-17 DOI: 10.3389/fceng.2023.1267210
V. Zambare, M. F. Md. Din
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引用次数: 0
Solubilization of inclusion bodies: insights from explainable machine learning approaches 包容体的溶解:来自可解释机器学习方法的见解
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-08-07 DOI: 10.3389/fceng.2023.1227620
C. Walther, Michael C. Martinetz, Anja Friedrich, Anne Tscheliessnig, M. Voigtmann, Alexander Jung, C. Brocard, E. Bluhmki, J. Smiatek
We present explainable machine learning approaches for gaining deeper insights into the solubilization processes of inclusion bodies. The machine learning model with the highest prediction accuracy for the protein yield is further evaluated with regard to Shapley additive explanation (SHAP) values in terms of feature importance studies. Our results highlight an inverse fractional relationship between the protein yield and total protein concentration. Further correlations can also be observed for the dominant influences of the urea concentration and the underlying pH values. All findings are used to develop an analytical expression that is in reasonable agreement with experimental data. The resulting master curve highlights the benefits of explainable machine learning approaches for the detailed understanding of certain biopharmaceutical manufacturing steps.
我们提出了可解释的机器学习方法,以更深入地了解包涵体的溶解过程。在特征重要性研究方面,关于Shapley加性解释(SHAP)值,进一步评估对蛋白质产量具有最高预测精度的机器学习模型。我们的结果强调了蛋白质产量和总蛋白质浓度之间的反比分数关系。尿素浓度和潜在pH值的主要影响也可以观察到进一步的相关性。所有发现都用于开发一个与实验数据合理一致的分析表达式。由此产生的主曲线突出了可解释的机器学习方法对详细理解某些生物制药制造步骤的好处。
{"title":"Solubilization of inclusion bodies: insights from explainable machine learning approaches","authors":"C. Walther, Michael C. Martinetz, Anja Friedrich, Anne Tscheliessnig, M. Voigtmann, Alexander Jung, C. Brocard, E. Bluhmki, J. Smiatek","doi":"10.3389/fceng.2023.1227620","DOIUrl":"https://doi.org/10.3389/fceng.2023.1227620","url":null,"abstract":"We present explainable machine learning approaches for gaining deeper insights into the solubilization processes of inclusion bodies. The machine learning model with the highest prediction accuracy for the protein yield is further evaluated with regard to Shapley additive explanation (SHAP) values in terms of feature importance studies. Our results highlight an inverse fractional relationship between the protein yield and total protein concentration. Further correlations can also be observed for the dominant influences of the urea concentration and the underlying pH values. All findings are used to develop an analytical expression that is in reasonable agreement with experimental data. The resulting master curve highlights the benefits of explainable machine learning approaches for the detailed understanding of certain biopharmaceutical manufacturing steps.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49240909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Biochemical/biomaterial production from lignocellulosic biomass 社论:利用木质纤维素生物质生产生化/生物材料
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-08-02 DOI: 10.3389/fceng.2023.1266904
Jie-jie Dong, Daehwan Kim, C. Yoo
{"title":"Editorial: Biochemical/biomaterial production from lignocellulosic biomass","authors":"Jie-jie Dong, Daehwan Kim, C. Yoo","doi":"10.3389/fceng.2023.1266904","DOIUrl":"https://doi.org/10.3389/fceng.2023.1266904","url":null,"abstract":"","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47297266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three basic open access software tools for academic analysis of photocatalytic particles 用于光催化颗粒学术分析的三个基本开放访问软件工具
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-07-20 DOI: 10.3389/fceng.2023.1153795
Alexander Mendoza-Acosta, Suleyka Torres-Romero, Martín Orozco, M. Cota, Ricarda L. Basurto, Luis L. Galaviz
There is currently great interest in photocatalytic degradation technologies of pollutants in industrial effluents. This is due to the need to reduce the environmental pollution generated by the textile industry’s high demand of clothing for fast fashion; in addition to severe environmental problems, this also generates social problems. Since the catalysts of this type of processes are usually nanoparticles of metal oxides such as zinc and titanium, it is necessary to promote research into the synthesis and evaluation of photocatalysts. Therefore, this article describes three free basic access tools for the academic analysis of nanoparticles, from experimental design to representation, using the study of kinetics and particle size analysis. After pre-selecting easily accessible software, it was found that RStudio, J-Image, and Vesta are very useful programs for the analysis of nanoparticles in the respective areas of statistical processing, image analysis, and three-dimensional representation.
目前,人们对工业废水中污染物的光催化降解技术非常感兴趣。这是因为需要减少纺织业对快时尚服装的高需求所产生的环境污染;除了严重的环境问题,这也产生了社会问题。由于这类工艺的催化剂通常是锌和钛等金属氧化物的纳米颗粒,因此有必要促进对光催化剂合成和评价的研究。因此,本文介绍了三种免费的基本访问工具,用于纳米颗粒的学术分析,从实验设计到表示,利用动力学和粒度分析的研究。在预先选择了易于访问的软件后,发现RStudio、J-Image和Vesta是在统计处理、图像分析和三维表示等各个领域分析纳米颗粒的非常有用的程序。
{"title":"Three basic open access software tools for academic analysis of photocatalytic particles","authors":"Alexander Mendoza-Acosta, Suleyka Torres-Romero, Martín Orozco, M. Cota, Ricarda L. Basurto, Luis L. Galaviz","doi":"10.3389/fceng.2023.1153795","DOIUrl":"https://doi.org/10.3389/fceng.2023.1153795","url":null,"abstract":"There is currently great interest in photocatalytic degradation technologies of pollutants in industrial effluents. This is due to the need to reduce the environmental pollution generated by the textile industry’s high demand of clothing for fast fashion; in addition to severe environmental problems, this also generates social problems. Since the catalysts of this type of processes are usually nanoparticles of metal oxides such as zinc and titanium, it is necessary to promote research into the synthesis and evaluation of photocatalysts. Therefore, this article describes three free basic access tools for the academic analysis of nanoparticles, from experimental design to representation, using the study of kinetics and particle size analysis. After pre-selecting easily accessible software, it was found that RStudio, J-Image, and Vesta are very useful programs for the analysis of nanoparticles in the respective areas of statistical processing, image analysis, and three-dimensional representation.","PeriodicalId":73073,"journal":{"name":"Frontiers in chemical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42953818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Frontiers in chemical engineering
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