Pub Date : 2025-01-01DOI: 10.1016/j.gastha.2024.10.021
Evangelin Shaloom Vitus , Simran Mann , Charlie W. Lees , Tine Jess , Rahma Elmahdi
Background and Aims
Respiratory viral infections have been implicated in the exacerbation of immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD). To understand the impact of early SARS-CoV-2 variants on the risk of adverse IBD outcomes, we aimed to perform a meta-analysis of high-quality studies.
Methods
Cohort studies investigating adverse IBD outcomes (IBD flares, change in disease activity, change in medication, IBD-related hospitalization, and surgery) following COVID-19 were retrieved from MEDLINE and Embase. The Risk Of Bias In Nonrandomized Studies—of Exposure tool was used to assess risk of bias. Random effects model meta-analysis was used to calculate the hazard ratio (HR) for risk of adverse outcomes. Subgroup analysis was performed to estimate risk of outcomes for ulcerative colitis and Crohn’s disease patients. Metaregression was performed for sex and duration of follow-up.
Results
Of the 3119 identified studies, 5 were included in the meta-analysis. A total of 34,977 IBD patients with COVID-19 and 53,270 IBD patients without recorded COVID-19 infection were identified. Two of the studies showed a high risk of bias. The random effects model did not show a statistically significant increase in the risk of adverse IBD outcomes following COVID infection (HR:1.05 [0.75–1.46]). There was no significant difference in adverse outcomes between Crohn’s disease (HR: 0.91 [0.82–1.02]) and ulcerative colitis patients (HR: 0.83 [0.76–0.90]). Neither the proportion of male participants nor the mean duration of follow-up were found to be significant predictors of effect size.
Conclusion
In this systematic review and meta-analysis, we find that COVID-19 did not increase the risk of adverse IBD outcomes.
{"title":"A Systematic Review and Meta-Analysis: Adverse Inflammatory Bowel Disease Outcomes Following Acute COVID-19","authors":"Evangelin Shaloom Vitus , Simran Mann , Charlie W. Lees , Tine Jess , Rahma Elmahdi","doi":"10.1016/j.gastha.2024.10.021","DOIUrl":"10.1016/j.gastha.2024.10.021","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Respiratory viral infections have been implicated in the exacerbation of immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD). To understand the impact of early SARS-CoV-2 variants on the risk of adverse IBD outcomes, we aimed to perform a meta-analysis of high-quality studies.</div></div><div><h3>Methods</h3><div>Cohort studies investigating adverse IBD outcomes (IBD flares, change in disease activity, change in medication, IBD-related hospitalization, and surgery) following COVID-19 were retrieved from MEDLINE and Embase. The Risk Of Bias In Nonrandomized Studies—of Exposure tool was used to assess risk of bias. Random effects model meta-analysis was used to calculate the hazard ratio (HR) for risk of adverse outcomes. Subgroup analysis was performed to estimate risk of outcomes for ulcerative colitis and Crohn’s disease patients. Metaregression was performed for sex and duration of follow-up.</div></div><div><h3>Results</h3><div>Of the 3119 identified studies, 5 were included in the meta-analysis. A total of 34,977 IBD patients with COVID-19 and 53,270 IBD patients without recorded COVID-19 infection were identified. Two of the studies showed a high risk of bias. The random effects model did not show a statistically significant increase in the risk of adverse IBD outcomes following COVID infection (HR:1.05 [0.75–1.46]). There was no significant difference in adverse outcomes between Crohn’s disease (HR: 0.91 [0.82–1.02]) and ulcerative colitis patients (HR: 0.83 [0.76–0.90]). Neither the proportion of male participants nor the mean duration of follow-up were found to be significant predictors of effect size.</div></div><div><h3>Conclusion</h3><div>In this systematic review and meta-analysis, we find that COVID-19 did not increase the risk of adverse IBD outcomes.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100581"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/S2772-5723(25)00018-4
{"title":"Cover: Selective Epithelial Caspase-4 Expression During Colorectal Dysplasia and Carcinoma","authors":"","doi":"10.1016/S2772-5723(25)00018-4","DOIUrl":"10.1016/S2772-5723(25)00018-4","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 2","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.gastha.2024.100599
Alia Hadefi , Morgane Leprovots , Gilles Dinsart , Maryam Marefati , Marjorie Vermeersch , Daniel Monteyne , David Pérez-Morga , Anne Lefort , Frédérick Libert , Laurine Verset , Claire Liefferinckx , Christophe Moreno , Jacques Devière , Eric Trépo , Marie-Isabelle Garcia
Background and Aims
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Though MASH is closely tied to metabolic risk factors, the underlying pathogenic mechanisms remain scarcely understood. Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. Here, we investigated whether the duodenal epithelium of MASH patients could exhibit intrinsic dysfunctions.
Methods
Duodenal epithelial organoids were generated from 16 MASH patients and 14 healthy controls. Biopsies and patient-derived organoid transcriptomes were then analyzed to evaluate if specific intestinal pathways were differentially modulated in MASH subjects. Functional assays were performed to assess the duodenal epithelial absorptive potential and barrier functionality.
Results
Organoid formation efficiency was similar between control-derived duodenal epithelial organoids and MASH-derived duodenal epithelial organoids (MDEOs) (71% and 69%, respectively). Despite global heterogeneity in growth patterns, MDEOs frequently exhibited cystic spheroid morphology. MDEOs displayed altered digestive potential associated with reduced mature absorptive cell fate, but they retained their lipid metabolic capacity, possibly mediated by lipid oxidation in stem/progenitor cells. Additionally, MDEOs misexpressed components of tight and adherens junctions and desmosomes compared to controls. However, MDEOs maintained pore and leak pathway integrity, indicating that the duodenal epithelial barrier remained functionally preserved under tested conditions.
Conclusion
This study provides evidence that the duodenal epithelium of MASH patients exhibits significant alterations in its nutrition-related and barrier functions. This study sheds light on the intricate dynamics of duodenal epithelial alterations in MASH, highlighting potential therapeutic avenues for restoring intestinal functions.
{"title":"Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations","authors":"Alia Hadefi , Morgane Leprovots , Gilles Dinsart , Maryam Marefati , Marjorie Vermeersch , Daniel Monteyne , David Pérez-Morga , Anne Lefort , Frédérick Libert , Laurine Verset , Claire Liefferinckx , Christophe Moreno , Jacques Devière , Eric Trépo , Marie-Isabelle Garcia","doi":"10.1016/j.gastha.2024.100599","DOIUrl":"10.1016/j.gastha.2024.100599","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Though MASH is closely tied to metabolic risk factors, the underlying pathogenic mechanisms remain scarcely understood. Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. Here, we investigated whether the duodenal epithelium of MASH patients could exhibit intrinsic dysfunctions.</div></div><div><h3>Methods</h3><div>Duodenal epithelial organoids were generated from 16 MASH patients and 14 healthy controls. Biopsies and patient-derived organoid transcriptomes were then analyzed to evaluate if specific intestinal pathways were differentially modulated in MASH subjects. Functional assays were performed to assess the duodenal epithelial absorptive potential and barrier functionality.</div></div><div><h3>Results</h3><div>Organoid formation efficiency was similar between control-derived duodenal epithelial organoids and MASH-derived duodenal epithelial organoids (MDEOs) (71% and 69%, respectively). Despite global heterogeneity in growth patterns, MDEOs frequently exhibited cystic spheroid morphology. MDEOs displayed altered digestive potential associated with reduced mature absorptive cell fate, but they retained their lipid metabolic capacity, possibly mediated by lipid oxidation in stem/progenitor cells. Additionally, MDEOs misexpressed components of tight and adherens junctions and desmosomes compared to controls. However, MDEOs maintained pore and leak pathway integrity, indicating that the duodenal epithelial barrier remained functionally preserved under tested conditions.</div></div><div><h3>Conclusion</h3><div>This study provides evidence that the duodenal epithelium of MASH patients exhibits significant alterations in its nutrition-related and barrier functions. This study sheds light on the intricate dynamics of duodenal epithelial alterations in MASH, highlighting potential therapeutic avenues for restoring intestinal functions.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 4","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.gastha.2024.08.020
James Flanary , Elizabeth A. King , FNU Baimaji , Alexandra T. Strauss , Nicole Welch , Annette Bellar , Courtney B. Sherman , Bilal Hameed , Mandana Khalili , Srinivasan Dasarathy , Andrew M. Cameron , Po-Hung Chen
{"title":"Recipients of Early Liver Transplants for Alcohol-Related Liver Disease May Reside in Areas With Lower Social Vulnerability","authors":"James Flanary , Elizabeth A. King , FNU Baimaji , Alexandra T. Strauss , Nicole Welch , Annette Bellar , Courtney B. Sherman , Bilal Hameed , Mandana Khalili , Srinivasan Dasarathy , Andrew M. Cameron , Po-Hung Chen","doi":"10.1016/j.gastha.2024.08.020","DOIUrl":"10.1016/j.gastha.2024.08.020","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100542"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.gastha.2024.10.019
Hannah Zuercher , Juan Gonzalez , Andreas Zori
{"title":"Hematemesis as a Result of Hepatic Arterioportal Fistula Formation","authors":"Hannah Zuercher , Juan Gonzalez , Andreas Zori","doi":"10.1016/j.gastha.2024.10.019","DOIUrl":"10.1016/j.gastha.2024.10.019","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 3","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.gastha.2024.08.010
Richard H. Goodheart , Dilini Gunawardena , Adam Doyle
{"title":"Histological Findings of Hypervitaminosis A Liver Disease","authors":"Richard H. Goodheart , Dilini Gunawardena , Adam Doyle","doi":"10.1016/j.gastha.2024.08.010","DOIUrl":"10.1016/j.gastha.2024.08.010","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 1","pages":"Article 100531"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.gastha.2024.01.013
Hiroyuki Suzuki, Miwa Sakai, H. Iwamoto, S. Shimose, T. Niizeki, M. Nakano, T. Shirono, Y. Noda, Etsuko Moriyama, R. Kuromatsu, H. Koga, Takumi Kawaguchi
{"title":"The immune inductive role of hepatic arterial infusion chemotherapy prior to atezolizumab plus bevacizumab combination therapy in hepatocellular carcinoma","authors":"Hiroyuki Suzuki, Miwa Sakai, H. Iwamoto, S. Shimose, T. Niizeki, M. Nakano, T. Shirono, Y. Noda, Etsuko Moriyama, R. Kuromatsu, H. Koga, Takumi Kawaguchi","doi":"10.1016/j.gastha.2024.01.013","DOIUrl":"https://doi.org/10.1016/j.gastha.2024.01.013","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"135 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.gastha.2024.01.014
Karen Curtin, Michael J. Madsen, Zhe Yu, Priyanka Kanth
{"title":"Using a Population Database to Assess Lifestyle Factors in Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.","authors":"Karen Curtin, Michael J. Madsen, Zhe Yu, Priyanka Kanth","doi":"10.1016/j.gastha.2024.01.014","DOIUrl":"https://doi.org/10.1016/j.gastha.2024.01.014","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"26 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139871457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.gastha.2024.02.001
Naoki Hayata, Norio Araki, Shin’ichi Miyamoto
{"title":"Image of the Month Penile metastasis from esophageal squamous cell cancer.","authors":"Naoki Hayata, Norio Araki, Shin’ichi Miyamoto","doi":"10.1016/j.gastha.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.gastha.2024.02.001","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"129 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}