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Genome instability & disease最新文献

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Primary microcephaly with an unstable genome 原发性小头畸形，基因组不稳定
Genome instability & disease
Pub Date : 2020-09-01 DOI: 10.1007/s42764-020-00020-z
Shibin Xu, Xingxuan Wu, Bin Peng, Shenghan Cao, Xingzhi Xu
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引用次数: 5
ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738 ATM缺陷的肺癌、前列腺癌和胰腺癌细胞对奥拉帕利和ATR抑制剂AZD6738的组合具有急性敏感性
Genome instability & disease
Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00011-0
N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller
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引用次数: 0
Deacetylation of a deacetylase drives the DNA damage response 去乙酰化酶的去乙酰化驱动DNA损伤反应
Genome instability & disease
Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00018-7
Raissa Ng, M. Huen
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引用次数: 1
Autophagy and DNA damage repair 自噬和DNA损伤修复
Genome instability & disease
Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00016-9
Congting Guo, Ying Zhao
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引用次数: 9
Mechanisms of UV-induced mutations and skin cancer. 紫外线诱导突变与皮肤癌的机制。
Genome instability & disease
Pub Date : 2020-05-01 Epub Date: 2020-03-19 DOI: 10.1007/s42764-020-00009-8
Gerd P Pfeifer

Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans, often decades after initial exposure. Different UV wavelengths cause the formation of prominent UV-induced DNA lesions. Most of these lesions are removed by the nucleotide excision repair pathway, which is defective in rare genetic skin disorders referred to as xeroderma pigmentosum. A major role in inducing sunlight-dependent skin cancer mutations is assigned to the cyclobutane pyrimidine dimers (CPDs). In this review, we discuss the mechanisms of UV damage induction, the genomic distribution of this damage, relevant DNA repair mechanisms, the proposed mechanisms of how UV-induced CPDs bring about DNA replication-dependent mutagenicity in mammalian cells, and the strong signature of UV damage and mutagenesis found in skin cancer genomes.

紫外线(UV)照射引起各种类型的DNA损伤，从而导致特定的突变和人类皮肤癌的出现，通常在初次暴露后几十年。不同的紫外线波长导致形成明显的紫外线诱导的DNA损伤。大多数这些病变是由核苷酸切除修复途径，这是有缺陷的罕见遗传性皮肤病，称为色素性干皮病。环丁烷嘧啶二聚体(CPDs)在诱导阳光依赖性皮肤癌突变中起主要作用。本文综述了紫外线损伤诱导的机制、损伤的基因组分布、相关的DNA修复机制、紫外线诱导CPDs在哺乳动物细胞中产生DNA复制依赖性诱变的可能机制，以及在皮肤癌基因组中发现的紫外线损伤和诱变的强特征。
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引用次数: 44
Helicobacter pylori infection induced genome instability and gastric cancer 幽门螺杆菌感染诱发基因组不稳定和胃癌
Genome instability & disease
Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00010-1
Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall
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引用次数: 0
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells 真核细胞中 DNA 复制-转录冲突的预防与解决
Genome instability & disease
Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00012-z
Wei Wu, I. Hickson, Ying Liu
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引用次数: 0
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells 真核细胞中 DNA 复制-转录冲突的预防与解决
Genome instability & disease
Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00012-z
Wei Wu, I. Hickson, Ying Liu
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引用次数: 0
Suppression of genomic instability by replicative senescence and crisis 通过复制衰老和危机抑制基因组不稳定性
Genome instability & disease
Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00013-y
J. Karlseder
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引用次数: 1
Helicobacter pylori infection induced genome instability and gastric cancer 幽门螺杆菌感染诱发基因组不稳定和胃癌
Genome instability & disease
Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00010-1
Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall
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引用次数: 0
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