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Prevalence of Anemia and Its Associated Factors in Antiretroviral-Treated HIV/AIDS-Positive Adults from 2013 to 2018 at Debre Berhan Referral Hospital, Ethiopia. 2013 - 2018年埃塞俄比亚Debre Berhan转诊医院接受抗逆转录病毒治疗的艾滋病毒/艾滋病阳性成年人贫血患病率及其相关因素
Q3 Medicine Pub Date : 2020-03-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2513578
Yared Asmare Aynalem, Wondimeneh Shibabaw Shiferaw, Zeleke Woldiye

Introduction. Anemia was defined as a hemoglobin level of less than or equal to 13.9 g/dl for male and less than or equal to 12.2 g/dl for female adults. It is one of the most common hematological abnormalities in people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and is a determining factor for disease progression and death. Among the countries in sub-Saharan Africa, Ethiopia is one of the most affected nations by HIV. Therefore, this study aimed to assess the prevalence of anemia and its associated factors among HIV-positive adults that had received antiretroviral treatment (ART) at Debre Berhan Referral Hospital.

Methods: An institution-based, descriptive, cross-sectional study was conducted involving 263 adults with HIV/AIDS that had undergone ART at Debre Berhan Referral Hospital, Ethiopia. Data were collected from patient charts using systematic sampling with a pretested data extraction tool and entered using EpiData 3.1. Variables having a p value ≤0.25 in the bivariate were fitted to a multivariable regression model with a 95% confidence interval. p value ≤0.25 in the bivariate were fitted to a multivariable regression model with a 95% confidence interval.

Results: Among the 263 HIV-positive patients, 237 (90.11%) were included in the final analysis. The overall prevalence of anemia was 26.2%. Factors that were significantly associated with anemia were past opportunistic infections, patients being in WHO clinical stage III and IV, and a BMI <18.5. Conversely, those patients who took anti-TB medication were less likely to have anemia.

Conclusion: Our study shows that the severity of anemia among HIV/AIDS patients that had undergone ART is lower than most studies conducted in Ethiopia. We also found that opportunistic infection, WHO clinical staging, anti-TB treatment, and low BMI were significantly associated with anemia. Therefore, routine screening of patient nutritional status and opportunistic infections may be useful in predicting and controlling anemia in HIV/AIDS patients.

介绍。贫血被定义为男性血红蛋白水平低于或等于13.9 g/dl,女性成人血红蛋白水平低于或等于12.2 g/dl。它是人类免疫缺陷病毒/获得性免疫缺陷综合征(艾滋病毒/艾滋病)患者中最常见的血液学异常之一,是疾病进展和死亡的决定性因素。在撒哈拉以南的非洲国家中,埃塞俄比亚是受艾滋病影响最严重的国家之一。因此,本研究旨在评估在Debre Berhan转诊医院接受抗逆转录病毒治疗(ART)的hiv阳性成人中贫血的患病率及其相关因素。方法:对263名在埃塞俄比亚Debre Berhan转诊医院接受抗逆转录病毒治疗的成人艾滋病毒/艾滋病患者进行了一项以机构为基础的描述性横断面研究。采用预先测试的数据提取工具进行系统抽样,从患者病历中收集数据,并使用EpiData 3.1输入数据。双变量中p值≤0.25的变量拟合到多变量回归模型中,置信区间为95%。双变量P值≤0.25拟合为多变量回归模型,置信区间为95%。结果:263例hiv阳性患者中,最终纳入237例(90.11%)。贫血的总患病率为26.2%。与贫血显著相关的因素是过去的机会性感染,患者处于世卫组织临床III期和IV期,以及BMI。结论:我们的研究表明,接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者的贫血严重程度低于在埃塞俄比亚进行的大多数研究。我们还发现机会性感染、WHO临床分期、抗结核治疗和低BMI与贫血显著相关。因此,常规筛查患者的营养状况和机会性感染可能有助于预测和控制HIV/AIDS患者的贫血。
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引用次数: 11
Laboratory Biomarkers, Cerebral Blood Flow Velocity, and Intellectual Function in Children with Sickle Cell Disease. 镰状细胞病儿童的实验室生物标志物、脑血流速度和智力功能
Q3 Medicine Pub Date : 2020-02-26 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8181425
Nataly Apollonsky, Norma B Lerner, Fengqing Zhang, Deepti Raybagkar, Jennifer Eng, Reem Tarazi

Objective: The aim of this preliminary study was to describe putative markers of cerebral vasculopathy and investigate relationships among these markers, demographic factors, and cognitive function in a young sample of neurologically normal children with SCD. Study Design. Thirty-eight children with homozygous HbS, aged 4-11 years, were included. Estimated IQ and markers of coagulation and endothelial activation, hemolysis, and inflammation, as well as transcranial Doppler velocities, hydroxyurea use, and demographic information were obtained.

Results: Using multiple regression analyses, there were few significant independent associations between biomarkers or blood flow velocity and estimated IQ. Lactic dehydrogenase (LDH) independently predicted cognitive function, but blood flow velocity did not mediate this relationship. Maternal education, patient age, and hydroxyurea status were independent predictors of cognition. Given the small sample size, a LASSO statistical model was employed to further identify potential predictors of IQ, which identified LDH, absolute neutrophil count (ANC), platelet count, thrombin-antithrombin (TAT), tissue factor (TF), maternal education, age, and hydroxyurea as potential predictors of cognition.

Conclusions: In addition to effects of age and maternal education, some vasculopathic markers are associated with cognitive function in young children with SCD, and these relationships do not appear to be mediated through blood flow velocity. Although the lack of association among certain variables was not as predicted, results provide support for further research regarding the influence of vasculopathic markers on cognitive function in children with SCD without stroke, especially intravascular hemolysis and coagulation/endothelial activation, and a possible role for HU treatment in preventing or reversing cognitive decline.

目的:本初步研究的目的是描述脑血管病的推定标志物,并调查这些标志物、人口统计学因素和年轻神经正常SCD患儿认知功能之间的关系。研究设计。38例4-11岁的纯合子HbS患儿被纳入研究。估计的智商和凝血和内皮活化、溶血和炎症标志物,以及经颅多普勒速度、羟基脲使用和人口统计信息。结果:采用多元回归分析,生物标志物或血流速度与智商之间没有显著的独立关联。乳酸脱氢酶(LDH)独立预测认知功能,但血流速度没有介导这种关系。产妇教育程度、患者年龄和羟基脲状态是认知的独立预测因素。由于样本量小,采用LASSO统计模型进一步确定智商的潜在预测因素,其中LDH、绝对中性粒细胞计数(ANC)、血小板计数、凝血酶-抗凝血酶(TAT)、组织因子(TF)、母亲教育程度、年龄和羟脲是认知的潜在预测因素。结论:除了年龄和母亲教育的影响外,一些血管病变标志物与SCD幼儿的认知功能有关,而这些关系似乎不是通过血流速度介导的。虽然某些变量之间缺乏相关性,但结果为进一步研究血管病变标志物对无卒中SCD儿童认知功能的影响,特别是血管内溶血和凝血/内皮活化,以及HU治疗在预防或逆转认知功能下降方面的可能作用提供了支持。
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引用次数: 7
Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar. 缅甸仰光国家血液中心rh阴性献血者Rh-Del表型的血清学检测
Q3 Medicine Pub Date : 2020-02-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3482124
Saw Thu Wah, Saung Nay Chi, Kyi Kyi Kyaing, Aye Aye Khin, Thida Aung

Background: Red cell Rhesus (Rh) antigen expression is influenced by the genetic polymorphism of RHD and RHCE genes and reveals serologically different reactions of RhD variants such as partial D, weak D, and Rh-Del. Serologically, Rh-Del type can only be detected by an adsorption-elution technique, and it might be mistyped as Rh-negative. The prevalence of Rh-Del has not been reported yet in Myanmar.

Method: A total of 222 Rh-negative blood donors in the National Blood Center were tested for weak D and Rh-Del by indirect antihuman globulin and adsorption-elution method, respectively. RhCE typing was performed among Rh-negative and Rh-Del.

Results: Of them, 75.2% (167/222) were Rh-negative, 15.8% (35/222) were Rh-Del, and 9% (20/222) were weak D. Of 202 blood donors (167 true Rh-negative and 35 Rh-Del), all of the Rh-Del positives were C-antigen-positive with 94.3% Ccee phenotype (33/35) and 5.7% CCee (2/35). Most of the Rh-negative donors (80.2%) were ccee phenotype (134/167).

Conclusion: About half of Rh-Del subjects were repeated donors, and attention was needed to avoid transfusion of truly Rh-negative patients to prevent alloimmunization. It is recommended to do Rh-Del typing of Rh-negative donors who are C-antigen-positive and consider moving them to the Rh-positive pool. Further study is needed to clarify the alloimmunization status for transfusion of Rh-Del blood to Rh-negative recipients. Molecular markers for RhD-negative and D variants should be established in the Myanmar population to improve selection of antisera for Rh typing and enhance safety of the transfusion services.

背景:Rh抗原的表达受RHD和RHCE基因多态性的影响,并揭示了部分D、弱D和Rh- del等RHD变异在血清学上的不同反应。血清学上,Rh-Del型只能通过吸附-洗脱技术检测,可能被误认为rh阴性。缅甸尚未报告Rh-Del的流行情况。方法:对国家血液中心222例rh阴性献血者分别采用间接抗人球蛋白法和吸附洗脱法检测弱D和Rh-Del。对rh阴性和Rh-Del进行RhCE分型。结果:rh阴性者占75.2% (167/222),Rh-Del阳性者占15.8%(35/222),弱d阳性者占9%(20/222)。202名献血者(真rh阴性167人,Rh-Del阳性35人)Rh-Del阳性均为c抗原阳性,Ccee表型占94.3% (33/35),Ccee表型占5.7%(2/35)。rh阴性供者(80.2%)为ccee表型(134/167)。结论:Rh-Del患者中约有一半是重复供体,需要注意避免真正rh阴性患者输血,防止同种异体免疫。建议对c抗原阳性的rh阴性供者进行Rh-Del分型,并考虑将其转移到rh阳性供者池中。需要进一步的研究来阐明Rh-Del血输注给rh阴性受体的同种异体免疫状况。应在缅甸人群中建立Rh阴性和D变异的分子标记物,以改进Rh分型抗血清的选择,并加强输血服务的安全性。
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引用次数: 2
Haematological Profile of Adults with Malaria Parasitaemia Visiting the Volta Regional Hospital, Ghana. 加纳Volta地区医院成人疟疾寄生虫病血液学分析
Q3 Medicine Pub Date : 2020-02-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9369758
Daniel Sakzabre, Emmanuel Akomanin Asiamah, Elliot Elikplim Akorsu, Albert Abaka-Yawson, Noble Dei Dika, David Annor Kwasie, Emmanuel Ativi, Confidence Tseyiboe, George Yiadom Osei

Background: Malaria is known to cause severe health consequences due to its marked effects and alteration on the haematological parameters of infected individuals. This study evaluated the haematological profile of adult individuals infected with the malaria parasite.

Methods: A retrospective study was conducted using archived data of malaria positive cases from January 2017 to March 15, 2019. Data retrieved included subjects' demographics, malaria parasite count, malaria parasite species, and full blood count parameters. A total of 236 malaria positive subjects were included in the study.

Results: The study showed that more females were infected with the malaria parasite than males (69.07% and 30.93%, respectively). A total of 87.3% of the study population were infected with Plasmodium falciparum as compared to 12.7% infected with Plasmodium malariae. The commonest haematological abnormalities that were seen in this study were lymphopenia (56.78%), anaemia (55.51%), thrombocytopenia (47.46%), eosinopenia (45.76%), neutropenia (29.24%), monocytosis (21.19%), and leucocytosis (17.37%) in the infected subjects. The mean platelet count of P. falciparum-infected subjects was decreased as compared to the mean platelet count of P. malariae-infected subjects. There was a significant (P value <0.05) decrease in the number of platelet count with every unit increase in parasite density.

Conclusion: Study participants infected with malaria demonstrated vital changes in haematological parameters with anaemia, thrombocytopenia, lymphopenia, monocytosis, and eosinopenia being the most important predictors of malaria infection especially with P. falciparum species.P. falciparum-infected subjects was decreased as compared to the mean platelet count of.

背景:众所周知,疟疾会造成严重的健康后果,因为它对受感染个体的血液学参数有显著影响和改变。本研究评估了感染疟疾寄生虫的成年个体的血液学特征。方法:对2017年1月至2019年3月15日云南省疟疾阳性病例档案资料进行回顾性研究。检索的数据包括受试者的人口统计学、疟疾寄生虫计数、疟疾寄生虫种类和全血细胞计数参数。研究共纳入236名疟疾阳性受试者。结果:研究显示,女性感染疟疾的比例高于男性(分别为69.07%和30.93%)。共有87.3%的研究人群感染了恶性疟原虫,而12.7%的研究人群感染了疟疾疟原虫。本研究中最常见的血液学异常是淋巴细胞减少(56.78%)、贫血(55.51%)、血小板减少(47.46%)、嗜酸性粒细胞减少(45.76%)、中性粒细胞减少(29.24%)、单核细胞增多(21.19%)和白细胞增多(17.37%)。恶性疟原虫感染者的平均血小板计数低于疟疾疟原虫感染者的平均血小板计数。结论:感染疟疾的研究参与者血液学参数发生重大变化,贫血、血小板减少、淋巴细胞减少、单核细胞增多和嗜酸性粒细胞减少是疟疾感染尤其是恶性疟原虫感染的最重要预测因子。与平均血小板计数相比,恶性疟原虫感染的受试者减少。
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引用次数: 16
An Update on the Reversal of Non-Vitamin K Antagonist Oral Anticoagulants. 非维生素K拮抗剂口服抗凝剂逆转的最新进展。
Q3 Medicine Pub Date : 2020-01-27 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7636104
Mark Terence P Mujer, Manoj P Rai, Varunsiri Atti, Ian Limuel Dimaandal, Abigail S Chan, Shiva Shrotriya, Krishna Gundabolu, Prajwal Dhakal

Non-vitamin K antagonist oral anticoagulants (NOACs) include thrombin inhibitor dabigatran and coagulation factor Xa inhibitors rivaroxaban, apixaban, edoxaban, and betrixaban. NOACs have several benefits over warfarin, including faster time to the achieve effect, rapid onset of action, fewer documented food and drug interactions, lack of need for routine INR monitoring, and improved patient satisfaction. Local hemostatic measures, supportive care, and withholding the next NOAC dose are usually sufficient to achieve hemostasis among patients presenting with minor bleeding. The administration of reversal agents should be considered in patients on NOAC's with major bleeding manifestations (life-threatening bleeding, or major uncontrolled bleeding), or those who require rapid anticoagulant reversal for an emergent surgical procedure. The Food and Drug Administration (FDA) has approved two reversal agents for NOACs: idarucizumab for dabigatran and andexanet alfa for apixaban and rivaroxaban. The American College of Cardiology (ACC), American Heart Association (AHA), and Heart Rhythm Society (HRS) have released an updated guideline for the management of patients with atrial fibrillation that provides indications for the use of these reversal agents. In addition, the final results of the ANNEXA-4 study that evaluated the efficacy and safety of andexanet alfa were recently published. Several agents are in different phases of clinical trials, and among them, ciraparantag has shown promising results. However, their higher cost and limited availability remains a concern. Here, we provide a brief review of the available reversal agents for NOACs (nonspecific and specific), recent updates on reversal strategies, lab parameters (including point-of-care tests), NOAC resumption, and agents in development.

非维生素K拮抗剂口服抗凝剂(NOACs)包括凝血酶抑制剂达比加群和凝血因子Xa抑制剂利伐沙班、阿哌沙班、依多沙班和贝曲沙班。与华法林相比,noac有几个优点,包括更快地达到效果,快速起效,较少记录的食物和药物相互作用,不需要常规INR监测,以及提高患者满意度。局部止血措施、支持性护理和不给下一次NOAC剂量通常足以使出现轻微出血的患者实现止血。对于有严重出血表现(危及生命的出血,或严重不受控制的出血)的NOAC患者,或在紧急外科手术中需要快速抗凝逆转的患者,应考虑给予逆转药物。美国食品和药物管理局(FDA)已经批准了两种用于NOACs的逆转药物:用于达比加群的idarucizumab和用于阿哌沙班和利伐沙班的anddexanet alfa。美国心脏病学会(ACC)、美国心脏协会(AHA)和心律学会(HRS)发布了心房颤动患者管理的最新指南,为这些逆转药物的使用提供了适应症。此外,最近公布了评估anddexanet alfa有效性和安全性的附件4研究的最终结果。几种药物正处于临床试验的不同阶段,其中ciraparantag显示出令人鼓舞的结果。然而,它们的高成本和有限的可用性仍然是一个问题。在这里,我们简要回顾了NOAC的可用逆转药物(非特异性和特异性),逆转策略的最新进展,实验室参数(包括护理点测试),NOAC恢复和正在开发的药物。
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引用次数: 23
Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study. 护士主导干预对阿曼镰状细胞病儿童健康相关生活质量的有效性:一项试点研究
Q3 Medicine Pub Date : 2019-12-28 eCollection Date: 2019-01-01 DOI: 10.1155/2019/6045214
Suthan Pandarakutty, Kamala Murali, Judie Arulappan, Deepa Shaji Thomas

Introduction. The children with Sickle Cell Disease (SCD) generally have poor Health Related Quality of Life (HRQOL). The study aimed to evaluate the effectiveness of nurse led intervention on HRQOL among children with SCD.

Methods: A total of 30 samples were selected using convenient sampling. Children with SCD and their caregivers completed Pediatric Quality of Life Inventory (PedsQL) SCD-Module version 3.0. The nurse led intervention was given to the study group for 10 consecutive weeks. The control group received the routine medical care. On completion of 10 weeks, the post-test was conducted.

Results: The participants in study group had poor HRQOL scores (P > 0.05) in pre-test. After nurse led intervention, the HRQOL score in the study group significantly improved (P > 0.05) in pre-test. After nurse led intervention, the HRQOL score in the study group significantly improved (Discussion. Therefore nurse led intervention is effective in improving HRQOL among children with SCD.

介绍。镰状细胞病(SCD)患儿的健康相关生活质量(HRQOL)普遍较差。本研究旨在评价护士主导干预对SCD患儿HRQOL的影响。方法:采用方便抽样法抽取30份样本。患有SCD的儿童及其护理人员完成了儿童生活质量量表(PedsQL) SCD- module 3.0版。实验组采用护士主导干预,连续10周。对照组给予常规医疗护理。10周结束后进行后测。结果:研究组受试者HRQOL前测评分较差(P > 0.05)。经护理主导干预后,研究组HRQOL前测评分显著提高(P > 0.05)。经护理主导干预后,研究组HRQOL评分明显提高(讨论)。因此,护理主导干预对改善SCD患儿的HRQOL是有效的。
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引用次数: 6
Prognostic Impact of Lymphoid Enhancer Factor 1 Expression and Serum Galectin.3 in Egyptian AML Patients. 淋巴细胞增强因子1表达和血清半凝集素3对埃及AML患者预后的影响。
Q3 Medicine Pub Date : 2019-12-18 eCollection Date: 2019-01-01 DOI: 10.1155/2019/2352919
M A ElBaiomy, S Aref, M El Zaafarany, Sara Atwa, Tamer Akl, Wafaa El-Beshbishi, Shaimaa El-Ashwah, L Ibrahim, M El-Ghonemy

Background: Deregulation of the Wnt signaling pathway had a role in haematological malignancies. Previous studies reported that lymphoid enhancer factor 1 (LEF1) expression and serum Galectin-3 level could affect clinical parameters and outcome in acute myeloid leukemia patients, but as far as we know, no study has addressed their combined effect on AML patients.

Aim: We studied the expression of LEF1 by real-time qPCR and measured serum level of Gal.3 by ELISA technique in peripheral blood of 69 AML patients and correlated it with different clinicopathological criteria of patients, response, PFS and OS.

Results: We found high expression (LEF1high) was associated with better OS (p = 0.02) and EFS (p = 0.019) compared to LEF1low, low serum Gal.3 level had better OS (p = 0.014) and EFS (p = 0.02) compared to high serum Gal.3 level. LEF1high less likely to carry a FLT3-ITD (p = 0.047) compared to LEF1low patient, also LEF1high characterized by favorable risk (p = 0.02) than LEF1low patients. While patients with higher Gal-3 levels characterized by poor risk (p = 0.02) than lower Gal.3 lels, also more likely to carry a FLT3-ITD with borderline significance (p = 0.054). Combined LEF1high/Gal.3 low patients had lower baseline blast percentages (p = 0.02), favorable risk (p = 0.01), less likely to carry FLT3-ITD (p = 0.02), higher CR rate (p = 0.055), shorter time to CR (0.001) than other groups. Among high Gal.3 level group, LEF1highexpression improved OS and EFS (20 and 15 months respectively) vs LEF1low expression (13 and 8 months respectively).

Conclusion: We conclude that high LEF1 expression was a favorable prognostic marker which can define AML patient risk and outcome independent from assessing the serum galectin.3 level.

背景:Wnt信号通路的解除在血液恶性肿瘤中起作用。以往的研究报道了淋巴细胞增强因子1 (LEF1)表达和血清半凝集素-3水平可影响急性髓系白血病患者的临床参数和预后,但据我们所知,尚未有研究探讨它们对急性髓系白血病患者的联合影响。目的:采用实时荧光定量pcr (real-time qPCR)技术研究69例AML患者外周血中LEF1的表达,ELISA技术检测血清中gal3的水平,并将其与患者不同临床病理标准、疗效、PFS和OS进行相关性分析。结果:与LEF1low相比,高表达(LEF1high)与更好的OS (p = 0.02)和EFS (p = 0.019)相关,与高表达(gal3)相比,低表达(LEF1high)与更好的OS (p = 0.014)和EFS (p = 0.02)相关。与LEF1low患者相比,LEF1high患者携带FLT3-ITD的可能性更低(p = 0.047), LEF1high患者也比LEF1low患者具有有利的风险(p = 0.02)。虽然Gal-3水平较高的患者比Gal.3水平较低的患者风险较低(p = 0.02),但也更容易携带FLT3-ITD,具有临界意义(p = 0.054)。结合LEF1high /加。与其他组相比,3例低组患者的基线爆炸百分率较低(p = 0.02),风险较好(p = 0.01),携带FLT3-ITD的可能性较低(p = 0.02), CR率较高(p = 0.055),到达CR所需时间较短(0.001)。在高gal3水平组中,lef1high表达(20个月和15个月)比LEF1low表达(13个月和8个月)改善OS和EFS。结论:高水平的LEF1表达是一个良好的预后标志物,它可以独立于评估血清凝集素来确定AML患者的风险和预后。3级。
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引用次数: 4
Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine 地中海贫血患者红细胞同种免疫频率和特征的研究:来自巴勒斯坦的多中心研究
Q3 Medicine Pub Date : 2019-11-12 DOI: 10.1155/2019/3295786
A. Abu Taha, Ahmad Yaseen, S. Suleiman, Omar Abu Zenah, Hammam Ali, R. Abu Seir, Khaled Younis
Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were examined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen patients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years (range: 12–24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D (33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age, sex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization.
背景β-地中海贫血是巴勒斯坦常见的遗传性溶血性疾病。红细胞(RBC)输注是主要的治疗方法,但它可能导致RBC同种免疫。本研究旨在确定巴勒斯坦北部省份地中海贫血患者红细胞同种免疫的流行率和特征。方法。在巴勒斯坦北部省份的地中海贫血输血中心进行了一项前瞻性多中心观察性研究。这项研究包括215名接受定期输血的地中海贫血患者。检查了患者的临床和输血记录。采用微凝胶技术进行抗体筛选和鉴定。后果215名患者被纳入研究。超过一半(52.1%)的患者是男性。患者的中位年龄为18岁 年(范围:12-24 年)。最常见的血型是A(40.5%),12.6%的患者检测到同种抗体。抗-D(33.3%)、抗K(25.9%)和抗E(14.8%)是最常见的分离抗体。年龄、性别、输血起始年龄、输血单位数、脾切除史和同种异体免疫之间没有关联。结论。抗Rh和抗K抗体在这组患者中很常见。年龄、性别、输血起始年龄、输血单位数和脾切除史不能预测同种免疫的发生。
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引用次数: 4
Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience 髓系和淋巴系肿瘤共存:单中心经验
Q3 Medicine Pub Date : 2019-11-03 DOI: 10.1155/2019/1486476
A. Bouchla, T. Thomopoulos, S. Papageorgiou, P. Tsirigotis, E. Bazani, K. Gkirkas, Diamantina Vasilatou, Eirini Glezou, Georgia Stavroulaki, Konstantinos Gkontopoulos, G. Dimitriadis, V. Pappa
The coexistence of a myeloid and a lymphoid neoplasm in the same patient is a rare finding. We retrospectively searched the records of the Hematology Division of the Second Department of Internal Medicine and Research Institute at Attikon University General Hospital of Athens from 2003 to 2018. Nine cases have been identified in a total of 244 BCR-/ABL1- negative MPN and 25 MDS/MPN patients and 1062 LPD patients referred to our institution between 2003 and 2018. Each case is distinct in the diversity of myeloid and lymphoid entities, the chronological occurrence of the two neoplasms, and the patient clinical course. All of them exhibit myeloproliferative (6 JAK2 V617F-positive cases) and lymphoproliferative features, with 1 monoclonal B-cell lymphocytosis (MBL), 3 B-chronic lymphocytic leukemias (B-CLL), 3 B-non-Hodgkin lymphomas (B-NHL), 1 multiple myeloma (MM), and 1 light and heavy deposition disease (LHCDD), while in three cases myelodysplasia is also present. The challenges in identifying and dealing with these rare situations in everyday clinical practice are depicted in this article.
骨髓和淋巴肿瘤在同一患者中共存是一种罕见的发现。我们回顾性检索了2003年至2018年雅典阿提康大学总医院第二内科和研究所血液科的记录。2003年至2018年间,在我们机构转诊的244名BCR-/ABL1阴性MPN患者、25名MDS/MPN患者和1062名LPD患者中,共发现9例病例。每个病例在骨髓和淋巴实体的多样性、两种肿瘤的发生时间和患者的临床病程方面都不同。所有病例均表现出骨髓增生性(6例JAK2 V617F阳性病例)和淋巴增生性特征,其中1例为单克隆B细胞淋巴细胞增多症(MBL),3例为慢性B淋巴细胞白血病(B-CLL),2例为非霍奇金淋巴瘤(B-NHL),1例为多发性骨髓瘤(MM)和1例为轻度和重度沉积病(LHCDD),同时还有3例骨髓发育不良。本文描述了在日常临床实践中识别和处理这些罕见情况的挑战。
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引用次数: 5
Prevalence of Anemia and Associated Factors among Newly Diagnosed Patients with Solid Malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴Tikur Anbessa专科医院放射治疗中心新诊断的实体恶性肿瘤患者贫血患病率及相关因素
Q3 Medicine Pub Date : 2019-10-20 DOI: 10.1155/2019/8279789
Edosa Kifle Tola, Mintewab Hussein, Jemal Alemu, Wondemagegnhu Tigeneh
Background Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients, worsens disease status and impairs treatment outcome; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. In response to this, we have conducted research with the aim of assessing the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital (TASH), Radiotherapy center, Addis Ababa, Ethiopia. Methods Descriptive cross-sectional study was conducted from April to May 2014. A total of 422 newly diagnosed patients with solid malignancy attending Radiotherapy center, TASH were enrolled to assess anemia prevalence and associated factors. Data were coded, entered and analyzed using SPSS version16. Using logistic regression, chi squares, Odds ratio and 95% confidence intervals were computed to measure strength of association between variables. p-value < 0.05 was taken as statistically significant. Result Out of 422 respondents, 285 (68%) were females and 153 (36%) of respondents fell into 35–49 age group with age range between 18 and 80 years and the median age of 45. Magnitude of solid cancers was gynecologic (28.9%), breast (22.7%), nasopharyngeal carcinoma (NPC) (7.6%), colorectal (7.1%), sarcoma (6.9%), head and neck (4.5%), thyroid (3.3%), hepatoma (1.9%), and others (17.1%). The overall prevalence of anemia across different tumor was 23% and higher anemia prevalence was noted in gynecologic (37.7%) and colorectal carcinomas (26.7%). The majority of the anemic patients (68%) remained untreated for anemia. The mean trigger hemoglobin for transfusion was 7.7 g/dl. About 83.5% of anemia was mild to moderate type. Performance status (AOR = 3.344; 95% CI 1.410–7.927) and bleeding history (AOR = 3.628; 95% CI 1.800–7.314) showed statistically significant association with occurrence of anemia with p-value < 0.05. Conclusion Among solid cancers, gynecologic cancer remained the dominant one. Anemia prevalence was 23% in general, in which gynecologic and colorectal cancers were more prevalent. ECOG performance status and bleeding history showed a statistically significant association with the occurrence of anemia.
背景:贫血是癌症中常见的发现,它是由许多因素引起的。它是癌症患者发病的主要原因,使疾病状况恶化并损害治疗结果;然而,在埃塞俄比亚等发展中国家,人们对诊断期间癌症患者中贫血和相关因素的患病率知之甚少。为此,我们在埃塞俄比亚亚的斯亚贝巴的Tikur Anbessa专科医院(TASH)放射治疗中心开展了一项研究,目的是评估新诊断的实体恶性肿瘤患者中贫血的患病率及相关因素。方法描述性横断面研究于2014年4 - 5月进行。纳入422例在TASH放疗中心就诊的新诊断实体恶性肿瘤患者,评估贫血患病率及相关因素。使用SPSS version16对数据进行编码、录入和分析。采用逻辑回归,计算卡方、优势比和95%置信区间来衡量变量之间的关联强度。p值< 0.05为差异有统计学意义。结果422名受访者中,女性285人(68%),年龄在35 ~ 49岁之间的153人(36%),年龄在18 ~ 80岁之间,中位年龄为45岁。实体癌的大小为妇科(28.9%)、乳腺癌(22.7%)、鼻咽癌(NPC)(7.6%)、结直肠癌(7.1%)、肉瘤(6.9%)、头颈部(4.5%)、甲状腺(3.3%)、肝癌(1.9%)和其他(17.1%)。不同肿瘤的总体贫血率为23%,其中妇科(37.7%)和结直肠癌(26.7%)的贫血率较高。大多数贫血患者(68%)仍未接受治疗。输血触发血红蛋白平均值为7.7 g/dl。约83.5%的贫血为轻中度贫血。性能状态(AOR = 3.344;95% CI 1.410-7.927)和出血史(AOR = 3.628;95% CI(1.800 ~ 7.314)与贫血的发生有统计学意义,p值< 0.05。结论在实体癌中,以妇科癌为主。总体而言,贫血患病率为23%,其中妇科和结直肠癌更为普遍。ECOG表现状态和出血史与贫血的发生有统计学意义。
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引用次数: 14
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Advances in Hematology
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