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A Clearer Picture: MRI's Expanding Role in High-Risk Pregnancy Care 更清晰的图像:MRI在高危妊娠护理中的作用越来越大
Pub Date : 2025-06-13 DOI: 10.1002/ird3.70023
Su-Zhen Dong, Fu-Tsuen Lee, Lianxiang Xiao, Liqun Sun
<p>In recent decades, maternal–fetal medicine has undergone substantial advancements in the management of high-risk pregnancies. These include enhanced prenatal screening and diagnosis facilitated by innovations in ultrasound imaging, as well as the advances in fetal medical and interventional therapies informed by the deeper understanding of pathophysiological mechanisms underlying fetal and maternal disease processes. Collectively, these have contributed to measurable reductions in maternal and perinatal morbidity and mortality [<span>1</span>]. However, the identification of certain fetal conditions using ultrasound remains challenging because of suboptimal acoustic windows, fetal positioning, maternal body habitus, and limited soft tissue contrast [<span>2</span>]. These challenges can delay diagnosis and management, and potentially impact the timing of interventions, as well as the quality of prenatal counseling regarding the child's future health, development, and quality of life.</p><p>Recent advances in fetal magnetic resonance imaging (MRI) have emerged as a feasible alternative when ultrasound findings are inconclusive or limited. Fetal MRI offers superior soft tissue contrast which can enhance the characterization of complex fetal conditions. This was facilitated by the development of accelerated image acquisition techniques and motion-correction algorithms to reduce maternal breathing and fetal movement artifacts, thereby reducing scan times and improving the overall image quality [<span>3</span>]. Therefore, fetal MRI could serve as a valuable adjunct to clinical assessment, optimizing prenatal management and facilitating targeted interventions in high-risk pregnancies.</p><p>This special issue explores the expanding role of fetal MRI in the diagnosis, prognosis, and planning of interventions in complex fetal conditions in high-risk pregnancies.</p><p>Fetal MRI offers enhanced anatomical resolution and tissue characterization of the developing fetal brain [<span>4</span>]. Ren et al. provided a comprehensive review on the utility of fetal MRI on the diagnosis of congenital brain tumors including teratomas, astrocytomas, and choroid plexus tumors [<span>5</span>]. Key findings include superior tissue contrast to characterize tumor morphology, volume, and mass effect, which may prompt additional investigations for associated pathologies, guide the timing of delivery for postnatal interventions, and aid prenatal counseling [<span>6</span>]. Liu and Xiao presented a rare case of fetal periventricular nodular heterotopia identified by fetal MRI after ultrasound detection of a posterior fossa cyst [<span>7</span>]. Fetal MRI detected a gray matter nodule in the right lateral ventricular wall leading to suspicion of fetal gray matter heterotopia, which was confirmed by brain MRI at 7 months of age with no associated abnormal neurological presentation. Although a neuronal migration disorder, these findings highlight some individuals may not
分析诊断为先天性肝血管瘤[14]患者的超声和胎儿MRI产前影像学特征及产后预后。总体而言,较大的肿瘤(≥4cm)伴有混合回声和更高的并发症风险。值得注意的是,先前未描述的增生-退行性生长模式被确定。这些发现为先天性肝血管瘤的特征和疾病进展提供了额外的信息。胎儿MRI越来越多地被整合到子宫内外科手术的术前计划中。Bian等人全面回顾了MRI在指导宫内治疗程序、开放式胎儿手术、胎儿镜干预和经皮技术中的作用[10]。胎儿MRI可以精确地绘制病变及其与邻近结构的关系,促进风险评估和个体化手术计划。在妊娠早期,MRI在诊断胎盘植入异常的非典型表现中也可能发挥重要作用。Song和Li报告了一例腹膜后异位妊娠,基于超声发现[16],最初怀疑为磨牙妊娠;然而,人绒毛膜促性腺激素在子宫引流后仍然升高。进一步的胎儿MRI检查显示骶骨前部有囊性肿块,手术切除证实了异位妊娠的诊断。本病例说明了当初步调查不确定或临床解决不完全时,MRI在澄清非典型表现方面的应用。随着胎儿MRI技术的不断进步,其在改善复杂胎儿状况的诊断和预测方面的潜力日益明显。除了高分辨率解剖成像,功能成像的整合,如胎儿四维血流MRI,提供了更详细地评估胎儿血流动力学的机会。这些方法可能为循环障碍对围产期结局的影响提供有价值的见解。此外,人工智能在产前成像方面的应用也越来越多。自动分割和模式识别算法有望简化图像分析,减少观察者之间的可变性,并支持预测风险分层模型的开发。最终,这些创新可能有助于指导临床决策,并有助于改善母胎结局。董素珍:构思(主笔),写作-原稿准备(主笔),写作-审稿编辑(主笔)。李富荃:构思(支持),写作-原稿准备(支持),写作-审查和编辑(支持)。肖莲香:构思(主导)、写作-原稿编写(主导)、写作-审稿编辑(主导)、监督(平等)。孙立群:构思(主讲)、撰写-原稿编写(主讲)、撰写-审稿编辑(主讲)、监督(主讲)。作者没有什么可报告的。作者没有什么可报告的。这篇文章属于特刊(SI)-胎儿成像,产妇和儿童成像。作为《科学》特邀编辑,董素珍、肖连祥和孙立群教授不参与与本文发表有关的所有编辑决策。其余的作者声明没有利益冲突。
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引用次数: 0
Automated Color Coding in Musculoskeletal MR Imaging 肌肉骨骼磁共振成像中的自动颜色编码
Pub Date : 2025-06-13 DOI: 10.1002/ird3.70022
Saavi Reddy Pellakuru, Sonal Saran, Syed Alam, Sameer Raniga, David Beale, Rajesh Botchu

Background

Magnetic resonance imaging (MRI) is crucial in modern medical diagnostics, providing detailed insights into soft tissue structures and pathological changes. Traditional grayscale images can sometimes obscure critical details, complicating accurate interpretations. Automated color coding of the MRI signal intensities may enhance the visualization of various pathologies, potentially leading to improved diagnostic accuracy and image quality. This paper aims to explore the effectiveness of color-coded MR image reconstruction in enhancing both diagnostic precision and overall image quality in musculoskeletal MRI.

Methods

Two fellowship-trained musculoskeletal radiologists evaluated the images reconstructed with color coding, rating their diagnostic value, image quality, and visual appeal using a five-point Likert scale. To assess interrater reliability, Cohen's Kappa statistical analysis was performed. Additionally, descriptive statistics summarizing the Likert scores for diagnostic value, image quality, and visual appeal of the reconstructed images have been described.

Results

Statistical analysis of the data revealed that the diagnostic value, image value, and visual appeal of the color-coded MR images were excellent in almost two-thirds of the data set. The minimum Likert score recorded was 3, signifying a good quality rating.

Conclusion

Our study shows positive results, supporting the efficiency of color-coded MR imaging in aiding the conventional gray scale MR imaging to improve its diagnostic efficiency.

磁共振成像(MRI)在现代医学诊断中至关重要,它提供了对软组织结构和病理变化的详细见解。传统的灰度图像有时会模糊关键细节,使准确的解释变得复杂。MRI信号强度的自动彩色编码可以增强各种病理的可视化,潜在地提高诊断准确性和图像质量。本文旨在探讨彩色编码磁共振图像重建在提高肌肉骨骼MRI诊断精度和整体图像质量方面的有效性。方法两名训练有素的肌肉骨骼放射科医师对彩色编码重建的图像进行评估,使用五点李克特量表评定其诊断价值、图像质量和视觉吸引力。为了评估互译者的信度,采用Cohen’s Kappa统计分析。此外,描述性统计总结了诊断价值,图像质量和重建图像的视觉吸引力的李克特分数。结果对数据的统计分析显示,在近三分之二的数据集中,彩色编码的MR图像的诊断价值、图像价值和视觉吸引力都很好。最低李克特评分记录为3,表示良好的质量评级。结论彩色编码磁共振成像在辅助传统灰度磁共振成像提高诊断效率方面具有积极意义。
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引用次数: 0
Retroperitoneal Ectopic Pregnancy 腹膜后异位妊娠
Pub Date : 2025-06-13 DOI: 10.1002/ird3.70019
Qingying Song, Dan Li

A 35-year-old woman with a history of regular menstruation presented with a positive urine pregnancy test and elevated blood human chorionic gonadotropin concentrations. Color Doppler ultrasound showed multiple slightly hyperechoic areas within the uterine cavity. She was admitted to the hospital with a preliminary outpatient diagnosis of “suspected molar pregnancy, pending further evaluation.” After electrocution and curettage, no villous tissue was identified, and postoperative human chorionic gonadotropin concentrations failed to decline. Pelvic MRI showed a round, thick-walled cystic mass in the anterior sacral region (Figure 1). Color Doppler ultrasound showed that the cystic mass contained a yolk sac, fetal bud, and fetal cardiac activity (Figure 2). Surgical pathology subsequently confirmed the presence of villous tissue, consistent with a diagnosis of ectopic pregnancy.

Qingying Song: writing – original draft preparation (lead), writing – review and editing (lead). Dan Li: writing – original draft preparation (supporting), writing – review and editing (supporting).

The study was reviewed and approved by the Ethics Committee of Linyi Maternal and Child Health Hospital (QTL-YXLL-2023080).

Informed consent was waived because the patient’s information has been anonymized, which was approved by the ethics committee.

The authors declare no conflicts of interest.

35岁女性,月经规律,尿妊娠试验阳性,血人绒毛膜促性腺激素浓度升高。彩色多普勒超声显示子宫腔内多发轻度高回声区。她入院时,初步门诊诊断为“疑似臼齿妊娠,有待进一步评估”。触电和刮除后,未发现绒毛组织,术后人绒毛膜促性腺激素浓度未下降。骨盆MRI显示骶前区一个圆形厚壁囊性肿块(图1)。彩色多普勒超声显示囊性肿块包含卵黄囊、胎儿芽和胎儿心脏活动(图2)。手术病理随后证实了绒毛组织的存在,与异位妊娠的诊断一致。宋庆英:写作-原稿准备(主笔),写作-审稿编辑(主笔)。李丹:写作-原稿准备(辅助),写作-审稿编辑(辅助)。本研究经临沂市妇幼保健院伦理委员会(QTL-YXLL-2023080)审核通过。由于患者的信息已经匿名化,因此放弃了知情同意,这得到了伦理委员会的批准。作者声明无利益冲突。
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引用次数: 0
Value of Magnetic Resonance Spectroscopy for Examining Fetal Brain Development in Mid- to Late Pregnancy 磁共振波谱在妊娠中后期胎儿脑发育检查中的价值
Pub Date : 2025-05-19 DOI: 10.1002/ird3.70012
Dejuan Shan, Yi Zhang, Maobo Wang, Yanyan Liu, Yudong Wang, Lianxiang Xiao

Background

Magnetic resonance spectroscopy (MRS) represents a significant advancement in the noninvasive assessment of brain metabolism. MRS can provide valuable metabolic information and facilitate more accurate diagnoses of intrauterine fetal brain development than was previously possible. To obtain information regarding normal intrauterine fetal brain metabolism and to establish gestational age-specific reference values for normal fetal brain metabolites for subsequent use in MRS, we conducted MRS scans of normal fetal brains during mid- to late-term pregnancies, along with related processing.

Methods

In this prospective study, MRS scans were conducted on 109 fetuses, with a total of 54 normal fetal brains enrolled on the basis of specific inclusion and exclusion criteria. We analyzed metabolic ratios, including the sum of N-acetylaspartate (NAA) and total N-acetylaspartate (tNAA), total choline (tCho), inositol (Ins), and total creatine (tCr), in relation to gestational age.

Results

Gestational age was significantly correlated with specific metabolic ratios (Ins/tCr: r = −0.75, p < 0.0001; tCho/tCr: r = −0.50, p < 0.0001), especially tNAA/tCho (tNAA/tCho: r = 0.54, p < 0.0001) and tNAA/Ins (r = 0.56, p < 0.0001), providing a baseline for fetal brain metabolic assessment. Linear regression analysis was used to calculate regression lines for fetal brain metabolite ratios. Slopes were tested at p of 0.05.

Conclusions

The current findings confirmed a significant correlation between fetal brain metabolites and gestational age, supporting the feasibility of establishing standard values for these metabolites in fetal brain assessment.

磁共振波谱(MRS)在无创脑代谢评估方面取得了重大进展。MRS可以提供有价值的代谢信息,并比以前更准确地诊断宫内胎儿大脑发育。为了获得有关正常宫内胎儿脑代谢的信息,并建立正常胎儿脑代谢物的孕龄特异性参考值,以供随后在MRS中使用,我们对妊娠中后期的正常胎儿脑进行了MRS扫描,并进行了相关处理。方法在这项前瞻性研究中,对109例胎儿进行了MRS扫描,根据特定的纳入和排除标准,共纳入54例正常胎儿脑。我们分析了代谢比率,包括n -乙酰天冬氨酸(NAA)和总n -乙酰天冬氨酸(tNAA)、总胆碱(tCho)、肌醇(Ins)和总肌酸(tCr)与胎龄的关系。结果胎龄与特定代谢比(Ins/tCr: r = - 0.75, p <;0.0001;tCho/tCr: r = - 0.50, p <;0.0001),尤其是tNAA/tCho (tNAA/tCho: r = 0.54, p <;0.0001)和tNAA/Ins (r = 0.56, p <;0.0001),为胎儿脑代谢评估提供基线。采用线性回归分析计算胎儿脑代谢物比值回归线。斜率检验p = 0.05。结论目前的研究结果证实了胎儿脑代谢物与胎龄之间的显著相关性,支持了在胎儿脑评估中建立这些代谢物标准值的可行性。
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引用次数: 0
Fetal Gray Matter Heterotopia 胎儿灰质异位
Pub Date : 2025-05-12 DOI: 10.1002/ird3.70010
Jiaojiao Liu, Lianxiang Xiao

A pregnant woman underwent fetal brain magnetic resonance imaging (MRI) following ultrasound detection of a posterior fossa cyst at 29 weeks' gestation. She presented with no relevant medical history and underwent a routine obstetric examination during pregnancy. The fetal head position, fetal cranial development, and limb development remained normal until 29 weeks. A fetal MRI examination showed a posterior fossa cyst, and another nodular gray matter signal was observed adjacent to the right lateral ventricle. Follow-up MRI at 31 weeks + 3 days showed no major changes (Figure 1). The patient successfully delivered a male neonate at 40 weeks' gestation. A brain MRI was performed at 7 months of age and confirmed the diagnosis of fetal gray matter heterotopia (GMH) (periventricular type) (Figure 2). He showed no neurological abnormalities such as epilepsy. Moreover, his skin manifestations were normal, and his growth and development were consistent with his monthly age.

Fetal GMH is a relatively uncommon congenital disorder that arises from impaired neuronal migration. The three main types of GMH are periventricular nodular heterotopia, subcortical heterotopia, and subcortical band heterotopia. The most common type is periventricular nodular heterotopia, as found in the present case. GMH can sometimes be accompanied by other abnormalities, such as ventriculomegaly, agenesis of the corpus callosum, and congenital heart disease. Fetal MRI is increasingly being used to diagnose fetal GMH because of its high soft tissue resolution. However, there have been few reports of pathological or postnatally confirmed fetal GMH.

Jiaojiao Liu: writing – original draft (lead). Lianxiang Xiao: conceptualization (lead), supervision (lead).

This study was approved by Shandong Provincial Maternal and Child Research Ethics Approval (Approval No.: 2024-13).

The case was retrospectively analysed, the fetal and postnatal imaging data used were from previous medical records, and the images were anonymised, which does not pose a risk of compromising the patient's privacy. Therefore, informed consent was exempted.

This article belongs to a special issue (SI)—fetal imaging, maternal and children imaging. As the SI's guest editor, Professor Lianxiang Xiao is excluded from all the editorial decisions related to the publication of this article. The remaining author declares no conflicts of interest.

一名怀孕妇女在妊娠29周超声检测后接受胎儿脑磁共振成像(MRI)检查后颅窝囊肿。她没有相关病史,并在怀孕期间接受了常规产科检查。胎儿头部位置、颅骨发育和肢体发育保持正常,直到29周。胎儿MRI检查显示后窝囊肿,右侧脑室附近观察到另一个结节状灰质信号。随访31周+ 3天MRI未见明显变化(图1)。患者在妊娠40周时成功产下一名男婴。7个月大时进行脑MRI检查,确诊为胎儿灰质异位(GMH)(脑室周围型)(图2)。他没有癫痫等神经系统异常。此外,他的皮肤表现正常,他的生长发育符合他的月龄。胎儿GMH是一种相对罕见的先天性疾病,由神经元迁移受损引起。GMH的三种主要类型是脑室周围结节性异位、皮质下异位和皮质下带状异位。最常见的类型是脑室周围结节性异位,如本病例所见。GMH有时可伴有其他异常,如脑室肿大、胼胝体发育不全和先天性心脏病。由于其高软组织分辨率,胎儿MRI越来越多地被用于诊断胎儿GMH。然而,很少有病理或出生后证实的胎儿GMH的报道。刘娇娇:写作——原稿(主笔)。肖连祥:概念化(引领)、监督(引领)。本研究经山东省妇幼研究伦理批准(批准号:: 2024 - 13)。对该病例进行回顾性分析,使用的胎儿和产后成像数据来自以前的医疗记录,并且图像是匿名的,这不会造成损害患者隐私的风险。因此,不需要知情同意。本文属于特刊(SI)——胎儿影像、母婴影像。作为《科学》特邀编辑,肖连祥教授不参与与本文发表有关的所有编辑决策。其余的作者声明没有利益冲突。
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引用次数: 0
Performance Review of Meta LLaMa 3.1 in Thoracic Imaging and Diagnostics Meta LLaMa 3.1在胸部成像和诊断中的性能评价
Pub Date : 2025-05-11 DOI: 10.1002/ird3.70013
Golnaz Lotfian, Keyur Parekh, Pokhraj P. Suthar

Background

The integration of artificial intelligence (AI) in radiology has opened new possibilities for diagnostic accuracy, with large language models (LLMs) showing potential for supporting clinical decision-making. While proprietary models like ChatGPT have gained attention, open-source alternatives such as Meta LLaMa 3.1 remain underexplored. This study aims to evaluate the diagnostic accuracy of LLaMa 3.1 in thoracic imaging and to discuss broader implications of open-source versus proprietary AI models in healthcare.

Methods

Meta LLaMa 3.1 (8B parameter version) was tested on 126 multiple-choice thoracic imaging questions selected from Thoracic Imaging: A Core Review by Hobbs et al. These questions required no image interpretation. The model’s answers were validated by two board-certified diagnostic radiologists. Accuracy was assessed overall and across subgroups, including intensive care, pathology, and anatomy. Additionally, a narrative review introduces three widely used AI platforms in thoracic imaging: DeepLesion, ChexNet, and 3D Slicer.

Results

LLaMa 3.1 achieved an overall accuracy of 61.1%. It performed well in intensive care (90.0%) and terms and signs (83.3%) but showed variability across subgroups, with lower accuracy in normal anatomy and basic imaging (40.0%). Subgroup analysis revealed strengths in infectious pneumonia and pleural disease, but notable weaknesses in lung cancer and vascular pathology.

Conclusion

LLaMa 3.1 demonstrates promise as an open-source NLP tool in thoracic diagnostics, though its performance variability highlights the need for refinement and domain-specific training. Open-source models offer transparency and accessibility, while proprietary models deliver consistency. Both hold value, depending on clinical context and resource availability.

人工智能(AI)在放射学中的整合为诊断准确性开辟了新的可能性,大型语言模型(llm)显示出支持临床决策的潜力。虽然像ChatGPT这样的专有模型已经引起了人们的注意,但像Meta LLaMa 3.1这样的开源替代方案仍未得到充分开发。本研究旨在评估LLaMa 3.1在胸部成像中的诊断准确性,并讨论开源与专有人工智能模型在医疗保健领域的更广泛影响。方法Meta LLaMa 3.1 (8B参数版)对Hobbs等人从《thoracic imaging: A Core Review》中选择的126道胸部影像学选择题进行测试。这些问题不需要图像解释。该模型的答案由两名委员会认证的诊断放射科医生验证。准确性进行了总体和跨亚组评估,包括重症监护、病理和解剖。此外,本文还介绍了三种广泛应用于胸部成像的人工智能平台:DeepLesion、ChexNet和3D Slicer。结果LLaMa 3.1的总体准确率为61.1%。它在重症监护(90.0%)和术语和体征(83.3%)方面表现良好,但在亚组之间表现出差异,正常解剖和基本影像学的准确性较低(40.0%)。亚组分析显示在感染性肺炎和胸膜疾病方面有优势,但在肺癌和血管病理学方面有明显的劣势。结论LLaMa 3.1有望成为胸腔诊断的开源NLP工具,但其性能的可变性突出了改进和特定领域训练的必要性。开源模型提供透明性和可访问性,而专有模型提供一致性。两者都有价值,取决于临床环境和资源的可用性。
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引用次数: 0
Association Between Fetal Myocardial Alterations and Congenital Heart Disease Based on Post-Mortem Myocardial MRI 基于死后心肌MRI的胎儿心肌改变与先天性心脏病的关系
Pub Date : 2025-05-09 DOI: 10.1002/ird3.70011
Weizeng Zheng, Xia Ying, Yuan Chen, Le Wang, Peiyue Jiang, Ying Jiang, Guohui Yan, Hong Wang, Yimin Zhou, Yun Liang, Yu Zou, Liqun Sun, Qiong Luo

Background

Congenital heart disease (CHD) results from abnormal heart development during fetal development, leading to life-threatening complications. This study aimed to evaluate the feasibility of applying myocardial parametric mapping in post-mortem magnetic resonance imaging and to examine differences in the left ventricular myocardium between fetuses with CHD and controls.

Methods

This prospective case–control study was conducted on 14 deceased fetuses with CHD (CHD group) and 24 fetuses without CHD (control group). Fetuses with CHD were further stratified into the cyanotic (n = 9) and non-cyanotic (n = 5) CHD groups. T1, T2, and proton density relaxation times of the left ventricular myocardium were calculated and compared using multiple-dynamic multiple-echo post-mortem magnetic resonance imaging technology.

Results

The myocardial T2 relaxation time was significantly different between the groups (p = 0.033), with no difference in T1 or proton density relaxation times between the groups. A one-way analysis of variance with Tukey's test showed that the mean cyanotic CHD group showed a longer myocardial T2 relaxation time than the control group (98.000 ± 13.143 vs. 83.542 ± 9.491 ms, p = 0.003). Additionally, the correlation coefficient in the CHD group was significantly different between the myocardial T2 relaxation time and peak systolic velocity of pulmonary artery on a fetal echocardiogram (r2 = 0.681, p = 0.010).

Conclusions

These results suggest that using myocardial alterations in the T2 relaxation time may provide a accurate early warning for myocardial injury and enable noninvasive recognition of cardiac involvement in fetuses with CHD.

先天性心脏病(CHD)是由胎儿发育过程中心脏发育异常引起的,可导致危及生命的并发症。本研究旨在探讨心肌参数定位在死后磁共振成像中应用的可行性,并探讨冠心病胎儿与对照组左心室心肌的差异。方法采用前瞻性病例对照研究,选取14例已死亡的冠心病胎儿(冠心病组)和24例未死亡的冠心病胎儿(对照组)。将合并冠心病的胎儿进一步分为紫绀型(n = 9)和非紫绀型(n = 5)冠心病组。采用多动态多回声死后磁共振成像技术计算并比较左心室心肌T1、T2、质子密度松弛时间。结果心肌T2舒张时间组间差异有统计学意义(p = 0.033), T1、质子密度舒张时间组间差异无统计学意义(p = 0.033)。单因素方差分析显示,紫绀型冠心病组心肌T2舒张时间明显长于对照组(98.000±13.143 ms∶83.542±9.491 ms, p = 0.003)。冠心病组胎儿超声心动图心肌T2舒张时间与肺动脉收缩峰值速度的相关系数差异有统计学意义(r2 = 0.681, p = 0.010)。结论利用心肌T2舒张时间的变化可以准确预警冠心病胎儿心肌损伤,实现无创识别心脏受累。
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引用次数: 0
Application of Artificial Intelligence in Medical Imaging: Current Status and Future Directions 人工智能在医学影像学中的应用:现状与未来方向
Pub Date : 2025-04-09 DOI: 10.1002/ird3.70008
Yixin Yang, Lan Ye, Zhanhui Feng

A revolution in medical diagnosis and treatment is being driven by the use of artificial intelligence (AI) in medical imaging. The diagnostic efficacy and accuracy of medical imaging are greatly enhanced by AI technologies, especially deep learning, that performs image recognition, feature extraction, and pattern analysis. Furthermore, AI has demonstrated significant promise in assessing the effects of treatments and forecasting the course of diseases. It also provides doctors with more advanced tools for managing the conditions of their patients. AI is poised to play a more significant role in medical imaging, especially in real-time image processing and multimodal fusion. By integrating multiple forms of image data, multimodal fusion technology provides more comprehensive disease information, whereas real-time image analysis can assist surgeons in making more precise decisions. By tailoring treatment regimens to each patient's unique needs, AI enhances both the effectiveness of treatment and the patient experience. Overall, AI in medical imaging promises a bright future, significantly enhancing diagnostic precision and therapeutic efficacy, and ultimately delivering higher-quality medical care to patients.

人工智能(AI)在医学成像中的应用正在推动医学诊断和治疗的革命。人工智能技术,特别是深度学习技术,可以进行图像识别、特征提取和模式分析,大大提高了医学成像的诊断效果和准确性。此外,人工智能在评估治疗效果和预测疾病进程方面显示出了巨大的前景。它还为医生提供了更先进的工具来管理病人的病情。人工智能将在医学成像领域发挥更重要的作用,特别是在实时图像处理和多模态融合方面。多模态融合技术通过整合多种形式的图像数据,提供更全面的疾病信息,而实时图像分析可以帮助外科医生做出更精确的决策。通过根据每位患者的独特需求定制治疗方案,人工智能提高了治疗效果和患者体验。总体而言,人工智能在医学成像领域的前景一片光明,它将显著提高诊断精度和治疗效果,最终为患者提供更高质量的医疗服务。
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引用次数: 0
Utilizing Radiomics as Predictive Factor in Brain Metastasis Treated With Stereotactic Radiosurgery: Systematic Review and Radiomic Quality Assessment 利用放射组学作为立体定向放射治疗脑转移的预测因素:系统评价和放射质量评估
Pub Date : 2025-04-07 DOI: 10.1002/ird3.70007
Abdulrahman Umaru, Hanani Abdul Manan, Ramesh Kumar Athi Kumar, Siti Khadijah Hamsan, Noorazrul Yahya

Radiomics and machine learning (ML) are increasingly utilized to predict treatment response by uncovering latent information in medical images. This study systematically reviews radiomics studies on brain metastasis treated with stereotactic radiosurgery (SRS) and quantifies their radiomic quality score (RQS). A systematic search on Scopus, Web of Science, and PubMed was conducted to identify original studies on radiomics for predicting treatment response, adhering to predefined patient, intervention, comparator, and outcome (PICO) criteria. No restrictions were placed on language or publication date. Two independent reviewers assessed eligible studies, and the RQS was calculated based on Lambin’s guidelines. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines were followed. Seventeen studies involving 2744 patients met the inclusion criteria out of 200 identified. All studies were retrospective and utilizing various MRI scanners models with different field strength. The average RQS across studies was low (39.2%), with a maximum score of 19 points (52.7%). Radiomic-based models demonstrated superior predictive accuracy compared to clinical or visual assessment, with AUC values ranging from 0.74 to 0.92. Integration of clinical features such as Karnofsky performance status, dose, and isodose line further improved model performance. Deep learning models achieved the highest predictive accuracy, with AUC of 0.92. Radiomics demonstrate significant potential in predicting treatment outcomes with high accuracy, offering opportunities to advance personalized management for BM. To facilitate clinical adoption, future studies must prioritize adherence to standardized guidelines and robust model validation to ensure reproducibility.

放射组学和机器学习(ML)越来越多地用于通过发现医学图像中的潜在信息来预测治疗反应。本研究系统回顾了立体定向放射外科(SRS)治疗脑转移的放射组学研究,并量化了它们的放射质量评分(RQS)。我们对Scopus、Web of Science和PubMed进行了系统搜索,以确定放射组学用于预测治疗反应的原始研究,并遵循预定义的患者、干预、比较物和结果(PICO)标准。对语言和出版日期没有限制。两名独立审稿人评估了符合条件的研究,RQS是根据Lambin的指南计算的。遵循系统评价和荟萃分析(PRISMA) 2020指南的首选报告项目。17项涉及2744名患者的研究符合纳入标准。所有的研究都是回顾性的,使用不同场强的MRI扫描仪模型。各研究的平均RQS较低(39.2%),最高得分为19分(52.7%)。与临床或视觉评估相比,基于放射组学的模型显示出更高的预测准确性,AUC值范围为0.74至0.92。临床特征如Karnofsky性能状态、剂量和等剂量线的整合进一步提高了模型的性能。深度学习模型的预测精度最高,AUC为0.92。放射组学在预测治疗结果方面具有很高的准确性,为BM的个性化管理提供了机会。为了促进临床应用,未来的研究必须优先遵循标准化指南和稳健的模型验证,以确保可重复性。
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引用次数: 0
Implications of Artificial Intelligence in Stroke Intervention and Care 人工智能在脑卒中干预和护理中的意义
Pub Date : 2025-04-04 DOI: 10.1002/ird3.70005
Jyoti Yadav, Aditya More, Bijoyani Ghosh, Doni Sinha, Nikita Chavane, Anita Kumari, Aishika Datta, Anupom Borah, Pallab Bhattacharya

Artificial intelligence (AI) technology is expanding at a rapid pace, offering means of improving the precision of judgments made by medical professionals. AI-driven machine learning (ML) facilitates rapid and effective data processing for diagnosis and treatment of different diseases including stroke. This technology has vastly improved the patient classification based on their predicted stroke outcome. It helps in quicker decision-making, improves diagnosis precision, and enhances patient care. ML techniques have occasionally been applied extensively to address complex issues related to stroke such as the prediction of stroke prevalence at an early stage. The ability of deep learning (DL) algorithms, a crucial element of AI, is becoming popular in stroke imaging analysis because it automatically extracts features without requiring domain expertise. In the preclinical setup for stroke studies, ML/DL models are commendably used for the detection of vascular thrombi, stroke core, and penumbra size, to identify artery occlusion, compute perfusion maps, detect intracranial hemorrhage (ICH), prediction of infarct, assessing the severity of hemorrhagic transformation, and forecasting patient outcomes. The robust automatic data processing, excellent generalization, self-learning, and precise decision-making abilities of such models have contributed immensely to the advancement of stroke therapy. In the preclinical setup, the time-investing behavioral studies of the animals are also effectively analyzed by AI based algorithms. Understanding the algorithms and models based on AI is yet to be simplified for its application in stroke therapy in present clinical settings, thus, in the present review attempts have been made to present it in a simplified manner to facilitate translation.

人工智能(AI)技术正在快速发展,为提高医疗专业人员的判断精度提供了手段。人工智能驱动的机器学习(ML)为包括中风在内的不同疾病的诊断和治疗提供了快速有效的数据处理。这项技术极大地改善了基于预测中风结果的患者分类。它有助于更快地做出决策,提高诊断精度,并加强对患者的护理。机器学习技术偶尔被广泛应用于解决与中风有关的复杂问题,如在早期阶段预测中风的患病率。深度学习(DL)算法是人工智能的关键组成部分,它在中风成像分析中越来越受欢迎,因为它可以自动提取特征,而不需要专业知识。在卒中研究的临床前设置中,ML/DL模型被广泛用于检测血管血栓、卒中核心和半暗带大小,以识别动脉闭塞、计算灌注图、检测颅内出血(ICH)、预测梗死、评估出血转化的严重程度和预测患者预后。这些模型具有强大的自动数据处理能力、出色的泛化能力、自我学习能力和精确的决策能力,极大地促进了脑卒中治疗的发展。在临床前设置中,动物的耗时行为研究也通过基于人工智能的算法进行有效分析。对基于AI的算法和模型的理解还有待简化,以便在目前的临床环境中应用于中风治疗,因此,在本综述中,我们试图以简化的方式呈现,以方便翻译。
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引用次数: 0
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