Su-Zhen Dong, Fu-Tsuen Lee, Lianxiang Xiao, Liqun Sun
<p>In recent decades, maternal–fetal medicine has undergone substantial advancements in the management of high-risk pregnancies. These include enhanced prenatal screening and diagnosis facilitated by innovations in ultrasound imaging, as well as the advances in fetal medical and interventional therapies informed by the deeper understanding of pathophysiological mechanisms underlying fetal and maternal disease processes. Collectively, these have contributed to measurable reductions in maternal and perinatal morbidity and mortality [<span>1</span>]. However, the identification of certain fetal conditions using ultrasound remains challenging because of suboptimal acoustic windows, fetal positioning, maternal body habitus, and limited soft tissue contrast [<span>2</span>]. These challenges can delay diagnosis and management, and potentially impact the timing of interventions, as well as the quality of prenatal counseling regarding the child's future health, development, and quality of life.</p><p>Recent advances in fetal magnetic resonance imaging (MRI) have emerged as a feasible alternative when ultrasound findings are inconclusive or limited. Fetal MRI offers superior soft tissue contrast which can enhance the characterization of complex fetal conditions. This was facilitated by the development of accelerated image acquisition techniques and motion-correction algorithms to reduce maternal breathing and fetal movement artifacts, thereby reducing scan times and improving the overall image quality [<span>3</span>]. Therefore, fetal MRI could serve as a valuable adjunct to clinical assessment, optimizing prenatal management and facilitating targeted interventions in high-risk pregnancies.</p><p>This special issue explores the expanding role of fetal MRI in the diagnosis, prognosis, and planning of interventions in complex fetal conditions in high-risk pregnancies.</p><p>Fetal MRI offers enhanced anatomical resolution and tissue characterization of the developing fetal brain [<span>4</span>]. Ren et al. provided a comprehensive review on the utility of fetal MRI on the diagnosis of congenital brain tumors including teratomas, astrocytomas, and choroid plexus tumors [<span>5</span>]. Key findings include superior tissue contrast to characterize tumor morphology, volume, and mass effect, which may prompt additional investigations for associated pathologies, guide the timing of delivery for postnatal interventions, and aid prenatal counseling [<span>6</span>]. Liu and Xiao presented a rare case of fetal periventricular nodular heterotopia identified by fetal MRI after ultrasound detection of a posterior fossa cyst [<span>7</span>]. Fetal MRI detected a gray matter nodule in the right lateral ventricular wall leading to suspicion of fetal gray matter heterotopia, which was confirmed by brain MRI at 7 months of age with no associated abnormal neurological presentation. Although a neuronal migration disorder, these findings highlight some individuals may not
{"title":"A Clearer Picture: MRI's Expanding Role in High-Risk Pregnancy Care","authors":"Su-Zhen Dong, Fu-Tsuen Lee, Lianxiang Xiao, Liqun Sun","doi":"10.1002/ird3.70023","DOIUrl":"https://doi.org/10.1002/ird3.70023","url":null,"abstract":"<p>In recent decades, maternal–fetal medicine has undergone substantial advancements in the management of high-risk pregnancies. These include enhanced prenatal screening and diagnosis facilitated by innovations in ultrasound imaging, as well as the advances in fetal medical and interventional therapies informed by the deeper understanding of pathophysiological mechanisms underlying fetal and maternal disease processes. Collectively, these have contributed to measurable reductions in maternal and perinatal morbidity and mortality [<span>1</span>]. However, the identification of certain fetal conditions using ultrasound remains challenging because of suboptimal acoustic windows, fetal positioning, maternal body habitus, and limited soft tissue contrast [<span>2</span>]. These challenges can delay diagnosis and management, and potentially impact the timing of interventions, as well as the quality of prenatal counseling regarding the child's future health, development, and quality of life.</p><p>Recent advances in fetal magnetic resonance imaging (MRI) have emerged as a feasible alternative when ultrasound findings are inconclusive or limited. Fetal MRI offers superior soft tissue contrast which can enhance the characterization of complex fetal conditions. This was facilitated by the development of accelerated image acquisition techniques and motion-correction algorithms to reduce maternal breathing and fetal movement artifacts, thereby reducing scan times and improving the overall image quality [<span>3</span>]. Therefore, fetal MRI could serve as a valuable adjunct to clinical assessment, optimizing prenatal management and facilitating targeted interventions in high-risk pregnancies.</p><p>This special issue explores the expanding role of fetal MRI in the diagnosis, prognosis, and planning of interventions in complex fetal conditions in high-risk pregnancies.</p><p>Fetal MRI offers enhanced anatomical resolution and tissue characterization of the developing fetal brain [<span>4</span>]. Ren et al. provided a comprehensive review on the utility of fetal MRI on the diagnosis of congenital brain tumors including teratomas, astrocytomas, and choroid plexus tumors [<span>5</span>]. Key findings include superior tissue contrast to characterize tumor morphology, volume, and mass effect, which may prompt additional investigations for associated pathologies, guide the timing of delivery for postnatal interventions, and aid prenatal counseling [<span>6</span>]. Liu and Xiao presented a rare case of fetal periventricular nodular heterotopia identified by fetal MRI after ultrasound detection of a posterior fossa cyst [<span>7</span>]. Fetal MRI detected a gray matter nodule in the right lateral ventricular wall leading to suspicion of fetal gray matter heterotopia, which was confirmed by brain MRI at 7 months of age with no associated abnormal neurological presentation. Although a neuronal migration disorder, these findings highlight some individuals may not ","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"3 3","pages":"188-190"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}