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Language and reading in attention-deficit/hyperactivity disorder and comorbid attention-deficit/hyperactivity disorder + developmental language disorder 注意缺陷/多动障碍和合并注意缺陷/多动障碍+发育性语言障碍患者的语言和阅读问题
Pub Date : 2024-04-17 DOI: 10.1002/jcv2.12218
Kaitlyn M. A. Parks, Janis Oram Cardy, Marc F. Joanisse

Background

The current study sought to examine whether psycholinguistic assessments could discriminate children and adolescents with developmental language disorder (DLD) from those with attention-deficit/hyperactivity disorder (ADHD; combined or inattentive subtype) and comorbid DLD + ADHD.

Methods

The Clinical Evaluation of Language Fundamentals—Screening Test (CELFST; Wiig et al., 2013), the Comprehensive Test of Phonological Processing (nonword repetition subtest; Wagner et al., 2013), and the Test of Word Reading Efficiency (sight word and phonemic decoding subtests; Torgesen et al., 2012) were examined in 441 children and adolescents between 6 and 16 years of age.

Results

The presence of a language disorder (with or without ADHD) predicted poor performance across tasks. Children and adolescents with ADHD (combined vs. inattentive) only significantly differed in sight word reading, in favor of those with combined type. Measures of reading efficiency could distinguish between the two types of ADHD, but not between other groups. Interestingly, scores on the standard language screener were no worse for children with ADHD + DLD than children with DLD only.

Conclusions

The combination of comorbid ADHD + DLD did not appear to be associated with lower language abilities, sight word reading, or phonemic decoding relative to DLD alone. Reading efficiency was effective in discriminating between ADHD subtypes. These findings offer valuable insights into differential diagnosis and the identification of comorbidity.

本研究旨在探讨心理语言学评估能否将患有发育性语言障碍(DLD)的儿童和青少年与患有注意缺陷/多动障碍(ADHD;合并或注意力不集中亚型)和合并DLD + ADHD的儿童和青少年区分开来、临床语言基础评估筛查测试(CELFST;Wiig 等人,2013 年)、语音处理综合测试(非单词重复子测试;Wagner 等人,2013 年)和单词阅读效率测试(视词和音位解码子测试;Torgesen 等人,2012 年)对 441 名 6 至 16 岁的儿童和青少年进行了测试。患有多动症的儿童和青少年(合并型与注意力不集中型)仅在视词阅读方面存在显著差异,而合并型的儿童和青少年更胜一筹。阅读效率测量可以区分两种类型的多动症,但不能区分其他组别。有趣的是,ADHD + DLD 儿童在标准语言筛选器上的得分并不比仅患有 DLD 的儿童差。与单独患有 DLD 的儿童相比,合并患有 ADHD + DLD 的儿童似乎与较低的语言能力、视词阅读能力或音位解码能力无关。阅读效率能有效区分多动症亚型。这些发现为鉴别诊断和确定合并症提供了宝贵的见解。
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引用次数: 0
Correction to “Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood” 对 "早期负面生活事件、眶额皮质厚度的发育与青年期抑郁症的相互作用 "的更正
Pub Date : 2024-04-15 DOI: 10.1002/jcv2.12237

Backhausen, L. L., Granzow, J., Fröhner, J. H., Artiges, E., Paillère-Martinot, M.-L., Lemaître, H., Sticca, F., Banaschewski, T., Desrivières, S., Grigis, A., Heinz, A., Brühl, R., Papadopoulos-Orfanos, D., Poustka, L., Hohmann, S., Robinson, L., Walter, H., Winterer, J., Schumann, G., Martinot, J.-L., Smolka, M. N., Vetter, N. C., the IMAGEN Consortium. (2024). Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood. JCPP Advances, 4(1), e12210. https://doi.org/10.1002/jcv2.12210.

The statement of equal contributions should have been: Lea L. Backhausen and Jonas Granzow (first authors) and Jean-Luc Martinot and Michael N. Smolka have contributed equally.

We apologize for the error.

Backhausen, L. L., Granzow, J., Fröhner, J. H., Artiges, E., Paillère-Martinot, M.-L., Lemaître, H., Sticca, F., Banaschewski, T., Desrivières, S., Grigis, A., Heinz, A., Brühl, R., D., Papadopoulos-Orfanos, D., Poustka, L., Hohmann, S., Robinson, L., Walter, H., Winterer, J., Schumann, G..、Papadopoulos-Orfanos, D., Poustka, L., Hohmann, S., Robinson, L., Walter, H., Winterer, J., Schumann, G., Martinot, J.-L., Smolka, M. N., Vetter, N. C., the IMAGEN Consortium.(2024).早期负面生活事件、眶额皮质厚度的发展和青年期抑郁症的相互作用。JCPP Advances, 4(1), e12210. https://doi.org/10.1002/jcv2.12210.The 同等贡献声明应为:Lea L. Backhausen和Jonas Granzow(第一作者)以及Jean-Luc Martinot和Michael N. Smolka做出了同等贡献。我们对这一错误表示歉意。
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引用次数: 0
Validity of the multidimensional assessment profile of disruptive behavior in autistic toddlers 自闭症幼儿破坏行为多维评估概况的有效性
Pub Date : 2024-04-15 DOI: 10.1002/jcv2.12233
Hannah Fipp-Rosenfield, Jeffrey Grauzer, Megan Y. Roberts, Aaron J. Kaat

Objective

Early measurement of atypical disruptive behavior within autistic children is critical for later referrals to behavioral screenings, diagnoses, and services. Disruptive behavior in autistic toddlers is often measured using a categorical approach and identifies the presence or absence of behavior. In contrast, dimensional approaches evaluate behavior on a spectrum of typical to atypical by measuring the clinical salience of disruptive behavior. We sought to assess the validity of the Infant/Toddler version of the multidimensional assessment profile of disruptive behavior (MAP-DB-IT), a dimensional approach measurement tool, in a sample of autistic toddlers.

Methods

Autistic toddlers (n = 82, Mage = 33.2 months, SD = 6.28 months) and their mothers received 8 weeks of caregiver-mediated social communication intervention. Mothers completed the MAP-DB-IT and the Infant Toddler Social Emotional Assessment (ITSEA) across three timepoints: before intervention, immediately after intervention, and at 3 months post-intervention follow-up. The MAP-DB-IT provided scores for three subdomains: temper loss, noncompliance, and aggression (generically or specifically with siblings). Ratings on the MAP-DB-IT were compared to the ITSEA using several analytic strategies such as evaluating (a) the internal consistency of the MAP-DB-IT domain scores; (b) the convergent validity between the two measures; and (c) its convergent change due to intervention and if this varied by child characteristics.

Results

The MAP-DB-IT demonstrated excellent internal consistency across all four subdomains. We evaluated convergent validity and found positive correlations between the (a) ITSEA externalizing and MAP-DB-IT aggression domain, (b) ITSEA externalizing and MAP-DB-IT aggression with siblings domain, and (c) ITSEA dysregulation and MAP-DB-IT temper loss domain.

Conclusion

The MAP-DB-IT is a valid measurement tool for disruptive behavior in autistic toddlers. Clinicians should consider the use of the MAP-DB-IT for young autistic clients presenting with disruptive behavior to (a) discriminate between early developmentally appropriate tantrums from clinically salient dysregulation, and (b) refer to additional behavioral evaluations and services.

对自闭症儿童的非典型破坏行为进行早期测量,对于日后的行为筛查、诊断和服务转介至关重要。自闭症幼儿的破坏性行为通常采用分类方法进行测量,并确定行为的存在与否。与此相反,维度法通过测量破坏性行为的临床显著性来评估从典型到非典型的行为。我们试图在自闭症幼儿样本中评估破坏性行为多维评估档案(MAP-DB-IT)婴幼儿版的有效性。自闭症幼儿(n = 82,年龄 = 33.2 个月,SD = 6.28 个月)和他们的母亲接受了为期 8 周的以照顾者为媒介的社交沟通干预。母亲们在三个时间点完成了 MAP-DB-IT 和婴幼儿社交情感评估 (ITSEA):干预前、干预后和干预后 3 个月的随访。MAP-DB-IT 提供了三个子域的分数:发脾气、不服从和攻击(一般或专门针对兄弟姐妹)。我们采用多种分析策略将 MAP-DB-IT 的评分与 ITSEA 的评分进行比较,如评估(a)MAP-DB-IT 领域评分的内部一致性;(b)两种测量方法之间的收敛有效性;以及(c)因干预而产生的收敛性变化,以及这种变化是否因儿童特征而异。我们对收敛有效性进行了评估,发现(a)ITSEA 外化与 MAP-DB-IT 攻击行为领域之间存在正相关;(b)ITSEA 外化与 MAP-DB-IT 攻击兄弟姐妹领域之间存在正相关;以及(c)ITSEA 调节障碍与 MAP-DB-IT 发脾气领域之间存在正相关。临床医生应考虑对出现破坏性行为的自闭症幼儿使用 MAP-DB-IT,以(a)区分早期符合发育规律的发脾气和临床突出的行为失调,以及(b)转介到额外的行为评估和服务。
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引用次数: 0
Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample 等待奖励对你有好处吗?在一个大型队列样本中,冲动选择、精神病理学和功能结果之间没有关联
Pub Date : 2024-04-15 DOI: 10.1002/jcv2.12231
Patricia P. Bado, Giovanni A. Salum, Luis A. Rohde, Ary Gadelha, Pedro M. Pan, Eurípedes C. Miguel, Gail Tripp, Emi Furukawa

Background

A stronger preference for immediate rewards has been reported in individuals with ADHD and other disorders. However, the consistency of the associations between this preference and psychiatric conditions as well as functional outcomes have been questioned. Research on its association with longitudinal outcomes is scarce.

Methods

The current study used data on a choice delay task (CDT) from a school-based cohort of Brazilian children with those at higher risk for psychiatric disorders over-sampled (n = 1917). The sample included typically developing children (n = 1379), those with ADHD (n = 213), and other disorders. The frequency of the trials where children chose a larger later reward versus a smaller sooner reward was compared for those with ADHD and typically developing children. Cross-sectionally and longitudinally, the study also evaluated whether children's preference for larger delayed rewards at baseline predicted the presence of psychiatric disorders and functional life outcomes (academic performance, alcohol use, early pregnancy, criminal conviction, BMI).

Results

Children with ADHD and their typically developing peers performed similarly on the CDT. Their baseline task performance was not related to psychiatric conditions or life outcomes.

Conclusions

The current results raise questions regarding the use of the CDT with diverse populations and whether a preference for larger delayed rewards is predictive of positive long-term outcomes as widely assumed.

据报道,多动症和其他疾病患者对即时奖励有更强烈的偏好。然而,这种偏好与精神状况和功能结果之间的关联的一致性一直受到质疑。本研究使用了巴西儿童校本队列中选择延迟任务(CDT)的数据,并对精神障碍高危儿童进行了过度抽样(n = 1917)。样本包括发育正常的儿童(n = 1379)、多动症儿童(n = 213)和其他疾病儿童。对患有多动症的儿童和发育正常的儿童在试验中选择较大的后期奖励和较小的前期奖励的频率进行了比较。该研究还横向和纵向评估了儿童在基线时对较大延迟奖励的偏好是否能预测是否存在精神障碍和生活功能性结果(学习成绩、酗酒、早孕、刑事定罪、体重指数)。目前的研究结果提出了一些问题,如 CDT 在不同人群中的应用,以及对较大延迟奖励的偏好是否如人们普遍认为的那样能预测积极的长期结果。
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引用次数: 0
Testing the modifiability of episodic future thinking and episodic memory among suicidal and nonsuicidal adolescents 测试有自杀倾向和无自杀倾向的青少年的偶发未来思维和偶发记忆的可修正性
Pub Date : 2024-04-08 DOI: 10.1002/jcv2.12236
Pauline Goger, Rachel J. Nam, Nathan Lowry, Kerri-Anne Bell, Neha Parvez, Olivia H. Pollak, Donald J. Robinaugh, Daniel L. Schacter, Christine B. Cha

Background

Despite increased attention on treatment and prevention for suicidal adolescents, we know little about potential intervention targets. Episodic future thinking—the ability to imagine detailed, personal, and future-oriented events—is a modifiable cognitive process that has been linked with suicidal ideation (SI) in adolescents. However, until now its modifiability has only been tested in adults.

Method

Adolescents (N = 176, ages 15–19; 71% SI) completed performance-based measures of episodic future thinking (i.e., Experimental Recombination Paradigm) and memory immediately before and after an Episodic Specificity Induction (ESI).

Results

Adolescents produced a greater number of future episodic details after (vs. before) the ESI but showed no change in non-episodic details (e.g., semantic information). Patterns of change in episodic future thinking were not moderated by SI history. Adolescents overall did not demonstrate change in past episodic detail counts after the ESI. However, there were select moderating effects of SI history on this effect.

Conclusion

Results show that episodic future thinking can change immediately following an episodic specificity induction among adolescents, regardless of whether they have previously experienced SI. This demonstration of within-person change constitutes a foundational first step in examining malleability of episodic future thinking in adolescents and offers preliminary evidence of a cognitive mechanism that may be leveraged in service of reducing adolescents' SI.

尽管人们越来越关注青少年自杀的治疗和预防,但我们对潜在的干预目标却知之甚少。情节性未来思维--想象详细的、个人的和面向未来的事件的能力--是一种可改变的认知过程,它与青少年的自杀意念(SI)有关。青少年(N = 176,15-19 岁;71% SI)在外显特异性诱导(ESI)前后完成了基于表现的外显未来思维(即实验重组范式)和记忆测量。外显未来思维的变化模式不受 SI 历史的影响。总体而言,青少年在接受 ESI 后,过去的情节细节计数没有发生变化。结果表明,无论青少年以前是否经历过外显性特异性诱导,外显性未来思维都会在诱导后立即发生变化。这种人内变化的证明为研究青少年外显未来思维的可塑性迈出了基础性的第一步,并提供了一种认知机制的初步证据,这种机制可能被用来减少青少年的外显性特异性。
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引用次数: 0
Exploring networks of complex developmental trauma symptomatology among children and adolescents involved in child welfare 探索涉及儿童福利的儿童和青少年的复杂发育创伤症状网络
Pub Date : 2024-03-12 DOI: 10.1002/jcv2.12224
Jackson A. Smith, Jasmine Zhang, Alexey Urusov, Laura Colucci, Imogen Sloss, Lillian Eckert, Mary Price-Cameron, Dillon T. Browne

Background

Clinical presentations of child and adolescent psychopathology can vary systematically for boys and girls. While network analysis is increasingly being applied to explore psychopathology in adults, there is a dearth of network studies considering differences in symptoms for boys and girls, particularly in developmental trauma-related symptomatology.

Methods

This study involves rural children (n = 375, 39.47% girls) and adolescents (n = 291, 51.20% girls) involved with child protection services in Ontario, Canada. Caregivers completed the Assessment Checklist for Children or Adolescents within the first 6 months of care. Psychometric network analyses were conducted using subscales for boys and girls. Differences were examined via network comparison permutation tests, moderated network models, and independent t-tests.

Results

Attachment-related interpersonal difficulties were the most central nodes in the child and adolescent networks for both boys and girls. Emotional dysregulation also had high strength centrality for adolescents. While network comparison tests found the overall network structures and global network strength to be invariant between boys and girls for children and adolescents, moderated network models and independent t-tests revealed several differences with regards to the expression of specific symptoms. Among children, girls exhibited more indiscriminate and pseudomature interpersonal behaviors, whereas boys expressed significantly more non-reciprocal interpersonal behaviors and self-injury. Adolescent girls exhibited more behavioral dysregulation and suicide discourse in the moderated network model; t-tests also indicated higher levels of emotional dysregulation, negative self-image, and other items considered clinically important complex trauma symptoms (e.g., distrust of adults, confused belonging).

Discussion

This study supports evidence of differences in the expression of complex trauma symptomatology for boys and girls. Additionally, girls exhibit more symptoms, in general. Consistent with the transdiagnostic conceptualization of the consequences of developmental trauma, findings demonstrate the primacy of attachment-specific difficulties and emotion dysregulation.

男孩和女孩在儿童和青少年心理病理学的临床表现上可能存在系统性差异。虽然网络分析越来越多地被应用于探讨成年人的精神病理学,但考虑男孩和女孩症状差异的网络研究却非常缺乏,尤其是在与发育创伤相关的症状方面。照护者在接受照护的前 6 个月内填写了儿童或青少年评估核对表。对男孩和女孩的分量表进行了心理计量网络分析。在男孩和女孩的儿童和青少年网络中,与情感相关的人际交往障碍是最核心的节点。在青少年中,情绪失调也具有较高的强度中心性。虽然网络比较测试发现,儿童和青少年的整体网络结构和整体网络强度在男孩和女孩之间是不变的,但调节网络模型和独立 t 检验显示了特定症状表现方面的一些差异。在儿童中,女孩表现出更多的滥交和假性人际交往行为,而男孩则表现出更多的非互惠人际交往行为和自伤行为。在缓和网络模型中,青春期女孩表现出更多的行为失调和自杀言论;t 检验还表明,女孩的情绪失调、消极自我形象以及其他被认为具有临床意义的复杂创伤症状(如不信任成人、归属感混乱)的水平更高。此外,女孩一般表现出更多的症状。与发育创伤后果的跨诊断概念相一致的是,研究结果表明,依恋障碍和情绪失调是主要问题。
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引用次数: 0
Social competencies of children with disinhibited social engagement disorder: A systematic review 患有社交抑制障碍的儿童的社交能力:系统回顾
Pub Date : 2024-03-08 DOI: 10.1002/jcv2.12226
Claire Davidson, Shahela Islam, Enrico Venturini, Anja Lowit, Christopher Gillberg, Helen Minnis

Background

Children with Disinhibited Social Engagement Disorder (DSED) have specific difficulties with indiscriminate sociability, yet little is known about their broader social competencies as DSED tends not to be identified within samples in the wider ‘maltreatment literature.’

Aim

To systematically review the literature to determine the social competencies of children with DSED.

Methods

A comprehensive search following PRISMA guidelines was undertaken using PsycINFO, Medline, Embase, and Cumulative Index to Nursing & Allied Health.

Results

From a total of 553 articles, 16 studies were selected and critically evaluated. Children with DSED were consistently reported to have poorer social competencies than non-maltreated peers and environmental controls. Greater peer problems were consistently found, and they may present with poor self-esteem/concept related to social acceptance. Findings regarding social interaction/communication skills were mixed.

Limitations

50% of studies were of moderate quality due to sampling and possible confounding variables.

Conclusion

Children with DSED present with social relationship problems, beyond the core symptoms of the disorder, but the relative impact of co-occurring neurodevelopmental conditions is not yet clear. In addition, pragmatic language and communication skills require further research.

背景患有抑制性社交参与障碍(Disinhibited Social Engagement Disorder,DSED)的儿童在不加区分的社交方面有特殊的困难,但人们对他们更广泛的社交能力知之甚少,因为在更广泛的 "虐待文献 "中,DSED往往不会在样本中被识别出来。 目的 系统回顾文献以确定 DSED 儿童的社交能力。 方法 按照 PRISMA 指南,使用 PsycINFO、Medline、Embase 和 Cumulative Index to Nursing & Allied Health 进行全面检索。 结果 从总共 553 篇文章中筛选出 16 项研究并对其进行了严格评估。据报道,患有 DSED 的儿童的社交能力一直低于未接受治疗的同龄人和环境对照组。他们的同伴问题也越来越多,而且他们的自尊心/与社会接纳有关的观念也可能很差。有关社会交往/沟通技能的研究结果不一。 局限性 由于抽样和可能的混杂变量,50%的研究质量中等。 结论 DSED 患儿除患有该障碍的核心症状外,还存在社会关系问题,但并发神经发育疾病的相对影响尚不明确。此外,实用语言和沟通技能也需要进一步研究。
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引用次数: 0
Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture? 多动和注意力不集中遗传风险的代际传递。是直接遗传还是基因熏陶?
Pub Date : 2024-03-04 DOI: 10.1002/jcv2.12222
Ivan Voronin, Isabelle Ouellet-Morin, Amélie Petitclerc, Geneviève Morneau-Vaillancourt, Mara Brendgen, Ginette Dione, Frank Vitaro, Michel Boivin

Background

Hyperactivity and inattention, the symptoms of ADHD, are marked by high levels of heritability and intergenerational transmission. Two distinct pathways of genetic intergenerational transmission are distinguished: direct genetic transmission when parental genetic variants are passed to the child's genome and genetic nurture when the parental genetic background contributes to the child's outcomes through rearing environment. This study assessed genetic contributions to hyperactivity and inattention in childhood through these transmission pathways.

Methods

The sample included 415 families from the Quebec Newborn Twin Study. Twins' hyperactivity and inattention were assessed in early childhood by parents and in primary school by teachers. The polygenic scores for ADHD (ADHD-PGS) and educational attainment (EA-PGS) were computed from twins' and parents' genotypes. A model of intergenerational transmission was developed to estimate (1) the contributions of parents' and children's PGS to the twins' ADHD symptoms and (2) whether these variances were explained by genetic transmission and/or genetic nurture.

Results

ADHD-PGS explained up to 1.6% of the variance of hyperactivity and inattention in early childhood and primary school. EA-PGS predicted ADHD symptoms at both ages, explaining up to 1.6% of the variance in early childhood and up to 5.5% in primary school. Genetic transmission was the only significant transmission pathway of both PGS. The genetic nurture channeled through EA-PGS explained up to 3.2% of the variance of inattention in primary school but this association was non-significant.

Conclusions

Genetic propensities to ADHD and education predicted ADHD symptoms in childhood, especially in primary school. Its intergenerational transmission was driven primarily by genetic variants passed to the child, rather than by environmentally mediated parental genetic effects. The model developed in this study can be leveraged in future research to investigate genetic transmission and genetic nurture while accounting for parental assortative mating.

多动和注意力不集中是多动症的症状,具有高度遗传性和代际传递性。遗传代际传递有两种不同的途径:一种是直接遗传传递,即父母的遗传变异传给子女的基因组;另一种是遗传培育,即父母的遗传背景通过抚养环境对子女的结果产生影响。本研究通过这些遗传途径评估了遗传对儿童期多动和注意力不集中的影响。样本包括魁北克新生双胞胎研究的 415 个家庭。双胞胎的多动和注意力不集中情况在幼儿时期由父母进行评估,在小学时期由教师进行评估。根据双胞胎和父母的基因型计算出多动症(ADHD-PGS)和教育程度(EA-PGS)的多基因分数。我们建立了一个代际传递模型,以估算(1)父母和子女的PGS对双胞胎ADHD症状的贡献,以及(2)这些变异是否由遗传传递和/或遗传培育解释。EA-PGS可预测两个年龄段的ADHD症状,在幼儿期最多可解释1.6%的变异,在小学阶段最多可解释5.5%的变异。遗传传递是两种 PGS 的唯一重要传递途径。多动症的遗传倾向和教育可预测儿童时期的多动症状,尤其是小学时期的多动症状。多动症的遗传倾向和教育可预测儿童时期的多动症症状,尤其是小学阶段的多动症症状,其代际传递主要是由遗传给孩子的基因变异驱动的,而不是由环境介导的父母遗传效应驱动的。在未来的研究中,可以利用本研究建立的模型来研究遗传传递和遗传养育,同时考虑父母的同类交配。
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引用次数: 0
How early environment influences the developing brain and long-term mental health 早期环境如何影响大脑发育和长期心理健康
Pub Date : 2024-02-28 DOI: 10.1002/jcv2.12230
Emma Sprooten

The March 2024 issue of JCPP Advances features two neuroimaging studies that investigate links between early environmental risk factors for mental health problems, brain development and psychopathology in children and young adults. The papers provide new insights into how adverse environments and negative experiences in childhood increase risk for depression and mental health problems, and how this may or may not be mediated, or moderated, by individual differences in the brain.

2024 年 3 月出版的《JCPP Advances》杂志刊登了两篇神经影像学研究报告,探讨了儿童和青少年精神健康问题的早期环境风险因素、大脑发育和精神病理学之间的联系。这两篇论文为我们提供了新的视角,让我们了解童年时期的不利环境和负面经历是如何增加抑郁和心理健康问题的风险的,以及这种风险是如何通过或不通过大脑中的个体差异来调节或缓和的。
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引用次数: 0
Bifactor models of psychopathology using multi-informant and multi-instrument dimensional measures in the ABCD study 在 ABCD 研究中使用多信息量和多工具维度测量的精神病理学双因素模型
Pub Date : 2024-02-26 DOI: 10.1002/jcv2.12228
Grace R. Jacobs, Stephanie H. Ameis, Peter Szatmari, John D. Haltigan, Aristotle N. Voineskos

Background

Due to limitations of categorical definitions of mental illness, there is a need for quantitative empirical investigations of the dimensional structure of psychopathology. Using exploratory bifactor methods, this study investigated a comprehensive and representative structure of psychopathology in children to better understand how psychotic-like experiences (PLEs), autism spectrum disorder (ASD) symptoms, impulsivity, and sensitivity to reward and punishment, may be integrated into extant general factor models of psychopathology.

Methods

We used seven child-report and three parent-report instruments capturing diverse mental health symptoms in 11,185 children aged 9–10 from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study. We built on previous modeling frameworks by conducting both split sample and full sample factor analytic approaches that harnessed recent methodological advances in bifactor exploratory structural equation modeling (B-ESEM) to examine a wide range of psychopathology measures not previously integrated into a single analysis. Validity of psychopathology dimensions was examined by investigating associations with sex, age, cognition, imaging measures, and medical service usage.

Results

All four factor analytic models showed excellent fit and similar structure within informant. PLEs loaded most highly onto a general psychopathology factor, suggesting that they may reflect non-specific risk for mental illness. ASD symptoms loaded separately from attention/hyperactivity symptoms. Symptoms of impulsivity and sensitivity to reward and punishment loaded onto specific factors, distinct from externalizing and internalizing factors. All identified factors were associated with clinically relevant risk factors, providing preliminary evidence for their construct validity.

Conclusion

By integrating diverse child-report and parent-report psychopathology measures for children in the ABCD sample, we deliver data on the quantitative structure of psychopathology for an exceptionally large set of measurements and discuss implications for the field.

由于精神疾病分类定义的局限性,需要对精神病理学的维度结构进行定量实证调查。本研究采用探索性双因素方法,调查了儿童心理病理学的综合代表性结构,以更好地了解如何将精神病样经历(PLE)、自闭症谱系障碍(ASD)症状、冲动性以及对奖惩的敏感性整合到现有的心理病理学一般因素模型中。我们使用了七种儿童报告工具和三种家长报告工具,捕捉了青少年大脑认知发展研究(ABCD)中 11,185 名 9-10 岁儿童的各种心理健康症状。我们在以往建模框架的基础上,采用了分离样本和全样本因子分析方法,利用双因子探索性结构方程建模(B-ESEM)在方法学上的最新进展,对以前未整合到单一分析中的多种心理病理学测量方法进行了研究。通过研究心理病理学维度与性别、年龄、认知能力、影像测量和医疗服务使用情况之间的关联,对心理病理学维度的有效性进行了检验。PLEs在一般精神病理学因子上的负荷最高,这表明它们可能反映了非特异性的精神疾病风险。ASD 症状与注意力/多动症状分别加载。冲动症状和对奖惩的敏感症状被加载到特定因子上,与外化和内化因子不同。通过整合ABCD样本中不同的儿童报告和家长报告精神病理学测量方法,我们提供了有关精神病理学定量结构的数据,这些数据的测量集合非常庞大,我们还讨论了这些数据对该领域的影响。
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