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Family history of ADHD associates with stronger problem-solving skills amongst 2- to 3-year-olds 2- 3岁儿童的ADHD家族史与较强的问题解决能力有关
IF 3.1 Pub Date : 2025-03-12 DOI: 10.1002/jcv2.70009
Alexandra Hendry, Emily J. H. Jones, Linn Andersson-Konke, Mary Agyapong, Tessel Bazelmans, Jannath Begum-Ali, Mutluhan Ersoy, Amy Goodwin, Greg Pasco, Terje Falck-Ytter, Mark H. Johnson, Tony Charman, and the EASE and STAARS Teams

Background

Attention-Deficit/Hyperactivity Disorder (ADHD) is linked to strengths in creative problem-solving amongst school-aged children and adults. In contrast, autism (which frequently co-occurs with ADHD) is associated with lower generativity, and perseverative responses during problem-solving. Little is known about how ADHD and autism traits—or broader heritable autism and ADHD phenotypes—associate with problem-solving skills in early childhood.

Methods

129 UK 2- and 3-year-olds (exploratory dataset) and 74 Swedish 3-year-olds (confirmatory dataset) with and without a family history (FH) of ADHD and autism, completed a problem-solving task. Parents reported on their 3-year-olds’ ADHD and autism traits using the Child Behaviour Checklist and Social Responsiveness Scale-2. FH group differences in problem-solving performance were tested using ANOVA (exploratory dataset, FH-autism and FH-ADHD as fixed factors) and t-test (confirmatory and combined datasets split by FH-ADHD). Linear regressions of problem-solving success on autism/ADHD traits were run in both samples.

Results

Compared with peers with no FH-ADHD, children with FH-ADHD showed higher problem-solving success at 2 (partial ω2 = 0.106) and 3 years (partial ω2 = 0.045) in the exploratory dataset. In the confirmatory dataset, a FH-ADHD-and-autism group trended towards higher success scores compared with a no-FH-ADHD group (comprising FH-autism-only and no-FH ADHD-or-autism sub-groups) but scores were only significantly higher for children with FH-ADHD-and-autism when compared with children with no FH-ADHD-or-autism (gs = 0.977). ADHD (but not autism) traits were positively associated with problem-solving performance in the exploratory (β = 0.212, p = 0.031) and combined samples (β = 0.173, p = 0.024). Effects were a consistent direction and magnitude, but not significant, in the confirmatory sample alone (β = 0.201, p = 0.103).

Conclusions

Considering a child's family history alongside their neurodivergent traits may help to identify their likely strengths, and how to access them: Children with ADHD traits and/or a family history of ADHD are likely to have an aptitude for generative problem-solving when presented with highly motivating, ecologically valid challenges.

在学龄儿童和成人中,注意力缺陷/多动障碍(ADHD)与创造性解决问题的能力有关。相反,自闭症(经常与多动症同时发生)在解决问题时具有较低的生成能力和持久的反应。关于多动症和自闭症的特征——或者更广泛的遗传性自闭症和多动症的表型——是如何与儿童早期解决问题的能力联系在一起的,我们知之甚少。方法129名英国2岁和3岁儿童(探索性数据集)和74名瑞典3岁儿童(验证性数据集),有或没有ADHD和自闭症家族史(FH),完成问题解决任务。父母使用儿童行为检查表和社会反应量表-2报告他们3岁孩子的多动症和自闭症特征。使用方差分析(探索性数据集,FH-自闭症和FH- adhd作为固定因素)和t检验(由FH- adhd分割的验证性数据集和组合数据集)检验FH组在问题解决能力方面的差异。在两个样本中对自闭症/ADHD特征的问题解决成功进行线性回归。结果在探索性数据集中,FH-ADHD患儿在2岁(偏ω2 = 0.106)和3岁(偏ω2 = 0.045)时的问题解决成功率高于非FH-ADHD患儿。在验证性数据集中,fh - adhd和自闭症组比无fh - adhd组(包括仅fh -自闭症和无fh - adhd或自闭症亚组)有更高的成功得分趋势,但与无fh - adhd或自闭症儿童相比,fh - adhd和自闭症儿童的得分显著更高(gs = 0.977)。在探索性样本(β = 0.212, p = 0.031)和联合样本(β = 0.173, p = 0.024)中,ADHD(但不包括自闭症)特征与解决问题的表现呈正相关。在单独的验证样本中,影响方向和幅度一致,但不显著(β = 0.201, p = 0.103)。考虑孩子的家族史和他们的神经发散性特征可能有助于确定他们可能的优势,以及如何利用它们:有多动症特征和/或有多动症家族史的孩子在面对高度激励的、生态有效的挑战时,可能具有生成解决问题的能力。
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引用次数: 0
Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population 注意缺陷多动障碍和其他神经发育特征与一般人群中儿童的功能影响有关
IF 3.1 Pub Date : 2025-03-07 DOI: 10.1002/jcv2.70004
Louise Horstmann, Charlotte A. Dennison, Evie Stergiakouli, Kate Langley, Joanna Martin

Background

Attention Deficit Hyperactivity Disorder (ADHD) is commonly defined as a categorical diagnosis requiring clinically severe symptoms and impact on functioning. However, ADHD and other neurodevelopmental traits are also distributed continuously in the general population, where their impact on functioning is less clear. This study aimed to examine the association between ADHD impact and (a) ADHD traits, (b) co-occurring neurodevelopmental traits (autistic traits, reading ability, IQ, and pragmatic communication), and (c) genetic risk for ADHD. We also examined sex differences in these associations.

Methods

We identified 12,439 children with parent or teacher reports of ADHD at ages 8 and 11 in a UK birth cohort. We examined ADHD impact (i.e., in school, home, friendships, leisure activities, and distress) as an outcome of ADHD traits and other neurodevelopmental traits at each timepoint for each informant. Polygenic scores for ADHD were derived for each child and used to predict ADHD impact. Analyses controlled for child's age at completion of ADHD measures. We also stratified analyses by sex and tested for interactions with sex.

Results

ADHD traits were associated with ADHD impact across informants, ages, and sex (β = 0.46–0.64). There were stronger associations among males according to parents, but no sex differences according to teachers. In multivariable analyses, ADHD traits had the strongest association with impact, autistic traits and reading ability predicted parent-rated impact and pragmatic communication predicted teacher-rated impact. There was no evidence of an association between genetic risk for ADHD and ADHD impact when controlling for ADHD traits.

Conclusions

ADHD and other neurodevelopmental traits were associated with ADHD impact in children from the general population. This reinforces the importance of inclusive environments for neurodivergent people. Clinicians and educators should consider the presence of impact and multiple neurodevelopmental difficulties when making decisions about support for all children.

背景注意缺陷多动障碍(ADHD)通常被定义为一种需要临床严重症状和对功能影响的分类诊断。然而,多动症和其他神经发育特征也在普通人群中持续分布,其对功能的影响尚不清楚。本研究旨在研究ADHD影响与以下因素之间的关系:(a) ADHD特征,(b)共同发生的神经发育特征(自闭症特征、阅读能力、智商和务实沟通),以及(c) ADHD遗传风险。我们还研究了这些关联的性别差异。方法:我们在英国的一个出生队列中确定了12439名8岁和11岁时父母或老师报告患有多动症的儿童。我们检查了ADHD在每个时间点的影响(即在学校、家庭、友谊、休闲活动和痛苦中),作为ADHD特征和其他神经发育特征的结果。ADHD的多基因评分是针对每个孩子得出的,并用于预测ADHD的影响。分析控制了儿童完成ADHD测量时的年龄。我们还按性别进行了分层分析,并测试了与性别的相互作用。结果ADHD特征与ADHD影响在被调查者、年龄和性别中存在相关性(β = 0.46-0.64)。根据家长的说法,男性之间的联系更强,但根据教师的说法,性别差异不大。在多变量分析中,ADHD特征与影响的相关性最强,自闭症特征和阅读能力预测父母评价的影响,语用交际预测教师评价的影响。在控制ADHD特征时,没有证据表明ADHD的遗传风险与ADHD影响之间存在关联。结论ADHD和其他神经发育特征与ADHD对普通儿童的影响有关。这加强了包容环境对神经发散型人群的重要性。临床医生和教育工作者在决定是否支持所有儿童时,应考虑影响和多重神经发育困难的存在。
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引用次数: 0
Change over time in perceived schoolwork pressure and associations with emotional problems among 11–16-year-olds: A repeat cross-sectional study in Wales, UK 随着时间的推移,11 - 16岁学生对学业压力的感知变化及其与情绪问题的关联:英国威尔士的一项重复横断面研究
IF 3.1 Pub Date : 2025-03-03 DOI: 10.1002/jcv2.70005
Jessica M. Armitage, Gemma Lewis, Nicholas Page, Foteini Tseliou, Rebecca Anthony, Simon Murphy, Graham Moore, Stephan Collishaw

Background

Emotional problems among adolescents have increased substantially in recent years, and there is evidence that schoolwork pressures have also increased globally. We examine trends in perceived schoolwork pressure and emotional problems in Wales between 2002 and 2021, and associations between the two over this period.

Methods

Repeat cross-sectional data were used from surveys conducted in secondary schools in Wales. Participants were 11–16-year-olds (n = 318,554). Measures included self-reported perceived schoolwork pressure and emotional problems (HBSC-SCL).

Results

The percentage of students reporting a lot of perceived schoolwork pressure increased from 21% in 2002, to 24% in 2004. Rates then declined until 2009, dropping to 13%, before increasing to nearly 26% by 2021. Students reporting the most pressure were females in older school years, with up to 57% of females in Year 11 reporting a lot of perceived pressure in 2021. Emotional problems followed a similar trend, decreasing between 2002 and 2009, and then increasing between 2009 and 2021. Between 2009 and 2019, estimates of the cohort difference in emotional problems reduced from 2.23 (95% CI = 2.12, 2.34) to 1.64 (95% CI = 1.54, 1.75) when adjusting for changes in schoolwork pressure. This is consistent with the hypothesis that schoolwork pressure may be driving some of the increase in emotional problems over time.

Conclusions

Our findings showed a decline in perceived school pressure until 2009, followed by a rise until 2021. Increases were particularly apparent among female adolescents, mirroring trends in emotional problems. Although a range of competing causal explanations cannot be ruled out, overall increases in schoolwork pressure from the late 2000s may have contributed to the rise in adolescent emotional problems over this period.

近年来,青少年的情绪问题大幅增加,有证据表明,全球范围内的学业压力也在增加。我们研究了2002年至2021年期间威尔士感知到的学业压力和情绪问题的趋势,以及这一时期两者之间的联系。方法采用在威尔士中学进行的重复横断面调查数据。参与者为11 - 16岁的青少年(n = 318,554)。测量包括自我报告的学业压力和情绪问题(HBSC-SCL)。结果认为自己有很大学业压力的学生比例从2002年的21%上升到2004年的24%。此后,这一比例一直下降,直到2009年降至13%,到2021年上升至近26%。报告压力最大的学生是高年级的女生,在2021年,高达57%的11年级女生表示感受到很大的压力。情绪问题也有类似的趋势,在2002年至2009年期间减少,然后在2009年至2021年期间增加。在2009年至2019年期间,在调整学业压力变化后,情绪问题的队列差异估计值从2.23 (95% CI = 2.12, 2.34)降至1.64 (95% CI = 1.54, 1.75)。这与一种假设是一致的,即随着时间的推移,学业压力可能会导致情绪问题的增加。我们的研究结果显示,在2009年之前,人们对学校压力的感知有所下降,随后在2021年之前有所上升。这一增长在女性青少年中尤为明显,反映了情感问题的趋势。虽然不能排除一系列相互竞争的因果解释,但从2000年代末开始,学业压力的总体增加可能导致了这一时期青少年情绪问题的增加。
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引用次数: 0
Editorial: A granular approach to internalizing disorders in adolescents: Examining developmental pathways and environmental influences to identify high-risk youth 社论:青少年内化障碍的细粒度方法:检查发育途径和环境影响以确定高危青少年
IF 3.1 Pub Date : 2025-03-02 DOI: 10.1002/jcv2.70000
Pablo Vidal-Ribas

Adolescence is a critical developmental period during which internalizing disorders, such as depression and anxiety, frequently emerge. This editorial highlights six studies from this issue that investigate the complex interplay of genetic, physiological, cognitive, social, and environmental factors contributing to these disorders. By employing robust methods, these studies inform on mechanisms and trajectories, enhancing the identification of high-risk individuals for targeted interventions. Together, these studies emphasize the importance of nuanced, multi-factorial approaches in advancing research and practice in adolescent internalizing psychopathology. Nevertheless, future research must prioritize diverse samples, dynamic longitudinal designs, and multi-informant approaches to increase generalizability and impact.

青春期是一个关键的发育时期,在此期间,经常出现抑郁和焦虑等内化障碍。这篇社论重点介绍了本期的六项研究,这些研究调查了导致这些疾病的遗传、生理、认知、社会和环境因素之间复杂的相互作用。通过采用稳健的方法,这些研究揭示了机制和轨迹,加强了对高危个体的识别,以便进行有针对性的干预。总之,这些研究强调了微妙的、多因素的方法在推进青少年内化精神病理学研究和实践中的重要性。然而,未来的研究必须优先考虑多样化的样本、动态纵向设计和多信息方法,以增加普遍性和影响。
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引用次数: 0
The association between attention-deficit/hyperactivity disorder and narrative language: What is the role of executive function? 注意缺陷/多动障碍与叙事语言的关系:执行功能的作用是什么?
IF 3.1 Pub Date : 2025-02-25 DOI: 10.1002/jcv2.70007
Ida Bonnerup Jepsen, Cecilia Brynskov, Per Hove Thomsen, Charlotte Ulrikka Rask, Rikke Lambek

Background

Research suggests that Attention-Deficit/Hyperactivity Disorder (ADHD) may be associated with narrative language (or storytelling) difficulties, and executive functioning is hypothesized to underlie this association. However, the contribution of executive function to the narrative language production of children with ADHD is unclear and understudied. Accordingly, this study examined the association between ADHD and narrative language and whether it was mediated by executive function.

Methods

Children with a clinical diagnosis of ADHD (n = 46) and a comparison group of neurotypical children (n = 40) aged 7–11 years completed a narrative language task, as well as laboratory measures of executive function (i.e., working memory updating and response inhibition) and core language.

Results

Children with ADHD produced narratives with more ambiguous references (β = 0.72, p < 0.001), less overall coherency (β = −0.59, p = 0.001), and more morpho-syntactic errors (β = 0.47, p < 0.05). There was a significant indirect effect of core language on the association between ADHD and morpho-syntactic errors (β = 0.25, p < 0.05). No other indirect effects were statistically significant.

Conclusions

While ADHD was associated with several central aspects of narrative language production, executive function did not mediate this association. Clinicians working with children with ADHD should be aware of the potential presence of co-occurring narrative language difficulties and that narrative language support may need to target language (e.g., grammar).

研究表明,注意力缺陷/多动障碍(ADHD)可能与叙事语言(或讲故事)困难有关,而执行功能被假设为这种联系的基础。然而,执行功能对ADHD儿童叙事语言产生的贡献尚不清楚,研究不足。因此,本研究考察了ADHD与叙事语言之间的关系,以及它是否由执行功能介导。方法临床诊断为ADHD的儿童(n = 46)和对照组(n = 40) 7-11岁的神经正常儿童(n = 40)完成叙述语言任务,以及执行功能(即工作记忆更新和反应抑制)和核心语言的实验室测量。结果ADHD患儿的叙述内容歧义性较高(β = 0.72, p < 0.001),整体连贯性较差(β = - 0.59, p = 0.001),形态句法错误较多(β = 0.47, p < 0.05)。核心语言在ADHD与形态句法错误之间存在显著的间接影响(β = 0.25, p < 0.05)。其他间接影响无统计学意义。结论:虽然ADHD与叙事语言产生的几个核心方面有关,但执行功能并没有调解这种联系。与ADHD儿童一起工作的临床医生应该意识到可能同时出现的叙述性语言困难,并且叙述性语言支持可能需要针对语言(例如语法)。
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引用次数: 0
Associations between socioeconomic status and mental health trajectories during early adolescence: Findings from the Adolescent Brain Cognitive Development study 青少年早期社会经济地位与心理健康轨迹之间的关系:来自青少年大脑认知发展研究的发现
IF 3.1 Pub Date : 2025-02-25 DOI: 10.1002/jcv2.70001
Divyangana Rakesh, John C. Flournoy, Katie A. McLaughlin
<div> <section> <h3> Background</h3> <p>Low socioeconomic status (SES) during childhood is associated with higher levels of youth psychopathology. However, limited longitudinal work has examined the role of both household and neighborhood SES in shaping mental health trajectories over time using population-based data. The goal of the present study was to characterize associations between SES and changes in mental health problems during early adolescence.</p> </section> <section> <h3> Methods</h3> <p>We investigated independent and joint associations of household income-to-needs ratio, parent educational attainment, material hardship, and neighborhood disadvantage with internalizing, externalizing, and attention symptom trajectories using longitudinal data from the Adolescent Brain Cognitive Development (ABCD) Study. Given sex-based differences in mental health trajectories in the ABCD study, analyses were conducted separately in males and females. SES was assessed at baseline and youth-reported mental health was assessed across six time-points from age 10–13 years (<i>M</i> = 10.4, SD = 0.63 years; first assessed at the 6-month follow-up; <i>N</i> = 9488).</p> </section> <section> <h3> Results</h3> <p>Main effects indicated that, in general, high SES was associated with lower mental health symptoms. However, longitudinally, lower SES was associated with lower increases in mental health problems over time relative to higher SES. In females, while internalizing symptoms increased at all levels of income-to-needs, the association was most positive at higher levels of income-to-needs (<i>B</i> = 0.036, SE = 0.008, <i>p</i> < 0.001). In males, income-to-needs positively predicted externalizing (<i>B</i> = 0.022, SE = 0.007, <i>p</i> = 0.002) and attention (<i>B</i> = 0.023, SE = 0.007, <i>p</i> = 0.001) symptom trajectories, with lower income-to-needs linked to lower increases in externalizing and attention symptoms relative to higher income-to-needs. Two-way interactions between SES indicators predicting changes in symptoms were non-significant.</p> </section> <section> <h3> Conclusion</h3> <p>Our finding that youth from lower-SES backgrounds exhibited lower increases in mental health problems during early adolescence contrasts with findings from prior cross-sectional studies. However, mental health problems are on the rise and the landscape of risk for psychopathology is changing. More research is needed to understand how childhood SES contributes to risk and resilience for psychopathology during the transition to adolescence.</p> </
背景童年时期低社会经济地位(SES)与青少年较高的精神病理水平相关。然而,有限的纵向工作已经使用基于人口的数据研究了家庭和社区SES在长期塑造心理健康轨迹中的作用。本研究的目的是表征社会经济地位与青少年早期心理健康问题变化之间的关系。方法利用青少年大脑认知发展(ABCD)研究的纵向数据,研究家庭收入与需求比、父母受教育程度、物质困难和邻里劣势与内化、外化和注意症状轨迹的独立和联合关系。鉴于ABCD研究中基于性别的心理健康轨迹差异,对男性和女性分别进行了分析。在基线时对SES进行评估,在10-13岁的6个时间点对青少年报告的心理健康进行评估(M = 10.4, SD = 0.63岁;第一次评估是在6个月的随访中;N = 9488)。结果主效应表明,总体而言,高社会经济地位与较低的心理健康症状相关。然而,从纵向上看,相对于较高的社会地位,较低的社会地位与较低的心理健康问题的增长有关。在女性中,虽然内化症状在所有收入到需求的水平上都有所增加,但在收入到需求的较高水平上,这种关联最为正(B = 0.036, SE = 0.008, p < 0.001)。在男性中,收入到需求正向预测外化(B = 0.022, SE = 0.007, p = 0.002)和注意力(B = 0.023, SE = 0.007, p = 0.001)症状轨迹,相对于收入到需求较高,收入到需求较低与外化和注意力症状的增加程度较低相关。预测症状变化的SES指标之间的双向相互作用不显著。结论:我们的研究发现,来自低社会经济地位背景的青少年在青春期早期表现出较低的心理健康问题的增加,这与之前的横断面研究结果形成了对比。然而,精神健康问题正在上升,精神病理学的风险正在发生变化。需要更多的研究来了解童年时期的社会经济地位如何促进青春期过渡期间精神病理的风险和恢复能力。
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引用次数: 0
Do the early social environment and persistent peripartum depressive symptoms shape toddlers' expressive language? 早期的社会环境和持续的围产期抑郁症状是否会影响幼儿的表达性语言?
IF 3.1 Pub Date : 2025-02-11 DOI: 10.1002/jcv2.12299
Hsing-Fen Tu, Linda Forssman, Emma Fransson, Alkistis Skalkidou

Background

Extensive research suggests that peripartum depression is a risk factor for children's early language development. Yet, previous research on this association shows mixed results, often lacking information on the persistence of depression and the social context. This population-based cohort study addresses this gap by investigating the longitudinal influence of peripartum depressive symptoms on toddlers' expressive language. Specifically, we systematically examined the influences of timing, severity, and persistence of depressive symptoms during pregnancy and the first 6 months postpartum on child expressive language development, while accounting for important social and environmental factors.

Methods

This study is part of a prospective, population-based investigation conducted within the follow-up Uppsala Birth Cohort study in Uppsala, Sweden. The final analysis included 2176 mother-infant dyads (1122 boys, mean age = 18.3 months, SD = 0.7). Perinatal depressive symptoms were assessed at gestational weeks 17 and 32 and at postpartum six weeks and six months, using the Edinburgh Postnatal Depression Scale (cut-off >12). At 6 months postpartum, mothers were also invited to fill out the Postnatal Bonding Difficulty Questionnaire. At 18 months postpartum, mothers completed the Language Development Survey, which assessed expressive vocabulary and word combinations. Multivariable linear regression models were applied to examine the associations between peripartum depressive symptoms and child language development. Adjusted models incorporated background and social context variables to account for potential confounding factors.

Results

Depressive symptoms during prenatal and postnatal periods were not significantly associated with language outcomes. Our final model identified negative associations with second-born status, family history of late talkers, countryside residence, and maternal age at childbirth. Positive correlations were found for sex (girl) and pregnancy length. The final model explained 8.4% of the variance (F(22, 1566) = 6.525, p < 0.001). Furthermore, we found that persistent depressive symptoms were not significantly related to language outcomes (Kruskal-Wallis test: H = 2.227, df = 2, p = 0.21).

Conclusions

Our findings found no negative link between peripartum depressive symptoms and expressive language in toddlers, even after considering timing, seve

背景大量研究表明围产期抑郁是影响儿童早期语言发育的危险因素。然而,之前对这种关联的研究显示出好坏参半的结果,往往缺乏关于抑郁症持久性和社会背景的信息。这项以人群为基础的队列研究通过调查围产期抑郁症状对幼儿表达性语言的纵向影响来解决这一空白。具体而言,我们系统地研究了怀孕期间和产后前6个月抑郁症状的时间、严重程度和持续时间对儿童表达性语言发展的影响,同时考虑了重要的社会和环境因素。方法:本研究是在瑞典乌普萨拉进行的一项前瞻性、基于人群的随访乌普萨拉出生队列研究的一部分。最终的分析包括2176对母子,其中1122对是男孩,平均年龄18.3个月,SD = 0.7。使用爱丁堡产后抑郁量表(cut- cut >12)在妊娠第17周和32周以及产后6周和6个月时评估围产期抑郁症状。在产后6个月,母亲们也被邀请填写产后联系困难问卷。在产后18个月,妈妈们完成了语言发展调查,评估表达词汇和单词组合。采用多变量线性回归模型检验围生期抑郁症状与儿童语言发展之间的关系。调整后的模型纳入了背景和社会背景变量,以解释潜在的混杂因素。结果产前和产后抑郁症状与语言预后无显著相关。我们的最终模型确定了与第二胎身份、晚说话家族史、农村居住和母亲分娩年龄的负相关。性别(女孩)与怀孕时间呈正相关。最终模型解释了8.4%的方差(F(22,1566) = 6.525, p < 0.001)。此外,我们发现持续抑郁症状与语言结果无显著相关(Kruskal-Wallis检验:H = 2.227, df = 2, p = 0.21)。结论:我们的研究发现围产期抑郁症状与幼儿的表达性语言之间没有负相关,即使考虑了时间、严重程度和持续时间。虽然没有观察到围产期抑郁症状的直接负面影响,但在生命后期的长期累积效应仍不清楚。
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引用次数: 0
Characteristics of the parent-child relationship at 18-months of age predict the onset and type of mental disorders in childhood and adolescence: A longitudinal nested birth cohort study 18月龄亲子关系特征预测儿童和青少年精神障碍的发病和类型:一项纵向嵌套出生队列研究
IF 3.1 Pub Date : 2025-02-04 DOI: 10.1002/jcv2.12304
Kristine Kahr Nilsson, Lasse Grønnebæk, Ole Karkov Østergård, Susanne Landorph, Tine Houmann, Else Marie Olsen, Anne Mette Skovgaard

Background

The quality of the parent-child relationship in the first years of childhood has been associated with various long-term mental health outcomes. However, it is unclear whether specific characteristics of the early parent-child relationship predict the onset of mental disorders. The aim of this study was therefore to examine child, parent, and dyadic characteristics of the early parent-child relationship as predictors of mental disorders in childhood and adolescence.

Method

As a part of the Copenhagen Child Cohort 2000, a child cohort of 295 children participated in the study at 18-months of age and were subsequently followed until late adolescence. Child, parent, and dyadic dimensions of the early parent-child relationship were assessed using the observational Parent-Child Early Relational Assessment. The outcomes were mental disorders subsequently diagnosed in childhood and adolescence.

Results

Cox-regression analyses suggested that parent characteristics involving negative affect and behavior, intrusiveness and insensitivity during early parent child interactions were associated with increased risk of the child being diagnosed with a mental disorder at later ages. However, variation was noted across specific diagnoses. Parental negative affect and behavior was specifically associated with increased risk of attention deficit hyperactivity disorder, while infant dysregulation and irritability was specifically associated with increased risk of autism spectrum disorders. These results remained significant after adjusting for parental mental disorders and early mental health problems of the child.

Conclusion

Disorder-specific associations were observed between dysfunctions in the early parent-child relationship and subsequent mental disorders. Improving such early relational dysfunctions may support the goals of early interventions that aim to mitigate the risk of mental disorders from a very early age.

儿童最初几年的亲子关系质量与各种长期心理健康结果有关。然而,尚不清楚早期亲子关系的具体特征是否能预测精神障碍的发生。因此,本研究的目的是检验儿童、父母和早期亲子关系的二元特征作为儿童和青少年精神障碍的预测因素。方法:作为哥本哈根儿童队列2000的一部分,295名儿童在18个月大时参加了这项研究,并随后被跟踪到青春期后期。使用观察性亲子早期关系评估来评估早期亲子关系的子女、父母和二元维度。结果是随后在儿童和青少年时期被诊断出精神障碍。结果cox回归分析表明,父母在早期亲子互动中的负面影响和行为、侵入性和不敏感等特征与儿童日后被诊断为精神障碍的风险增加有关。然而,在特定的诊断中存在差异。父母的负面影响和行为与注意力缺陷多动障碍的风险增加特别相关,而婴儿的调节障碍和易怒与自闭症谱系障碍的风险增加特别相关。在调整了父母精神障碍和儿童早期精神健康问题后,这些结果仍然显著。结论早期亲子关系功能障碍与后续精神障碍存在障碍特异性关联。改善这种早期的关系功能障碍可能支持早期干预的目标,即从很小的年龄开始减轻精神障碍的风险。
{"title":"Characteristics of the parent-child relationship at 18-months of age predict the onset and type of mental disorders in childhood and adolescence: A longitudinal nested birth cohort study","authors":"Kristine Kahr Nilsson,&nbsp;Lasse Grønnebæk,&nbsp;Ole Karkov Østergård,&nbsp;Susanne Landorph,&nbsp;Tine Houmann,&nbsp;Else Marie Olsen,&nbsp;Anne Mette Skovgaard","doi":"10.1002/jcv2.12304","DOIUrl":"10.1002/jcv2.12304","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The quality of the parent-child relationship in the first years of childhood has been associated with various long-term mental health outcomes. However, it is unclear whether specific characteristics of the early parent-child relationship predict the onset of mental disorders. The aim of this study was therefore to examine child, parent, and dyadic characteristics of the early parent-child relationship as predictors of mental disorders in childhood and adolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>As a part of the Copenhagen Child Cohort 2000, a child cohort of 295 children participated in the study at 18-months of age and were subsequently followed until late adolescence. Child, parent, and dyadic dimensions of the early parent-child relationship were assessed using the observational Parent-Child Early Relational Assessment. The outcomes were mental disorders subsequently diagnosed in childhood and adolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cox-regression analyses suggested that parent characteristics involving negative affect and behavior, intrusiveness and insensitivity during early parent child interactions were associated with increased risk of the child being diagnosed with a mental disorder at later ages. However, variation was noted across specific diagnoses. Parental negative affect and behavior was specifically associated with increased risk of attention deficit hyperactivity disorder, while infant dysregulation and irritability was specifically associated with increased risk of autism spectrum disorders. These results remained significant after adjusting for parental mental disorders and early mental health problems of the child.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Disorder-specific associations were observed between dysfunctions in the early parent-child relationship and subsequent mental disorders. Improving such early relational dysfunctions may support the goals of early interventions that aim to mitigate the risk of mental disorders from a very early age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73542,"journal":{"name":"JCPP advances","volume":"5 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1002/jcv2.12304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of CBCL depression scores of adolescents in three independent datasets 三个独立数据集对青少年CBCL抑郁评分的验证
IF 3.1 Pub Date : 2025-01-29 DOI: 10.1002/jcv2.12298
Marie Zelenina, Daniel S. Pine, Argyris Stringaris, Dylan M. Nielson

Background

Depression is common, burdensome, and is frequently first diagnosed in adolescents. The popular Adolescent Brain Cognitive Development dataset (ABCD) provides an attractive opportunity to research depression in adolescents. The only continuous measure of depression, as defined by DSM-5, in ABCD is the Child Behavior Checklist's DSM-5-Oriented Affective Problems scale (CBCL-Aff). We validated CBCL-Aff in the ABCD data and confirmed our results on two independent datasets: the Healthy Brain Network (HBN) and the Brazilian High Risk Cohort Study (BHRC).

Methods

We tested Sensitivity, Specificity and Strict Specificity. Our participants were aged 8–11 years (ABCD) or 8–12 years (HBN, BHRC). Sample size was 183–1189 participants, depending on the analysis. Sample sizes and positive case ratios were established from power estimations. We evaluated goodness of prediction with AUCROCs.

Results

In ABCD with parent-report diagnoses, CBCL-Aff had the AUCROC value of 0.95 in the Sensitivity and 0.87 in the Specificity analysis. In ABCD with child-report diagnoses, CBCL-Aff had the AUCROC of 0.62 (Sensitivity), 0.48 (Specificity) and 0.46 (Strict Specificity). In HBN and BHRC, CBCL-Aff successfully predicted clinician-report diagnoses (HBN Sensitivity: AUCROC = 0.86, Specificity: AUCROC = 0.71; BHRC Sensitivity: AUCROC = 0.90, Specificity: AUCROC = 0.80, Strict Specificity: AUCROC = 0.78).

Conclusions

We validated CBCL-Aff as a measure of depression in adolescents aged 8–11 years and we recommend its use with the following limitation: as parents and children disagreed on the child's symptoms, we discuss implications of using a parent-report only measure of child depression.

背景:抑郁症是一种常见的、令人负担的疾病,并且经常在青少年中首次被诊断出来。流行的青少年大脑认知发展数据集(ABCD)为研究青少年抑郁症提供了一个有吸引力的机会。根据DSM-5的定义,ABCD中唯一持续测量抑郁症的方法是儿童行为检查表的DSM-5导向情感问题量表(CBCL-Aff)。我们在ABCD数据中验证了CBCL-Aff,并在两个独立的数据集上证实了我们的结果:健康大脑网络(HBN)和巴西高风险队列研究(BHRC)。方法进行敏感性、特异性和严格特异性检测。我们的参与者年龄为8-11岁(ABCD)或8-12岁(HBN, BHRC)。根据分析结果,样本量为183-1189名参与者。样本量和阳性病例比由功率估计确定。我们用aucroc评估预测的优度。结果在父母报告诊断的ABCD中,CBCL-Aff的AUCROC敏感性为0.95,特异性为0.87。在儿童报告诊断的ABCD中,CBCL-Aff的AUCROC分别为0.62(敏感性)、0.48(特异性)和0.46(严格特异性)。在HBN和BHRC中,CBCL-Aff成功预测临床报告诊断(HBN敏感性:AUCROC = 0.86,特异性:AUCROC = 0.71; BHRC敏感性:AUCROC = 0.90,特异性:AUCROC = 0.80,严格特异性:AUCROC = 0.78)。结论:我们验证了CBCL-Aff是8-11岁青少年抑郁的一种测量方法,我们建议使用它,但有以下局限性:由于父母和孩子对孩子的症状不一致,我们讨论了使用父母报告的儿童抑郁测量方法的含义。
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引用次数: 0
Emotion and peer problems in autistic adolescents: The role of puberty, school adjustment and bullying 自闭症青少年的情绪和同伴问题:青春期、学校适应和欺凌的作用
IF 3.1 Pub Date : 2025-01-25 DOI: 10.1002/jcv2.12305
Erin O. Dawe-Lane, Rob Saunders, Eirini Flouri, William P. L. Mandy

Background

Emotion and peer problems tend to increase in autistic young people during adolescence. However, the extent to which endogenous (e.g., pubertal maturation) and exogenous (e.g., school adjustment, bullying) factors contribute to trajectories of emotion and peer problems in autistic young people is unclear.

Methods

Using data from the Millennium Cohort Study (MCS), we fitted latent growth curves to model initial levels and growth in emotion and peer problems during adolescence. We used generalised structural equation models to investigate whether pubertal maturation, school adjustment, bullying, and timing of autism diagnosis (none, early [<8 years] or late [≥8 years]) predict initial levels and growth of emotion and peer problems in autistic and non-autistic young people, separately for males (n = 780) and females (n = 172).

Results

In females, there were significant interactions between timing of diagnosis and (a) school adjustment and (b) bullying. In females with a late diagnosis of autism, lower school adjustment and greater bullying were associated with greater growth of emotion problems during adolescence. Furthermore, in females with an early diagnosis, lower school adjustment was associated with greater initial levels of peer problems. In males, later pubertal maturation was associated with greater growth of emotion and peer problems during adolescence, irrespective of autism diagnosis. In males with an early diagnosis of autism, greater bullying was associated with greater growth of emotion problems during adolescence.

Conclusion

School adjustment and bullying were associated with increasing emotion and peer problems in autistic adolescents, but their relative contribution varied according to timing of autism diagnosis and sex. Overall, this study supports the need for early identification and intervention for young autistic people experiencing poor school adjustment and bullying during adolescence.

青少年自闭症患者的情绪和同伴问题倾向于增加。然而,内源性因素(如青春期成熟)和外源性因素(如学校适应、欺凌)在多大程度上影响了自闭症青少年的情感和同伴问题轨迹尚不清楚。方法使用来自千禧年队列研究(MCS)的数据,我们拟合了潜在增长曲线,以模拟青春期情绪和同伴问题的初始水平和增长。我们使用广义结构方程模型分别对男性(n = 780)和女性(n = 172)的自闭症和非自闭症青少年的情绪和同伴问题的初始水平和发展进行了研究,研究对象包括青春期成熟、学校适应、欺凌和自闭症诊断时间(无、早[<;8年]或晚[≥8年])。结果在女性中,诊断时间与(a)学校适应和(b)欺凌之间存在显著的相互作用。在诊断为自闭症较晚的女性中,较低的学校适应能力和较强的欺凌行为与青春期情绪问题的严重增长有关。此外,在早期诊断的女性中,较低的学校适应与较高的同伴问题初始水平相关。在男性中,较晚的青春期成熟与青春期情绪和同伴问题的增长有关,与自闭症诊断无关。在早期诊断为自闭症的男性中,更严重的欺凌行为与青春期情绪问题的严重增长有关。结论学校适应和欺凌与自闭症青少年情绪和同伴问题的增加有关,但其相对作用因自闭症诊断时间和性别而异。总的来说,本研究支持早期识别和干预青少年自闭症患者在青春期经历学校适应不良和欺凌的必要性。
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引用次数: 0
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