James F Leckman, Michael H Bloch, Robert A King, Lawrence Scahill
{"title":"Phenomenology of tics and natural history of tic disorders.","authors":"James F Leckman, Michael H Bloch, Robert A King, Lawrence Scahill","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"99 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25904967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous electroencephalogram-functional magnetic resonance imaging in neocortical epilepsies.","authors":"Zheng Wang, John R Ives, Seyed M Mirsattari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"129-39"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Basic mechanisms in status epilepticus: role of calcium in neuronal injury and the induction of epileptogenesis.","authors":"Robert J DeLorenzo, David A Sun","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"187-97"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical evidence that epilepsy is not a progressive disorder with special emphasis on epilepsy syndromes that do not progress.","authors":"Peter Camfield, Carol Camfield","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"315-22"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25775496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannes Lohi, Elayne M Chan, Stephen W Scherer, Berge A Minassian
{"title":"On the road to tractability: the current biochemical understanding of progressive myoclonus epilepsies.","authors":"Hannes Lohi, Elayne M Chan, Stephen W Scherer, Berge A Minassian","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"399-415"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25775507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The definition and prediction of intractable epilepsy in children.","authors":"Kevin Farrell, Elaine Wirrell, Sharon Whiting","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"435-42"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25775510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yazmín Morales, Joseph E Parisi, Claudia F Lucchinetti
The idiopathic inflammatory demyelinating diseases (IIDDs) consist of a broad spectrum of disorders that vary in their clinical course, regional distribution, and pathology. Though pathology of these demyelinating disorders demonstrates extensive interindividual heterogeneity, there is notable homogeneity within individual patients. The relation between the diverse underlying pathology of IIDDs and the various clinical, paraclinical, and radiological findings is unclear. Finding less-invasive clinical or paraclinical surrogate markers, which accurately and reliably predict the underlying distinct pathologies within the family of IIDDs, can potentially guide future therapies that better target specific pathogenic mechanisms.
{"title":"The pathology of multiple sclerosis: evidence for heterogeneity.","authors":"Yazmín Morales, Joseph E Parisi, Claudia F Lucchinetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The idiopathic inflammatory demyelinating diseases (IIDDs) consist of a broad spectrum of disorders that vary in their clinical course, regional distribution, and pathology. Though pathology of these demyelinating disorders demonstrates extensive interindividual heterogeneity, there is notable homogeneity within individual patients. The relation between the diverse underlying pathology of IIDDs and the various clinical, paraclinical, and radiological findings is unclear. Finding less-invasive clinical or paraclinical surrogate markers, which accurately and reliably predict the underlying distinct pathologies within the family of IIDDs, can potentially guide future therapies that better target specific pathogenic mechanisms.</p>","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"98 ","pages":"27-45"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25790353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ADHD is a complex co-morbidity, as it is heteregeneous in terms of the clinical subtypes, but also in terms of the circuits involved and the level of involvement within those circuits. Specially focusing on the relationship of ADHD to TS, this author's studies have added some neurobehavioral and some anatomical magnetic resonance imaging evidence suggesting the ADHD occurring with TS, appears like "garden-variety" ADHD, at least in the matched research sample. The similarities of neuroanatomical findings in the TS plus ADHD and ADHD groups and their distinctness from neuroanatomical findings in childdren with "pure TS provide some parallels to the observed similarity of functional deficit in TS plus ADHD and ADHD alone groups and the relative lack of functional deficits in children with TS only. More specifically, the results of a decade of this author's research with the approximately 40% of children with TS who are free of ADHD indicate that they are entirely free of the motor control and executive control deficits of children with ADHD alone or TS plus ADHD, but they do have oculomotor control deficits in the initiation of prosaccades, regardless of their ADHD status. The neuroanatomical data in TS only is also of interest because it reflects increased white matter, particularly in the right frontal lobe and four out of five regions of the corps callosum, including the rostral portion most affiliated with the frontal lobes. It should be emphasized that almost everything summarized abouve is true for boys, whereas samples of girls grouped similarly have not yielded the same results.
{"title":"Attention deficit hyperactivity disorder: the childhood co-morbidity that most influences the disability burden in Tourette syndrome.","authors":"Martha Bridge Denckla","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>ADHD is a complex co-morbidity, as it is heteregeneous in terms of the clinical subtypes, but also in terms of the circuits involved and the level of involvement within those circuits. Specially focusing on the relationship of ADHD to TS, this author's studies have added some neurobehavioral and some anatomical magnetic resonance imaging evidence suggesting the ADHD occurring with TS, appears like \"garden-variety\" ADHD, at least in the matched research sample. The similarities of neuroanatomical findings in the TS plus ADHD and ADHD groups and their distinctness from neuroanatomical findings in childdren with \"pure TS provide some parallels to the observed similarity of functional deficit in TS plus ADHD and ADHD alone groups and the relative lack of functional deficits in children with TS only. More specifically, the results of a decade of this author's research with the approximately 40% of children with TS who are free of ADHD indicate that they are entirely free of the motor control and executive control deficits of children with ADHD alone or TS plus ADHD, but they do have oculomotor control deficits in the initiation of prosaccades, regardless of their ADHD status. The neuroanatomical data in TS only is also of interest because it reflects increased white matter, particularly in the right frontal lobe and four out of five regions of the corps callosum, including the rostral portion most affiliated with the frontal lobes. It should be emphasized that almost everything summarized abouve is true for boys, whereas samples of girls grouped similarly have not yielded the same results.</p>","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"99 ","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25903757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A genome-wide scan and fine mapping in Tourette syndrome families.","authors":"David L Pauls","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"99 ","pages":"130-5"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25903766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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