Lawrence Scahill, Susan Williams, Mary Schwab-Stone, Judy Applegate, James F Leckman
{"title":"Disruptive behavior problems in a community sample of children with tic disorders.","authors":"Lawrence Scahill, Susan Williams, Mary Schwab-Stone, Judy Applegate, James F Leckman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"99 ","pages":"184-90"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25903773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Future and alternative therapies in Tourette syndrome.","authors":"Roger Kurlan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"99 ","pages":"248-53"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25905949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of interferon-beta in the treatment of multiple sclerosis.","authors":"Joy Derwenskus, Fred D Lublin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"98 ","pages":"257-71"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25790220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The genetics and genetic epidemiology of multiple sclerosis: the \"hard facts\".","authors":"A D Sadovnick","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"98 ","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25790352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Making the diagnosis of multiple sclerosis.","authors":"Gary Birnbaum","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"98 ","pages":"111-24"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25790358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominik Zumsteg, Danielle M Andrade, Richard A Wennberg
{"title":"Clinical electrophysiology factors indicative of intractability in patients with temporal lobe epilepsy.","authors":"Dominik Zumsteg, Danielle M Andrade, Richard A Wennberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"45-62"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clearly, the root cause of intractability in epilepsy is currently unknown. Whereas the aforementioned findings may shed light on putative underpinnings, they are by no means an exhaustive list of possibilities. However, new and more effective animal models are continually being created or discovered that take into account genetic predisposition for seizure. At the moment, amygdala kindling appears to be the best choice of the intact animal models. In this vein, the genetically predisposed seizure-prone (Fast kindling) and seizure-resistant (Slow kindling) strains may help speak to many important remaining questions in human epilepsy. Hopefully, these models, to some degree, target correct human subpopulations that are prone or resistant to epilepsy and, when used appropriately, could expedite epilepsy research and future discoveries leading to pharmacoresistance and intractability.
{"title":"Parahippocampal networks, intractability, and the chronic epilepsy of kindling.","authors":"Dan C McIntyre, Krista L Gilby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clearly, the root cause of intractability in epilepsy is currently unknown. Whereas the aforementioned findings may shed light on putative underpinnings, they are by no means an exhaustive list of possibilities. However, new and more effective animal models are continually being created or discovered that take into account genetic predisposition for seizure. At the moment, amygdala kindling appears to be the best choice of the intact animal models. In this vein, the genetically predisposed seizure-prone (Fast kindling) and seizure-resistant (Slow kindling) strains may help speak to many important remaining questions in human epilepsy. Hopefully, these models, to some degree, target correct human subpopulations that are prone or resistant to epilepsy and, when used appropriately, could expedite epilepsy research and future discoveries leading to pharmacoresistance and intractability.</p>","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What intractability information is there in the type of generalized seizure?","authors":"Ismail S Mohamed, Berge A Minassian","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"141-7"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology and clinical presentation of status epilepticus.","authors":"Robert J DeLorenzo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"97 ","pages":"199-215"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25774403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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